Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
FLT3	53 (27%)	142	0.00031	0.0387	8.9999e-05	0.0118	9.9999e-06	0.00144	0.00012	0.0154	0.00060999	0.0744	0.00036	0.0446
NPM1	52 (27%)	143	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144	9.9999e-06	0.00144
DNMT3A	49 (25%)	146	0.85424	1	9.9999e-06	0.00144	0.02417	1	0.00301	0.343	0.00228	0.264	0.00286	0.329
IDH2	20 (10%)	175	0.10002	1	2e-05	0.00266	0.68574	1	0.34286	1	0.7479	1	0.18349	1
IDH1	18 (9%)	177	1	1	0.00218	0.257	0.2549	1	0.25625	1	0.23645	1	0.8045	1
RUNX1	18 (9%)	177	0.36146	1	4e-05	0.00528	0.00187	0.223	8.9999e-05	0.0118	0.00043	0.0529	0.00107	0.128
TET2	17 (9%)	178	0.35478	1	0.51623	1	0.29238	1	0.57179	1	0.65761	1	0.84748	1
NRAS	15 (8%)	180	0.4183	1	0.88731	1	0.60471	1	0.9373	1	0.81313	1	0.66509	1
WT1	12 (6%)	183	0.42023	1	9.9999e-06	0.00144	0.081739	1	0.36551	1	0.068219	1	0.27375	1
U2AF1	8 (4%)	187	1	1	0.14919	1	0.23301	1	0.25633	1	0.076359	1	0.47123	1
TP53	15 (8%)	180	9.9999e-06	0.00144	9.9999e-06	0.00144	0.00094999	0.115	0.00222	0.26	0.00021	0.0265	0.00011	0.0142
CEBPA	13 (7%)	182	0.59297	1	0.0080399	0.9	0.19938	1	0.00012	0.0154	0.03551	1	0.01012	1
PHF6	6 (3%)	189	1	1	0.084349	1	0.72979	1	0.47056	1	0.72914	1	0.34334	1
KRAS	8 (4%)	187	0.075339	1	0.36298	1	0.32536	1	0.64661	1	0.25391	1	0.68243	1
SMC3	7 (4%)	188	1	1	0.29773	1	0.55074	1	0.44374	1	0.21665	1	0.41653	1
KIT	8 (4%)	187	0.10233	1	0.12994	1	0.32422	1	0.0052699	0.596	0.35681	1	0.19096	1
RAD21	5 (3%)	190	0.47769	1	0.66321	1	0.60617	1	0.18369	1	0.2142	1	0.60479	1
EZH2	3 (2%)	192	0.10275	1	NA	NA	0.25644	1	0.59112	1	0.1589	1	0.41911	1
STAG2	6 (3%)	189	0.5632	1	0.33053	1	0.13163	1	0.02632	1	0.68592	1	0.063809	1
PTPN11	9 (5%)	186	0.68091	1	0.3899	1	0.04658	1	0.50585	1	0.099999	1	0.20499	1
ASXL1	5 (3%)	190	0.73662	1	0.21685	1	0.2588	1	0.59092	1	0.1571	1	0.41654	1
SUZ12	3 (2%)	192	0.28596	1	0.33164	1	0.25565	1	0.59023	1	0.19842	1	0.14139	1
PHACTR1	3 (2%)	192	NA	NA	0.33104	1	NA	NA	NA	NA	0.8898	1	0.41768	1
SMC1A	6 (3%)	189	0.76103	1	0.55222	1	0.57287	1	0.24397	1	0.17374	1	0.66258	1
KDM6A	3 (2%)	192	0.54994	1	1	1	NA	NA	NA	NA	0.89042	1	0.78453	1