Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.005 0.148 -9999.0 0.0 -0.6 3.0 3.0 IHH -0.062 0.253 -9999.0 0.0 -0.831 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.014 0.132 -9999.0 0.0 -0.505 19.0 19.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.014 0.131 0.501 19.0 -9999.0 0.0 19.0 SMO/beta Arrestin2 0.003 0.163 -9999.0 0.0 -0.572 7.0 7.0 SMO -0.003 0.172 -9999.0 0.0 -0.505 29.0 29.0 AKT1 0.022 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.018 -9999.0 0.0 -0.292 1.0 1.0 BOC 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.003 0.169 -9999.0 0.0 -0.497 29.0 29.0 STIL 0.005 0.136 -9999.0 0.0 -0.46 8.0 8.0 DHH N/PTCH2 -0.026 0.16 -9999.0 0.0 -0.623 19.0 19.0 DHH N/PTCH1 -0.037 0.19 -9999.0 0.0 -0.466 46.0 46.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.043 0.204 -9999.0 0.0 -0.812 19.0 19.0 PTHLH -0.003 0.175 -9999.0 0.0 -0.772 3.0 3.0 determination of left/right symmetry -0.003 0.169 -9999.0 0.0 -0.497 29.0 29.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.002 0.174 -9999.0 0.0 -0.764 3.0 3.0 IHH N/Hhip -0.063 0.211 -9999.0 0.0 -0.587 39.0 39.0 DHH N/Hhip -0.052 0.209 -9999.0 0.0 -0.679 27.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.003 0.169 -9999.0 0.0 -0.497 29.0 29.0 pancreas development -0.026 0.162 -9999.0 0.0 -0.627 17.0 17.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.033 0.189 -9999.0 0.0 -0.812 16.0 16.0 somite specification -0.003 0.169 -9999.0 0.0 -0.497 29.0 29.0 SHH Np/Cholesterol/PTCH1 -0.0 0.138 -9999.0 0.0 -0.465 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.013 0.058 -9999.0 0.0 -0.497 3.0 3.0 SHH Np/Cholesterol/Megalin -0.033 0.165 -9999.0 0.0 -0.518 29.0 29.0 SHH 0.011 0.071 -9999.0 0.0 -0.624 3.0 3.0 catabolic process -0.008 0.159 -9999.0 0.0 -0.487 28.0 28.0 SMO/Vitamin D3 0.0 0.155 -9999.0 0.0 -0.55 6.0 6.0 SHH Np/Cholesterol/Hhip -0.009 0.115 -9999.0 0.0 -0.498 14.0 14.0 LRP2 -0.065 0.24 -9999.0 0.0 -0.812 27.0 27.0 receptor-mediated endocytosis -0.023 0.199 -9999.0 0.0 -0.659 15.0 15.0 SHH Np/Cholesterol/BOC 0.015 0.056 -9999.0 0.0 -0.497 3.0 3.0 SHH Np/Cholesterol/CDO 0.013 0.059 -9999.0 0.0 -0.497 3.0 3.0 mesenchymal cell differentiation 0.009 0.114 0.494 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.002 0.141 -9999.0 0.0 -0.467 8.0 8.0 IHH N/PTCH2 -0.034 0.17 -9999.0 0.0 -0.547 28.0 28.0 CDON 0.008 0.036 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.008 0.161 -9999.0 0.0 -0.493 28.0 28.0 Megalin/LRPAP1 -0.041 0.187 -9999.0 0.0 -0.623 27.0 27.0 PTCH2 0.009 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.008 0.054 -9999.0 0.0 -0.505 3.0 3.0 PTCH1 -0.008 0.16 -9999.0 0.0 -0.489 28.0 28.0 HHIP -0.026 0.162 -9999.0 0.0 -0.628 17.0 17.0