E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.183 -9999.0 0.0 -0.428 31.0 31.0 KLHL20 -0.022 0.098 0.167 1.0 -0.212 23.0 24.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.339 2.0 2.0 Rac1/GDP -0.039 0.117 -9999.0 0.0 -0.24 33.0 33.0 ENAH -0.063 0.173 -9999.0 0.0 -0.401 31.0 31.0 AP1M1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.095 0.139 2.0 -0.191 28.0 30.0 ABI1/Sra1/Nap1 -0.039 0.06 -9999.0 0.0 -0.162 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.096 -9999.0 0.0 -0.178 28.0 28.0 RAPGEF1 -0.066 0.146 -9999.0 0.0 -0.345 31.0 31.0 CTNND1 0.024 0.05 -9999.0 0.0 -0.339 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.169 -9999.0 0.0 -0.388 31.0 31.0 CRK -0.065 0.155 -9999.0 0.0 -0.375 29.0 29.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.124 -9999.0 0.0 -0.224 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.229 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.339 1.0 1.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.339 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.056 -9999.0 0.0 -0.179 9.0 9.0 DLG1 -0.053 0.161 -9999.0 0.0 -0.387 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.063 -9999.0 0.0 -0.146 28.0 28.0 MLLT4 0.008 0.084 -9999.0 0.0 -0.339 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.179 11.0 11.0 PI3K -0.032 0.083 -9999.0 0.0 -0.185 28.0 28.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.132 -9999.0 0.0 -0.268 36.0 36.0 TIAM1 0.003 0.092 -9999.0 0.0 -0.339 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.097 -9999.0 0.0 -0.176 31.0 31.0 AKT1 -0.026 0.049 -9999.0 0.0 -0.148 9.0 9.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.133 -9999.0 0.0 -0.339 26.0 26.0 RhoA/GDP -0.04 0.118 -9999.0 0.0 -0.243 32.0 32.0 actin cytoskeleton organization -0.014 0.075 0.151 3.0 -0.155 23.0 26.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.244 32.0 33.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.214 43.0 43.0 ITGB7 0.023 0.057 -9999.0 0.0 -0.339 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.104 -9999.0 0.0 -0.188 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.085 -9999.0 0.0 -0.173 28.0 28.0 mol:GDP -0.06 0.126 -9999.0 0.0 -0.273 34.0 34.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.196 1.0 1.0 JUP -0.008 0.112 -9999.0 0.0 -0.339 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.123 -9999.0 0.0 -0.249 32.0 32.0 RAC1/GTP/IQGAP1 0.037 0.022 -9999.0 0.0 -0.17 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.339 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.013 0.052 -9999.0 0.0 -0.127 17.0 17.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.166 -9999.0 0.0 -0.389 31.0 31.0 regulation of cell-cell adhesion -0.024 0.08 -9999.0 0.0 -0.169 28.0 28.0 WASF2 -0.01 0.042 0.08 2.0 -0.089 24.0 26.0 Rap1/GTP -0.023 0.104 0.176 2.0 -0.21 28.0 30.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.124 -9999.0 0.0 -0.192 41.0 41.0 CCND1 -0.016 0.063 -9999.0 0.0 -0.156 17.0 17.0 VAV2 -0.093 0.217 -9999.0 0.0 -0.55 21.0 21.0 RAP1/GDP -0.028 0.111 0.19 2.0 -0.219 28.0 30.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.378 31.0 31.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.111 -9999.0 0.0 -0.189 39.0 39.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.275 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.07 0.167 -9999.0 0.0 -0.388 32.0 32.0 PIK3CA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.132 -9999.0 0.0 -0.328 25.0 25.0 E-cadherin/beta catenin/alpha catenin 0.01 0.101 -9999.0 0.0 -0.206 28.0 28.0 ITGAE 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.396 31.0 31.0