Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.0 0.099 -9999.0 0.0 -0.33 24.0 24.0 epithelial cell differentiation -0.038 0.127 -9999.0 0.0 -0.46 24.0 24.0 CYFIP2 0.01 0.048 -9999.0 0.0 -0.812 1.0 1.0 ENAH 0.034 0.091 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.011 0.018 -9999.0 0.0 -0.292 1.0 1.0 MYO6 -0.003 0.13 -9999.0 0.0 -0.437 24.0 24.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.002 0.032 -9999.0 0.0 -0.539 1.0 1.0 AQP5 -0.098 0.212 -9999.0 0.0 -0.611 33.0 33.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.003 0.128 -9999.0 0.0 -0.429 24.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.041 0.191 -9999.0 0.0 -0.482 43.0 43.0 EGF -0.729 0.247 -9999.0 0.0 -0.812 260.0 260.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.243 0.31 -9999.0 0.0 -0.629 106.0 106.0 cortical microtubule organization -0.038 0.127 -9999.0 0.0 -0.46 24.0 24.0 GO:0000145 -0.003 0.122 -9999.0 0.0 -0.41 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.039 0.129 -9999.0 0.0 -0.466 24.0 24.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.03 0.099 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.123 -9999.0 0.0 -0.401 24.0 24.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.003 0.13 -9999.0 0.0 -0.437 24.0 24.0 ARF6/GTP -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.056 0.227 -9999.0 0.0 -0.812 24.0 24.0 EGFR/EGFR/EGF/EGF -0.416 0.164 -9999.0 0.0 -0.454 265.0 265.0 RhoA/GDP -0.036 0.119 -9999.0 0.0 -0.432 24.0 24.0 actin cytoskeleton organization 0.003 0.125 -9999.0 0.0 -0.412 24.0 24.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.005 0.118 -9999.0 0.0 -0.812 6.0 6.0 DIAPH1 -0.004 0.039 -9999.0 0.0 -0.653 1.0 1.0 Wnt receptor signaling pathway 0.038 0.127 0.46 24.0 -9999.0 0.0 24.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.031 0.101 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.003 0.128 -9999.0 0.0 -0.423 24.0 24.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.004 0.125 -9999.0 0.0 -0.41 24.0 24.0 Ephrin A1/EPHA2 -0.035 0.115 -9999.0 0.0 -0.418 24.0 24.0 SEC6/SEC8 -0.032 0.106 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.043 0.196 -9999.0 0.0 -0.492 43.0 43.0 HGF/MET -0.072 0.165 -9999.0 0.0 -0.473 38.0 38.0 HGF -0.037 0.195 -9999.0 0.0 -0.812 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.0 0.1 -9999.0 0.0 -0.332 24.0 24.0 actin cable formation 0.051 0.088 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.003 0.127 -9999.0 0.0 -0.411 25.0 25.0 KIFC3 -0.003 0.13 -9999.0 0.0 -0.437 24.0 24.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.13 -9999.0 0.0 -0.437 24.0 24.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.038 0.127 -9999.0 0.0 -0.46 24.0 24.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.003 0.13 -9999.0 0.0 -0.437 24.0 24.0 PIP5K1C -0.003 0.13 -9999.0 0.0 -0.437 24.0 24.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.027 0.104 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.02 0.121 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.043 0.128 -9999.0 0.0 -0.419 30.0 30.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.025 0.101 -9999.0 0.0 -0.292 36.0 36.0 PLEKHA7 -0.005 0.133 -9999.0 0.0 -0.437 25.0 25.0 mol:GTP -0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.023 0.117 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.0 0.099 -9999.0 0.0 -0.33 24.0 24.0 regulation of cell-cell adhesion 0.003 0.125 -9999.0 0.0 -0.412 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.0 0.1 -9999.0 0.0 -0.332 24.0 24.0