E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.142 0.222 -9999.0 0.0 -0.456 8.0 8.0 KLHL20 -0.028 0.107 0.224 1.0 -0.226 1.0 2.0 CYFIP2 0.027 0.033 -9999.0 0.0 -0.137 1.0 1.0 Rac1/GDP -0.074 0.143 -9999.0 0.0 -0.264 9.0 9.0 ENAH -0.142 0.219 -9999.0 0.0 -0.419 10.0 10.0 AP1M1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.001 0.116 -9999.0 0.0 -0.408 2.0 2.0 CDC42/GTP -0.046 0.112 -9999.0 0.0 -0.278 2.0 2.0 ABI1/Sra1/Nap1 -0.036 0.043 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.05 0.153 -9999.0 0.0 -0.245 9.0 9.0 RAPGEF1 -0.123 0.205 -9999.0 0.0 -0.395 9.0 9.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.149 0.235 -9999.0 0.0 -0.446 10.0 10.0 CRK -0.132 0.221 -9999.0 0.0 -0.426 9.0 9.0 E-cadherin/gamma catenin/alpha catenin -0.053 0.134 -9999.0 0.0 -0.241 8.0 8.0 alphaE/beta7 Integrin 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.058 -9999.0 0.0 -0.218 1.0 1.0 DLG1 -0.141 0.217 -9999.0 0.0 -0.435 9.0 9.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.045 0.065 -9999.0 0.0 -0.187 1.0 1.0 MLLT4 0.016 0.084 -9999.0 0.0 -0.408 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.054 0.055 -9999.0 0.0 -0.218 1.0 1.0 PI3K -0.054 0.084 -9999.0 0.0 -0.24 1.0 1.0 ARF6 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.08 0.145 -9999.0 0.0 -0.287 8.0 8.0 TIAM1 0.018 0.084 -9999.0 0.0 -0.408 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.05 0.141 -9999.0 0.0 -0.23 9.0 9.0 AKT1 -0.027 0.058 -9999.0 0.0 -0.141 1.0 1.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.19 -9999.0 0.0 -0.292 14.0 14.0 RhoA/GDP -0.067 0.16 -9999.0 0.0 -0.278 9.0 9.0 actin cytoskeleton organization -0.019 0.083 0.187 1.0 -0.165 1.0 2.0 CDC42/GDP -0.071 0.144 -9999.0 0.0 -0.308 3.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.055 0.102 -9999.0 0.0 -0.206 8.0 8.0 ITGB7 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.053 0.151 -9999.0 0.0 -0.245 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.057 0.134 -9999.0 0.0 -0.229 9.0 9.0 mol:GDP -0.091 0.161 -9999.0 0.0 -0.304 9.0 9.0 CDC42/GTP/IQGAP1 0.038 0.018 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.068 0.164 -9999.0 0.0 -0.281 9.0 9.0 RAC1/GTP/IQGAP1 0.042 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.084 -9999.0 0.0 -0.408 1.0 1.0 CDC42 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.011 0.065 0.142 1.0 -0.14 2.0 3.0 NME1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.147 0.226 -9999.0 0.0 -0.45 9.0 9.0 regulation of cell-cell adhesion -0.052 0.09 -9999.0 0.0 -0.244 2.0 2.0 WASF2 -0.004 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.058 0.124 -9999.0 0.0 -0.312 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.001 0.136 -9999.0 0.0 -0.206 8.0 8.0 CCND1 -0.014 0.077 0.163 1.0 -0.172 2.0 3.0 VAV2 -0.116 0.213 -9999.0 0.0 -0.507 2.0 2.0 RAP1/GDP -0.055 0.132 -9999.0 0.0 -0.309 2.0 2.0 adherens junction assembly -0.142 0.219 -9999.0 0.0 -0.419 10.0 10.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.044 0.138 -9999.0 0.0 -0.22 9.0 9.0 E-cadherin/beta catenin -0.075 0.141 -9999.0 0.0 -0.311 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.148 0.227 -9999.0 0.0 -0.434 10.0 10.0 PIK3CA 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.09 0.108 -9999.0 0.0 -0.31 2.0 2.0 E-cadherin/beta catenin/alpha catenin -0.068 0.156 -9999.0 0.0 -0.269 9.0 9.0 ITGAE 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.153 0.241 -9999.0 0.0 -0.456 10.0 10.0