Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.18 0.193 -9999.0 0.0 -0.585 32.0 32.0 IHH -0.08 0.192 -9999.0 0.0 -0.688 44.0 44.0 SHH Np/Cholesterol/GAS1 0.004 0.098 -9999.0 0.0 -0.373 30.0 30.0 LRPAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.003 0.098 0.37 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.085 0.148 -9999.0 0.0 -0.517 26.0 26.0 SMO -0.096 0.147 -9999.0 0.0 -0.539 25.0 25.0 AKT1 -0.034 0.109 -9999.0 0.0 -0.51 13.0 13.0 ARRB2 0.028 0.032 -9999.0 0.0 -0.707 1.0 1.0 BOC 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.095 0.145 -9999.0 0.0 -0.531 25.0 25.0 STIL -0.069 0.133 -9999.0 0.0 -0.543 5.0 5.0 DHH N/PTCH2 0.007 0.124 -9999.0 0.0 -0.444 36.0 36.0 DHH N/PTCH1 -0.106 0.152 -9999.0 0.0 -0.49 36.0 36.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.636 1.0 1.0 DHH 0.014 0.1 -9999.0 0.0 -0.636 12.0 12.0 PTHLH -0.281 0.271 -9999.0 0.0 -0.808 37.0 37.0 determination of left/right symmetry -0.095 0.145 -9999.0 0.0 -0.531 25.0 25.0 PIK3R1 0.026 0.03 -9999.0 0.0 -0.636 1.0 1.0 skeletal system development -0.279 0.269 -9999.0 0.0 -0.799 37.0 37.0 IHH N/Hhip -0.162 0.252 -9999.0 0.0 -0.534 156.0 156.0 DHH N/Hhip -0.094 0.229 -9999.0 0.0 -0.479 133.0 133.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.095 0.145 -9999.0 0.0 -0.531 25.0 25.0 pancreas development -0.133 0.282 -9999.0 0.0 -0.622 130.0 130.0 HHAT 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.035 -9999.0 0.0 -0.473 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.009 0.15 -9999.0 0.0 -0.586 32.0 32.0 somite specification -0.095 0.145 -9999.0 0.0 -0.531 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.082 0.128 -9999.0 0.0 -0.444 26.0 26.0 SHH Np/Cholesterol/PTCH2 0.007 0.091 -9999.0 0.0 -0.345 31.0 31.0 SHH Np/Cholesterol/Megalin -0.004 0.117 -9999.0 0.0 -0.406 36.0 36.0 SHH 0.011 0.068 -9999.0 0.0 -0.469 10.0 10.0 catabolic process -0.122 0.155 -9999.0 0.0 -0.521 32.0 32.0 SMO/Vitamin D3 -0.084 0.138 -9999.0 0.0 -0.488 26.0 26.0 SHH Np/Cholesterol/Hhip -0.069 0.175 -9999.0 0.0 -0.382 116.0 116.0 LRP2 -0.022 0.173 -9999.0 0.0 -0.592 43.0 43.0 receptor-mediated endocytosis -0.097 0.162 -9999.0 0.0 -0.648 17.0 17.0 SHH Np/Cholesterol/BOC 0.022 0.056 -9999.0 0.0 -0.364 10.0 10.0 SHH Np/Cholesterol/CDO -0.015 0.121 -9999.0 0.0 -0.341 61.0 61.0 mesenchymal cell differentiation 0.068 0.174 0.38 116.0 -9999.0 0.0 116.0 mol:Vitamin D3 -0.077 0.137 -9999.0 0.0 -0.448 26.0 26.0 IHH N/PTCH2 -0.057 0.163 -9999.0 0.0 -0.465 67.0 67.0 CDON -0.04 0.196 -9999.0 0.0 -0.59 59.0 59.0 IHH N/PTCH1 -0.122 0.158 -9999.0 0.0 -0.528 32.0 32.0 Megalin/LRPAP1 0.004 0.132 -9999.0 0.0 -0.47 35.0 35.0 PTCH2 -0.001 0.132 -9999.0 0.0 -0.59 25.0 25.0 SHH Np/Cholesterol 0.011 0.054 -9999.0 0.0 -0.369 10.0 10.0 PTCH1 -0.122 0.156 -9999.0 0.0 -0.523 32.0 32.0 HHIP -0.133 0.283 -9999.0 0.0 -0.623 130.0 130.0