Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	128.0	4367.0	34.0	-0.456	0.028	1000.0	-1000.0	-0.043	-1000.0
Angiopoietin receptor Tie2-mediated signaling	98.0	8705.0	88.0	-0.898	0.095	1000.0	-1000.0	-0.063	-1000.0
EGFR-dependent Endothelin signaling events	88.0	1863.0	21.0	-0.563	0.038	1000.0	-1000.0	-0.048	-1000.0
FOXA2 and FOXA3 transcription factor networks	79.0	3660.0	46.0	-1.083	0.031	1000.0	-1000.0	-0.11	-1000.0
PDGFR-alpha signaling pathway	63.0	2779.0	44.0	-0.253	0.038	1000.0	-1000.0	-0.053	-1000.0
Thromboxane A2 receptor signaling	52.0	5554.0	105.0	-0.563	0.098	1000.0	-1000.0	-0.04	-1000.0
Signaling mediated by p38-alpha and p38-beta	42.0	1864.0	44.0	-0.173	0.027	1000.0	-1000.0	-0.03	-1000.0
Glypican 1 network	37.0	1821.0	48.0	-0.326	0.051	1000.0	-1000.0	-0.045	-1000.0
BMP receptor signaling	33.0	2674.0	81.0	-0.373	0.055	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	33.0	2650.0	78.0	-0.272	0.064	1000.0	-1000.0	-0.046	-1000.0
Endothelins	31.0	3015.0	96.0	-0.609	0.034	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	29.0	3664.0	125.0	-0.134	0.062	1000.0	-1000.0	-0.065	-1000.0
IL4-mediated signaling events	28.0	2577.0	91.0	-0.872	0.525	1000.0	-1000.0	-0.103	-1000.0
Arf6 signaling events	26.0	1614.0	62.0	-0.563	0.059	1000.0	-1000.0	-0.033	-1000.0
Integrins in angiogenesis	23.0	1973.0	84.0	-0.411	0.06	1000.0	-1000.0	-0.058	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1559.0	68.0	-0.483	0.087	1000.0	-1000.0	-0.075	-1000.0
amb2 Integrin signaling	21.0	1749.0	82.0	-0.372	0.035	1000.0	-1000.0	-0.04	-1000.0
Ceramide signaling pathway	21.0	1625.0	76.0	-0.563	0.198	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	21.0	785.0	36.0	-0.163	0.027	1000.0	-1000.0	-0.048	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2554.0	120.0	-0.23	0.115	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PTP1B	19.0	1444.0	76.0	-0.565	0.084	1000.0	-1000.0	-0.047	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	19.0	1471.0	74.0	-0.563	0.064	1000.0	-1000.0	-0.071	-1000.0
FoxO family signaling	17.0	1103.0	64.0	-0.859	0.063	1000.0	-1000.0	-0.056	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1413.0	86.0	-0.135	0.048	1000.0	-1000.0	-0.057	-1000.0
Ephrin A  reverse signaling	15.0	105.0	7.0	-0.032	0.0	1000.0	-1000.0	-0.01	-1000.0
Glucocorticoid receptor regulatory network	14.0	1707.0	114.0	-0.578	0.147	1000.0	-1000.0	-0.054	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1175.0	82.0	-0.064	0.028	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by the Hedgehog family	13.0	699.0	52.0	-0.037	0.04	1000.0	-1000.0	-0.041	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1255.0	93.0	-0.201	0.108	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling events	13.0	66.0	5.0	-0.025	0.027	1000.0	-1000.0	0.003	-1000.0
LPA4-mediated signaling events	12.0	155.0	12.0	-0.142	0.007	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	12.0	973.0	76.0	-0.644	0.051	1000.0	-1000.0	-0.025	-1000.0
Nongenotropic Androgen signaling	12.0	660.0	52.0	-0.108	0.045	1000.0	-1000.0	-0.047	-1000.0
Caspase cascade in apoptosis	10.0	808.0	74.0	-0.417	0.066	1000.0	-1000.0	-0.04	-1000.0
p75(NTR)-mediated signaling	10.0	1351.0	125.0	-0.361	0.075	1000.0	-1000.0	-0.074	-1000.0
EPHB forward signaling	10.0	933.0	85.0	-0.153	0.074	1000.0	-1000.0	-0.069	-1000.0
IL23-mediated signaling events	10.0	611.0	60.0	-0.064	0.04	1000.0	-1000.0	-0.084	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1254.0	136.0	-0.481	0.095	1000.0	-1000.0	-0.043	-1000.0
Syndecan-3-mediated signaling events	9.0	329.0	35.0	-0.097	0.075	1000.0	-1000.0	-0.039	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	293.0	31.0	-0.106	0.028	1000.0	-1000.0	-0.042	-1000.0
IL27-mediated signaling events	9.0	485.0	51.0	-1.007	0.251	1000.0	-1000.0	-0.049	-1000.0
IL6-mediated signaling events	9.0	707.0	75.0	-0.223	0.041	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	734.0	76.0	-0.033	0.048	1000.0	-1000.0	-0.058	-1000.0
S1P3 pathway	9.0	402.0	42.0	-0.11	0.039	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling in keratinocytes	9.0	388.0	43.0	-0.22	0.042	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	8.0	337.0	38.0	-0.065	0.05	1000.0	-1000.0	-0.048	-1000.0
HIF-1-alpha transcription factor network	8.0	654.0	76.0	-0.105	0.084	1000.0	-1000.0	-0.086	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	734.0	85.0	-0.101	0.108	1000.0	-1000.0	-0.051	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	508.0	61.0	-0.155	0.084	1000.0	-1000.0	-0.057	-1000.0
Reelin signaling pathway	8.0	487.0	56.0	-0.121	0.072	1000.0	-1000.0	-0.055	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	453.0	52.0	-0.241	0.084	1000.0	-1000.0	-0.037	-1000.0
Effects of Botulinum toxin	8.0	228.0	26.0	-0.169	0.046	1000.0	-1000.0	-0.015	-1000.0
TCGA08_rtk_signaling	8.0	232.0	26.0	-0.222	0.062	1000.0	-1000.0	-0.014	-1000.0
Regulation of Telomerase	8.0	892.0	102.0	-0.563	0.068	1000.0	-1000.0	-0.044	-1000.0
Regulation of Androgen receptor activity	8.0	566.0	70.0	-0.754	0.044	1000.0	-1000.0	-0.051	-1000.0
ErbB4 signaling events	7.0	538.0	69.0	-0.225	0.087	1000.0	-1000.0	-0.053	-1000.0
Syndecan-1-mediated signaling events	7.0	270.0	34.0	-0.038	0.028	1000.0	-1000.0	-0.052	-1000.0
ceramide signaling pathway	7.0	377.0	49.0	0.0	0.041	1000.0	-1000.0	-0.042	-1000.0
Regulation of p38-alpha and p38-beta	7.0	399.0	54.0	-0.14	0.065	1000.0	-1000.0	-0.053	-1000.0
PDGFR-beta signaling pathway	7.0	714.0	97.0	-0.032	0.059	1000.0	-1000.0	-0.065	-1000.0
Visual signal transduction: Rods	7.0	413.0	52.0	-0.151	0.053	1000.0	-1000.0	-0.045	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	187.0	28.0	-0.11	0.045	1000.0	-1000.0	-0.028	-1000.0
Noncanonical Wnt signaling pathway	6.0	164.0	26.0	-0.137	0.028	1000.0	-1000.0	-0.051	-1000.0
Cellular roles of Anthrax toxin	6.0	242.0	39.0	-0.146	0.036	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	6.0	418.0	68.0	-0.251	0.067	1000.0	-1000.0	-0.064	-1000.0
Syndecan-4-mediated signaling events	6.0	447.0	67.0	-0.351	0.093	1000.0	-1000.0	-0.053	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.012	0.012	1000.0	-1000.0	-0.001	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	111.0	17.0	-0.006	0.042	1000.0	-1000.0	-0.029	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	303.0	54.0	-0.06	0.046	1000.0	-1000.0	-0.06	-1000.0
Syndecan-2-mediated signaling events	5.0	360.0	69.0	-0.372	0.054	1000.0	-1000.0	-0.035	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	567.0	97.0	-0.066	0.05	1000.0	-1000.0	-0.056	-1000.0
PLK1 signaling events	5.0	432.0	85.0	-0.008	0.054	1000.0	-1000.0	-0.039	-1000.0
IL1-mediated signaling events	5.0	326.0	62.0	-0.144	0.072	1000.0	-1000.0	-0.053	-1000.0
Ephrin B reverse signaling	5.0	277.0	48.0	-0.018	0.039	1000.0	-1000.0	-0.032	-1000.0
TCGA08_p53	5.0	39.0	7.0	-0.036	0.028	1000.0	-1000.0	-0.009	-1000.0
Canonical Wnt signaling pathway	5.0	264.0	51.0	-0.154	0.078	1000.0	-1000.0	-0.059	-1000.0
Wnt signaling	5.0	41.0	7.0	-0.004	0.028	1000.0	-1000.0	-0.025	-1000.0
Arf6 trafficking events	5.0	389.0	71.0	-0.252	0.047	1000.0	-1000.0	-0.037	-1000.0
BCR signaling pathway	5.0	588.0	99.0	-0.044	0.062	1000.0	-1000.0	-0.064	-1000.0
ErbB2/ErbB3 signaling events	4.0	288.0	65.0	-0.059	0.048	1000.0	-1000.0	-0.056	-1000.0
IL12-mediated signaling events	4.0	397.0	87.0	-0.165	0.06	1000.0	-1000.0	-0.081	-1000.0
S1P5 pathway	4.0	81.0	17.0	-0.012	0.027	1000.0	-1000.0	-0.021	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	344.0	83.0	-0.234	0.048	1000.0	-1000.0	-0.041	-1000.0
LPA receptor mediated events	4.0	472.0	102.0	-0.07	0.061	1000.0	-1000.0	-0.065	-1000.0
IGF1 pathway	4.0	229.0	57.0	-0.023	0.065	1000.0	-1000.0	-0.045	-1000.0
S1P4 pathway	4.0	116.0	25.0	-0.01	0.052	1000.0	-1000.0	-0.033	-1000.0
BARD1 signaling events	3.0	176.0	57.0	-0.049	0.06	1000.0	-1000.0	-0.054	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	202.0	65.0	-0.01	0.066	1000.0	-1000.0	-0.051	-1000.0
mTOR signaling pathway	3.0	194.0	53.0	-0.017	0.048	1000.0	-1000.0	-0.037	-1000.0
Nectin adhesion pathway	3.0	238.0	63.0	-0.025	0.056	1000.0	-1000.0	-0.061	-1000.0
FAS signaling pathway (CD95)	3.0	153.0	47.0	-0.119	0.04	1000.0	-1000.0	-0.035	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	46.0	15.0	-0.01	0.028	1000.0	-1000.0	-0.037	-1000.0
Insulin Pathway	3.0	242.0	74.0	-0.024	0.071	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PRL	3.0	110.0	34.0	-0.037	0.04	1000.0	-1000.0	-0.053	-1000.0
FOXM1 transcription factor network	3.0	162.0	51.0	-0.094	0.046	1000.0	-1000.0	-0.112	-1000.0
Aurora B signaling	3.0	213.0	67.0	-0.248	0.049	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class II	2.0	158.0	75.0	-0.106	0.071	1000.0	-1000.0	-0.025	-1000.0
Arf6 downstream pathway	2.0	108.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	2.0	162.0	55.0	-0.003	0.075	1000.0	-1000.0	-0.049	-1000.0
Insulin-mediated glucose transport	2.0	73.0	32.0	-0.03	0.049	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	199.0	68.0	-0.03	0.056	1000.0	-1000.0	-0.043	-1000.0
HIF-2-alpha transcription factor network	2.0	127.0	43.0	-0.173	0.097	1000.0	-1000.0	-0.063	-1000.0
Retinoic acid receptors-mediated signaling	2.0	136.0	58.0	-0.031	0.059	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by PI3K	2.0	151.0	58.0	-0.015	0.062	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events	2.0	214.0	73.0	-0.021	0.048	1000.0	-1000.0	-0.055	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	85.0	33.0	-0.054	0.068	1000.0	-1000.0	-0.04	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	-0.01	0.048	1000.0	-1000.0	-0.04	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	22.0	17.0	0.014	0.045	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class I	1.0	179.0	104.0	-0.106	0.067	1000.0	-1000.0	-0.037	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	65.0	45.0	0.0	0.077	1000.0	-1000.0	-0.047	-1000.0
TCGA08_retinoblastoma	1.0	9.0	8.0	-0.053	0.032	1000.0	-1000.0	-0.005	-1000.0
VEGFR1 specific signals	1.0	94.0	56.0	-0.012	0.064	1000.0	-1000.0	-0.064	-1000.0
Canonical NF-kappaB pathway	0.0	19.0	39.0	-0.0	0.061	1000.0	-1000.0	-0.045	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.009	0.026	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	0.0	29.0	38.0	-0.018	0.055	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.009	0.059	1000.0	-1000.0	-0.04	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.027	0.04	1000.0	-1000.0	0.001	-1000.0
Aurora A signaling	0.0	20.0	60.0	-0.009	0.062	1000.0	-1000.0	-0.026	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.02	0.028	1000.0	-1000.0	-0.025	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	7.0	37.0	-0.01	0.064	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	0.0	22.0	40.0	-0.049	0.05	1000.0	-1000.0	-0.02	-1000.0
TRAIL signaling pathway	0.0	7.0	48.0	-0.0	0.07	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	1.0	36.0	-0.054	0.057	1000.0	-1000.0	-0.046	-1000.0
Atypical NF-kappaB pathway	0.0	17.0	31.0	-0.0	0.04	1000.0	-1000.0	-0.032	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.005	-0.002	1000.0	-1000.0	0.003	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.062	1000.0	-1000.0	-0.036	-1000.0
IL2 signaling events mediated by STAT5	0.0	15.0	22.0	0.007	0.041	1000.0	-1000.0	-0.051	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.004	0.034	1000.0	-1000.0	-0.004	-1000.0
p38 MAPK signaling pathway	0.0	33.0	44.0	-0.0	0.055	1000.0	-1000.0	-0.032	-1000.0
Arf1 pathway	0.0	25.0	54.0	-0.001	0.048	1000.0	-1000.0	-0.026	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.075	1000.0	-1000.0	-0.006	-1000.0
Total	1500	96227	7203	-23.851748054	7.98100934431	131000	-131000	-5.83234974625	-131000