E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.124 -9999.0 0.0 -0.479 17.0 17.0 KLHL20 0.022 0.075 0.209 2.0 -0.321 2.0 4.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.636 7.0 7.0 Rac1/GDP 0.024 0.087 0.304 4.0 -9999.0 0.0 4.0 ENAH -0.02 0.123 -9999.0 0.0 -0.48 18.0 18.0 AP1M1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.028 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.034 -9999.0 0.0 -0.202 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.083 -9999.0 0.0 -0.368 14.0 14.0 RAPGEF1 -0.011 0.121 -9999.0 0.0 -0.429 12.0 12.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.129 -9999.0 0.0 -0.495 18.0 18.0 CRK -0.01 0.12 -9999.0 0.0 -0.467 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.028 0.089 -9999.0 0.0 -0.426 16.0 16.0 alphaE/beta7 Integrin 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.02 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.017 0.12 -9999.0 0.0 -0.48 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.006 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.05 0.025 -9999.0 0.0 -0.336 1.0 1.0 PI3K -0.007 0.038 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.022 0.102 -9999.0 0.0 -0.493 19.0 19.0 TIAM1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.031 0.074 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.021 0.032 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.03 -9999.0 0.0 -0.636 1.0 1.0 CDH1 0.006 0.119 -9999.0 0.0 -0.619 18.0 18.0 RhoA/GDP 0.04 0.085 0.362 7.0 -9999.0 0.0 7.0 actin cytoskeleton organization 0.023 0.062 0.174 15.0 -0.226 2.0 17.0 CDC42/GDP 0.032 0.108 0.424 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.063 -9999.0 0.0 -0.304 16.0 16.0 ITGB7 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.034 0.078 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.02 0.068 -9999.0 0.0 -0.346 14.0 14.0 mol:GDP 0.021 0.115 0.439 10.0 -9999.0 0.0 10.0 CDC42/GTP/IQGAP1 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.05 -9999.0 0.0 -0.636 3.0 3.0 p120 catenin/RhoA/GDP 0.019 0.081 0.308 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.02 0.062 0.184 11.0 -0.218 18.0 29.0 NME1 0.028 0.027 -9999.0 0.0 -0.59 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.124 -9999.0 0.0 -0.49 16.0 16.0 regulation of cell-cell adhesion 0.013 0.042 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.03 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.033 0.066 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.087 -9999.0 0.0 -0.662 1.0 1.0 CCND1 0.021 0.073 0.204 8.0 -0.273 18.0 26.0 VAV2 -0.016 0.158 -9999.0 0.0 -0.565 15.0 15.0 RAP1/GDP 0.043 0.078 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.02 0.121 -9999.0 0.0 -0.474 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.047 0.091 -9999.0 0.0 -0.638 1.0 1.0 E-cadherin/beta catenin -0.001 0.078 -9999.0 0.0 -0.408 18.0 18.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.123 -9999.0 0.0 -0.475 17.0 17.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.636 1.0 1.0 Rac1/GTP -0.031 0.078 -9999.0 0.0 -0.402 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.023 0.079 -9999.0 0.0 -0.401 14.0 14.0 ITGAE 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.132 -9999.0 0.0 -0.507 18.0 18.0