Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.054 0.092 -9999.0 0.0 -0.206 4.0 4.0 epithelial cell differentiation 0.006 0.108 -9999.0 0.0 -0.209 3.0 3.0 CYFIP2 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.055 0.205 0.692 1.0 -9999.0 0.0 1.0 EGFR -0.037 0.129 -9999.0 0.0 -0.284 3.0 3.0 EPHA2 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.051 0.129 0.331 1.0 -9999.0 0.0 1.0 CTNNB1 -0.045 0.154 -9999.0 0.0 -0.366 3.0 3.0 ABI1/Sra1/Nap1 0.058 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.047 0.072 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.05 0.128 0.328 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.05 0.128 0.328 1.0 -9999.0 0.0 1.0 EGF -0.024 0.106 -9999.0 0.0 -0.182 4.0 4.0 NCKAP1 0.022 0.037 -9999.0 0.0 -0.12 1.0 1.0 AQP3 -0.083 0.155 -9999.0 0.0 -0.471 2.0 2.0 cortical microtubule organization 0.006 0.108 -9999.0 0.0 -0.209 3.0 3.0 GO:0000145 -0.049 0.12 0.309 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.01 0.112 -9999.0 0.0 -0.211 3.0 3.0 MLLT4 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.101 0.069 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.055 0.048 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.053 0.089 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.058 0.092 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.071 0.054 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.016 0.103 -9999.0 0.0 -0.366 1.0 1.0 EGFR/EGFR/EGF/EGF -0.109 0.116 -9999.0 0.0 -0.261 5.0 5.0 RhoA/GDP -0.016 0.122 -9999.0 0.0 -0.219 4.0 4.0 actin cytoskeleton organization -0.057 0.123 0.303 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.02 0.037 -9999.0 0.0 -0.12 1.0 1.0 DIAPH1 0.014 0.146 -9999.0 0.0 -0.546 1.0 1.0 Wnt receptor signaling pathway -0.006 0.108 0.209 3.0 -9999.0 0.0 3.0 RHOA 0.005 0.096 -9999.0 0.0 -0.366 1.0 1.0 RhoA/GTP -0.111 0.08 -9999.0 0.0 -0.245 2.0 2.0 CTNNA1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.059 0.124 0.306 1.0 -9999.0 0.0 1.0 EFNA1 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.078 0.08 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.085 0.069 -9999.0 0.0 -0.215 3.0 3.0 SEC6/SEC8 -0.08 0.08 -9999.0 0.0 -0.224 2.0 2.0 MGAT3 -0.051 0.129 0.331 1.0 -9999.0 0.0 1.0 HGF/MET -0.061 0.068 -9999.0 0.0 -0.215 2.0 2.0 HGF 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.055 0.093 -9999.0 0.0 -0.208 4.0 4.0 actin cable formation -0.003 0.231 0.52 2.0 -9999.0 0.0 2.0 KIAA1543 -0.044 0.122 0.311 1.0 -9999.0 0.0 1.0 KIFC3 -0.091 0.074 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.05 0.128 0.331 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.006 0.108 -9999.0 0.0 -0.209 3.0 3.0 EXOC4 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.079 0.069 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.051 0.129 0.331 1.0 -9999.0 0.0 1.0 LIMA1 0.005 0.096 -9999.0 0.0 -0.366 1.0 1.0 ABI1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.057 0.219 0.732 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.045 0.168 0.437 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.09 0.07 -9999.0 0.0 -0.224 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.045 0.129 0.331 1.0 -9999.0 0.0 1.0 mol:GTP 0.053 0.047 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.053 0.115 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.054 0.092 -9999.0 0.0 -0.206 4.0 4.0 regulation of cell-cell adhesion -0.057 0.123 0.303 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.055 0.093 -9999.0 0.0 -0.208 4.0 4.0