E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.036 0.165 -9999.0 0.0 -0.459 60.0 60.0 KLHL20 -0.027 0.056 -9999.0 0.0 -0.266 9.0 9.0 CYFIP2 0.008 0.06 -9999.0 0.0 -0.541 6.0 6.0 Rac1/GDP 0.007 0.111 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.036 0.165 -9999.0 0.0 -0.459 60.0 60.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.022 -9999.0 0.0 -0.49 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.036 0.067 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.017 0.039 -9999.0 0.0 -0.182 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.093 0.153 -9999.0 0.0 -0.377 74.0 74.0 RAPGEF1 -0.015 0.146 -9999.0 0.0 -0.387 60.0 60.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.074 0.155 -9999.0 0.0 -0.479 60.0 60.0 CRK -0.025 0.156 -9999.0 0.0 -0.425 60.0 60.0 E-cadherin/gamma catenin/alpha catenin -0.085 0.146 -9999.0 0.0 -0.324 134.0 134.0 alphaE/beta7 Integrin -0.033 0.107 -9999.0 0.0 -0.381 44.0 44.0 IQGAP1 0.004 0.076 -9999.0 0.0 -0.531 10.0 10.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.001 0.018 -9999.0 0.0 -0.289 2.0 2.0 DLG1 -0.036 0.165 -9999.0 0.0 -0.457 61.0 61.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.026 0.048 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.027 -9999.0 0.0 -0.592 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.0 0.015 -9999.0 0.0 -0.324 1.0 1.0 PI3K -0.033 0.061 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.102 0.176 -9999.0 0.0 -0.391 134.0 134.0 TIAM1 0.013 0.027 -9999.0 0.0 -0.591 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.065 0.114 -9999.0 0.0 -0.298 60.0 60.0 AKT1 -0.019 0.035 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.122 0.24 -9999.0 0.0 -0.538 127.0 127.0 RhoA/GDP 0.007 0.111 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.02 0.041 -9999.0 0.0 -0.191 9.0 9.0 CDC42/GDP 0.007 0.111 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.033 0.108 -9999.0 0.0 -0.272 66.0 66.0 ITGB7 -0.033 0.155 -9999.0 0.0 -0.536 44.0 44.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.042 0.137 -9999.0 0.0 -0.316 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.067 0.118 -9999.0 0.0 -0.27 127.0 127.0 mol:GDP -0.003 0.125 -9999.0 0.0 -0.325 8.0 8.0 CDC42/GTP/IQGAP1 -0.006 0.044 -9999.0 0.0 -0.319 10.0 10.0 JUP 0.003 0.081 -9999.0 0.0 -0.571 10.0 10.0 p120 catenin/RhoA/GDP -0.043 0.086 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.006 0.044 -9999.0 0.0 -0.319 10.0 10.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.01 0.063 -9999.0 0.0 -0.211 29.0 29.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.165 -9999.0 0.0 -0.459 60.0 60.0 regulation of cell-cell adhesion -0.032 0.059 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.008 0.02 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.042 0.077 -9999.0 0.0 -0.323 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.091 0.15 -9999.0 0.0 -0.574 20.0 20.0 CCND1 0.01 0.077 -9999.0 0.0 -0.263 29.0 29.0 VAV2 -0.019 0.154 -9999.0 0.0 -0.416 60.0 60.0 RAP1/GDP -0.04 0.081 -9999.0 0.0 -0.306 1.0 1.0 adherens junction assembly -0.034 0.16 -9999.0 0.0 -0.444 60.0 60.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.052 0.161 -9999.0 0.0 -0.547 20.0 20.0 E-cadherin/beta catenin -0.068 0.132 -9999.0 0.0 -0.385 60.0 60.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.037 0.164 -9999.0 0.0 -0.459 60.0 60.0 PIK3CA 0.013 0.027 -9999.0 0.0 -0.592 1.0 1.0 Rac1/GTP -0.042 0.09 -9999.0 0.0 -0.453 9.0 9.0 E-cadherin/beta catenin/alpha catenin -0.078 0.138 -9999.0 0.0 -0.316 127.0 127.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.076 0.158 -9999.0 0.0 -0.49 60.0 60.0