E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.019 0.137 -9999.0 0.0 -0.534 14.0 14.0 KLHL20 -0.003 0.075 -9999.0 0.0 -0.267 6.0 6.0 CYFIP2 -0.016 0.159 -9999.0 0.0 -0.687 14.0 14.0 Rac1/GDP 0.001 0.092 -9999.0 0.0 -0.336 13.0 13.0 ENAH -0.012 0.125 -9999.0 0.0 -0.489 14.0 14.0 AP1M1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.007 0.07 -9999.0 0.0 -0.29 1.0 1.0 ABI1/Sra1/Nap1 -0.028 0.056 -9999.0 0.0 -0.201 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.018 0.12 -9999.0 0.0 -0.412 18.0 18.0 RAPGEF1 -0.016 0.121 -9999.0 0.0 -0.47 14.0 14.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.019 0.145 -9999.0 0.0 -0.545 15.0 15.0 CRK -0.014 0.124 -9999.0 0.0 -0.511 14.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.111 -9999.0 0.0 -0.451 14.0 14.0 alphaE/beta7 Integrin 0.023 0.071 -9999.0 0.0 -0.513 4.0 4.0 IQGAP1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.019 0.14 -9999.0 0.0 -0.545 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.051 -9999.0 0.0 -0.242 2.0 2.0 MLLT4 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.089 -9999.0 0.0 -0.414 10.0 10.0 PI3K -0.006 0.067 -9999.0 0.0 -0.318 2.0 2.0 ARF6 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.0 0.124 -9999.0 0.0 -0.52 14.0 14.0 TIAM1 -0.006 0.136 -9999.0 0.0 -0.687 10.0 10.0 E-cadherin(dimer)/Ca2+ 0.024 0.1 -9999.0 0.0 -0.392 14.0 14.0 AKT1 0.001 0.041 -9999.0 0.0 -0.2 1.0 1.0 PIK3R1 0.019 0.044 -9999.0 0.0 -0.687 1.0 1.0 CDH1 -0.017 0.159 -9999.0 0.0 -0.687 14.0 14.0 RhoA/GDP 0.002 0.094 -9999.0 0.0 -0.336 14.0 14.0 actin cytoskeleton organization -0.0 0.057 -9999.0 0.0 -0.199 5.0 5.0 CDC42/GDP 0.002 0.093 -9999.0 0.0 -0.336 14.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.0 0.073 -9999.0 0.0 -0.307 14.0 14.0 ITGB7 0.011 0.087 -9999.0 0.0 -0.687 4.0 4.0 RAC1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.027 0.106 -9999.0 0.0 -0.414 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.013 0.097 -9999.0 0.0 -0.392 14.0 14.0 mol:GDP -0.012 0.104 -9999.0 0.0 -0.392 14.0 14.0 CDC42/GTP/IQGAP1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.007 0.098 -9999.0 0.0 -0.344 14.0 14.0 RAC1/GTP/IQGAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.022 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.062 0.173 1.0 -0.258 10.0 11.0 NME1 0.024 0.029 0.348 2.0 -9999.0 0.0 2.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.02 0.14 -9999.0 0.0 -0.545 14.0 14.0 regulation of cell-cell adhesion 0.001 0.06 -9999.0 0.0 -0.254 1.0 1.0 WASF2 -0.004 0.036 -9999.0 0.0 -0.142 1.0 1.0 Rap1/GTP 0.009 0.081 -9999.0 0.0 -0.31 14.0 14.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.026 0.117 -9999.0 0.0 -0.391 18.0 18.0 CCND1 -0.006 0.075 -9999.0 0.0 -0.327 10.0 10.0 VAV2 -0.027 0.166 -9999.0 0.0 -0.517 23.0 23.0 RAP1/GDP 0.008 0.085 -9999.0 0.0 -0.314 14.0 14.0 adherens junction assembly -0.018 0.135 -9999.0 0.0 -0.525 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.017 0.11 -9999.0 0.0 -0.376 18.0 18.0 E-cadherin/beta catenin -0.012 0.103 -9999.0 0.0 -0.446 14.0 14.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.02 0.141 -9999.0 0.0 -0.545 14.0 14.0 PIK3CA 0.019 0.044 -9999.0 0.0 -0.687 1.0 1.0 Rac1/GTP -0.049 0.116 -9999.0 0.0 -0.397 15.0 15.0 E-cadherin/beta catenin/alpha catenin 0.015 0.111 -9999.0 0.0 -0.451 14.0 14.0 ITGAE 0.023 0.036 0.348 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.148 -9999.0 0.0 -0.559 15.0 15.0