Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.026 0.108 -9999.0 0.0 -0.26 68.0 68.0 epithelial cell differentiation -0.064 0.113 -9999.0 0.0 -0.295 60.0 60.0 CYFIP2 0.008 0.06 -9999.0 0.0 -0.541 6.0 6.0 ENAH 0.008 0.102 -9999.0 0.0 -0.315 7.0 7.0 EGFR -0.083 0.213 -9999.0 0.0 -0.546 89.0 89.0 EPHA2 -0.016 0.12 -9999.0 0.0 -0.497 30.0 30.0 MYO6 -0.029 0.123 -9999.0 0.0 -0.275 60.0 60.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.004 0.034 -9999.0 0.0 -0.318 6.0 6.0 AQP5 -0.136 0.181 -9999.0 0.0 -0.48 88.0 88.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.028 0.121 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.129 -9999.0 0.0 -0.283 69.0 69.0 EGF -0.05 0.181 -9999.0 0.0 -0.555 58.0 58.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.076 0.125 -9999.0 0.0 -0.513 19.0 19.0 cortical microtubule organization -0.064 0.113 -9999.0 0.0 -0.295 60.0 60.0 GO:0000145 -0.027 0.116 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.065 0.114 -9999.0 0.0 -0.298 60.0 60.0 MLLT4 0.013 0.027 -9999.0 0.0 -0.592 1.0 1.0 ARF6/GDP -0.058 0.096 -9999.0 0.0 -0.401 11.0 11.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.017 0.066 -9999.0 0.0 -0.401 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.124 -9999.0 0.0 -0.351 10.0 10.0 PVRL2 0.012 0.035 -9999.0 0.0 -0.541 2.0 2.0 ZYX -0.033 0.126 -9999.0 0.0 -0.279 60.0 60.0 ARF6/GTP -0.015 0.059 -9999.0 0.0 -0.527 1.0 1.0 CDH1 -0.123 0.24 -9999.0 0.0 -0.538 127.0 127.0 EGFR/EGFR/EGF/EGF -0.127 0.168 -9999.0 0.0 -0.523 47.0 47.0 RhoA/GDP -0.059 0.104 -9999.0 0.0 -0.273 60.0 60.0 actin cytoskeleton organization -0.022 0.121 -9999.0 0.0 -0.543 1.0 1.0 IGF-1R heterotetramer 0.013 0.022 -9999.0 0.0 -0.489 1.0 1.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.022 -9999.0 0.0 -0.49 1.0 1.0 IGF1 -0.008 0.112 -9999.0 0.0 -0.561 20.0 20.0 DIAPH1 -0.001 0.052 -9999.0 0.0 -0.647 3.0 3.0 Wnt receptor signaling pathway 0.064 0.113 0.295 60.0 -9999.0 0.0 60.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.058 0.097 -9999.0 0.0 -0.402 11.0 11.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.023 0.123 -9999.0 0.0 -0.559 1.0 1.0 EFNA1 0.01 0.044 -9999.0 0.0 -0.49 4.0 4.0 LPP -0.043 0.137 -9999.0 0.0 -0.451 10.0 10.0 Ephrin A1/EPHA2 -0.07 0.114 -9999.0 0.0 -0.463 10.0 10.0 SEC6/SEC8 -0.051 0.092 -9999.0 0.0 -0.471 3.0 3.0 MGAT3 -0.035 0.131 -9999.0 0.0 -0.287 69.0 69.0 HGF/MET -0.165 0.18 -9999.0 0.0 -0.507 74.0 74.0 HGF -0.079 0.202 -9999.0 0.0 -0.513 91.0 91.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.026 0.109 -9999.0 0.0 -0.262 68.0 68.0 actin cable formation 0.019 0.102 -9999.0 0.0 -0.32 3.0 3.0 KIAA1543 -0.064 0.169 -9999.0 0.0 -0.545 25.0 25.0 KIFC3 -0.03 0.125 -9999.0 0.0 -0.58 1.0 1.0 NCK1 0.013 0.027 -9999.0 0.0 -0.592 1.0 1.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.046 0.136 -9999.0 0.0 -0.296 67.0 67.0 NCK1/GIT1 -0.001 0.019 -9999.0 0.0 -0.427 1.0 1.0 mol:GDP -0.064 0.113 -9999.0 0.0 -0.295 60.0 60.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.123 -9999.0 0.0 -0.275 60.0 60.0 PIP5K1C -0.029 0.123 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.004 0.08 -9999.0 0.0 -0.592 9.0 9.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.003 0.113 -9999.0 0.0 -0.368 6.0 6.0 adherens junction assembly -0.044 0.166 -9999.0 0.0 -0.516 25.0 25.0 IGF-1R heterotetramer/IGF1 -0.066 0.116 -9999.0 0.0 -0.54 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.031 -9999.0 0.0 -0.399 3.0 3.0 MET -0.146 0.251 -9999.0 0.0 -0.533 150.0 150.0 PLEKHA7 -0.038 0.136 -9999.0 0.0 -0.302 65.0 65.0 mol:GTP -0.017 0.065 -9999.0 0.0 -0.399 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.003 0.115 -9999.0 0.0 -0.446 3.0 3.0 cortical actin cytoskeleton stabilization -0.026 0.108 -9999.0 0.0 -0.26 68.0 68.0 regulation of cell-cell adhesion -0.022 0.121 -9999.0 0.0 -0.543 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.026 0.109 -9999.0 0.0 -0.262 68.0 68.0