E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.01 0.168 -9999.0 0.0 -0.569 24.0 24.0 KLHL20 -0.014 0.048 -9999.0 0.0 -0.35 1.0 1.0 CYFIP2 0.01 0.048 -9999.0 0.0 -0.812 1.0 1.0 Rac1/GDP 0.025 0.111 -9999.0 0.0 -0.344 24.0 24.0 ENAH -0.01 0.168 -9999.0 0.0 -0.569 24.0 24.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.024 0.079 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.033 -9999.0 0.0 -0.225 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.011 0.144 -9999.0 0.0 -0.491 24.0 24.0 RAPGEF1 0.007 0.146 -9999.0 0.0 -0.477 24.0 24.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.049 0.163 -9999.0 0.0 -0.591 24.0 24.0 CRK -0.002 0.158 -9999.0 0.0 -0.526 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.045 0.149 -9999.0 0.0 -0.539 24.0 24.0 alphaE/beta7 Integrin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.01 0.168 -9999.0 0.0 -0.569 24.0 24.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.057 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.073 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.035 0.177 -9999.0 0.0 -0.623 24.0 24.0 TIAM1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.039 0.129 -9999.0 0.0 -0.466 24.0 24.0 AKT1 -0.012 0.041 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.056 0.228 -9999.0 0.0 -0.812 24.0 24.0 RhoA/GDP 0.024 0.111 -9999.0 0.0 -0.344 24.0 24.0 actin cytoskeleton organization 0.03 0.048 -9999.0 0.0 -0.245 1.0 1.0 CDC42/GDP 0.024 0.111 -9999.0 0.0 -0.36 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.006 0.1 -9999.0 0.0 -0.34 24.0 24.0 ITGB7 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.011 0.144 -9999.0 0.0 -0.491 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.019 0.137 -9999.0 0.0 -0.473 24.0 24.0 mol:GDP 0.017 0.128 -9999.0 0.0 -0.409 24.0 24.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.029 0.097 -9999.0 0.0 -0.35 24.0 24.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.025 0.036 -9999.0 0.0 -0.293 1.0 1.0 NME1 0.009 0.031 -9999.0 0.0 -0.292 3.0 3.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.168 -9999.0 0.0 -0.569 24.0 24.0 regulation of cell-cell adhesion -0.021 0.069 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.027 0.091 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.038 0.127 -9999.0 0.0 -0.459 24.0 24.0 CCND1 0.028 0.043 -9999.0 0.0 -0.376 1.0 1.0 VAV2 0.004 0.153 -9999.0 0.0 -0.503 24.0 24.0 RAP1/GDP 0.021 0.107 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.009 0.162 -9999.0 0.0 -0.548 24.0 24.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.004 0.132 -9999.0 0.0 -0.436 24.0 24.0 E-cadherin/beta catenin -0.041 0.137 -9999.0 0.0 -0.496 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.168 -9999.0 0.0 -0.569 24.0 24.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.023 0.079 -9999.0 0.0 -0.654 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.045 0.149 -9999.0 0.0 -0.539 24.0 24.0 ITGAE 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.05 0.168 -9999.0 0.0 -0.607 24.0 24.0