Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.084 -9999.0 0.0 -0.226 62.0 62.0 epithelial cell differentiation 0.024 0.086 -9999.0 0.0 -0.218 55.0 55.0 CYFIP2 0.022 0.037 -9999.0 0.0 -0.428 3.0 3.0 ENAH -0.025 0.061 0.27 3.0 -9999.0 0.0 3.0 EGFR -0.017 0.124 -9999.0 0.0 -0.402 46.0 46.0 EPHA2 0.012 0.045 -9999.0 0.0 -0.151 29.0 29.0 MYO6 -0.014 0.08 0.177 21.0 -0.211 51.0 72.0 CTNNB1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.028 -9999.0 0.0 -0.234 3.0 3.0 AQP5 -0.062 0.163 0.22 4.0 -0.442 67.0 71.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.078 0.175 20.0 -0.208 51.0 71.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.081 0.176 19.0 -0.211 56.0 75.0 EGF -0.01 0.114 -9999.0 0.0 -0.313 54.0 54.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.102 0.22 3.0 -0.446 17.0 20.0 cortical microtubule organization 0.024 0.086 -9999.0 0.0 -0.218 55.0 55.0 GO:0000145 -0.027 0.07 0.164 20.0 -0.199 51.0 71.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.089 -9999.0 0.0 -0.22 55.0 55.0 MLLT4 0.024 0.021 -9999.0 0.0 -0.428 1.0 1.0 ARF6/GDP -0.038 0.056 -9999.0 0.0 -0.23 6.0 6.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.054 0.037 -9999.0 0.0 -0.252 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.085 0.174 8.0 -0.337 18.0 26.0 PVRL2 0.02 0.023 -9999.0 0.0 -0.428 1.0 1.0 ZYX -0.013 0.069 0.177 11.0 -0.212 43.0 54.0 ARF6/GTP 0.059 0.038 -9999.0 0.0 -0.236 3.0 3.0 CDH1 -0.046 0.147 -9999.0 0.0 -0.428 59.0 59.0 EGFR/EGFR/EGF/EGF -0.02 0.119 -9999.0 0.0 -0.238 105.0 105.0 RhoA/GDP 0.026 0.083 -9999.0 0.0 -0.208 55.0 55.0 actin cytoskeleton organization -0.028 0.075 0.165 21.0 -0.213 49.0 70.0 IGF-1R heterotetramer 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.012 0.076 -9999.0 0.0 -0.339 20.0 20.0 DIAPH1 0.02 0.125 -9999.0 0.0 -0.613 7.0 7.0 Wnt receptor signaling pathway -0.024 0.086 0.218 55.0 -9999.0 0.0 55.0 RHOA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.038 0.056 -9999.0 0.0 -0.231 6.0 6.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.077 0.167 21.0 -0.218 49.0 70.0 EFNA1 0.024 0.014 -9999.0 0.0 -0.131 4.0 4.0 LPP -0.036 0.077 0.17 19.0 -0.208 60.0 79.0 Ephrin A1/EPHA2 0.013 0.08 -9999.0 0.0 -0.203 54.0 54.0 SEC6/SEC8 -0.015 0.06 -9999.0 0.0 -0.209 26.0 26.0 MGAT3 -0.016 0.082 0.177 19.0 -0.214 56.0 75.0 HGF/MET -0.025 0.119 -9999.0 0.0 -0.249 93.0 93.0 HGF -0.009 0.091 -9999.0 0.0 -0.205 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.085 -9999.0 0.0 -0.228 62.0 62.0 actin cable formation -0.005 0.096 0.282 18.0 -0.263 9.0 27.0 KIAA1543 -0.032 0.076 0.165 15.0 -0.217 55.0 70.0 KIFC3 -0.016 0.079 0.177 16.0 -0.214 54.0 70.0 NCK1 0.025 0.02 -9999.0 0.0 -0.428 1.0 1.0 EXOC3 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.081 0.177 19.0 -0.213 52.0 71.0 NCK1/GIT1 0.038 0.016 -9999.0 0.0 -0.305 1.0 1.0 mol:GDP 0.024 0.086 -9999.0 0.0 -0.218 55.0 55.0 EXOC4 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.08 0.177 20.0 -0.211 53.0 73.0 PIP5K1C -0.014 0.078 0.177 20.0 -0.211 51.0 71.0 LIMA1 0.019 0.056 -9999.0 0.0 -0.428 8.0 8.0 ABI1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.022 0.082 0.39 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.01 0.09 0.273 10.0 -0.407 5.0 15.0 IGF-1R heterotetramer/IGF1 0.014 0.09 -9999.0 0.0 -0.219 62.0 62.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.03 0.027 -9999.0 0.0 -0.305 2.0 2.0 MET -0.046 0.136 -9999.0 0.0 -0.428 50.0 50.0 PLEKHA7 -0.019 0.085 0.178 16.0 -0.227 55.0 71.0 mol:GTP 0.052 0.036 -9999.0 0.0 -0.251 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.02 0.117 0.326 27.0 -0.366 1.0 28.0 cortical actin cytoskeleton stabilization -0.01 0.084 -9999.0 0.0 -0.226 62.0 62.0 regulation of cell-cell adhesion -0.028 0.075 0.165 21.0 -0.213 49.0 70.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.085 -9999.0 0.0 -0.228 62.0 62.0