Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.073 0.141 -9999.0 0.0 -0.248 9.0 9.0 epithelial cell differentiation -0.053 0.137 -9999.0 0.0 -0.228 9.0 9.0 CYFIP2 0.027 0.033 -9999.0 0.0 -0.137 1.0 1.0 ENAH -0.059 0.085 -9999.0 0.0 -0.388 1.0 1.0 EGFR -0.007 0.118 -9999.0 0.0 -0.318 3.0 3.0 EPHA2 0.023 0.034 -9999.0 0.0 -0.137 1.0 1.0 MYO6 -0.073 0.142 0.185 1.0 -0.239 9.0 10.0 CTNNB1 0.001 0.116 -9999.0 0.0 -0.408 2.0 2.0 ABI1/Sra1/Nap1 0.055 0.035 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.049 0.112 -9999.0 0.0 -0.37 1.0 1.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.057 0.108 0.184 1.0 -0.198 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.066 0.118 0.184 1.0 -0.214 9.0 10.0 EGF 0.019 0.045 -9999.0 0.0 -0.137 2.0 2.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.056 0.134 -9999.0 0.0 -0.411 2.0 2.0 cortical microtubule organization -0.053 0.137 -9999.0 0.0 -0.228 9.0 9.0 GO:0000145 -0.066 0.095 0.169 1.0 -0.189 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.05 0.141 -9999.0 0.0 -0.23 9.0 9.0 MLLT4 0.016 0.084 -9999.0 0.0 -0.408 1.0 1.0 ARF6/GDP -0.073 0.098 -9999.0 0.0 -0.292 2.0 2.0 ARF6 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.05 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.063 0.101 -9999.0 0.0 -0.284 2.0 2.0 PVRL2 0.012 0.083 -9999.0 0.0 -0.408 1.0 1.0 ZYX -0.06 0.123 0.185 1.0 -0.219 9.0 10.0 ARF6/GTP 0.078 0.038 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.19 -9999.0 0.0 -0.292 14.0 14.0 EGFR/EGFR/EGF/EGF -0.075 0.128 -9999.0 0.0 -0.217 11.0 11.0 RhoA/GDP -0.053 0.152 -9999.0 0.0 -0.235 9.0 9.0 actin cytoskeleton organization -0.074 0.135 0.173 1.0 -0.233 9.0 10.0 IGF-1R heterotetramer 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.018 0.084 -9999.0 0.0 -0.408 1.0 1.0 DIAPH1 0.021 0.153 -9999.0 0.0 -0.549 1.0 1.0 Wnt receptor signaling pathway 0.053 0.137 0.228 9.0 -9999.0 0.0 9.0 RHOA 0.016 0.084 -9999.0 0.0 -0.408 1.0 1.0 RhoA/GTP -0.078 0.118 -9999.0 0.0 -0.362 2.0 2.0 CTNNA1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.076 0.138 0.174 1.0 -0.238 9.0 10.0 EFNA1 0.028 0.032 -9999.0 0.0 -0.137 1.0 1.0 LPP -0.063 0.101 0.177 1.0 -0.192 9.0 10.0 Ephrin A1/EPHA2 -0.058 0.127 -9999.0 0.0 -0.214 9.0 9.0 SEC6/SEC8 -0.075 0.127 -9999.0 0.0 -0.227 9.0 9.0 MGAT3 -0.067 0.12 0.185 1.0 -0.217 9.0 10.0 HGF/MET -0.057 0.128 -9999.0 0.0 -0.219 9.0 9.0 HGF 0.012 0.054 -9999.0 0.0 -0.137 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.073 0.142 -9999.0 0.0 -0.25 9.0 9.0 actin cable formation -0.036 0.082 -9999.0 0.0 -0.259 1.0 1.0 KIAA1543 -0.081 0.096 -9999.0 0.0 -0.207 9.0 9.0 KIFC3 -0.067 0.121 0.185 1.0 -0.219 9.0 10.0 NCK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.07 0.12 0.185 1.0 -0.219 9.0 10.0 NCK1/GIT1 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.053 0.137 -9999.0 0.0 -0.228 9.0 9.0 EXOC4 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.067 0.121 0.185 1.0 -0.219 9.0 10.0 PIP5K1C -0.058 0.109 0.185 1.0 -0.2 9.0 10.0 LIMA1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.068 0.106 -9999.0 0.0 -0.464 1.0 1.0 adherens junction assembly -0.043 0.114 0.293 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.056 0.147 -9999.0 0.0 -0.233 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.088 -9999.0 0.0 -0.287 2.0 2.0 MET 0.025 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.073 0.111 -9999.0 0.0 -0.217 9.0 9.0 mol:GTP 0.059 0.048 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.044 0.155 0.285 1.0 -0.359 2.0 3.0 cortical actin cytoskeleton stabilization -0.073 0.141 -9999.0 0.0 -0.248 9.0 9.0 regulation of cell-cell adhesion -0.074 0.135 0.173 1.0 -0.233 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.073 0.142 -9999.0 0.0 -0.25 9.0 9.0