Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.132 -9999.0 0.0 -0.384 12.0 12.0 IHH -0.01 0.065 -9999.0 0.0 -0.289 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.018 0.08 -9999.0 0.0 -0.191 23.0 23.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.079 0.19 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.052 0.145 -9999.0 0.0 -0.447 10.0 10.0 SMO -0.063 0.151 -9999.0 0.0 -0.441 12.0 12.0 AKT1 -0.008 0.073 -9999.0 0.0 -0.256 2.0 2.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.037 -9999.0 0.0 -0.322 2.0 2.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.062 0.149 -9999.0 0.0 -0.435 12.0 12.0 STIL -0.023 0.115 -9999.0 0.0 -0.293 16.0 16.0 DHH N/PTCH2 0.016 0.042 -9999.0 0.0 -0.224 5.0 5.0 DHH N/PTCH1 -0.027 0.127 -9999.0 0.0 -0.347 13.0 13.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.01 0.03 -9999.0 0.0 -0.262 2.0 2.0 PTHLH -0.026 0.135 -9999.0 0.0 -0.438 10.0 10.0 determination of left/right symmetry -0.062 0.149 -9999.0 0.0 -0.435 12.0 12.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.026 0.134 -9999.0 0.0 -0.435 10.0 10.0 IHH N/Hhip -0.044 0.109 -9999.0 0.0 -0.238 38.0 38.0 DHH N/Hhip -0.029 0.096 -9999.0 0.0 -0.204 38.0 38.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.062 0.149 -9999.0 0.0 -0.435 12.0 12.0 pancreas development -0.054 0.133 -9999.0 0.0 -0.303 37.0 37.0 HHAT 0.003 0.073 -9999.0 0.0 -0.381 6.0 6.0 PI3K 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.041 0.127 -9999.0 0.0 -0.32 29.0 29.0 somite specification -0.062 0.149 -9999.0 0.0 -0.435 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.027 0.12 -9999.0 0.0 -0.313 16.0 16.0 SHH Np/Cholesterol/PTCH2 0.009 0.052 -9999.0 0.0 -0.189 9.0 9.0 SHH Np/Cholesterol/Megalin 0.001 0.056 -9999.0 0.0 -0.21 6.0 6.0 SHH 0.003 0.059 -9999.0 0.0 -0.217 11.0 11.0 catabolic process -0.037 0.14 -9999.0 0.0 -0.31 26.0 26.0 SMO/Vitamin D3 -0.045 0.13 -9999.0 0.0 -0.368 15.0 15.0 SHH Np/Cholesterol/Hhip -0.025 0.082 -9999.0 0.0 -0.18 28.0 28.0 LRP2 -0.003 0.064 -9999.0 0.0 -0.262 10.0 10.0 receptor-mediated endocytosis -0.037 0.133 -9999.0 0.0 -0.432 10.0 10.0 SHH Np/Cholesterol/BOC 0.01 0.048 -9999.0 0.0 -0.188 7.0 7.0 SHH Np/Cholesterol/CDO -0.01 0.073 -9999.0 0.0 -0.192 18.0 18.0 mesenchymal cell differentiation 0.025 0.082 0.179 28.0 -9999.0 0.0 28.0 mol:Vitamin D3 -0.026 0.121 -9999.0 0.0 -0.313 16.0 16.0 IHH N/PTCH2 0.005 0.053 -9999.0 0.0 -0.262 4.0 4.0 CDON -0.026 0.108 -9999.0 0.0 -0.292 24.0 24.0 IHH N/PTCH1 -0.035 0.142 -9999.0 0.0 -0.311 26.0 26.0 Megalin/LRPAP1 0.011 0.044 -9999.0 0.0 -0.166 10.0 10.0 PTCH2 0.01 0.052 -9999.0 0.0 -0.381 3.0 3.0 SHH Np/Cholesterol 0.003 0.044 -9999.0 0.0 -0.161 11.0 11.0 PTCH1 -0.037 0.141 -9999.0 0.0 -0.311 26.0 26.0 HHIP -0.054 0.133 -9999.0 0.0 -0.304 37.0 37.0