Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.047 0.088 -9999.0 0.0 -0.16 5.0 5.0 epithelial cell differentiation -0.036 0.089 -9999.0 0.0 -0.183 2.0 2.0 CYFIP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.017 0.094 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.054 0.143 -9999.0 0.0 -0.35 3.0 3.0 EPHA2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.031 0.083 -9999.0 0.0 -0.17 2.0 2.0 CTNNB1 -0.048 0.131 -9999.0 0.0 -0.321 3.0 3.0 ABI1/Sra1/Nap1 0.014 0.062 -9999.0 0.0 -0.226 1.0 1.0 AQP5 -0.057 0.104 -9999.0 0.0 -0.334 1.0 1.0 CTNND1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.031 0.082 -9999.0 0.0 -0.168 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.082 -9999.0 0.0 -0.168 2.0 2.0 EGF -0.106 0.181 -9999.0 0.0 -0.373 5.0 5.0 NCKAP1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 AQP3 -0.042 0.112 -9999.0 0.0 -0.284 2.0 2.0 cortical microtubule organization -0.036 0.089 -9999.0 0.0 -0.183 2.0 2.0 GO:0000145 -0.031 0.078 -9999.0 0.0 -0.16 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.034 0.091 -9999.0 0.0 -0.185 2.0 2.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.057 0.084 -9999.0 0.0 -0.239 2.0 2.0 ARF6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.012 0.07 -9999.0 0.0 -0.198 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.02 0.078 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.031 0.083 -9999.0 0.0 -0.17 2.0 2.0 ARF6/GTP 0.018 0.065 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.059 0.155 -9999.0 0.0 -0.379 3.0 3.0 EGFR/EGFR/EGF/EGF -0.125 0.135 -9999.0 0.0 -0.324 4.0 4.0 RhoA/GDP -0.04 0.103 -9999.0 0.0 -0.314 1.0 1.0 actin cytoskeleton organization -0.027 0.081 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 DIAPH1 0.001 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.036 0.089 0.183 2.0 -9999.0 0.0 2.0 RHOA -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 RhoA/GTP -0.065 0.096 -9999.0 0.0 -0.247 3.0 3.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.027 0.082 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 -0.033 0.126 -9999.0 0.0 -0.365 2.0 2.0 LPP -0.025 0.079 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.068 0.099 -9999.0 0.0 -0.277 2.0 2.0 SEC6/SEC8 -0.041 0.055 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.031 0.083 -9999.0 0.0 -0.17 2.0 2.0 HGF/MET -0.07 0.089 -9999.0 0.0 -0.301 1.0 1.0 HGF 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.048 0.089 -9999.0 0.0 -0.161 5.0 5.0 actin cable formation 0.002 0.083 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.029 0.077 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.033 0.082 -9999.0 0.0 -0.17 2.0 2.0 NCK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.031 0.083 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.036 0.089 -9999.0 0.0 -0.183 2.0 2.0 EXOC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.031 0.083 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.031 0.083 -9999.0 0.0 -0.17 2.0 2.0 LIMA1 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.026 0.106 -9999.0 0.0 -0.229 2.0 2.0 adherens junction assembly -0.052 0.125 -9999.0 0.0 -0.422 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.06 0.087 -9999.0 0.0 -0.301 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.038 0.14 -9999.0 0.0 -0.408 2.0 2.0 PLEKHA7 -0.031 0.083 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.011 0.069 -9999.0 0.0 -0.197 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.007 0.075 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.047 0.088 -9999.0 0.0 -0.16 5.0 5.0 regulation of cell-cell adhesion -0.027 0.081 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.048 0.089 -9999.0 0.0 -0.161 5.0 5.0