Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	241.0	8206.0	34.0	-0.514	0.03	1000.0	-1000.0	-0.05	-1000.0
HIF-1-alpha transcription factor network	171.0	13059.0	76.0	-1.11	0.045	1000.0	-1000.0	-0.178	-1000.0
TCGA08_retinoblastoma	171.0	1370.0	8.0	-0.578	0.16	1000.0	-1000.0	-0.004	-1000.0
TCGA08_p53	158.0	1107.0	7.0	-0.422	0.223	1000.0	-1000.0	-0.013	-1000.0
TCR signaling in naïve CD8+ T cells	136.0	12740.0	93.0	-0.436	0.204	1000.0	-1000.0	-0.075	-1000.0
FOXA2 and FOXA3 transcription factor networks	126.0	5840.0	46.0	-1.098	0.036	1000.0	-1000.0	-0.09	-1000.0
PDGFR-alpha signaling pathway	99.0	4378.0	44.0	-0.226	0.037	1000.0	-1000.0	-0.057	-1000.0
Syndecan-4-mediated signaling events	96.0	6494.0	67.0	-0.432	0.089	1000.0	-1000.0	-0.061	-1000.0
IL12-mediated signaling events	95.0	8273.0	87.0	-0.445	0.113	1000.0	-1000.0	-0.126	-1000.0
Aurora B signaling	92.0	6172.0	67.0	-0.259	0.042	1000.0	-1000.0	-0.055	-1000.0
Glypican 1 network	85.0	4081.0	48.0	-0.401	0.046	1000.0	-1000.0	-0.046	-1000.0
EGFR-dependent Endothelin signaling events	85.0	1797.0	21.0	-0.567	0.042	1000.0	-1000.0	-0.066	-1000.0
amb2 Integrin signaling	76.0	6232.0	82.0	-0.452	0.038	1000.0	-1000.0	-0.06	-1000.0
FOXM1 transcription factor network	75.0	3845.0	51.0	-0.565	0.03	1000.0	-1000.0	-0.129	-1000.0
Aurora C signaling	69.0	486.0	7.0	-0.26	0.027	1000.0	-1000.0	-0.017	-1000.0
BMP receptor signaling	69.0	5596.0	81.0	-0.526	0.054	1000.0	-1000.0	-0.098	-1000.0
Glypican 2 network	62.0	250.0	4.0	-0.041	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Caspase cascade in apoptosis	57.0	4273.0	74.0	-0.291	0.093	1000.0	-1000.0	-0.053	-1000.0
JNK signaling in the CD4+ TCR pathway	56.0	959.0	17.0	-0.222	0.03	1000.0	-1000.0	-0.055	-1000.0
IL4-mediated signaling events	56.0	5106.0	91.0	-0.79	0.492	1000.0	-1000.0	-0.121	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	52.0	1717.0	33.0	-0.57	0.055	1000.0	-1000.0	-0.042	-1000.0
Syndecan-1-mediated signaling events	51.0	1762.0	34.0	-0.25	0.03	1000.0	-1000.0	-0.073	-1000.0
HIF-2-alpha transcription factor network	47.0	2047.0	43.0	-0.527	0.25	1000.0	-1000.0	-0.069	-1000.0
Fc-epsilon receptor I signaling in mast cells	43.0	4266.0	97.0	-0.231	0.04	1000.0	-1000.0	-0.091	-1000.0
Effects of Botulinum toxin	41.0	1077.0	26.0	-0.231	0.04	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	39.0	2430.0	62.0	-0.567	0.065	1000.0	-1000.0	-0.051	-1000.0
Calcium signaling in the CD4+ TCR pathway	39.0	1210.0	31.0	-0.368	0.029	1000.0	-1000.0	-0.055	-1000.0
Coregulation of Androgen receptor activity	36.0	2761.0	76.0	-0.855	0.055	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by the Hedgehog family	35.0	1859.0	52.0	-0.281	0.068	1000.0	-1000.0	-0.068	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	34.0	2321.0	68.0	-0.327	0.059	1000.0	-1000.0	-0.097	-1000.0
Ephrin A  reverse signaling	33.0	232.0	7.0	-0.026	0.012	1000.0	-1000.0	-0.023	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	32.0	1764.0	54.0	-0.441	0.041	1000.0	-1000.0	-0.099	-1000.0
p75(NTR)-mediated signaling	32.0	4018.0	125.0	-0.303	0.079	1000.0	-1000.0	-0.096	-1000.0
PLK1 signaling events	32.0	2721.0	85.0	-0.183	0.042	1000.0	-1000.0	-0.04	-1000.0
IL27-mediated signaling events	32.0	1682.0	51.0	-0.603	0.059	1000.0	-1000.0	-0.057	-1000.0
IL2 signaling events mediated by STAT5	32.0	710.0	22.0	-0.291	0.036	1000.0	-1000.0	-0.063	-1000.0
VEGFR1 specific signals	32.0	1797.0	56.0	-0.314	0.03	1000.0	-1000.0	-0.07	-1000.0
LPA4-mediated signaling events	31.0	380.0	12.0	-0.104	0.011	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	30.0	1684.0	56.0	-0.174	0.079	1000.0	-1000.0	-0.079	-1000.0
S1P1 pathway	29.0	1055.0	36.0	-0.249	0.029	1000.0	-1000.0	-0.062	-1000.0
Integrins in angiogenesis	28.0	2357.0	84.0	-0.265	0.067	1000.0	-1000.0	-0.07	-1000.0
IL23-mediated signaling events	27.0	1670.0	60.0	-0.259	0.029	1000.0	-1000.0	-0.111	-1000.0
Glucocorticoid receptor regulatory network	25.0	2938.0	114.0	-0.337	0.15	1000.0	-1000.0	-0.079	-1000.0
BCR signaling pathway	24.0	2455.0	99.0	-0.222	0.057	1000.0	-1000.0	-0.094	-1000.0
Ceramide signaling pathway	23.0	1768.0	76.0	-0.567	0.206	1000.0	-1000.0	-0.066	-1000.0
IL2 signaling events mediated by PI3K	23.0	1390.0	58.0	-0.289	0.047	1000.0	-1000.0	-0.066	-1000.0
Wnt signaling	23.0	162.0	7.0	-0.042	0.028	1000.0	-1000.0	-0.036	-1000.0
Angiopoietin receptor Tie2-mediated signaling	22.0	1973.0	88.0	-0.204	0.046	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	22.0	1780.0	78.0	-0.247	0.046	1000.0	-1000.0	-0.064	-1000.0
FoxO family signaling	21.0	1392.0	64.0	-0.556	0.095	1000.0	-1000.0	-0.062	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	21.0	970.0	45.0	-0.365	0.078	1000.0	-1000.0	-0.082	-1000.0
Regulation of Telomerase	21.0	2204.0	102.0	-0.568	0.062	1000.0	-1000.0	-0.08	-1000.0
Visual signal transduction: Rods	20.0	1068.0	52.0	-0.156	0.04	1000.0	-1000.0	-0.07	-1000.0
Syndecan-2-mediated signaling events	19.0	1324.0	69.0	-0.452	0.063	1000.0	-1000.0	-0.044	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2369.0	120.0	-0.11	0.081	1000.0	-1000.0	-0.073	-1000.0
Noncanonical Wnt signaling pathway	18.0	472.0	26.0	-0.098	0.029	1000.0	-1000.0	-0.066	-1000.0
Thromboxane A2 receptor signaling	18.0	1923.0	105.0	-0.567	0.046	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by PTP1B	18.0	1435.0	76.0	-0.57	0.065	1000.0	-1000.0	-0.078	-1000.0
EPO signaling pathway	18.0	1026.0	55.0	-0.167	0.036	1000.0	-1000.0	-0.079	-1000.0
Aurora A signaling	17.0	1061.0	60.0	-0.148	0.063	1000.0	-1000.0	-0.039	-1000.0
Endothelins	17.0	1639.0	96.0	-0.328	0.049	1000.0	-1000.0	-0.067	-1000.0
IL6-mediated signaling events	17.0	1300.0	75.0	-0.226	0.059	1000.0	-1000.0	-0.061	-1000.0
Presenilin action in Notch and Wnt signaling	16.0	989.0	61.0	-0.14	0.085	1000.0	-1000.0	-0.052	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	15.0	573.0	37.0	-0.172	0.057	1000.0	-1000.0	-0.044	-1000.0
LPA receptor mediated events	15.0	1564.0	102.0	-0.246	0.052	1000.0	-1000.0	-0.09	-1000.0
IFN-gamma pathway	14.0	994.0	68.0	-0.242	0.043	1000.0	-1000.0	-0.087	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1178.0	82.0	-0.03	0.03	1000.0	-1000.0	-0.096	-1000.0
Canonical Wnt signaling pathway	14.0	714.0	51.0	-0.14	0.098	1000.0	-1000.0	-0.074	-1000.0
Nongenotropic Androgen signaling	14.0	733.0	52.0	-0.116	0.045	1000.0	-1000.0	-0.049	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1079.0	74.0	-0.567	0.106	1000.0	-1000.0	-0.098	-1000.0
Class I PI3K signaling events	14.0	1076.0	73.0	-0.313	0.08	1000.0	-1000.0	-0.069	-1000.0
Regulation of nuclear SMAD2/3 signaling	13.0	1833.0	136.0	-0.294	0.1	1000.0	-1000.0	-0.063	-1000.0
Signaling mediated by p38-alpha and p38-beta	13.0	597.0	44.0	-0.042	0.053	1000.0	-1000.0	-0.039	-1000.0
Regulation of Androgen receptor activity	13.0	975.0	70.0	-0.912	0.054	1000.0	-1000.0	-0.06	-1000.0
Sphingosine 1-phosphate (S1P) pathway	12.0	338.0	28.0	-0.077	0.048	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	12.0	38.0	3.0	0.005	0.026	1000.0	-1000.0	-0.016	-1000.0
S1P5 pathway	12.0	217.0	17.0	-0.077	0.029	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1048.0	86.0	-0.146	0.053	1000.0	-1000.0	-0.091	-1000.0
S1P3 pathway	12.0	529.0	42.0	-0.247	0.051	1000.0	-1000.0	-0.058	-1000.0
FAS signaling pathway (CD95)	11.0	563.0	47.0	-0.28	0.049	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1401.0	125.0	-0.246	0.044	1000.0	-1000.0	-0.091	-1000.0
TCGA08_rtk_signaling	11.0	304.0	26.0	-0.226	0.057	1000.0	-1000.0	-0.023	-1000.0
E-cadherin signaling events	11.0	57.0	5.0	0.006	0.025	1000.0	-1000.0	-0.009	-1000.0
ErbB4 signaling events	10.0	744.0	69.0	-0.161	0.095	1000.0	-1000.0	-0.085	-1000.0
S1P4 pathway	10.0	264.0	25.0	-0.077	0.039	1000.0	-1000.0	-0.051	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	0.01	0.029	1000.0	-1000.0	-0.006	-1000.0
ceramide signaling pathway	9.0	458.0	49.0	-0.064	0.045	1000.0	-1000.0	-0.071	-1000.0
Visual signal transduction: Cones	8.0	312.0	38.0	-0.013	0.044	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	634.0	85.0	-0.039	0.082	1000.0	-1000.0	-0.07	-1000.0
mTOR signaling pathway	7.0	396.0	53.0	-0.062	0.054	1000.0	-1000.0	-0.055	-1000.0
Ephrin B reverse signaling	7.0	376.0	48.0	-0.046	0.052	1000.0	-1000.0	-0.041	-1000.0
Syndecan-3-mediated signaling events	7.0	267.0	35.0	-0.012	0.079	1000.0	-1000.0	-0.048	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.021	0.021	1000.0	-1000.0	-0.001	-1000.0
Canonical NF-kappaB pathway	6.0	269.0	39.0	-0.115	0.057	1000.0	-1000.0	-0.062	-1000.0
IL1-mediated signaling events	6.0	392.0	62.0	-0.041	0.064	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by PRL	6.0	237.0	34.0	-0.044	0.063	1000.0	-1000.0	-0.054	-1000.0
ErbB2/ErbB3 signaling events	5.0	329.0	65.0	-0.124	0.042	1000.0	-1000.0	-0.066	-1000.0
Cellular roles of Anthrax toxin	5.0	213.0	39.0	-0.01	0.039	1000.0	-1000.0	-0.034	-1000.0
Insulin-mediated glucose transport	5.0	188.0	32.0	-0.041	0.056	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by HDAC Class III	5.0	231.0	40.0	-0.054	0.054	1000.0	-1000.0	-0.023	-1000.0
EPHB forward signaling	5.0	457.0	85.0	-0.055	0.073	1000.0	-1000.0	-0.102	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	439.0	76.0	-0.031	0.05	1000.0	-1000.0	-0.095	-1000.0
PDGFR-beta signaling pathway	5.0	531.0	97.0	-0.018	0.087	1000.0	-1000.0	-0.085	-1000.0
E-cadherin signaling in keratinocytes	5.0	247.0	43.0	-0.218	0.041	1000.0	-1000.0	-0.068	-1000.0
p38 MAPK signaling pathway	5.0	250.0	44.0	-0.063	0.057	1000.0	-1000.0	-0.05	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	100.0	17.0	-0.011	0.054	1000.0	-1000.0	-0.04	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	71.0	15.0	-0.0	0.03	1000.0	-1000.0	-0.044	-1000.0
Regulation of p38-alpha and p38-beta	4.0	266.0	54.0	-0.022	0.067	1000.0	-1000.0	-0.066	-1000.0
Insulin Pathway	4.0	339.0	74.0	-0.031	0.08	1000.0	-1000.0	-0.086	-1000.0
BARD1 signaling events	3.0	209.0	57.0	-0.097	0.076	1000.0	-1000.0	-0.075	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	238.0	65.0	-0.005	0.104	1000.0	-1000.0	-0.068	-1000.0
Nectin adhesion pathway	3.0	222.0	63.0	0.0	0.057	1000.0	-1000.0	-0.07	-1000.0
Arf6 trafficking events	3.0	266.0	71.0	-0.116	0.064	1000.0	-1000.0	-0.059	-1000.0
Osteopontin-mediated events	2.0	113.0	38.0	-0.0	0.085	1000.0	-1000.0	-0.072	-1000.0
Arf6 downstream pathway	2.0	120.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	198.0	68.0	-0.041	0.055	1000.0	-1000.0	-0.051	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	155.0	52.0	-0.015	0.1	1000.0	-1000.0	-0.049	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	220.0	83.0	-0.041	0.074	1000.0	-1000.0	-0.058	-1000.0
Retinoic acid receptors-mediated signaling	2.0	125.0	58.0	-0.016	0.053	1000.0	-1000.0	-0.055	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	91.0	36.0	-0.052	0.054	1000.0	-1000.0	-0.059	-1000.0
IGF1 pathway	2.0	136.0	57.0	-0.048	0.078	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by HDAC Class II	1.0	113.0	75.0	-0.041	0.062	1000.0	-1000.0	-0.045	-1000.0
Circadian rhythm pathway	1.0	25.0	22.0	-0.014	0.069	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class I	1.0	185.0	104.0	-0.057	0.076	1000.0	-1000.0	-0.047	-1000.0
Atypical NF-kappaB pathway	1.0	61.0	31.0	-0.0	0.037	1000.0	-1000.0	-0.055	-1000.0
Arf1 pathway	1.0	70.0	54.0	-0.0	0.049	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	15.0	23.0	-0.026	0.056	1000.0	-1000.0	-0.044	-1000.0
TRAIL signaling pathway	0.0	32.0	48.0	-0.0	0.072	1000.0	-1000.0	-0.062	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.07	1000.0	-1000.0	-0.057	-1000.0
Rapid glucocorticoid signaling	0.0	13.0	20.0	-0.008	0.036	1000.0	-1000.0	-0.007	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	0.0	0.062	1000.0	-1000.0	-0.015	-1000.0
Total	3735	199930	7203	-29.762401049	-991.543378405	131000	-131000	-7.96633701712	-131000