E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.095 0.188 -9999.0 0.0 -0.441 32.0 32.0 KLHL20 -0.04 0.098 -9999.0 0.0 -0.196 35.0 35.0 CYFIP2 0.013 0.043 -9999.0 0.0 -0.381 2.0 2.0 Rac1/GDP -0.038 0.117 -9999.0 0.0 -0.229 35.0 35.0 ENAH -0.092 0.173 -9999.0 0.0 -0.406 33.0 33.0 AP1M1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.05 0.073 -9999.0 0.0 -0.239 14.0 14.0 ABI1/Sra1/Nap1 -0.05 0.061 -9999.0 0.0 -0.147 41.0 41.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.101 -9999.0 0.0 -0.199 32.0 32.0 RAPGEF1 -0.059 0.15 -9999.0 0.0 -0.342 32.0 32.0 CTNND1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.068 0.167 -9999.0 0.0 -0.399 31.0 31.0 CRK -0.069 0.162 -9999.0 0.0 -0.368 33.0 33.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.126 -9999.0 0.0 -0.244 43.0 43.0 alphaE/beta7 Integrin 0.011 0.056 -9999.0 0.0 -0.199 11.0 11.0 IQGAP1 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 NCKAP1 -0.046 0.132 -9999.0 0.0 -0.313 33.0 33.0 Rap1/GTP/I-afadin 0.004 0.065 -9999.0 0.0 -0.186 9.0 9.0 DLG1 -0.06 0.162 -9999.0 0.0 -0.396 29.0 29.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.054 -9999.0 0.0 -0.188 11.0 11.0 MLLT4 -0.037 0.121 -9999.0 0.0 -0.298 30.0 30.0 ARF6/GTP/NME1/Tiam1 0.003 0.068 -9999.0 0.0 -0.172 15.0 15.0 PI3K -0.045 0.068 -9999.0 0.0 -0.242 11.0 11.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.083 0.142 -9999.0 0.0 -0.239 71.0 71.0 TIAM1 -0.04 0.126 -9999.0 0.0 -0.31 30.0 30.0 E-cadherin(dimer)/Ca2+ -0.028 0.093 -9999.0 0.0 -0.179 34.0 34.0 AKT1 -0.023 0.042 -9999.0 0.0 -0.141 10.0 10.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.098 0.163 -9999.0 0.0 -0.319 59.0 59.0 RhoA/GDP -0.037 0.117 -9999.0 0.0 -0.229 35.0 35.0 actin cytoskeleton organization -0.028 0.073 -9999.0 0.0 -0.144 35.0 35.0 CDC42/GDP -0.037 0.117 -9999.0 0.0 -0.229 35.0 35.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.057 0.117 -9999.0 0.0 -0.226 46.0 46.0 ITGB7 0.005 0.066 -9999.0 0.0 -0.342 6.0 6.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.03 0.1 -9999.0 0.0 -0.191 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.032 0.087 -9999.0 0.0 -0.143 62.0 62.0 mol:GDP -0.052 0.131 -9999.0 0.0 -0.267 36.0 36.0 CDC42/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 JUP -0.026 0.123 -9999.0 0.0 -0.375 19.0 19.0 p120 catenin/RhoA/GDP -0.038 0.12 -9999.0 0.0 -0.248 29.0 29.0 RAC1/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 PIP5K1C/AP1M1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.027 0.068 -9999.0 0.0 -0.13 40.0 40.0 NME1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.084 0.166 -9999.0 0.0 -0.402 31.0 31.0 regulation of cell-cell adhesion -0.045 0.065 -9999.0 0.0 -0.211 14.0 14.0 WASF2 -0.024 0.033 -9999.0 0.0 -0.09 21.0 21.0 Rap1/GTP -0.033 0.103 -9999.0 0.0 -0.261 16.0 16.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.12 -9999.0 0.0 -0.212 46.0 46.0 CCND1 -0.033 0.082 -9999.0 0.0 -0.161 39.0 39.0 VAV2 -0.103 0.217 -9999.0 0.0 -0.457 40.0 40.0 RAP1/GDP -0.035 0.108 -9999.0 0.0 -0.26 17.0 17.0 adherens junction assembly -0.082 0.161 -9999.0 0.0 -0.39 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.114 -9999.0 0.0 -0.298 15.0 15.0 E-cadherin/beta catenin -0.052 0.111 -9999.0 0.0 -0.285 28.0 28.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.171 -9999.0 0.0 -0.396 33.0 33.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.096 0.131 -9999.0 0.0 -0.312 37.0 37.0 E-cadherin/beta catenin/alpha catenin -0.039 0.103 -9999.0 0.0 -0.171 62.0 62.0 ITGAE 0.009 0.047 -9999.0 0.0 -0.262 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.17 -9999.0 0.0 -0.408 31.0 31.0