Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.022 0.072 -9999.0 0.0 -0.359 5.0 5.0 IHH 0.034 0.037 -9999.0 0.0 -0.148 5.0 5.0 SHH Np/Cholesterol/GAS1 0.004 0.058 -9999.0 0.0 -0.177 15.0 15.0 LRPAP1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.058 0.176 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 -0.007 0.13 -9999.0 0.0 -0.458 6.0 6.0 SMO -0.015 0.122 -9999.0 0.0 -0.513 5.0 5.0 AKT1 0.017 0.068 -9999.0 0.0 -0.34 2.0 2.0 ARRB2 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.029 -9999.0 0.0 -0.339 1.0 1.0 ADRBK1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.014 0.12 -9999.0 0.0 -0.505 5.0 5.0 STIL 0.008 0.067 0.185 2.0 -0.315 5.0 7.0 DHH N/PTCH2 0.04 0.033 -9999.0 0.0 -0.238 2.0 2.0 DHH N/PTCH1 0.033 0.071 -9999.0 0.0 -0.364 5.0 5.0 PIK3CA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.017 0.086 -9999.0 0.0 -0.448 5.0 5.0 determination of left/right symmetry -0.014 0.12 -9999.0 0.0 -0.505 5.0 5.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.017 0.085 -9999.0 0.0 -0.445 5.0 5.0 IHH N/Hhip 0.019 0.079 -9999.0 0.0 -0.261 11.0 11.0 DHH N/Hhip 0.02 0.07 -9999.0 0.0 -0.238 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.014 0.12 -9999.0 0.0 -0.505 5.0 5.0 pancreas development 0.0 0.091 -9999.0 0.0 -0.338 11.0 11.0 HHAT 0.025 0.05 -9999.0 0.0 -0.339 3.0 3.0 PI3K 0.046 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.095 -9999.0 0.0 -0.339 12.0 12.0 somite specification -0.014 0.12 -9999.0 0.0 -0.505 5.0 5.0 SHH Np/Cholesterol/PTCH1 0.014 0.064 -9999.0 0.0 -0.299 6.0 6.0 SHH Np/Cholesterol/PTCH2 0.02 0.036 -9999.0 0.0 -0.176 5.0 5.0 SHH Np/Cholesterol/Megalin 0.019 0.028 -9999.0 0.0 -0.166 3.0 3.0 SHH -0.001 0.03 -9999.0 0.0 -0.238 2.0 2.0 catabolic process 0.013 0.075 -9999.0 0.0 -0.405 5.0 5.0 SMO/Vitamin D3 -0.006 0.09 0.201 1.0 -0.435 5.0 6.0 SHH Np/Cholesterol/Hhip 0.003 0.056 -9999.0 0.0 -0.177 14.0 14.0 LRP2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.002 0.093 -9999.0 0.0 -0.476 5.0 5.0 SHH Np/Cholesterol/BOC 0.02 0.032 -9999.0 0.0 -0.169 4.0 4.0 SHH Np/Cholesterol/CDO 0.015 0.042 -9999.0 0.0 -0.176 7.0 7.0 mesenchymal cell differentiation -0.003 0.056 0.176 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.015 0.07 0.197 4.0 -0.328 5.0 9.0 IHH N/PTCH2 0.041 0.043 -9999.0 0.0 -0.263 2.0 2.0 CDON 0.018 0.057 -9999.0 0.0 -0.339 4.0 4.0 IHH N/PTCH1 0.024 0.078 -9999.0 0.0 -0.406 5.0 5.0 Megalin/LRPAP1 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.041 -9999.0 0.0 -0.339 2.0 2.0 SHH Np/Cholesterol 0.016 0.027 -9999.0 0.0 -0.169 3.0 3.0 PTCH1 0.013 0.075 -9999.0 0.0 -0.406 5.0 5.0 HHIP 0.0 0.091 -9999.0 0.0 -0.339 11.0 11.0