Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	9.0	74.0	8.0	-0.153	0.146	1000.0	-1000.0	-0.011	-1000.0
Ephrin A  reverse signaling	8.0	61.0	7.0	-0.222	0.0	1000.0	-1000.0	-0.006	-1000.0
FOXM1 transcription factor network	8.0	409.0	51.0	-1.092	0.017	1000.0	-1000.0	-0.153	-1000.0
E-cadherin signaling events	7.0	39.0	5.0	-0.244	0.017	1000.0	-1000.0	-0.012	-1000.0
PLK2 and PLK4 events	5.0	16.0	3.0	-0.084	-1000.0	1000.0	-1000.0	-0.006	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	353.0	68.0	-0.626	0.394	1000.0	-1000.0	-0.096	-1000.0
IL23-mediated signaling events	5.0	315.0	60.0	-0.733	0.019	1000.0	-1000.0	-0.137	-1000.0
IL12-mediated signaling events	4.0	360.0	87.0	-0.492	0.111	1000.0	-1000.0	-0.105	-1000.0
Endothelins	4.0	457.0	96.0	-0.363	0.039	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by the Hedgehog family	3.0	185.0	52.0	-0.214	0.125	1000.0	-1000.0	-0.026	-1000.0
Thromboxane A2 receptor signaling	3.0	394.0	105.0	-0.315	0.07	1000.0	-1000.0	-0.055	-1000.0
HIF-1-alpha transcription factor network	3.0	243.0	76.0	-0.227	0.04	1000.0	-1000.0	-0.074	-1000.0
PDGFR-alpha signaling pathway	3.0	167.0	44.0	-0.353	0.034	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	436.0	125.0	-0.179	0.03	1000.0	-1000.0	-0.089	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	250.0	76.0	-0.244	0.025	1000.0	-1000.0	-0.068	-1000.0
Aurora B signaling	3.0	217.0	67.0	-0.272	0.017	1000.0	-1000.0	-0.062	-1000.0
Syndecan-1-mediated signaling events	2.0	79.0	34.0	-0.308	0.017	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	2.0	88.0	38.0	-0.113	0.025	1000.0	-1000.0	-0.022	-1000.0
Osteopontin-mediated events	2.0	105.0	38.0	-0.192	0.017	1000.0	-1000.0	-0.077	-1000.0
Arf6 signaling events	2.0	148.0	62.0	-0.15	0.027	1000.0	-1000.0	-0.024	-1000.0
BMP receptor signaling	2.0	162.0	81.0	-0.17	0.039	1000.0	-1000.0	-0.075	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	217.0	97.0	-0.193	0.043	1000.0	-1000.0	-0.075	-1000.0
PLK1 signaling events	2.0	242.0	85.0	-0.24	0.025	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	77.0	37.0	-0.308	0.025	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	2.0	153.0	62.0	-0.219	0.071	1000.0	-1000.0	-0.072	-1000.0
Ephrin B reverse signaling	2.0	132.0	48.0	-0.15	0.123	1000.0	-1000.0	-0.057	-1000.0
S1P1 pathway	2.0	79.0	36.0	-0.153	0.017	1000.0	-1000.0	-0.062	-1000.0
TCGA08_p53	2.0	19.0	7.0	-0.118	0.077	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	88.0	44.0	-0.1	0.017	1000.0	-1000.0	-0.025	-1000.0
Effects of Botulinum toxin	2.0	64.0	26.0	-0.265	0.017	1000.0	-1000.0	-0.058	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	82.0	31.0	-0.194	0.026	1000.0	-1000.0	-0.051	-1000.0
Nongenotropic Androgen signaling	2.0	153.0	52.0	-0.23	0.122	1000.0	-1000.0	-0.042	-1000.0
IL6-mediated signaling events	2.0	169.0	75.0	-0.193	0.068	1000.0	-1000.0	-0.061	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	197.0	74.0	-0.244	0.122	1000.0	-1000.0	-0.081	-1000.0
Syndecan-4-mediated signaling events	2.0	178.0	67.0	-0.178	0.035	1000.0	-1000.0	-0.032	-1000.0
Rapid glucocorticoid signaling	2.0	40.0	20.0	-0.216	0.017	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by PRL	2.0	68.0	34.0	-0.142	0.025	1000.0	-1000.0	-0.023	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	34.0	17.0	-0.072	0.021	1000.0	-1000.0	-0.019	-1000.0
LPA4-mediated signaling events	1.0	14.0	12.0	-0.081	0.022	1000.0	-1000.0	-0.015	-1000.0
Caspase cascade in apoptosis	1.0	84.0	74.0	-0.1	0.028	1000.0	-1000.0	-0.032	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	224.0	136.0	-0.407	0.109	1000.0	-1000.0	-0.049	-1000.0
Coregulation of Androgen receptor activity	1.0	126.0	76.0	-0.203	0.037	1000.0	-1000.0	-0.022	-1000.0
ErbB4 signaling events	1.0	95.0	69.0	-0.229	0.072	1000.0	-1000.0	-0.08	-1000.0
BARD1 signaling events	1.0	60.0	57.0	-0.128	0.034	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	38.0	28.0	-0.084	0.025	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	1.0	26.0	22.0	-0.15	0.04	1000.0	-1000.0	-0.016	-1000.0
Noncanonical Wnt signaling pathway	1.0	34.0	26.0	-0.084	0.02	1000.0	-1000.0	-0.036	-1000.0
Syndecan-2-mediated signaling events	1.0	84.0	69.0	-0.135	0.04	1000.0	-1000.0	-0.021	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	9.0	5.0	-0.034	0.017	1000.0	-1000.0	-0.01	-1000.0
Cellular roles of Anthrax toxin	1.0	73.0	39.0	-0.24	0.018	1000.0	-1000.0	-0.019	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	91.0	61.0	-0.301	0.043	1000.0	-1000.0	-0.051	-1000.0
Aurora A signaling	1.0	109.0	60.0	-0.171	0.051	1000.0	-1000.0	-0.019	-1000.0
p75(NTR)-mediated signaling	1.0	186.0	125.0	-0.308	0.043	1000.0	-1000.0	-0.07	-1000.0
IL4-mediated signaling events	1.0	145.0	91.0	-0.523	0.261	1000.0	-1000.0	-0.114	-1000.0
Glypican 1 network	1.0	54.0	48.0	-0.107	0.032	1000.0	-1000.0	-0.027	-1000.0
amb2 Integrin signaling	1.0	142.0	82.0	-0.14	0.023	1000.0	-1000.0	-0.069	-1000.0
Nectin adhesion pathway	1.0	104.0	63.0	-0.244	0.026	1000.0	-1000.0	-0.054	-1000.0
Glucocorticoid receptor regulatory network	1.0	138.0	114.0	-0.31	0.069	1000.0	-1000.0	-0.061	-1000.0
TRAIL signaling pathway	1.0	51.0	48.0	-0.026	0.035	1000.0	-1000.0	-0.06	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	163.0	82.0	-0.172	0.017	1000.0	-1000.0	-0.071	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	59.0	52.0	-0.271	0.05	1000.0	-1000.0	-0.035	-1000.0
FAS signaling pathway (CD95)	1.0	55.0	47.0	-0.107	0.047	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	16.0	15.0	-0.12	0.03	1000.0	-1000.0	-0.015	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	45.0	36.0	-0.308	0.034	1000.0	-1000.0	-0.058	-1000.0
Syndecan-3-mediated signaling events	1.0	54.0	35.0	-0.135	0.043	1000.0	-1000.0	-0.027	-1000.0
Integrins in angiogenesis	1.0	162.0	84.0	-0.164	0.031	1000.0	-1000.0	-0.08	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	121.0	93.0	-0.12	0.028	1000.0	-1000.0	-0.06	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	52.0	45.0	-0.1	0.017	1000.0	-1000.0	-0.076	-1000.0
Canonical Wnt signaling pathway	1.0	68.0	51.0	-0.301	0.136	1000.0	-1000.0	-0.049	-1000.0
EPHB forward signaling	1.0	92.0	85.0	-0.15	0.06	1000.0	-1000.0	-0.076	-1000.0
Glypican 2 network	1.0	6.0	4.0	-0.012	-0.0	1000.0	-1000.0	-0.008	-1000.0
IL27-mediated signaling events	1.0	56.0	51.0	-0.19	0.025	1000.0	-1000.0	-0.058	-1000.0
Wnt signaling	1.0	12.0	7.0	-0.084	0.017	1000.0	-1000.0	-0.015	-1000.0
LPA receptor mediated events	1.0	124.0	102.0	-0.193	0.036	1000.0	-1000.0	-0.062	-1000.0
IL2 signaling events mediated by STAT5	1.0	25.0	22.0	-0.179	0.078	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	1.0	103.0	102.0	-0.194	0.049	1000.0	-1000.0	-0.098	-1000.0
BCR signaling pathway	1.0	194.0	99.0	-0.141	0.03	1000.0	-1000.0	-0.074	-1000.0
EGFR-dependent Endothelin signaling events	1.0	40.0	21.0	-0.099	0.025	1000.0	-1000.0	-0.052	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	141.0	88.0	-0.194	0.026	1000.0	-1000.0	-0.078	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	162.0	120.0	-0.28	0.129	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Rods	1.0	99.0	52.0	-0.113	0.017	1000.0	-1000.0	-0.065	-1000.0
E-cadherin signaling in keratinocytes	1.0	84.0	43.0	-0.243	0.05	1000.0	-1000.0	-0.027	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	138.0	78.0	-0.112	0.076	1000.0	-1000.0	-0.066	-1000.0
p38 MAPK signaling pathway	1.0	44.0	44.0	-0.12	0.033	1000.0	-1000.0	-0.057	-1000.0
ErbB2/ErbB3 signaling events	0.0	43.0	65.0	-0.101	0.026	1000.0	-1000.0	-0.053	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	-0.012	0.034	1000.0	-1000.0	-0.029	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	1.0	34.0	-0.026	0.053	1000.0	-1000.0	-0.029	-1000.0
Canonical NF-kappaB pathway	0.0	22.0	39.0	-0.1	0.082	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class II	0.0	35.0	75.0	-0.085	0.041	1000.0	-1000.0	-0.039	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	30.0	54.0	-0.071	0.032	1000.0	-1000.0	-0.078	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	7.0	17.0	-0.019	0.034	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	49.0	85.0	-0.194	0.049	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by PTP1B	0.0	62.0	76.0	-0.101	0.034	1000.0	-1000.0	-0.06	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	62.0	65.0	-0.048	0.043	1000.0	-1000.0	-0.061	-1000.0
Arf6 downstream pathway	0.0	10.0	43.0	-0.027	0.032	1000.0	-1000.0	-0.036	-1000.0
Aurora C signaling	0.0	3.0	7.0	-0.012	0.002	1000.0	-1000.0	-0.025	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	15.0	46.0	-0.038	0.1	1000.0	-1000.0	-0.061	-1000.0
EPO signaling pathway	0.0	18.0	55.0	-0.049	0.052	1000.0	-1000.0	-0.07	-1000.0
Insulin-mediated glucose transport	0.0	13.0	32.0	-0.014	0.047	1000.0	-1000.0	-0.019	-1000.0
mTOR signaling pathway	0.0	14.0	53.0	-0.017	0.049	1000.0	-1000.0	-0.052	-1000.0
IFN-gamma pathway	0.0	64.0	68.0	-0.1	0.069	1000.0	-1000.0	-0.074	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	18.0	68.0	-0.071	0.066	1000.0	-1000.0	-0.049	-1000.0
Ceramide signaling pathway	0.0	62.0	76.0	-0.1	0.025	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	0.0	31.0	40.0	-0.188	0.097	1000.0	-1000.0	-0.025	-1000.0
Reelin signaling pathway	0.0	47.0	56.0	-0.113	0.038	1000.0	-1000.0	-0.066	-1000.0
S1P5 pathway	0.0	5.0	17.0	-0.02	0.025	1000.0	-1000.0	-0.019	-1000.0
ceramide signaling pathway	0.0	34.0	49.0	-0.099	0.025	1000.0	-1000.0	-0.04	-1000.0
HIF-2-alpha transcription factor network	0.0	28.0	43.0	-0.159	0.124	1000.0	-1000.0	-0.055	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	65.0	83.0	-0.087	0.05	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by HDAC Class I	0.0	47.0	104.0	-0.1	0.052	1000.0	-1000.0	-0.06	-1000.0
FoxO family signaling	0.0	21.0	64.0	-0.051	0.102	1000.0	-1000.0	-0.055	-1000.0
Retinoic acid receptors-mediated signaling	0.0	36.0	58.0	-0.12	0.063	1000.0	-1000.0	-0.064	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.056	0.038	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by PI3K	0.0	36.0	58.0	-0.048	0.066	1000.0	-1000.0	-0.063	-1000.0
Regulation of p38-alpha and p38-beta	0.0	40.0	54.0	-0.084	0.043	1000.0	-1000.0	-0.05	-1000.0
TCGA08_rtk_signaling	0.0	21.0	26.0	-0.092	0.035	1000.0	-1000.0	-0.014	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.008	0.043	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events	0.0	66.0	73.0	-0.121	0.037	1000.0	-1000.0	-0.039	-1000.0
Arf6 trafficking events	0.0	27.0	71.0	-0.113	0.066	1000.0	-1000.0	-0.067	-1000.0
IGF1 pathway	0.0	37.0	57.0	-0.07	0.051	1000.0	-1000.0	-0.075	-1000.0
Insulin Pathway	0.0	39.0	74.0	-0.107	0.054	1000.0	-1000.0	-0.071	-1000.0
Plasma membrane estrogen receptor signaling	0.0	57.0	86.0	-0.063	0.056	1000.0	-1000.0	-0.073	-1000.0
VEGFR1 specific signals	0.0	19.0	56.0	-0.07	0.048	1000.0	-1000.0	-0.03	-1000.0
S1P3 pathway	0.0	16.0	42.0	-0.063	0.051	1000.0	-1000.0	-0.025	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	21.0	33.0	-0.164	0.05	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	0.0	69.0	97.0	-0.092	0.044	1000.0	-1000.0	-0.07	-1000.0
S1P4 pathway	0.0	2.0	25.0	-0.005	0.032	1000.0	-1000.0	-0.019	-1000.0
Arf1 pathway	0.0	2.0	54.0	-0.004	0.037	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.005	0.031	1000.0	-1000.0	-0.017	-1000.0
Regulation of Androgen receptor activity	0.0	61.0	70.0	-0.308	0.073	1000.0	-1000.0	-0.061	-1000.0
Total	167	11935	7203	-21.6660308048	-993.506384229	131000	-131000	-6.38022455177	-131000