Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.001 0.081 -9999.0 0.0 -0.279 22.0 22.0 epithelial cell differentiation 0.021 0.112 -9999.0 0.0 -0.36 22.0 22.0 CYFIP2 0.025 0.04 -9999.0 0.0 -0.642 1.0 1.0 ENAH -0.0 0.133 0.525 11.0 -9999.0 0.0 11.0 EGFR 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.001 0.119 0.344 8.0 -0.348 22.0 30.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.031 -9999.0 0.0 -0.418 1.0 1.0 AQP5 -0.07 0.189 -9999.0 0.0 -0.561 31.0 31.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.003 0.119 0.342 9.0 -0.343 22.0 31.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.15 0.346 6.0 -0.379 35.0 41.0 EGF -0.563 0.207 -9999.0 0.0 -0.631 257.0 257.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.172 0.27 -9999.0 0.0 -0.561 87.0 87.0 cortical microtubule organization 0.021 0.112 -9999.0 0.0 -0.36 22.0 22.0 GO:0000145 -0.015 0.113 0.331 9.0 -0.327 22.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.114 -9999.0 0.0 -0.364 22.0 22.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.035 0.077 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.012 0.097 0.345 2.0 -0.322 20.0 22.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.105 0.348 3.0 -0.348 20.0 23.0 ARF6/GTP 0.064 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.025 0.178 -9999.0 0.0 -0.642 22.0 22.0 EGFR/EGFR/EGF/EGF -0.275 0.159 -9999.0 0.0 -0.372 185.0 185.0 RhoA/GDP 0.023 0.108 -9999.0 0.0 -0.345 22.0 22.0 actin cytoskeleton organization -0.017 0.113 0.328 8.0 -0.337 22.0 30.0 IGF-1R heterotetramer 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.013 0.096 -9999.0 0.0 -0.642 6.0 6.0 DIAPH1 0.035 0.106 -9999.0 0.0 -0.555 1.0 1.0 Wnt receptor signaling pathway -0.021 0.112 0.36 22.0 -9999.0 0.0 22.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.079 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.115 0.331 8.0 -0.345 22.0 30.0 EFNA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.023 0.102 0.342 3.0 -0.332 22.0 25.0 Ephrin A1/EPHA2 0.016 0.104 -9999.0 0.0 -0.336 22.0 22.0 SEC6/SEC8 -0.014 0.086 -9999.0 0.0 -0.325 20.0 20.0 MGAT3 -0.025 0.152 0.348 6.0 -0.386 35.0 41.0 HGF/MET -0.002 0.121 -9999.0 0.0 -0.365 26.0 26.0 HGF -0.004 0.128 -9999.0 0.0 -0.642 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.0 0.082 -9999.0 0.0 -0.281 22.0 22.0 actin cable formation 0.03 0.151 0.566 14.0 -9999.0 0.0 14.0 KIAA1543 -0.016 0.116 0.333 9.0 -0.331 23.0 32.0 KIFC3 -0.015 0.097 -9999.0 0.0 -0.348 22.0 22.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.003 0.12 0.344 9.0 -0.345 22.0 31.0 NCK1/GIT1 0.038 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.021 0.112 -9999.0 0.0 -0.36 22.0 22.0 EXOC4 0.022 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.098 -9999.0 0.0 -0.348 22.0 22.0 PIP5K1C 0.003 0.121 0.344 9.0 -0.348 22.0 31.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.002 0.146 0.542 12.0 -9999.0 0.0 12.0 adherens junction assembly 0.006 0.13 0.435 10.0 -9999.0 0.0 10.0 IGF-1R heterotetramer/IGF1 0.009 0.115 -9999.0 0.0 -0.339 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.018 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.002 0.122 0.344 9.0 -0.347 23.0 32.0 mol:GTP 0.058 0.027 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.002 0.114 0.317 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.001 0.081 -9999.0 0.0 -0.279 22.0 22.0 regulation of cell-cell adhesion -0.017 0.113 0.328 8.0 -0.337 22.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.0 0.082 -9999.0 0.0 -0.281 22.0 22.0