E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.142 -9999.0 0.0 -0.425 55.0 55.0 KLHL20 0.011 0.071 0.157 7.0 -0.219 6.0 13.0 CYFIP2 0.022 0.037 -9999.0 0.0 -0.428 3.0 3.0 Rac1/GDP -0.004 0.095 0.256 4.0 -0.26 48.0 52.0 ENAH -0.032 0.146 -9999.0 0.0 -0.423 59.0 59.0 AP1M1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.004 0.066 -9999.0 0.0 -0.237 1.0 1.0 ABI1/Sra1/Nap1 -0.014 0.036 -9999.0 0.0 -0.154 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.117 -9999.0 0.0 -0.26 70.0 70.0 RAPGEF1 -0.02 0.135 0.236 5.0 -0.374 55.0 60.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.152 -9999.0 0.0 -0.428 62.0 62.0 CRK -0.031 0.135 0.225 1.0 -0.4 56.0 57.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.105 -9999.0 0.0 -0.262 63.0 63.0 alphaE/beta7 Integrin 0.019 0.069 -9999.0 0.0 -0.305 19.0 19.0 IQGAP1 0.02 0.043 -9999.0 0.0 -0.428 4.0 4.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.025 -9999.0 0.0 -0.233 1.0 1.0 DLG1 -0.031 0.145 -9999.0 0.0 -0.42 60.0 60.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.014 0.045 -9999.0 0.0 -0.179 1.0 1.0 MLLT4 0.024 0.021 -9999.0 0.0 -0.428 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.015 0.058 -9999.0 0.0 -0.23 1.0 1.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.021 0.117 -9999.0 0.0 -0.31 63.0 63.0 TIAM1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.029 0.089 -9999.0 0.0 -0.22 55.0 55.0 AKT1 -0.003 0.043 0.121 2.0 -0.136 1.0 3.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.046 0.147 -9999.0 0.0 -0.428 59.0 59.0 RhoA/GDP 0.004 0.103 0.252 8.0 -0.259 52.0 60.0 actin cytoskeleton organization 0.014 0.06 0.161 19.0 -0.16 6.0 25.0 CDC42/GDP -0.0 0.1 0.255 5.0 -0.254 52.0 57.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.078 -9999.0 0.0 -0.222 60.0 60.0 ITGB7 0.002 0.091 -9999.0 0.0 -0.428 19.0 19.0 RAC1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.095 -9999.0 0.0 -0.234 55.0 55.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.015 0.086 -9999.0 0.0 -0.218 59.0 59.0 mol:GDP -0.012 0.113 0.255 9.0 -0.297 52.0 61.0 CDC42/GTP/IQGAP1 0.027 0.028 -9999.0 0.0 -0.232 4.0 4.0 JUP 0.02 0.049 -9999.0 0.0 -0.428 6.0 6.0 p120 catenin/RhoA/GDP 0.008 0.105 0.257 6.0 -0.265 51.0 57.0 RAC1/GTP/IQGAP1 0.027 0.03 -9999.0 0.0 -0.256 4.0 4.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.052 0.135 21.0 -0.167 15.0 36.0 NME1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.032 0.146 -9999.0 0.0 -0.42 61.0 61.0 regulation of cell-cell adhesion -0.009 0.055 -9999.0 0.0 -0.209 1.0 1.0 WASF2 0.009 0.029 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.001 0.082 0.235 2.0 -0.263 1.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.121 -9999.0 0.0 -0.251 74.0 74.0 CCND1 0.012 0.061 0.156 17.0 -0.206 15.0 32.0 VAV2 -0.013 0.152 -9999.0 0.0 -0.555 8.0 8.0 RAP1/GDP 0.007 0.091 0.27 4.0 -0.246 7.0 11.0 adherens junction assembly -0.03 0.142 -9999.0 0.0 -0.407 61.0 61.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.016 0.113 -9999.0 0.0 -0.245 71.0 71.0 E-cadherin/beta catenin -0.029 0.105 -9999.0 0.0 -0.321 57.0 57.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.032 0.144 -9999.0 0.0 -0.418 59.0 59.0 PIK3CA 0.025 0.02 -9999.0 0.0 -0.428 1.0 1.0 Rac1/GTP -0.017 0.084 -9999.0 0.0 -0.338 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.016 0.1 -9999.0 0.0 -0.257 59.0 59.0 ITGAE 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.029 0.155 -9999.0 0.0 -0.437 62.0 62.0