E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.022 0.149 -9999.0 0.0 -0.515 22.0 22.0 KLHL20 0.018 0.086 0.183 4.0 -0.263 3.0 7.0 CYFIP2 0.025 0.04 -9999.0 0.0 -0.642 1.0 1.0 Rac1/GDP -0.003 0.11 0.316 5.0 -0.326 19.0 24.0 ENAH -0.024 0.149 -9999.0 0.0 -0.513 22.0 22.0 AP1M1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.005 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.016 0.041 -9999.0 0.0 -0.193 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.026 0.12 -9999.0 0.0 -0.385 21.0 21.0 RAPGEF1 -0.019 0.133 -9999.0 0.0 -0.448 21.0 21.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.155 -9999.0 0.0 -0.527 22.0 22.0 CRK -0.025 0.137 -9999.0 0.0 -0.478 22.0 22.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.124 -9999.0 0.0 -0.418 21.0 21.0 alphaE/beta7 Integrin 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.024 0.15 -9999.0 0.0 -0.515 22.0 22.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.009 0.054 -9999.0 0.0 -0.21 1.0 1.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.044 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.007 0.071 -9999.0 0.0 -0.272 1.0 1.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.003 0.137 -9999.0 0.0 -0.473 22.0 22.0 TIAM1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.026 0.114 -9999.0 0.0 -0.364 22.0 22.0 AKT1 -0.0 0.046 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.025 0.178 -9999.0 0.0 -0.642 22.0 22.0 RhoA/GDP 0.01 0.12 0.343 8.0 -0.325 21.0 29.0 actin cytoskeleton organization 0.022 0.072 0.18 10.0 -0.206 2.0 12.0 CDC42/GDP 0.02 0.137 0.409 13.0 -0.323 21.0 34.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.004 0.081 -9999.0 0.0 -0.287 21.0 21.0 ITGB7 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.028 0.122 -9999.0 0.0 -0.385 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.012 0.109 -9999.0 0.0 -0.362 22.0 22.0 mol:GDP 0.002 0.152 0.412 14.0 -0.377 21.0 35.0 CDC42/GTP/IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.011 0.116 0.318 2.0 -0.333 21.0 23.0 RAC1/GTP/IQGAP1 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.041 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.028 0.074 0.25 14.0 -0.27 1.0 15.0 NME1 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.024 0.149 -9999.0 0.0 -0.514 22.0 22.0 regulation of cell-cell adhesion -0.001 0.067 -9999.0 0.0 -0.242 1.0 1.0 WASF2 0.012 0.033 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.008 0.092 -9999.0 0.0 -0.305 4.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.117 -9999.0 0.0 -0.366 21.0 21.0 CCND1 0.027 0.071 0.226 11.0 -0.344 1.0 12.0 VAV2 -0.033 0.189 -9999.0 0.0 -0.505 35.0 35.0 RAP1/GDP 0.016 0.105 0.299 5.0 -0.319 6.0 11.0 adherens junction assembly -0.023 0.145 -9999.0 0.0 -0.496 22.0 22.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.023 0.11 -9999.0 0.0 -0.354 21.0 21.0 E-cadherin/beta catenin -0.022 0.115 -9999.0 0.0 -0.419 22.0 22.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.149 -9999.0 0.0 -0.515 22.0 22.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.023 0.1 -9999.0 0.0 -0.352 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.014 0.126 -9999.0 0.0 -0.418 22.0 22.0 ITGAE 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.019 0.159 -9999.0 0.0 -0.54 22.0 22.0