Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.058 -9999.0 0.0 -0.407 3.0 3.0 epithelial cell differentiation 0.027 0.071 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.014 0.077 -9999.0 0.0 -0.636 7.0 7.0 ENAH 0.062 0.102 0.39 17.0 -9999.0 0.0 17.0 EGFR 0.02 0.067 -9999.0 0.0 -0.597 6.0 6.0 EPHA2 0.027 0.03 -9999.0 0.0 -0.636 1.0 1.0 MYO6 0.058 0.11 0.383 13.0 -0.477 2.0 15.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.037 0.058 -9999.0 0.0 -0.402 7.0 7.0 AQP5 -0.106 0.239 -9999.0 0.0 -0.512 108.0 108.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.062 0.108 0.395 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion 0.052 0.117 0.405 11.0 -0.461 1.0 12.0 EGF -0.567 0.199 -9999.0 0.0 -0.631 472.0 472.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.007 0.159 -9999.0 0.0 -0.547 30.0 30.0 cortical microtubule organization 0.027 0.071 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.052 0.106 0.387 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.073 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.041 -9999.0 0.0 -0.357 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.041 0.084 0.375 2.0 -9999.0 0.0 2.0 PVRL2 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.048 0.094 0.36 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.069 0.044 -9999.0 0.0 -0.341 2.0 2.0 CDH1 0.006 0.119 -9999.0 0.0 -0.619 18.0 18.0 EGFR/EGFR/EGF/EGF -0.242 0.144 -9999.0 0.0 -0.59 19.0 19.0 RhoA/GDP 0.029 0.068 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.051 0.103 0.346 12.0 -0.448 2.0 14.0 IGF-1R heterotetramer 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.023 0.06 -9999.0 0.0 -0.59 5.0 5.0 DIAPH1 0.032 0.107 -9999.0 0.0 -0.683 6.0 6.0 Wnt receptor signaling pathway -0.027 0.071 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.048 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.051 0.104 0.348 12.0 -0.46 2.0 14.0 EFNA1 0.027 0.028 -9999.0 0.0 -0.59 1.0 1.0 LPP 0.046 0.095 0.39 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.023 0.065 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.001 0.05 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.053 0.119 0.407 11.0 -0.469 1.0 12.0 HGF/MET 0.012 0.091 -9999.0 0.0 -0.595 3.0 3.0 HGF 0.003 0.121 -9999.0 0.0 -0.597 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.058 -9999.0 0.0 -0.41 3.0 3.0 actin cable formation 0.106 0.13 0.319 85.0 -9999.0 0.0 85.0 KIAA1543 0.048 0.107 0.355 10.0 -0.529 2.0 12.0 KIFC3 0.051 0.095 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.03 -9999.0 0.0 -0.636 1.0 1.0 EXOC3 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.052 0.101 0.43 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.04 0.025 -9999.0 0.0 -0.473 1.0 1.0 mol:GDP 0.027 0.071 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.051 0.093 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.062 0.109 0.397 13.0 -9999.0 0.0 13.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.075 0.112 0.411 19.0 -9999.0 0.0 19.0 adherens junction assembly 0.071 0.137 0.507 16.0 -0.712 2.0 18.0 IGF-1R heterotetramer/IGF1 0.022 0.069 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.039 -9999.0 0.0 -0.59 2.0 2.0 PLEKHA7 0.057 0.109 0.362 10.0 -0.556 2.0 12.0 mol:GTP 0.063 0.04 -9999.0 0.0 -0.354 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.083 0.128 0.381 49.0 -9999.0 0.0 49.0 cortical actin cytoskeleton stabilization 0.013 0.058 -9999.0 0.0 -0.407 3.0 3.0 regulation of cell-cell adhesion 0.051 0.103 0.346 12.0 -0.448 2.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.058 -9999.0 0.0 -0.41 3.0 3.0