Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	133.0	4537.0	34.0	-0.606	0.013	1000.0	-1000.0	-0.064	-1000.0
EGFR-dependent Endothelin signaling events	113.0	2373.0	21.0	-0.729	0.019	1000.0	-1000.0	-0.069	-1000.0
Angiopoietin receptor Tie2-mediated signaling	97.0	8609.0	88.0	-0.979	0.084	1000.0	-1000.0	-0.096	-1000.0
FOXA2 and FOXA3 transcription factor networks	75.0	3461.0	46.0	-1.207	0.019	1000.0	-1000.0	-0.082	-1000.0
PDGFR-alpha signaling pathway	66.0	2924.0	44.0	-0.324	0.028	1000.0	-1000.0	-0.054	-1000.0
Thromboxane A2 receptor signaling	53.0	5616.0	105.0	-0.729	0.088	1000.0	-1000.0	-0.064	-1000.0
Glypican 2 network	46.0	187.0	4.0	-0.121	-1000.0	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-alpha and p38-beta	45.0	1990.0	44.0	-0.199	0.013	1000.0	-1000.0	-0.045	-1000.0
Arf6 signaling events	42.0	2615.0	62.0	-0.729	0.032	1000.0	-1000.0	-0.065	-1000.0
Glypican 1 network	40.0	1926.0	48.0	-0.416	0.031	1000.0	-1000.0	-0.044	-1000.0
amb2 Integrin signaling	36.0	3016.0	82.0	-0.475	0.013	1000.0	-1000.0	-0.073	-1000.0
Endothelins	35.0	3429.0	96.0	-0.62	0.013	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	35.0	2768.0	78.0	-0.339	0.059	1000.0	-1000.0	-0.066	-1000.0
IL4-mediated signaling events	33.0	3069.0	91.0	-0.929	0.572	1000.0	-1000.0	-0.14	-1000.0
BMP receptor signaling	33.0	2705.0	81.0	-0.525	0.019	1000.0	-1000.0	-0.089	-1000.0
TCGA08_p53	32.0	228.0	7.0	-0.153	0.096	1000.0	-1000.0	-0.014	-1000.0
TCGA08_retinoblastoma	32.0	259.0	8.0	-0.229	0.061	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	31.0	3979.0	125.0	-0.163	0.032	1000.0	-1000.0	-0.094	-1000.0
Effects of Botulinum toxin	30.0	797.0	26.0	-0.234	0.015	1000.0	-1000.0	-0.061	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	29.0	2022.0	68.0	-0.626	0.098	1000.0	-1000.0	-0.124	-1000.0
S1P1 pathway	25.0	904.0	36.0	-0.199	0.013	1000.0	-1000.0	-0.056	-1000.0
Integrins in angiogenesis	25.0	2132.0	84.0	-0.54	0.037	1000.0	-1000.0	-0.088	-1000.0
FOXM1 transcription factor network	24.0	1261.0	51.0	-0.224	0.024	1000.0	-1000.0	-0.164	-1000.0
Syndecan-4-mediated signaling events	22.0	1495.0	67.0	-0.451	0.077	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by PTP1B	21.0	1661.0	76.0	-0.734	0.098	1000.0	-1000.0	-0.076	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2633.0	120.0	-0.307	0.138	1000.0	-1000.0	-0.073	-1000.0
TCR signaling in naïve CD8+ T cells	20.0	1866.0	93.0	-0.584	0.275	1000.0	-1000.0	-0.082	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	20.0	1531.0	74.0	-0.729	0.051	1000.0	-1000.0	-0.083	-1000.0
Syndecan-1-mediated signaling events	17.0	603.0	34.0	-0.116	0.013	1000.0	-1000.0	-0.051	-1000.0
Glucocorticoid receptor regulatory network	17.0	1949.0	114.0	-0.66	0.175	1000.0	-1000.0	-0.06	-1000.0
FoxO family signaling	17.0	1122.0	64.0	-0.904	0.09	1000.0	-1000.0	-0.064	-1000.0
Ephrin A  reverse signaling	16.0	116.0	7.0	-0.048	0.0	1000.0	-1000.0	-0.028	-1000.0
Signaling events regulated by Ret tyrosine kinase	16.0	1345.0	82.0	-0.132	0.013	1000.0	-1000.0	-0.076	-1000.0
LPA4-mediated signaling events	15.0	189.0	12.0	-0.254	0.019	1000.0	-1000.0	-0.029	-1000.0
IL27-mediated signaling events	15.0	781.0	51.0	-1.064	0.178	1000.0	-1000.0	-0.062	-1000.0
Coregulation of Androgen receptor activity	14.0	1071.0	76.0	-0.723	0.022	1000.0	-1000.0	-0.048	-1000.0
Sphingosine 1-phosphate (S1P) pathway	14.0	399.0	28.0	-0.162	0.018	1000.0	-1000.0	-0.036	-1000.0
Nongenotropic Androgen signaling	14.0	734.0	52.0	-0.087	0.023	1000.0	-1000.0	-0.071	-1000.0
IL6-mediated signaling events	14.0	1076.0	75.0	-0.275	0.053	1000.0	-1000.0	-0.077	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1263.0	86.0	-0.17	0.024	1000.0	-1000.0	-0.09	-1000.0
E-cadherin signaling events	14.0	72.0	5.0	-0.056	0.013	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by the Hedgehog family	13.0	711.0	52.0	-0.065	0.022	1000.0	-1000.0	-0.072	-1000.0
p75(NTR)-mediated signaling	13.0	1735.0	125.0	-0.46	0.032	1000.0	-1000.0	-0.092	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	423.0	31.0	-0.156	0.014	1000.0	-1000.0	-0.076	-1000.0
HIF-1-alpha transcription factor network	12.0	963.0	76.0	-0.157	0.049	1000.0	-1000.0	-0.13	-1000.0
Aurora B signaling	12.0	855.0	67.0	-0.31	0.013	1000.0	-1000.0	-0.075	-1000.0
IL12-mediated signaling events	11.0	991.0	87.0	-0.177	0.025	1000.0	-1000.0	-0.121	-1000.0
ErbB4 signaling events	11.0	788.0	69.0	-0.301	0.118	1000.0	-1000.0	-0.088	-1000.0
Presenilin action in Notch and Wnt signaling	11.0	700.0	61.0	-0.223	0.104	1000.0	-1000.0	-0.073	-1000.0
Reelin signaling pathway	11.0	648.0	56.0	-0.182	0.019	1000.0	-1000.0	-0.075	-1000.0
Visual signal transduction: Rods	11.0	616.0	52.0	-0.211	0.013	1000.0	-1000.0	-0.08	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1450.0	136.0	-0.626	0.069	1000.0	-1000.0	-0.067	-1000.0
S1P3 pathway	10.0	449.0	42.0	-0.162	0.02	1000.0	-1000.0	-0.036	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.009	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Regulation of Androgen receptor activity	10.0	741.0	70.0	-0.832	0.028	1000.0	-1000.0	-0.063	-1000.0
Osteopontin-mediated events	9.0	355.0	38.0	-0.113	0.038	1000.0	-1000.0	-0.09	-1000.0
Syndecan-3-mediated signaling events	9.0	322.0	35.0	-0.181	0.019	1000.0	-1000.0	-0.066	-1000.0
EPHB forward signaling	9.0	827.0	85.0	-0.219	0.072	1000.0	-1000.0	-0.09	-1000.0
Regulation of Telomerase	9.0	986.0	102.0	-0.73	0.043	1000.0	-1000.0	-0.09	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	9.0	306.0	33.0	-0.228	0.036	1000.0	-1000.0	-0.058	-1000.0
Syndecan-2-mediated signaling events	8.0	587.0	69.0	-0.475	0.04	1000.0	-1000.0	-0.046	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	440.0	52.0	-0.336	0.057	1000.0	-1000.0	-0.072	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	659.0	76.0	-0.056	0.03	1000.0	-1000.0	-0.081	-1000.0
E-cadherin signaling in keratinocytes	8.0	382.0	43.0	-0.306	0.036	1000.0	-1000.0	-0.064	-1000.0
PLK2 and PLK4 events	7.0	22.0	3.0	-0.011	0.01	1000.0	-1000.0	-0.026	-1000.0
Insulin-mediated glucose transport	7.0	248.0	32.0	-0.139	0.07	1000.0	-1000.0	-0.07	-1000.0
Ceramide signaling pathway	7.0	606.0	76.0	-0.729	0.25	1000.0	-1000.0	-0.053	-1000.0
BCR signaling pathway	7.0	730.0	99.0	-0.081	0.032	1000.0	-1000.0	-0.092	-1000.0
IL23-mediated signaling events	7.0	467.0	60.0	-0.118	0.023	1000.0	-1000.0	-0.155	-1000.0
PDGFR-beta signaling pathway	7.0	728.0	97.0	-0.138	0.046	1000.0	-1000.0	-0.08	-1000.0
Caspase cascade in apoptosis	6.0	515.0	74.0	-0.417	0.041	1000.0	-1000.0	-0.039	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	361.0	54.0	-0.237	0.025	1000.0	-1000.0	-0.097	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	663.0	97.0	-0.129	0.03	1000.0	-1000.0	-0.081	-1000.0
IL1-mediated signaling events	6.0	420.0	62.0	-0.205	0.059	1000.0	-1000.0	-0.105	-1000.0
Wnt signaling	6.0	47.0	7.0	-0.033	0.013	1000.0	-1000.0	-0.033	-1000.0
TCGA08_rtk_signaling	6.0	178.0	26.0	-0.299	0.028	1000.0	-1000.0	-0.022	-1000.0
BARD1 signaling events	5.0	336.0	57.0	-0.118	0.027	1000.0	-1000.0	-0.063	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	100.0	17.0	-0.033	0.029	1000.0	-1000.0	-0.052	-1000.0
Noncanonical Wnt signaling pathway	5.0	143.0	26.0	-0.165	0.013	1000.0	-1000.0	-0.065	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	500.0	85.0	-0.113	0.034	1000.0	-1000.0	-0.07	-1000.0
S1P5 pathway	5.0	92.0	17.0	-0.059	0.03	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	486.0	83.0	-0.274	0.049	1000.0	-1000.0	-0.073	-1000.0
Canonical Wnt signaling pathway	5.0	286.0	51.0	-0.222	0.11	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	5.0	316.0	54.0	-0.196	0.062	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by PRL	5.0	191.0	34.0	-0.03	0.022	1000.0	-1000.0	-0.034	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	101.0	17.0	-0.008	0.026	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	4.0	332.0	68.0	-0.323	0.068	1000.0	-1000.0	-0.094	-1000.0
Nectin adhesion pathway	4.0	295.0	63.0	-0.085	0.049	1000.0	-1000.0	-0.077	-1000.0
Ephrin B reverse signaling	4.0	221.0	48.0	-0.085	0.036	1000.0	-1000.0	-0.065	-1000.0
FAS signaling pathway (CD95)	4.0	190.0	47.0	-0.111	0.022	1000.0	-1000.0	-0.05	-1000.0
LPA receptor mediated events	4.0	438.0	102.0	-0.116	0.054	1000.0	-1000.0	-0.081	-1000.0
Class I PI3K signaling events	4.0	333.0	73.0	-0.063	0.038	1000.0	-1000.0	-0.066	-1000.0
ErbB2/ErbB3 signaling events	3.0	226.0	65.0	-0.12	0.034	1000.0	-1000.0	-0.068	-1000.0
Cellular roles of Anthrax toxin	3.0	150.0	39.0	-0.201	0.018	1000.0	-1000.0	-0.029	-1000.0
PLK1 signaling events	3.0	284.0	85.0	-0.092	0.024	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	3.0	208.0	58.0	-0.057	0.057	1000.0	-1000.0	-0.08	-1000.0
Arf6 trafficking events	3.0	255.0	71.0	-0.347	0.041	1000.0	-1000.0	-0.07	-1000.0
IGF1 pathway	3.0	193.0	57.0	-0.039	0.043	1000.0	-1000.0	-0.094	-1000.0
S1P4 pathway	3.0	96.0	25.0	-0.059	0.027	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by HDAC Class II	2.0	187.0	75.0	-0.159	0.038	1000.0	-1000.0	-0.061	-1000.0
Aurora A signaling	2.0	143.0	60.0	-0.095	0.04	1000.0	-1000.0	-0.057	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	140.0	68.0	-0.139	0.047	1000.0	-1000.0	-0.055	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	83.0	37.0	-0.03	0.032	1000.0	-1000.0	-0.051	-1000.0
HIF-2-alpha transcription factor network	2.0	105.0	43.0	-0.219	0.127	1000.0	-1000.0	-0.079	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	34.0	15.0	-0.0	0.025	1000.0	-1000.0	-0.03	-1000.0
Retinoic acid receptors-mediated signaling	2.0	153.0	58.0	-0.059	0.034	1000.0	-1000.0	-0.069	-1000.0
IL2 signaling events mediated by STAT5	2.0	61.0	22.0	-0.047	0.046	1000.0	-1000.0	-0.054	-1000.0
Visual signal transduction: Cones	1.0	70.0	38.0	-0.015	0.016	1000.0	-1000.0	-0.064	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	100.0	65.0	-0.059	0.062	1000.0	-1000.0	-0.063	-1000.0
EPO signaling pathway	1.0	60.0	55.0	-0.035	0.075	1000.0	-1000.0	-0.089	-1000.0
TRAIL signaling pathway	1.0	55.0	48.0	-0.009	0.044	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by HDAC Class I	1.0	184.0	104.0	-0.159	0.053	1000.0	-1000.0	-0.067	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	39.0	36.0	-0.036	0.038	1000.0	-1000.0	-0.068	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	63.0	45.0	-0.027	0.059	1000.0	-1000.0	-0.085	-1000.0
Insulin Pathway	1.0	140.0	74.0	-0.045	0.034	1000.0	-1000.0	-0.089	-1000.0
VEGFR1 specific signals	1.0	97.0	56.0	-0.007	0.048	1000.0	-1000.0	-0.066	-1000.0
p38 MAPK signaling pathway	1.0	62.0	44.0	-0.042	0.041	1000.0	-1000.0	-0.065	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	0.0	0.045	1000.0	-1000.0	-0.055	-1000.0
Canonical NF-kappaB pathway	0.0	38.0	39.0	-0.011	0.078	1000.0	-1000.0	-0.083	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.012	0.044	1000.0	-1000.0	-0.041	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	1.0	5.0	0.011	0.018	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	0.0	3.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.037	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.132	0.012	1000.0	-1000.0	-0.032	-1000.0
mTOR signaling pathway	0.0	41.0	53.0	-0.006	0.033	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by HDAC Class III	0.0	29.0	40.0	-0.02	0.022	1000.0	-1000.0	-0.04	-1000.0
ceramide signaling pathway	0.0	44.0	49.0	-0.011	0.046	1000.0	-1000.0	-0.043	-1000.0
Atypical NF-kappaB pathway	0.0	25.0	31.0	-0.0	0.046	1000.0	-1000.0	-0.038	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.001	0.032	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	0.0	14.0	20.0	-0.002	0.013	1000.0	-1000.0	-0.041	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.006	0.03	1000.0	-1000.0	-0.046	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.019	1000.0	-1000.0	-0.061	-1000.0
Total	1845	109436	7203	-32.1110671455	-1993.58682258	131000	-131000	-8.62830552272	-131000