Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.102 0.293 -9999.0 0.0 -0.717 65.0 65.0 IHH -0.014 0.086 -9999.0 0.0 -0.509 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.069 0.16 -9999.0 0.0 -0.36 83.0 83.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.086 0.148 0.357 83.0 -9999.0 0.0 83.0 SMO/beta Arrestin2 -0.036 0.175 -9999.0 0.0 -0.694 16.0 16.0 SMO -0.046 0.184 -9999.0 0.0 -0.674 20.0 20.0 AKT1 0.002 0.083 -9999.0 0.0 -0.307 7.0 7.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.062 -9999.0 0.0 -0.558 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.181 -9999.0 0.0 -0.612 24.0 24.0 STIL -0.093 0.217 -9999.0 0.0 -0.523 74.0 74.0 DHH N/PTCH2 -0.058 0.144 -9999.0 0.0 -0.404 73.0 73.0 DHH N/PTCH1 -0.069 0.193 -9999.0 0.0 -0.535 39.0 39.0 PIK3CA 0.013 0.027 -9999.0 0.0 -0.592 1.0 1.0 DHH -0.046 0.173 -9999.0 0.0 -0.544 55.0 55.0 PTHLH -0.115 0.344 -9999.0 0.0 -0.921 63.0 63.0 determination of left/right symmetry -0.045 0.181 -9999.0 0.0 -0.612 24.0 24.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.113 0.339 -9999.0 0.0 -0.906 63.0 63.0 IHH N/Hhip -0.115 0.209 -9999.0 0.0 -0.44 145.0 145.0 DHH N/Hhip -0.146 0.21 -9999.0 0.0 -0.421 178.0 178.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.181 -9999.0 0.0 -0.612 24.0 24.0 pancreas development -0.139 0.251 -9999.0 0.0 -0.546 140.0 140.0 HHAT -0.006 0.109 -9999.0 0.0 -0.575 18.0 18.0 PI3K -0.001 0.019 -9999.0 0.0 -0.427 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.014 0.117 -9999.0 0.0 -0.501 28.0 28.0 somite specification -0.045 0.181 -9999.0 0.0 -0.612 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.093 0.214 -9999.0 0.0 -0.536 64.0 64.0 SHH Np/Cholesterol/PTCH2 -0.067 0.157 -9999.0 0.0 -0.347 86.0 86.0 SHH Np/Cholesterol/Megalin -0.167 0.217 -9999.0 0.0 -0.36 257.0 257.0 SHH -0.079 0.188 -9999.0 0.0 -0.406 123.0 123.0 catabolic process -0.047 0.184 -9999.0 0.0 -0.598 26.0 26.0 SMO/Vitamin D3 -0.084 0.216 -9999.0 0.0 -0.562 54.0 54.0 SHH Np/Cholesterol/Hhip -0.139 0.211 -9999.0 0.0 -0.353 223.0 223.0 LRP2 -0.189 0.273 -9999.0 0.0 -0.55 185.0 185.0 receptor-mediated endocytosis -0.179 0.219 -9999.0 0.0 -0.554 97.0 97.0 SHH Np/Cholesterol/BOC -0.057 0.152 -9999.0 0.0 -0.313 126.0 126.0 SHH Np/Cholesterol/CDO -0.075 0.168 -9999.0 0.0 -0.326 148.0 148.0 mesenchymal cell differentiation 0.152 0.198 0.35 223.0 -9999.0 0.0 223.0 mol:Vitamin D3 -0.091 0.215 -9999.0 0.0 -0.539 63.0 63.0 IHH N/PTCH2 -0.011 0.106 -9999.0 0.0 -0.446 25.0 25.0 CDON -0.025 0.145 -9999.0 0.0 -0.557 35.0 35.0 IHH N/PTCH1 -0.047 0.186 -9999.0 0.0 -0.602 26.0 26.0 Megalin/LRPAP1 -0.142 0.19 -9999.0 0.0 -0.393 185.0 185.0 PTCH2 -0.009 0.114 -9999.0 0.0 -0.558 21.0 21.0 SHH Np/Cholesterol -0.075 0.14 -9999.0 0.0 -0.315 123.0 123.0 PTCH1 -0.047 0.185 -9999.0 0.0 -0.6 26.0 26.0 HHIP -0.139 0.251 -9999.0 0.0 -0.547 140.0 140.0