Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.002 0.11 -9999.0 0.0 -0.384 3.0 3.0 IHH -0.032 0.21 -9999.0 0.0 -0.667 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.001 0.086 -9999.0 0.0 -0.378 12.0 12.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.085 0.376 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 -0.007 0.133 -9999.0 0.0 -0.412 21.0 21.0 SMO -0.016 0.131 -9999.0 0.0 -0.429 22.0 22.0 AKT1 -0.01 0.131 -9999.0 0.0 -0.622 7.0 7.0 ARRB2 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.016 0.129 -9999.0 0.0 -0.423 22.0 22.0 STIL 0.021 0.121 0.256 1.0 -0.325 7.0 8.0 DHH N/PTCH2 0.004 0.126 -9999.0 0.0 -0.48 18.0 18.0 DHH N/PTCH1 -0.019 0.151 -9999.0 0.0 -0.362 45.0 45.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.018 0.162 -9999.0 0.0 -0.642 18.0 18.0 PTHLH -0.014 0.136 -9999.0 0.0 -0.488 3.0 3.0 determination of left/right symmetry -0.016 0.129 -9999.0 0.0 -0.423 22.0 22.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.014 0.136 -9999.0 0.0 -0.485 3.0 3.0 IHH N/Hhip -0.026 0.171 -9999.0 0.0 -0.452 39.0 39.0 DHH N/Hhip -0.016 0.166 -9999.0 0.0 -0.526 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.016 0.129 -9999.0 0.0 -0.423 22.0 22.0 pancreas development -0.004 0.129 -9999.0 0.0 -0.641 11.0 11.0 HHAT 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.142 -9999.0 0.0 -0.6 15.0 15.0 somite specification -0.016 0.129 -9999.0 0.0 -0.423 22.0 22.0 SHH Np/Cholesterol/PTCH1 -0.007 0.098 -9999.0 0.0 -0.314 21.0 21.0 SHH Np/Cholesterol/PTCH2 0.015 0.043 -9999.0 0.0 -0.377 3.0 3.0 SHH Np/Cholesterol/Megalin -0.021 0.126 -9999.0 0.0 -0.396 28.0 28.0 SHH 0.005 0.051 -9999.0 0.0 -0.484 3.0 3.0 catabolic process -0.007 0.124 -9999.0 0.0 -0.381 28.0 28.0 SMO/Vitamin D3 -0.009 0.115 -9999.0 0.0 -0.375 22.0 22.0 SHH Np/Cholesterol/Hhip -0.0 0.084 -9999.0 0.0 -0.383 12.0 12.0 LRP2 -0.034 0.193 -9999.0 0.0 -0.63 27.0 27.0 receptor-mediated endocytosis -0.037 0.158 -9999.0 0.0 -0.6 12.0 12.0 SHH Np/Cholesterol/BOC 0.016 0.043 -9999.0 0.0 -0.383 3.0 3.0 SHH Np/Cholesterol/CDO 0.015 0.044 -9999.0 0.0 -0.383 3.0 3.0 mesenchymal cell differentiation 0.0 0.083 0.381 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 0.028 0.127 -9999.0 0.0 -0.317 21.0 21.0 IHH N/PTCH2 -0.005 0.139 -9999.0 0.0 -0.423 28.0 28.0 CDON 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.001 0.128 -9999.0 0.0 -0.385 28.0 28.0 Megalin/LRPAP1 -0.008 0.15 -9999.0 0.0 -0.471 27.0 27.0 PTCH2 0.025 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.008 0.041 -9999.0 0.0 -0.381 3.0 3.0 PTCH1 -0.007 0.125 -9999.0 0.0 -0.382 28.0 28.0 HHIP -0.004 0.129 -9999.0 0.0 -0.642 11.0 11.0