Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.192 -9999.0 0.0 -0.581 53.0 53.0 IHH 0.011 0.056 0.181 1.0 -0.202 6.0 7.0 SHH Np/Cholesterol/GAS1 -0.012 0.084 0.156 12.0 -0.237 53.0 65.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.012 0.083 0.236 53.0 -0.155 12.0 65.0 SMO/beta Arrestin2 -0.005 0.115 -9999.0 0.0 -0.405 18.0 18.0 SMO -0.02 0.111 -9999.0 0.0 -0.412 20.0 20.0 AKT1 -0.003 0.106 -9999.0 0.0 -0.53 13.0 13.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.036 -9999.0 0.0 -0.309 5.0 5.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.02 0.11 -9999.0 0.0 -0.407 20.0 20.0 STIL -0.012 0.133 0.248 2.0 -0.299 37.0 39.0 DHH N/PTCH2 0.005 0.085 -9999.0 0.0 -0.308 31.0 31.0 DHH N/PTCH1 -0.02 0.122 -9999.0 0.0 -0.303 58.0 58.0 PIK3CA 0.025 0.02 -9999.0 0.0 -0.428 1.0 1.0 DHH -0.007 0.105 -9999.0 0.0 -0.428 27.0 27.0 PTHLH -0.061 0.256 -9999.0 0.0 -0.776 53.0 53.0 determination of left/right symmetry -0.02 0.11 -9999.0 0.0 -0.407 20.0 20.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.06 0.253 -9999.0 0.0 -0.766 53.0 53.0 IHH N/Hhip -0.039 0.135 -9999.0 0.0 -0.337 76.0 76.0 DHH N/Hhip -0.048 0.14 -9999.0 0.0 -0.313 99.0 99.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.02 0.11 -9999.0 0.0 -0.407 20.0 20.0 pancreas development -0.057 0.158 -9999.0 0.0 -0.291 133.0 133.0 HHAT 0.012 0.077 -9999.0 0.0 -0.393 17.0 17.0 PI3K 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.016 0.047 -9999.0 0.0 -0.165 26.0 26.0 somite specification -0.02 0.11 -9999.0 0.0 -0.407 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.036 0.113 -9999.0 0.0 -0.28 67.0 67.0 SHH Np/Cholesterol/PTCH2 -0.017 0.082 0.154 2.0 -0.238 56.0 58.0 SHH Np/Cholesterol/Megalin -0.059 0.124 0.154 8.0 -0.269 114.0 122.0 SHH -0.03 0.097 -9999.0 0.0 -0.308 52.0 52.0 catabolic process -0.018 0.117 -9999.0 0.0 -0.342 52.0 52.0 SMO/Vitamin D3 -0.033 0.117 0.342 1.0 -0.377 21.0 22.0 SHH Np/Cholesterol/Hhip -0.047 0.119 0.155 8.0 -0.271 97.0 105.0 LRP2 -0.092 0.181 -9999.0 0.0 -0.307 181.0 181.0 receptor-mediated endocytosis -0.066 0.143 -9999.0 0.0 -0.416 42.0 42.0 SHH Np/Cholesterol/BOC -0.014 0.08 -9999.0 0.0 -0.237 54.0 54.0 SHH Np/Cholesterol/CDO -0.02 0.089 0.173 1.0 -0.25 59.0 60.0 mesenchymal cell differentiation 0.047 0.118 0.269 97.0 -0.154 8.0 105.0 mol:Vitamin D3 -0.002 0.146 0.323 3.0 -0.281 66.0 69.0 IHH N/PTCH2 0.023 0.051 -9999.0 0.0 -0.371 5.0 5.0 CDON 0.001 0.096 -9999.0 0.0 -0.428 23.0 23.0 IHH N/PTCH1 -0.011 0.122 -9999.0 0.0 -0.344 52.0 52.0 Megalin/LRPAP1 -0.051 0.137 -9999.0 0.0 -0.304 107.0 107.0 PTCH2 0.016 0.048 -9999.0 0.0 -0.28 10.0 10.0 SHH Np/Cholesterol -0.019 0.075 0.203 1.0 -0.233 52.0 53.0 PTCH1 -0.019 0.118 -9999.0 0.0 -0.343 52.0 52.0 HHIP -0.057 0.158 -9999.0 0.0 -0.292 133.0 133.0