Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	383.0	3069.0	8.0	-0.841	0.217	1000.0	-1000.0	-0.031	-1000.0
HIF-1-alpha transcription factor network	212.0	16112.0	76.0	-1.331	0.026	1000.0	-1000.0	-0.164	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	188.0	6408.0	34.0	-0.607	0.016	1000.0	-1000.0	-0.098	-1000.0
TCGA08_p53	146.0	1023.0	7.0	-0.652	0.313	1000.0	-1000.0	-0.022	-1000.0
TCR signaling in naïve CD8+ T cells	141.0	13123.0	93.0	-0.655	0.328	1000.0	-1000.0	-0.12	-1000.0
FOXA2 and FOXA3 transcription factor networks	120.0	5537.0	46.0	-1.22	0.025	1000.0	-1000.0	-0.1	-1000.0
Syndecan-4-mediated signaling events	119.0	7998.0	67.0	-0.637	0.108	1000.0	-1000.0	-0.142	-1000.0
Aurora B signaling	119.0	7979.0	67.0	-0.404	0.016	1000.0	-1000.0	-0.11	-1000.0
FOXM1 transcription factor network	110.0	5633.0	51.0	-0.823	0.04	1000.0	-1000.0	-0.187	-1000.0
IL12-mediated signaling events	107.0	9370.0	87.0	-0.69	0.162	1000.0	-1000.0	-0.158	-1000.0
Glypican 1 network	106.0	5100.0	48.0	-0.557	0.045	1000.0	-1000.0	-0.069	-1000.0
PDGFR-alpha signaling pathway	104.0	4618.0	44.0	-0.275	0.034	1000.0	-1000.0	-0.09	-1000.0
JNK signaling in the CD4+ TCR pathway	84.0	1429.0	17.0	-0.412	0.016	1000.0	-1000.0	-0.092	-1000.0
amb2 Integrin signaling	84.0	6941.0	82.0	-0.552	0.016	1000.0	-1000.0	-0.124	-1000.0
IL4-mediated signaling events	75.0	6852.0	91.0	-0.839	0.544	1000.0	-1000.0	-0.175	-1000.0
EGFR-dependent Endothelin signaling events	74.0	1561.0	21.0	-0.667	0.016	1000.0	-1000.0	-0.117	-1000.0
HIF-2-alpha transcription factor network	72.0	3104.0	43.0	-0.762	0.342	1000.0	-1000.0	-0.114	-1000.0
Aurora C signaling	71.0	497.0	7.0	-0.393	0.012	1000.0	-1000.0	-0.064	-1000.0
Caspase cascade in apoptosis	70.0	5239.0	74.0	-0.325	0.161	1000.0	-1000.0	-0.076	-1000.0
Glypican 2 network	69.0	278.0	4.0	-0.123	-1000.0	1000.0	-1000.0	-0.054	-1000.0
Syndecan-1-mediated signaling events	67.0	2282.0	34.0	-0.411	0.016	1000.0	-1000.0	-0.102	-1000.0
BMP receptor signaling	64.0	5240.0	81.0	-0.691	0.016	1000.0	-1000.0	-0.131	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	60.0	2004.0	33.0	-0.83	0.016	1000.0	-1000.0	-0.094	-1000.0
IL23-mediated signaling events	59.0	3582.0	60.0	-0.392	0.021	1000.0	-1000.0	-0.185	-1000.0
Signaling events mediated by the Hedgehog family	49.0	2577.0	52.0	-0.437	0.119	1000.0	-1000.0	-0.124	-1000.0
Fc-epsilon receptor I signaling in mast cells	46.0	4510.0	97.0	-0.32	0.04	1000.0	-1000.0	-0.122	-1000.0
S1P1 pathway	43.0	1562.0	36.0	-0.381	0.018	1000.0	-1000.0	-0.088	-1000.0
IL27-mediated signaling events	42.0	2159.0	51.0	-0.62	0.074	1000.0	-1000.0	-0.132	-1000.0
Ephrin A  reverse signaling	41.0	292.0	7.0	-0.059	0.0	1000.0	-1000.0	-0.042	-1000.0
Effects of Botulinum toxin	41.0	1083.0	26.0	-0.361	0.016	1000.0	-1000.0	-0.099	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	41.0	2829.0	68.0	-0.542	0.063	1000.0	-1000.0	-0.177	-1000.0
Arf6 signaling events	39.0	2448.0	62.0	-0.667	0.016	1000.0	-1000.0	-0.089	-1000.0
VEGFR1 specific signals	38.0	2131.0	56.0	-0.466	0.045	1000.0	-1000.0	-0.111	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1175.0	31.0	-0.455	0.016	1000.0	-1000.0	-0.17	-1000.0
p75(NTR)-mediated signaling	36.0	4539.0	125.0	-0.415	0.016	1000.0	-1000.0	-0.149	-1000.0
LPA4-mediated signaling events	34.0	417.0	12.0	-0.166	0.026	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by STAT5	34.0	759.0	22.0	-0.435	0.038	1000.0	-1000.0	-0.07	-1000.0
IL2 signaling events mediated by PI3K	33.0	1953.0	58.0	-0.433	0.032	1000.0	-1000.0	-0.114	-1000.0
PLK1 signaling events	31.0	2651.0	85.0	-0.376	0.016	1000.0	-1000.0	-0.075	-1000.0
IL6-mediated signaling events	31.0	2367.0	75.0	-0.288	0.076	1000.0	-1000.0	-0.12	-1000.0
BCR signaling pathway	31.0	3150.0	99.0	-0.342	0.035	1000.0	-1000.0	-0.142	-1000.0
Coregulation of Androgen receptor activity	30.0	2349.0	76.0	-0.915	0.033	1000.0	-1000.0	-0.07	-1000.0
Regulation of Telomerase	29.0	3020.0	102.0	-0.668	0.051	1000.0	-1000.0	-0.152	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	29.0	2335.0	78.0	-0.317	0.045	1000.0	-1000.0	-0.107	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	28.0	1550.0	54.0	-0.651	0.031	1000.0	-1000.0	-0.136	-1000.0
Reelin signaling pathway	28.0	1570.0	56.0	-0.24	0.016	1000.0	-1000.0	-0.113	-1000.0
Glucocorticoid receptor regulatory network	27.0	3146.0	114.0	-0.407	0.161	1000.0	-1000.0	-0.107	-1000.0
Integrins in angiogenesis	27.0	2331.0	84.0	-0.381	0.04	1000.0	-1000.0	-0.129	-1000.0
Aurora A signaling	24.0	1484.0	60.0	-0.239	0.053	1000.0	-1000.0	-0.091	-1000.0
EPO signaling pathway	24.0	1372.0	55.0	-0.286	0.018	1000.0	-1000.0	-0.142	-1000.0
Angiopoietin receptor Tie2-mediated signaling	24.0	2125.0	88.0	-0.313	0.075	1000.0	-1000.0	-0.152	-1000.0
Visual signal transduction: Rods	24.0	1285.0	52.0	-0.288	0.016	1000.0	-1000.0	-0.114	-1000.0
Signaling events mediated by PTP1B	23.0	1755.0	76.0	-0.67	0.049	1000.0	-1000.0	-0.111	-1000.0
Syndecan-2-mediated signaling events	20.0	1439.0	69.0	-0.552	0.053	1000.0	-1000.0	-0.092	-1000.0
Endothelins	20.0	1958.0	96.0	-0.347	0.086	1000.0	-1000.0	-0.107	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	20.0	900.0	45.0	-0.566	0.062	1000.0	-1000.0	-0.123	-1000.0
Regulation of nuclear SMAD2/3 signaling	19.0	2673.0	136.0	-0.451	0.1	1000.0	-1000.0	-0.108	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2347.0	120.0	-0.165	0.142	1000.0	-1000.0	-0.129	-1000.0
Wnt signaling	18.0	127.0	7.0	-0.068	0.016	1000.0	-1000.0	-0.077	-1000.0
S1P3 pathway	17.0	719.0	42.0	-0.377	0.062	1000.0	-1000.0	-0.084	-1000.0
Thromboxane A2 receptor signaling	16.0	1732.0	105.0	-0.667	0.067	1000.0	-1000.0	-0.113	-1000.0
Presenilin action in Notch and Wnt signaling	16.0	1035.0	61.0	-0.188	0.093	1000.0	-1000.0	-0.106	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	16.0	609.0	37.0	-0.294	0.026	1000.0	-1000.0	-0.116	-1000.0
Ceramide signaling pathway	15.0	1159.0	76.0	-0.667	0.232	1000.0	-1000.0	-0.085	-1000.0
FoxO family signaling	15.0	1003.0	64.0	-0.569	0.122	1000.0	-1000.0	-0.1	-1000.0
LPA receptor mediated events	15.0	1612.0	102.0	-0.396	0.061	1000.0	-1000.0	-0.12	-1000.0
Sphingosine 1-phosphate (S1P) pathway	14.0	416.0	28.0	-0.135	0.024	1000.0	-1000.0	-0.076	-1000.0
PLK2 and PLK4 events	14.0	44.0	3.0	-0.016	0.011	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling events	14.0	71.0	5.0	-0.023	0.016	1000.0	-1000.0	-0.066	-1000.0
FAS signaling pathway (CD95)	13.0	638.0	47.0	-0.424	0.027	1000.0	-1000.0	-0.066	-1000.0
Canonical Wnt signaling pathway	13.0	708.0	51.0	-0.187	0.096	1000.0	-1000.0	-0.085	-1000.0
Class I PI3K signaling events	13.0	1003.0	73.0	-0.471	0.036	1000.0	-1000.0	-0.114	-1000.0
Regulation of Androgen receptor activity	13.0	932.0	70.0	-0.957	0.04	1000.0	-1000.0	-0.096	-1000.0
ErbB4 signaling events	12.0	839.0	69.0	-0.179	0.105	1000.0	-1000.0	-0.129	-1000.0
IFN-gamma pathway	12.0	879.0	68.0	-0.373	0.018	1000.0	-1000.0	-0.143	-1000.0
Nongenotropic Androgen signaling	12.0	638.0	52.0	-0.177	0.07	1000.0	-1000.0	-0.088	-1000.0
S1P5 pathway	11.0	193.0	17.0	-0.135	0.045	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1495.0	125.0	-0.392	0.043	1000.0	-1000.0	-0.155	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	863.0	74.0	-0.667	0.098	1000.0	-1000.0	-0.131	-1000.0
S1P4 pathway	11.0	277.0	25.0	-0.135	0.034	1000.0	-1000.0	-0.078	-1000.0
Noncanonical Wnt signaling pathway	10.0	270.0	26.0	-0.115	0.016	1000.0	-1000.0	-0.131	-1000.0
Visual signal transduction: Cones	9.0	370.0	38.0	-0.041	0.016	1000.0	-1000.0	-0.088	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	-0.02	0.016	1000.0	-1000.0	-0.048	-1000.0
TCGA08_rtk_signaling	9.0	239.0	26.0	-0.277	0.041	1000.0	-1000.0	-0.033	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	731.0	82.0	-0.064	0.025	1000.0	-1000.0	-0.123	-1000.0
Class IB PI3K non-lipid kinase events	8.0	24.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by PRL	7.0	245.0	34.0	-0.055	0.045	1000.0	-1000.0	-0.089	-1000.0
Canonical NF-kappaB pathway	6.0	270.0	39.0	-0.189	0.075	1000.0	-1000.0	-0.112	-1000.0
Insulin-mediated glucose transport	6.0	194.0	32.0	-0.083	0.068	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by HDAC Class III	6.0	240.0	40.0	-0.057	0.032	1000.0	-1000.0	-0.074	-1000.0
IL1-mediated signaling events	6.0	401.0	62.0	-0.091	0.059	1000.0	-1000.0	-0.137	-1000.0
Ephrin B reverse signaling	6.0	319.0	48.0	-0.03	0.031	1000.0	-1000.0	-0.117	-1000.0
p38 MAPK signaling pathway	6.0	276.0	44.0	-0.099	0.049	1000.0	-1000.0	-0.088	-1000.0
ErbB2/ErbB3 signaling events	5.0	388.0	65.0	-0.127	0.059	1000.0	-1000.0	-0.106	-1000.0
Arf6 downstream pathway	5.0	225.0	43.0	-0.033	0.033	1000.0	-1000.0	-0.063	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	85.0	15.0	-0.0	0.036	1000.0	-1000.0	-0.05	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	211.0	36.0	-0.027	0.031	1000.0	-1000.0	-0.098	-1000.0
Syndecan-3-mediated signaling events	5.0	209.0	35.0	-0.039	0.016	1000.0	-1000.0	-0.099	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	430.0	76.0	-0.026	0.067	1000.0	-1000.0	-0.115	-1000.0
Arf6 trafficking events	5.0	411.0	71.0	-0.124	0.058	1000.0	-1000.0	-0.105	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	369.0	85.0	-0.037	0.079	1000.0	-1000.0	-0.102	-1000.0
EPHB forward signaling	4.0	369.0	85.0	-0.075	0.069	1000.0	-1000.0	-0.138	-1000.0
Plasma membrane estrogen receptor signaling	4.0	372.0	86.0	-0.162	0.07	1000.0	-1000.0	-0.119	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	84.0	17.0	-0.038	0.055	1000.0	-1000.0	-0.069	-1000.0
BARD1 signaling events	3.0	222.0	57.0	-0.168	0.044	1000.0	-1000.0	-0.096	-1000.0
Osteopontin-mediated events	3.0	122.0	38.0	-0.03	0.097	1000.0	-1000.0	-0.156	-1000.0
Cellular roles of Anthrax toxin	3.0	119.0	39.0	-0.022	0.027	1000.0	-1000.0	-0.042	-1000.0
PDGFR-beta signaling pathway	3.0	380.0	97.0	-0.056	0.087	1000.0	-1000.0	-0.121	-1000.0
E-cadherin signaling in keratinocytes	3.0	164.0	43.0	-0.291	0.054	1000.0	-1000.0	-0.111	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	135.0	65.0	-0.06	0.093	1000.0	-1000.0	-0.09	-1000.0
ceramide signaling pathway	2.0	131.0	49.0	-0.117	0.054	1000.0	-1000.0	-0.068	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	130.0	52.0	-0.031	0.092	1000.0	-1000.0	-0.088	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	181.0	83.0	-0.083	0.081	1000.0	-1000.0	-0.11	-1000.0
Retinoic acid receptors-mediated signaling	2.0	126.0	58.0	-0.025	0.062	1000.0	-1000.0	-0.11	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	115.0	44.0	-0.046	0.049	1000.0	-1000.0	-0.072	-1000.0
Regulation of p38-alpha and p38-beta	2.0	153.0	54.0	-0.04	0.073	1000.0	-1000.0	-0.086	-1000.0
Insulin Pathway	2.0	214.0	74.0	-0.032	0.055	1000.0	-1000.0	-0.125	-1000.0
Signaling events mediated by HDAC Class II	1.0	124.0	75.0	-0.026	0.051	1000.0	-1000.0	-0.099	-1000.0
Circadian rhythm pathway	1.0	33.0	22.0	-0.019	0.064	1000.0	-1000.0	-0.089	-1000.0
mTOR signaling pathway	1.0	103.0	53.0	-0.01	0.044	1000.0	-1000.0	-0.089	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	104.0	68.0	-0.083	0.059	1000.0	-1000.0	-0.103	-1000.0
Nectin adhesion pathway	1.0	98.0	63.0	-0.016	0.078	1000.0	-1000.0	-0.108	-1000.0
Signaling events mediated by HDAC Class I	1.0	194.0	104.0	-0.028	0.063	1000.0	-1000.0	-0.102	-1000.0
Atypical NF-kappaB pathway	1.0	55.0	31.0	-0.02	0.037	1000.0	-1000.0	-0.099	-1000.0
IGF1 pathway	1.0	98.0	57.0	-0.065	0.071	1000.0	-1000.0	-0.137	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.062	1000.0	-1000.0	-0.104	-1000.0
TRAIL signaling pathway	0.0	27.0	48.0	-0.002	0.07	1000.0	-1000.0	-0.092	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.087	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.006	0.016	1000.0	-1000.0	-0.068	-1000.0
Arf1 pathway	0.0	31.0	54.0	-0.01	0.043	1000.0	-1000.0	-0.077	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.005	0.016	1000.0	-1000.0	-0.097	-1000.0
Total	4254	222079	7203	-39.9066087291	-991.853072278	131000	-131000	-13.4513717761	-131000