Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	322.0	51.0	-0.786	0.035	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	-0.135	0.035	1000.0	-1000.0	0.019	-1000.0
Ephrin A  reverse signaling	4.0	32.0	7.0	-0.106	0.002	1000.0	-1000.0	-0.0	-1000.0
Thromboxane A2 receptor signaling	4.0	468.0	105.0	-0.247	0.047	1000.0	-1000.0	-0.032	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	291.0	68.0	-0.511	0.324	1000.0	-1000.0	-0.078	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	345.0	74.0	-0.135	0.078	1000.0	-1000.0	-0.046	-1000.0
TCGA08_retinoblastoma	4.0	36.0	8.0	-0.052	0.083	1000.0	-1000.0	-0.002	-1000.0
IL23-mediated signaling events	4.0	282.0	60.0	-0.667	0.037	1000.0	-1000.0	-0.076	-1000.0
IL12-mediated signaling events	3.0	312.0	87.0	-0.411	0.06	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.038	-1000.0	1000.0	-1000.0	0.002	-1000.0
Signaling events mediated by the Hedgehog family	3.0	162.0	52.0	-0.137	0.065	1000.0	-1000.0	-0.029	-1000.0
Ephrin B reverse signaling	3.0	163.0	48.0	-0.111	0.047	1000.0	-1000.0	-0.028	-1000.0
Endothelins	3.0	357.0	96.0	-0.334	0.046	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	273.0	76.0	-0.153	0.054	1000.0	-1000.0	-0.048	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	285.0	136.0	-0.424	0.087	1000.0	-1000.0	-0.04	-1000.0
Syndecan-1-mediated signaling events	2.0	84.0	34.0	-0.18	0.035	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Cones	2.0	79.0	38.0	-0.064	0.04	1000.0	-1000.0	-0.002	-1000.0
Osteopontin-mediated events	2.0	89.0	38.0	-0.105	0.035	1000.0	-1000.0	-0.024	-1000.0
HIF-1-alpha transcription factor network	2.0	207.0	76.0	-0.213	0.059	1000.0	-1000.0	-0.036	-1000.0
Arf6 signaling events	2.0	141.0	62.0	-0.055	0.069	1000.0	-1000.0	-0.009	-1000.0
PLK1 signaling events	2.0	220.0	85.0	-0.132	0.051	1000.0	-1000.0	-0.034	-1000.0
Syndecan-3-mediated signaling events	2.0	82.0	35.0	-0.091	0.083	1000.0	-1000.0	-0.014	-1000.0
Nongenotropic Androgen signaling	2.0	139.0	52.0	-0.207	0.1	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	308.0	125.0	-0.092	0.082	1000.0	-1000.0	-0.039	-1000.0
IL6-mediated signaling events	2.0	159.0	75.0	-0.151	0.056	1000.0	-1000.0	-0.029	-1000.0
BCR signaling pathway	2.0	202.0	99.0	-0.104	0.052	1000.0	-1000.0	-0.058	-1000.0
Syndecan-4-mediated signaling events	2.0	167.0	67.0	-0.1	0.046	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in keratinocytes	2.0	111.0	43.0	-0.134	0.039	1000.0	-1000.0	-0.021	-1000.0
Aurora B signaling	2.0	158.0	67.0	-0.174	0.052	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	1.0	125.0	74.0	-0.063	0.037	1000.0	-1000.0	-0.033	-1000.0
Coregulation of Androgen receptor activity	1.0	95.0	76.0	-0.083	0.06	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	1.0	80.0	69.0	-0.116	0.052	1000.0	-1000.0	-0.035	-1000.0
Noncanonical Wnt signaling pathway	1.0	26.0	26.0	-0.027	0.034	1000.0	-1000.0	-0.035	-1000.0
Syndecan-2-mediated signaling events	1.0	88.0	69.0	-0.064	0.05	1000.0	-1000.0	-0.015	-1000.0
Cellular roles of Anthrax toxin	1.0	64.0	39.0	-0.177	0.035	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PTP1B	1.0	79.0	76.0	-0.035	0.055	1000.0	-1000.0	-0.033	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	86.0	61.0	-0.174	0.083	1000.0	-1000.0	-0.044	-1000.0
Aurora A signaling	1.0	66.0	60.0	-0.089	0.082	1000.0	-1000.0	-0.011	-1000.0
p75(NTR)-mediated signaling	1.0	167.0	125.0	-0.18	0.083	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	1.0	124.0	91.0	-0.519	0.27	1000.0	-1000.0	-0.104	-1000.0
BMP receptor signaling	1.0	135.0	81.0	-0.065	0.068	1000.0	-1000.0	-0.025	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	128.0	97.0	-0.105	0.057	1000.0	-1000.0	-0.06	-1000.0
PDGFR-alpha signaling pathway	1.0	81.0	44.0	-0.238	0.043	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	1.0	120.0	82.0	-0.077	0.051	1000.0	-1000.0	-0.023	-1000.0
Nectin adhesion pathway	1.0	86.0	63.0	-0.135	0.068	1000.0	-1000.0	-0.038	-1000.0
Glucocorticoid receptor regulatory network	1.0	144.0	114.0	-0.274	0.076	1000.0	-1000.0	-0.036	-1000.0
Ceramide signaling pathway	1.0	123.0	76.0	-0.067	0.055	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	49.0	37.0	-0.093	0.059	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by HDAC Class III	1.0	55.0	40.0	-0.135	0.094	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	1.0	54.0	48.0	-0.004	0.062	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	1.0	120.0	62.0	-0.105	0.058	1000.0	-1000.0	-0.022	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	157.0	82.0	-0.06	0.052	1000.0	-1000.0	-0.048	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	63.0	52.0	-0.253	0.1	1000.0	-1000.0	-0.029	-1000.0
S1P1 pathway	1.0	57.0	36.0	-0.097	0.034	1000.0	-1000.0	-0.022	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.042	0.034	1000.0	-1000.0	-0.01	-1000.0
FAS signaling pathway (CD95)	1.0	49.0	47.0	-0.042	0.048	1000.0	-1000.0	-0.021	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	77.0	44.0	-0.065	0.034	1000.0	-1000.0	-0.019	-1000.0
Integrins in angiogenesis	1.0	122.0	84.0	-0.08	0.082	1000.0	-1000.0	-0.026	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	51.0	45.0	-0.031	0.061	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	1.0	71.0	51.0	-0.174	0.08	1000.0	-1000.0	-0.028	-1000.0
EPHB forward signaling	1.0	121.0	85.0	-0.059	0.078	1000.0	-1000.0	-0.046	-1000.0
Effects of Botulinum toxin	1.0	40.0	26.0	-0.151	0.056	1000.0	-1000.0	-0.001	-1000.0
Glypican 2 network	1.0	6.0	4.0	-0.0	0.015	1000.0	-1000.0	-0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	48.0	31.0	-0.106	0.045	1000.0	-1000.0	-0.035	-1000.0
Wnt signaling	1.0	11.0	7.0	-0.023	0.034	1000.0	-1000.0	-0.011	-1000.0
LPA receptor mediated events	1.0	112.0	102.0	-0.157	0.05	1000.0	-1000.0	-0.068	-1000.0
Class I PI3K signaling events	1.0	87.0	73.0	-0.059	0.068	1000.0	-1000.0	-0.026	-1000.0
EGFR-dependent Endothelin signaling events	1.0	32.0	21.0	-0.028	0.061	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	127.0	88.0	-0.143	0.046	1000.0	-1000.0	-0.056	-1000.0
Rapid glucocorticoid signaling	1.0	29.0	20.0	-0.094	0.028	1000.0	-1000.0	-0.0	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	135.0	120.0	-0.152	0.1	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Rods	1.0	97.0	52.0	-0.064	0.045	1000.0	-1000.0	-0.007	-1000.0
Signaling events mediated by PRL	1.0	61.0	34.0	-0.155	0.046	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	132.0	78.0	-0.078	0.048	1000.0	-1000.0	-0.048	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	27.0	17.0	-0.045	0.037	1000.0	-1000.0	-0.014	-1000.0
LPA4-mediated signaling events	0.0	8.0	12.0	-0.049	0.01	1000.0	-1000.0	-0.008	-1000.0
ErbB2/ErbB3 signaling events	0.0	55.0	65.0	-0.072	0.049	1000.0	-1000.0	-0.06	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.002	0.063	1000.0	-1000.0	-0.024	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	1.0	34.0	-0.044	0.083	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	0.0	20.0	39.0	-0.031	0.079	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class II	0.0	26.0	75.0	-0.047	0.087	1000.0	-1000.0	-0.016	-1000.0
BARD1 signaling events	0.0	52.0	57.0	-0.056	0.068	1000.0	-1000.0	-0.034	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	27.0	28.0	-0.039	0.046	1000.0	-1000.0	-0.011	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.074	0.059	1000.0	-1000.0	-0.023	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	41.0	54.0	-0.021	0.086	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	6.0	17.0	0.0	0.067	1000.0	-1000.0	-0.015	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.011	0.034	1000.0	-1000.0	0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	69.0	85.0	-0.249	0.073	1000.0	-1000.0	-0.047	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	54.0	65.0	-0.041	0.073	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.052	0.07	1000.0	-1000.0	-0.031	-1000.0
Aurora C signaling	0.0	3.0	7.0	-0.0	0.043	1000.0	-1000.0	-0.008	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	18.0	46.0	-0.035	0.057	1000.0	-1000.0	-0.08	-1000.0
Glypican 1 network	0.0	37.0	48.0	-0.04	0.063	1000.0	-1000.0	-0.02	-1000.0
EPO signaling pathway	0.0	43.0	55.0	-0.001	0.091	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	0.0	8.0	32.0	-0.0	0.071	1000.0	-1000.0	-0.012	-1000.0
mTOR signaling pathway	0.0	23.0	53.0	-0.028	0.07	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	0.0	43.0	68.0	-0.041	0.059	1000.0	-1000.0	-0.034	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	15.0	68.0	-0.053	0.069	1000.0	-1000.0	-0.025	-1000.0
Reelin signaling pathway	0.0	27.0	56.0	-0.049	0.088	1000.0	-1000.0	-0.014	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.008	0.035	1000.0	-1000.0	-0.004	-1000.0
ceramide signaling pathway	0.0	42.0	49.0	-0.031	0.05	1000.0	-1000.0	-0.027	-1000.0
HIF-2-alpha transcription factor network	0.0	28.0	43.0	-0.116	0.118	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	39.0	83.0	-0.023	0.068	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class I	0.0	44.0	104.0	-0.065	0.073	1000.0	-1000.0	-0.029	-1000.0
FoxO family signaling	0.0	32.0	64.0	-0.085	0.064	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.055	0.034	1000.0	-1000.0	-0.012	-1000.0
Retinoic acid receptors-mediated signaling	0.0	30.0	58.0	-0.04	0.068	1000.0	-1000.0	-0.054	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	29.0	36.0	-0.093	0.065	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	0.0	13.0	31.0	-0.011	0.048	1000.0	-1000.0	-0.011	-1000.0
IL2 signaling events mediated by PI3K	0.0	22.0	58.0	-0.015	0.06	1000.0	-1000.0	-0.04	-1000.0
TCR signaling in naïve CD8+ T cells	0.0	67.0	93.0	-0.108	0.126	1000.0	-1000.0	-0.035	-1000.0
Regulation of p38-alpha and p38-beta	0.0	40.0	54.0	-0.037	0.08	1000.0	-1000.0	-0.043	-1000.0
IL27-mediated signaling events	0.0	37.0	51.0	-0.099	0.068	1000.0	-1000.0	-0.057	-1000.0
TCGA08_rtk_signaling	0.0	24.0	26.0	-0.054	0.07	1000.0	-1000.0	-0.005	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.083	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	0.0	18.0	22.0	-0.077	0.045	1000.0	-1000.0	-0.032	-1000.0
Arf6 trafficking events	0.0	16.0	71.0	-0.05	0.065	1000.0	-1000.0	-0.024	-1000.0
Regulation of Telomerase	0.0	88.0	102.0	-0.131	0.089	1000.0	-1000.0	-0.046	-1000.0
IGF1 pathway	0.0	17.0	57.0	-0.036	0.091	1000.0	-1000.0	-0.027	-1000.0
Insulin Pathway	0.0	43.0	74.0	-0.041	0.083	1000.0	-1000.0	-0.026	-1000.0
Plasma membrane estrogen receptor signaling	0.0	59.0	86.0	-0.042	0.05	1000.0	-1000.0	-0.031	-1000.0
VEGFR1 specific signals	0.0	15.0	56.0	-0.017	0.074	1000.0	-1000.0	-0.028	-1000.0
S1P3 pathway	0.0	17.0	42.0	-0.038	0.051	1000.0	-1000.0	-0.031	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	16.0	33.0	-0.053	0.089	1000.0	-1000.0	-0.026	-1000.0
PDGFR-beta signaling pathway	0.0	74.0	97.0	-0.037	0.096	1000.0	-1000.0	-0.024	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.032	0.032	1000.0	-1000.0	-0.02	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.0	0.046	1000.0	-1000.0	-0.008	-1000.0
p38 MAPK signaling pathway	0.0	39.0	44.0	-0.04	0.062	1000.0	-1000.0	-0.016	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.001	0.047	1000.0	-1000.0	-0.009	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.0	0.068	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	52.0	70.0	-0.184	0.059	1000.0	-1000.0	-0.042	-1000.0
Total	130	10874	7203	-13.6607603172	-991.679836845	131000	-131000	-3.67118362512	-131000