rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(8), ATM(22), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1A(1), E2F1(3), GADD45A(1), MDM2(2), PCNA(1), RB1(13), TP53(128) 6266585 192 143 169 16 16 37 42 29 68 0 1.90e-06 <1.00e-15 <1.54e-13 2 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(20), ATM(22), BAX(1), CDKN1A(1), CPB2(4), CSNK1A1(1), CSNK1D(2), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NQO1(3), TP53(128) 7172280 191 138 167 18 17 40 45 27 62 0 1.17e-05 <1.00e-15 <1.54e-13 3 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(4), IFNGR1(3), IFNGR2(3), IKBKB(3), JAK2(4), LIN7A(2), NFKB1(3), NFKBIA(1), RB1(13), TNFRSF1B(1), TP53(128), USH1C(4), WT1(8) 6332308 177 133 155 16 15 35 41 21 65 0 1.85e-06 <1.00e-15 <1.54e-13 4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CCND1(2), CDK2(4), CDK4(2), CDKN1A(1), CDKN1B(3), CDKN2A(14), E2F1(3), MDM2(2), NXT1(1), PRB1(2), TP53(128) 2958909 163 125 141 8 15 29 38 24 57 0 1.12e-09 <1.00e-15 <1.54e-13 5 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(2), ATM(22), BRCA1(8), CDKN1A(1), CHEK1(6), CHEK2(2), GADD45A(1), JUN(1), MAPK8(3), MDM2(2), MRE11A(6), NFKB1(3), NFKBIA(1), RAD50(3), RAD51(1), RBBP8(3), TP53(128), TP73(4) 10278207 197 139 174 16 15 41 53 28 60 0 1.68e-06 1.78e-15 2.19e-13 6 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CDK2(4), CDK4(2), CHEK1(6), MYT1(6), RB1(13), TP53(128), WEE1(3) 6070332 192 140 169 13 15 37 43 29 68 0 1.57e-07 2.22e-15 2.28e-13 7 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(22), ATR(16), CDC25C(3), CHEK1(6), CHEK2(2), TP53(128) 5517526 177 136 154 7 10 35 48 28 56 0 1.04e-08 3.77e-15 3.16e-13 8 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(3), MAX(3), SP1(1), SP3(4), TP53(128), WT1(8) 2427858 147 122 125 10 9 29 35 21 53 0 1.22e-06 4.11e-15 3.16e-13 9 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(3), DNAJC3(3), MAP3K14(1), NFKB1(3), NFKBIA(1), TP53(128) 3372941 139 121 117 9 9 23 36 18 53 0 2.18e-06 5.77e-15 3.95e-13 10 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(6), HRAS(1), PAX3(6), PML(7), RARA(3), RB1(13), SIRT1(1), SP100(9), TNFRSF1B(1), TP53(128) 6622222 179 131 157 15 14 30 47 25 63 0 3.82e-07 7.77e-15 4.60e-13 11 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(2), CDKN2A(14), E2F1(3), MDM2(2), PIK3CA(11), PIK3R1(3), POLR1A(8), POLR1B(10), POLR1D(2), RB1(13), TBX2(1), TP53(128), TWIST1(1) 7038773 198 132 172 15 16 33 53 29 67 0 2.83e-08 8.22e-15 4.60e-13 12 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(2), ATM(22), ATR(16), CCNA1(2), CCND1(2), CCNE1(3), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), CDKN2A(14), DHFR(1), E2F1(3), GSK3B(2), HDAC1(3), RB1(13), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), TP53(128) 10469193 246 149 223 28 18 55 59 38 76 0 1.38e-05 1.47e-12 7.55e-11 13 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(22), ATR(16), BRCA1(8), CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(6), CHEK2(2), EP300(2), GADD45A(1), MDM2(2), MYT1(6), PRKDC(23), RPS6KA1(1), TP53(128), WEE1(3) 14627375 232 150 209 23 16 52 61 35 68 0 5.82e-06 8.47e-08 4.01e-06 14 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), CASP3(4), CASP6(1), CASP7(1), CASP9(3), PRKCA(7), PTK2(11), PXN(1), STAT1(4), TLN1(13), TP53(128) 9452891 206 147 183 29 18 42 47 33 66 0 0.000621 1.42e-06 6.26e-05 15 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(1), FXYD2(1), JUN(1), KEAP1(39), MAFG(1), MAPK14(1), MAPK8(3), NFE2L2(5), PRKCA(7) 3083027 59 53 57 7 9 12 18 11 9 0 0.00966 0.000188 0.00772 16 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(22), ATR(16), BRCA1(8), BRCA2(16), CHEK1(6), CHEK2(2), FANCA(5), FANCC(1), FANCD2(3), FANCE(3), FANCF(2), FANCG(4), HUS1(2), MRE11A(6), RAD1(5), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TP53(128), TREX1(1) 15187967 238 142 215 28 15 55 64 38 66 0 0.000156 0.00119 0.0458 17 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), FBXW7(4), RB1(13), TFDP1(3) 2895018 37 30 37 3 5 8 9 6 9 0 0.0231 0.0568 1.000 18 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(4), CDKN1B(3), CUL1(6), E2F1(3), NEDD8(2), RB1(13), SKP2(4), TFDP1(3), UBE2M(1) 2978832 42 33 42 5 5 8 11 7 11 0 0.0506 0.0968 1.000 19 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(4), IL12A(3), IL2(5) 1033019 14 12 13 1 2 7 2 2 1 0 0.149 0.228 1.000 20 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 BCL2(1), EGFR(33), IGF1R(10), POLR2A(9), PPP2CA(1), PRKCA(7), RB1(13), TEP1(22), TERF1(1), TERT(4), TNKS(3), TP53(128), XRCC5(6) 9682578 238 146 202 35 26 45 50 38 79 0 0.000176 0.243 1.000 21 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(4), COQ5(5), COQ6(3), COQ7(1), NDUFA12(2), NDUFA13(4), NDUFB11(1) 1380412 20 14 20 2 5 5 5 1 4 0 0.0820 0.297 1.000 22 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(7), SNAP25(4), STX1A(3) 1118665 16 13 16 3 5 3 5 1 2 0 0.203 0.342 1.000 23 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(9), CYP2C9(3) 690893 12 11 12 3 2 3 3 2 2 0 0.540 0.389 1.000 24 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), RB1(13), SKP2(4), TFDP1(3) 2974481 39 31 39 6 6 9 9 6 9 0 0.125 0.398 1.000 25 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NFS1(4), PHPT1(1), TPK1(5) 2218323 25 20 25 3 1 9 6 7 1 1 0.150 0.532 1.000 26 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(6) 566088 6 5 6 0 0 3 2 1 0 0 0.237 0.597 1.000 27 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(9), BCMO1(4) 1334612 16 14 16 3 2 4 5 1 4 0 0.329 0.628 1.000 28 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(12), GGT1(1), SHMT1(2), SHMT2(2) 1431937 17 16 17 4 4 4 5 1 3 0 0.350 0.670 1.000 29 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2), ALDOB(4), ALDOC(1), TPI1(6) 1340337 13 10 13 0 0 5 4 2 2 0 0.0430 0.713 1.000 30 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(2) 390674 2 2 2 1 0 0 1 1 0 0 0.860 0.760 1.000 31 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 173582 1 1 1 3 0 0 0 0 1 0 0.995 0.765 1.000 32 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(3), GRIA2(15), PPP1R1B(1) 1325681 20 19 20 8 1 6 5 1 7 0 0.779 0.857 1.000 33 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(3), MMP2(13), MMP9(10), RECK(6), TIMP1(1), TIMP4(1) 2582662 35 26 35 6 3 6 15 6 5 0 0.106 0.871 1.000 34 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(3), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PGK1(5), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(2), TPI1(6) 6166283 65 42 64 7 10 19 16 10 10 0 0.00257 0.875 1.000 35 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(1), HGD(4) 772188 6 5 6 1 1 3 0 0 2 0 0.479 0.897 1.000 36 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), TGDS(2), UGDH(4), UXS1(4) 1340337 13 12 13 3 1 3 5 1 3 0 0.590 0.903 1.000 37 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(6), GOT1(2), GOT2(3), TAT(4), TYR(14) 1613763 29 26 29 7 7 10 3 5 4 0 0.338 0.905 1.000 38 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(1), BRAF(17), CAMP(2), CREB5(7), RAF1(3), SNX13(3), SRC(2) 3939029 37 29 32 5 7 13 6 7 4 0 0.0764 0.911 1.000 39 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), HADH(4), HADHA(3), HADHB(4), HSD17B4(5), MECR(1), PPT1(2), PPT2(7) 2924330 30 23 28 5 4 5 9 3 8 1 0.129 0.914 1.000 40 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(3), TAT(4) 902718 9 8 9 3 4 3 1 1 0 0 0.595 0.918 1.000 41 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL16(9), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2) 3410955 36 29 35 5 2 15 11 6 2 0 0.0670 0.927 1.000 42 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), SPCS1(1), SPCS3(1) 1063476 7 7 7 2 0 1 3 2 1 0 0.615 0.941 1.000 43 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), NFYC(2), RB1(13), SP1(1), SP3(4) 2300534 21 19 21 6 1 3 3 4 10 0 0.741 0.944 1.000 44 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), TGDS(2), UGDH(4), UGP2(1), UXS1(4) 1699180 14 12 14 3 2 3 5 1 3 0 0.522 0.947 1.000 45 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(3), CSF1(1), HLA-DRA(3), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2), PDGFA(6), TGFB1(2), TGFB2(8), TGFB3(1) 4545421 51 39 50 9 4 17 13 10 7 0 0.0994 0.955 1.000 46 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNA2(4), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1B(3), CDKN2A(14), E2F1(3), PRB1(2) 3146002 39 29 39 8 6 7 11 7 8 0 0.214 0.972 1.000 47 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), ACAT2(1), OXCT1(4) 1160343 6 5 6 2 1 1 1 1 1 1 0.778 0.984 1.000 48 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(3), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME3(2), PGK1(5), PGK2(14), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(2), TKTL1(10), TKTL2(12), TPI1(6) 6892442 94 64 93 15 13 32 20 14 15 0 0.00929 0.986 1.000 49 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 524181 2 1 2 0 1 1 0 0 0 0 0.608 0.986 1.000 50 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(3), CD80(4), HLA-DRA(3), IL10(1), IL2(5), IL4(1) 1359344 18 16 17 5 0 8 4 3 3 0 0.674 0.991 1.000 51 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(3), HLA-DRA(3) 809744 7 7 7 3 0 2 3 1 1 0 0.821 0.993 1.000 52 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(8), HADHA(3), SDS(2) 1650174 13 11 12 4 1 5 3 1 2 1 0.726 0.993 1.000 53 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(4), ACAT1(1), ACAT2(1), EHHADH(8), HADHA(3), HADHB(4), SDS(2) 2851966 23 19 22 5 1 6 8 2 5 1 0.406 0.994 1.000 54 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLS2(2), GLUD1(3), GLUD2(5) 1555597 13 12 13 4 1 4 6 2 0 0 0.636 0.994 1.000 55 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(1) 581889 1 1 1 1 0 0 1 0 0 0 0.956 0.995 1.000 56 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(4), CD3D(2), CD4(3), CD58(1), CD8A(2), IL3(1) 2134738 16 13 16 4 3 2 6 2 3 0 0.329 0.996 1.000 57 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(7), EPHX2(1), HSD3B7(2), RDH11(2) 1676509 12 11 12 3 3 5 4 0 0 0 0.434 0.996 1.000 58 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(5), CSAD(3), GAD1(5), GAD2(9), GGT1(1) 1941004 23 19 23 6 5 3 6 6 3 0 0.434 0.997 1.000 59 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(4), CASP8(4), CFLAR(1), PDE6D(1) 1316521 11 7 11 5 4 0 4 1 2 0 0.793 0.998 1.000 60 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), FADD(1), FAS(3), FASLG(3), GZMB(3), JUN(1), MAP2K4(3), MAP3K1(4), MAP3K14(1), MAPK10(5), MCL1(1), MDM2(2), NFKB1(3), NFKBIA(1), PARP1(2), PRF1(5), RIPK1(4), TNFRSF1B(1), TNFSF10(1), TP53(128), TRAF2(1) 12900944 209 136 187 32 17 45 48 34 65 0 0.00140 0.998 1.000 61 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3D(2), CD4(3) 1101948 7 7 7 6 0 2 2 1 2 0 0.969 0.999 1.000 62 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(3), ACAT1(1), HADHA(3) 1846885 7 7 7 5 0 0 1 2 3 1 0.971 0.999 1.000 63 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACAT2(1), ACYP2(1), EHHADH(8), GCDH(3), HADHA(3), SDHB(1), SDS(2) 2671972 20 17 18 5 1 5 9 1 3 1 0.530 0.999 1.000 64 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(2), IFNG(4), IL2(5), IL2RA(3), IL4(1), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(12), TOB1(1), TOB2(3) 3648199 47 35 45 10 6 19 8 7 7 0 0.279 0.999 1.000 65 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(1), FMOD(2), KERA(3), LUM(6) 1242783 18 15 18 5 2 5 3 6 2 0 0.587 0.999 1.000 66 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CHEK1(6), MYT1(6), WEE1(3) 4733659 45 34 44 8 2 12 11 10 10 0 0.253 0.999 1.000 67 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(1) 1101032 5 5 5 3 0 2 2 0 1 0 0.873 0.999 1.000 68 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(4), IFNGR1(3), IFNGR2(3), JAK1(8), JAK2(4), STAT1(4) 2833188 26 23 26 6 4 4 8 5 5 0 0.380 0.999 1.000 69 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(7), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(2), PON1(3), PON3(5), RDH11(2) 3117148 27 24 27 6 4 9 9 4 1 0 0.240 0.999 1.000 70 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), DHFR(1), FPGS(1), GCH1(4), GGH(4), SPR(1) 2288626 25 20 25 7 2 2 8 6 7 0 0.518 0.999 1.000 71 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2) 1931157 41 26 41 11 2 29 3 4 3 0 0.600 1.000 1.000 72 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(7), SNCA(3), SNCAIP(4), UBE2E2(1), UBE2G2(1), UBE2L6(1) 2197713 22 19 22 5 2 11 6 2 1 0 0.431 1.000 1.000 73 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2A(14), CDKN2D(1), E2F1(3), RB1(13), RBL1(7), TFDP1(3) 5608439 72 53 72 14 8 18 16 12 18 0 0.177 1.000 1.000 74 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(14), PNPO(1), PSAT1(2) 1669868 17 15 17 7 2 7 2 2 4 0 0.863 1.000 1.000 75 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(5), BCKDK(2), CBS(1), CTH(1), MUT(6) 1685440 15 13 15 9 2 5 3 1 4 0 0.963 1.000 1.000 76 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(4), JAK1(8), PTPRU(10), REG1A(9), STAT1(4), STAT2(5), TYK2(2) 4318711 42 33 41 8 4 13 8 10 7 0 0.202 1.000 1.000 77 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(5), HDC(7), TH(2), TPH1(11) 2096495 27 17 27 8 7 6 5 6 3 0 0.577 1.000 1.000 78 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(5), PRKCA(7), PTK2B(8) 2300534 20 16 20 5 8 6 5 1 0 0 0.369 1.000 1.000 79 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(2), IFNB1(4), JAK1(8), STAT1(4), STAT2(5), TYK2(2) 3732929 25 23 25 5 1 4 6 8 6 0 0.418 1.000 1.000 80 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), HPRT1(1), IMPDH1(4), MTHFD2(1), POLB(2), POLD1(2), POLG(10), PRPS2(2), RRM1(5), SRM(2) 4356954 30 21 30 5 11 3 9 4 3 0 0.0746 1.000 1.000 81 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(1), CRY1(3), CRY2(2), CSNK1E(5), PER1(3) 2947917 16 11 16 3 7 3 5 0 1 0 0.215 1.000 1.000 82 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3) 2760595 31 24 31 9 5 10 9 4 3 0 0.452 1.000 1.000 83 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3) 2760595 31 24 31 9 5 10 9 4 3 0 0.452 1.000 1.000 84 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2), HLA-DRA(3), IL3(1) 1035309 6 6 6 3 0 1 3 2 0 0 0.878 1.000 1.000 85 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(11), GNA12(1), PRKACB(3), PRKACG(1), PRKAR2A(1) 3484922 17 13 17 3 2 5 6 2 2 0 0.274 1.000 1.000 86 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(6), ANKRD1(6), CYR61(1), DUSP14(1), EIF4E(3), HBEGF(1), IFNG(4), IFRD1(1), IL1A(3), IL1R1(1), MYOG(1), NR4A3(2), WDR1(2) 3770714 32 24 32 7 6 7 13 4 2 0 0.233 1.000 1.000 87 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(7), GBA3(12), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TPO(16), TYR(14) 3297600 64 52 64 16 6 21 16 12 9 0 0.332 1.000 1.000 88 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(1), FUT1(2), FUT3(2), ST3GAL3(1), ST3GAL4(2) 2472284 14 10 14 4 4 4 4 1 1 0 0.471 1.000 1.000 89 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), GGPS1(1), IDI1(1), SQLE(1) 1470867 6 6 6 4 0 3 2 0 1 0 0.922 1.000 1.000 90 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(6), EGF(8), EGFR(33), RAB5A(1), TF(4), TFRC(6) 4416036 58 40 44 12 4 15 10 17 12 0 0.464 1.000 1.000 91 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(4), FADD(1), RIPK1(4), TNFRSF1B(1), TRAF2(1) 2916544 15 12 15 3 1 2 7 2 3 0 0.382 1.000 1.000 92 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(2), CREBBP(4), DFFA(3), DFFB(2), GZMA(4), GZMB(3), HMGB2(4), PRF1(5), SET(1) 3651634 29 21 29 6 5 9 7 4 4 0 0.336 1.000 1.000 93 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(3), GLUD1(3), OAT(1) 1919478 11 10 11 4 2 1 6 1 1 0 0.672 1.000 1.000 94 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(3), GBA3(12), GGT1(1), SHMT1(2), SHMT2(2) 1924287 21 19 21 9 4 6 7 1 3 0 0.801 1.000 1.000 95 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(4), CD36(4), FOS(1), FYN(3), JUN(1), MAPK14(1), THBS1(4) 2528847 18 12 17 5 5 4 2 3 4 0 0.583 1.000 1.000 96 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(4), CASP7(1), DFFA(3), DFFB(2), GZMB(3), HMGB2(4), TOP2A(6), TOP2B(4) 3305615 27 18 26 6 8 6 4 5 4 0 0.461 1.000 1.000 97 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(4), LPL(5), NR3C1(3), PPARG(3), RXRA(1) 1996193 16 15 16 8 1 6 3 3 3 0 0.943 1.000 1.000 98 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDC25A(4), CDC25B(1), CDC25C(3), CDK7(3), MNAT1(2), SHH(4), XPO1(3) 3034937 22 18 22 5 1 7 6 5 3 0 0.484 1.000 1.000 99 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(4), HRAS(1), PTK2B(8), SHC1(2), SOS1(12), SRC(2) 3031273 29 19 29 8 8 8 5 7 1 0 0.438 1.000 1.000 100 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(7), APC(23), AXIN1(3), BTRC(9), CTNNB1(11), DLL1(5), DVL1(1), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(1), WNT1(3) 7428531 76 52 73 12 10 18 24 10 14 0 0.0331 1.000 1.000 101 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), ACAT2(1), BDH2(1), HMGCS1(5), HMGCS2(5), OXCT1(4) 2479383 17 12 17 5 1 5 4 3 2 2 0.676 1.000 1.000 102 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(1), LDLR(5), LPL(5) 1832916 12 12 12 6 1 3 3 3 2 0 0.922 1.000 1.000 103 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB4A(2), RAB5A(1) 1469493 7 7 7 3 0 2 1 3 1 0 0.895 1.000 1.000 104 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(9), LARS(7), LARS2(2), PDHA1(3), PDHA2(13) 3442557 35 28 35 9 3 11 8 8 5 0 0.572 1.000 1.000 105 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), WASF1(8), WASL(5) 2788991 28 22 28 9 1 9 9 3 6 0 0.847 1.000 1.000 106 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(7), ERBB4(21), NRG2(2), NRG3(19), PRKCA(7), PSEN1(1) 3078676 57 40 57 14 6 21 19 7 4 0 0.371 1.000 1.000 107 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(2), PRKCA(7), TGM2(3) 1714523 16 14 16 5 4 5 4 2 1 0 0.577 1.000 1.000 108 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(2), HRAS(1), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NGFR(2), RAF1(3) 2857691 21 18 21 6 3 6 5 5 2 0 0.397 1.000 1.000 109 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(5), SRP19(1), SRP54(2), SRP68(2), SRP72(2), SRPR(4) 2570754 17 11 16 9 3 5 6 0 3 0 0.967 1.000 1.000 110 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST6GALNAC4(1), ST8SIA1(2) 1949706 11 11 11 8 3 0 6 0 2 0 0.935 1.000 1.000 111 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(5), LDLR(5), MBTPS1(6), MBTPS2(2), SCAP(4), SREBF1(2), SREBF2(1) 4127496 25 20 25 6 3 4 10 4 3 1 0.303 1.000 1.000 112 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(7), KARS(4) 1625442 14 10 14 6 3 4 3 3 1 0 0.883 1.000 1.000 113 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(3), CD8A(2), CSF1(1), EPO(3), IL2(5), IL3(1), IL4(1) 2063748 16 14 15 5 0 8 4 2 2 0 0.592 1.000 1.000 114 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(16), HSD17B2(3), HSD17B3(1), HSD17B4(5), HSD17B7(1), HSD3B1(7), HSD3B2(13) 2802273 49 36 48 13 6 17 12 7 6 1 0.460 1.000 1.000 115 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(3), FUT1(2), FUT9(7), GCNT2(2), ST8SIA1(2) 2110693 17 17 16 9 3 3 5 4 2 0 0.912 1.000 1.000 116 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(3), CPOX(4), FECH(2), HMBS(3), PPOX(3) 2627546 17 12 17 5 4 4 4 3 2 0 0.551 1.000 1.000 117 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), CD4(3), HLA-DRA(3), IL4(1), IL5RA(5) 1824443 14 14 14 5 0 4 6 3 1 0 0.754 1.000 1.000 118 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(7), DLL1(5), FURIN(7), NOTCH1(8), PSEN1(1) 3239434 28 22 28 8 7 6 5 3 7 0 0.539 1.000 1.000 119 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(33), MAP2K1(6), MAP3K1(4), MAPK14(1), NCOR2(13), RARA(3), RXRA(1), THRA(1), THRB(5) 5922398 75 52 61 18 8 14 14 22 17 0 0.404 1.000 1.000 120 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(18), RANGAP1(2) 2892499 20 14 20 8 5 7 4 1 2 1 0.870 1.000 1.000 121 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(1), CHEK1(6), NEK1(6), WEE1(3) 2473429 24 19 24 8 1 9 6 6 2 0 0.827 1.000 1.000 122 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(6), EIF2AK4(6), EIF2B5(3), EIF2S3(2), EIF5(1), GSK3B(2), PPP1CA(2) 3996966 22 15 22 5 4 10 5 1 2 0 0.533 1.000 1.000 123 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), KARS(4) 2393279 22 17 22 8 5 7 4 4 2 0 0.833 1.000 1.000 124 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(4), IFNGR1(3), JAK1(8), JAK2(4), PLA2G2A(3), PTPRU(10), REG1A(9), STAT1(4) 3982997 45 35 44 10 5 14 9 9 8 0 0.313 1.000 1.000 125 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CSNK1D(2), DRD1(3), DRD2(9), GRM1(26), PLCB1(18), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 5549128 80 61 79 18 11 27 28 3 11 0 0.120 1.000 1.000 126 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(1), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2), SDHB(1) 3049364 21 18 21 6 2 6 5 4 4 0 0.593 1.000 1.000 127 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(1), ACP5(3), ACPP(7), ENPP1(6), ENPP3(12), FLAD1(3), TYR(14) 3340652 48 44 48 12 5 14 16 7 6 0 0.375 1.000 1.000 128 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SUOX(5) 2092144 20 18 20 7 2 6 7 4 1 0 0.740 1.000 1.000 129 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(5), NR0B2(1), NR1H3(3), NR1H4(5), RXRA(1) 1876884 16 13 16 6 1 3 7 4 1 0 0.742 1.000 1.000 130 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(3), EIF2S3(2), EIF4E(3), GSK3B(2), IGF1(5), IGF1R(10), INPPL1(6), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2) 6777484 59 37 55 11 10 18 18 5 8 0 0.0983 1.000 1.000 131 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(2), AKT3(5), CDKN1A(1), ELK1(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), NGFR(2), NTRK1(12), PIK3CA(11), PIK3CD(1), SHC1(2), SOS1(12) 5622866 62 47 58 14 4 17 18 15 8 0 0.200 1.000 1.000 132 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMD14(2), RPN2(4), UBE2A(4), UBE3A(8) 4451531 31 22 31 7 6 8 8 6 3 0 0.255 1.000 1.000 133 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2) 3607666 23 22 23 7 1 5 6 7 4 0 0.683 1.000 1.000 134 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2) 3607666 23 22 23 7 1 5 6 7 4 0 0.683 1.000 1.000 135 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(30), PGM1(2), PYGL(3), PYGM(6), TPI1(6), TREH(1) 4612976 53 40 53 12 8 20 19 3 3 0 0.144 1.000 1.000 136 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(3), CPO(3), FECH(2), GATA1(2), HBB(4), HMBS(3) 2723039 19 14 19 7 3 10 2 2 2 0 0.757 1.000 1.000 137 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2) 2714337 23 17 22 8 8 1 9 2 3 0 0.487 1.000 1.000 138 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(5), BMPR2(2) 2163363 13 10 13 6 3 2 4 3 1 0 0.883 1.000 1.000 139 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(9), EPHB1(30), FYN(3), ITGA1(9), ITGB1(3), L1CAM(15), LYN(4), RAP1B(1), SELP(14) 5406003 92 59 90 22 16 23 20 23 10 0 0.313 1.000 1.000 140 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(2), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5) 2119166 14 11 14 6 1 5 4 3 1 0 0.795 1.000 1.000 141 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(1), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(4), MTHFD2(1) 4388785 29 23 29 9 6 10 5 3 5 0 0.569 1.000 1.000 142 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), GSR(1), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), OPLAH(5), TXNDC12(1) 7431279 71 43 71 14 9 21 26 7 7 1 0.0419 1.000 1.000 143 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ENPP1(6), ENPP3(12), FLAD1(3), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PHPT1(1), TYR(14) 5193262 67 54 67 16 6 19 22 13 7 0 0.300 1.000 1.000 144 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17) 5740343 54 37 53 12 16 5 20 7 6 0 0.114 1.000 1.000 145 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), SDS(2) 4179479 44 33 43 12 6 15 12 5 5 1 0.403 1.000 1.000 146 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMC2(2), PSMD1(4), PSMD11(5), PSMD12(4), PSMD13(2), PSMD2(3), PSMD6(1) 5480886 34 24 34 8 8 10 9 4 3 0 0.233 1.000 1.000 147 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(23), AXIN1(3), CCND1(2), CD14(1), CTNNB1(11), DVL1(1), FZD1(3), GJA1(6), GNAI1(3), GSK3B(2), IRAK1(3), LBP(5), LEF1(8), LY96(1), MYD88(3), NFKB1(3), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), TLR4(31), TOLLIP(1), WNT1(3) 10579800 129 81 124 24 13 32 42 18 24 0 0.0338 1.000 1.000 148 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), ENPP3(12), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCS(1) 4794573 56 43 56 14 7 17 16 7 8 1 0.334 1.000 1.000 149 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(4), ACO2(1), ACSS1(4), ACSS2(4), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2) 4555955 30 23 30 9 5 7 7 6 5 0 0.505 1.000 1.000 150 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GUSB(5), HEXA(1), IDS(3), IDUA(2), LCT(30), NAGLU(1) 4924874 43 37 43 11 5 14 13 4 7 0 0.372 1.000 1.000 151 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(3), B3GAT3(1), CHPF(3), CHST11(1), CHST12(3), CHST13(3), CHST3(2), CHSY1(2), DSE(10), UST(1), XYLT1(19) 4717629 49 42 49 12 4 12 20 8 5 0 0.188 1.000 1.000 152 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 ATF2(5), CDC42(2), DLD(6), DUSP10(6), DUSP8(1), GAB1(2), GADD45A(1), GCK(4), IL1R1(1), JUN(1), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(6), MAP3K13(7), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK10(5), MAPK7(5), MAPK8(3), MAPK9(6), MYEF2(4), NFATC3(10), NR2C2(2), PAPPA(12), SHC1(2), TP53(128), TRAF6(4), ZAK(3) 17286065 294 154 271 48 48 59 78 43 66 0 0.000139 1.000 1.000 153 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(4), HRAS(1), KLK2(4), NTRK1(12), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), SHC1(2), SOS1(12) 5335700 61 47 57 15 9 17 18 10 7 0 0.308 1.000 1.000 154 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(23), AXIN1(3), BTRC(9), CCND1(2), CREBBP(4), CSNK1A1(1), CSNK1D(2), CTNNB1(11), DVL1(1), FZD1(3), GSK3B(2), HDAC1(3), MAP3K7(5), PPARD(2), PPP2CA(1), TLE1(3), WNT1(3) 10187065 78 54 75 14 11 19 25 10 13 0 0.0579 1.000 1.000 155 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(11), PIK3R1(3), PLCB1(18), PLCG1(5), PRKCA(7), VAV1(1) 4363824 45 38 42 11 7 12 17 2 7 0 0.365 1.000 1.000 156 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMB9(1) 3000587 14 9 14 7 4 4 4 1 1 0 0.811 1.000 1.000 157 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), CS(1), MDH1(2), ME1(1), PC(1), PDHA1(3), SLC25A11(2) 3167986 12 11 12 6 3 2 3 3 1 0 0.823 1.000 1.000 158 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(1), CTH(1), GGT1(1), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), PAPSS1(3), PAPSS2(4), SCLY(2), SEPHS1(4) 4248179 36 25 36 10 9 10 10 2 5 0 0.357 1.000 1.000 159 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS(9), IARS2(7), ILVBL(1), LARS(7), LARS2(2), PDHA1(3), PDHA2(13), VARS(6), VARS2(8) 6351773 58 43 58 14 8 16 14 11 9 0 0.305 1.000 1.000 160 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), E2F1(3), HRAS(1), MAPK3(1), NFKB1(3), NFKBIA(1), PAK1(5), PIK3CA(11), PIK3R1(3), RAF1(3), RB1(13), TFDP1(3) 6952211 65 46 62 16 15 14 15 7 14 0 0.254 1.000 1.000 161 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(20), ABCB11(15), ABCB4(17), ABCC1(7), ABCC3(7), GSTP1(2) 4930599 68 52 67 20 6 18 22 10 12 0 0.477 1.000 1.000 162 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(4), CHIT1(4), CMAS(3), CYB5R1(1), GFPT1(4), GFPT2(6), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NAGK(1), NANS(2), NPL(3), PGM3(4), PHPT1(1), RENBP(3), UAP1(6) 9867381 87 58 87 19 15 23 17 22 10 0 0.135 1.000 1.000 163 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(23), AXIN1(3), CREBBP(4), CTNNB1(11), DVL1(1), EP300(2), FZD1(3), GSK3B(2), HDAC1(3), LDB1(1), LEF1(8), PITX2(4), TRRAP(24), WNT1(3) 11428703 92 56 90 16 17 19 27 13 16 0 0.0195 1.000 1.000 164 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(4), CD2(3), CD33(10), CD5(4), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL3(1), IL4(1), ITGAX(20), TLR2(2), TLR4(31), TLR7(8), TLR9(6) 6388184 103 69 103 28 9 35 24 19 15 1 0.325 1.000 1.000 165 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(8), BAX(1), BCL2(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(3), BIRC5(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CHUK(3), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(3), GZMB(3), HELLS(1), IKBKB(3), IRF1(1), IRF2(1), IRF3(1), IRF4(3), IRF6(5), IRF7(1), JUN(1), LTA(2), MAP2K4(3), MAP3K1(4), MAPK10(5), MDM2(2), NFKB1(3), NFKBIA(1), NFKBIE(1), PLEKHG5(5), PRF1(5), RIPK1(4), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFSF10(1), TP53(128), TP73(4), TRAF2(1), TRAF3(3) 19907657 262 144 240 45 23 59 64 39 77 0 0.00183 1.000 1.000 166 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(23), MAP2(17), PPP1CA(2), PPP2CA(1), PRKACB(3), PRKACG(1), PRKAR2A(1), PRKCE(3) 6259028 51 40 51 11 2 22 13 9 5 0 0.627 1.000 1.000 167 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), ITPKA(1), PDE1A(8), PDE1B(6), PLCB1(18), PLCB2(6), PRL(1), TRH(1), VIP(1) 3826590 46 37 46 13 7 14 13 3 9 0 0.505 1.000 1.000 168 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 ELK1(2), FOS(1), GRB2(4), HRAS(1), JUN(1), KLK2(4), MAP2K1(6), MAPK3(1), MAPK8(3), NGFR(2), PIK3CA(11), PIK3R1(3), PLCG1(5), RAF1(3), SHC1(2), SOS1(12) 6555125 61 45 58 16 9 16 19 12 5 0 0.327 1.000 1.000 169 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(23), ASAH1(2), CAMP(2), CASP3(4), CERK(3), CREB5(7), DAG1(2), EPHB2(5), FOS(1), GNAQ(2), ITPKA(1), ITPKB(5), JUN(1), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6) 9859137 85 58 85 19 12 19 25 10 19 0 0.175 1.000 1.000 170 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6) 5739656 52 45 52 14 6 19 20 4 3 0 0.404 1.000 1.000 171 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), ENPP3(12), ILVBL(1), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCDC(1), PPCS(1), VNN1(4) 5940718 63 47 63 17 7 18 20 9 8 1 0.390 1.000 1.000 172 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(10), GLI3(17), GSK3B(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SHH(4), SMO(5) 5808356 55 44 55 15 14 17 9 6 9 0 0.360 1.000 1.000 173 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(8), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), PRF1(5), SCAP(4), SREBF1(2), SREBF2(1) 6305515 51 36 51 13 7 11 12 10 11 0 0.352 1.000 1.000 174 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), MTR(11) 6019952 59 43 59 16 10 16 19 7 6 1 0.329 1.000 1.000 175 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3) 4584351 65 39 65 20 5 37 9 8 6 0 0.646 1.000 1.000 176 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), APC(23), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(11), ARHGEF4(4), ARHGEF6(9), ARHGEF7(6), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), ARPC5(1), BAIAP2(2), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(17), CD14(1), CDC42(2), CFL2(2), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CRKL(2), CYFIP1(7), CYFIP2(8), DIAPH1(4), DIAPH2(7), DIAPH3(6), DOCK1(7), EGF(8), EGFR(33), EZR(1), F2(5), F2R(4), FGD1(2), FGD3(6), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF14(9), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FN1(13), GNA12(1), GNA13(5), GNG12(2), GRLF1(9), GSN(3), HRAS(1), IQGAP1(5), IQGAP2(13), IQGAP3(6), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), KRAS(60), LIMK2(1), MAP2K1(6), MAP2K2(1), MAPK3(1), MOS(2), MRAS(1), MSN(1), MYH10(6), MYH14(2), MYH9(8), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLK(15), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(12), NRAS(4), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PFN1(1), PFN2(3), PFN4(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(11), PXN(1), RAC2(1), RAF1(3), RDX(2), RHOA(1), ROCK1(10), ROCK2(4), RRAS(1), RRAS2(1), SCIN(4), SLC9A1(3), SOS1(12), SOS2(6), SSH1(4), SSH2(4), SSH3(2), TIAM1(19), TIAM2(11), TMSL3(1), VAV1(1), VAV2(3), VAV3(14), VCL(2), WAS(3), WASF1(8), WASF2(1), WASL(5) 95772838 1022 211 943 304 132 324 256 171 137 2 0.572 1.000 1.000 177 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(5), ACVR1C(3), AKT2(2), AKT3(5), ARRB1(2), ARRB2(1), ATF2(5), ATF4(1), BDNF(1), BRAF(17), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(11), CACNA2D1(19), CACNA2D2(1), CACNA2D3(14), CACNA2D4(6), CACNB1(1), CACNB2(7), CACNB4(1), CACNG1(1), CACNG2(1), CACNG3(7), CACNG4(2), CACNG5(6), CACNG6(3), CACNG7(1), CACNG8(2), CASP3(4), CD14(1), CDC25B(1), CDC42(2), CHUK(3), CRKL(2), DAXX(6), DDIT3(4), DUSP10(6), DUSP14(1), DUSP16(2), DUSP2(1), DUSP6(3), DUSP7(2), DUSP8(1), DUSP9(2), EGF(8), EGFR(33), ELK1(2), ELK4(4), FAS(3), FASLG(3), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF14(9), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FLNA(11), FLNB(12), FLNC(19), FOS(1), GADD45A(1), GNA12(1), GNG12(2), GRB2(4), HRAS(1), IKBKB(3), IL1A(3), IL1R1(1), IL1R2(4), JUN(1), KRAS(60), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K12(6), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP4K1(5), MAP4K3(5), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAPT(8), MAX(3), MEF2C(2), MKNK1(2), MKNK2(1), MOS(2), MRAS(1), NF1(30), NFATC2(8), NFATC4(8), NFKB1(3), NFKB2(6), NR4A1(2), NRAS(4), NTF3(7), NTRK1(12), NTRK2(9), PAK1(5), PAK2(3), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PPM1B(4), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PPP5C(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTPN5(4), PTPRR(8), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF2(10), RASA1(3), RASA2(3), RASGRF1(1), RASGRF2(14), RASGRP1(2), RASGRP3(8), RASGRP4(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(5), RRAS(1), RRAS2(1), SOS1(12), SOS2(6), STK4(4), STMN1(1), TAOK1(1), TAOK2(6), TAOK3(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TP53(128), TRAF2(1), TRAF6(4), ZAK(3) 99176007 1171 210 1068 311 158 312 306 195 195 5 0.0239 1.000 1.000 178 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), ARHGAP5(7), BCAR1(2), BCL2(1), BIRC2(2), BIRC3(3), BRAF(17), CAPN2(3), CAV3(2), CCND1(2), CCND2(1), CCND3(1), CDC42(2), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(34), COL4A1(16), COL4A2(15), COL4A4(13), COL4A6(17), COL5A1(18), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(34), COL6A6(24), COMP(2), CRKL(2), CTNNB1(11), DIAPH1(4), DOCK1(7), EGF(8), EGFR(33), ELK1(2), ERBB2(10), FARP2(3), FIGF(1), FLNA(11), FLNB(12), FLNC(19), FLT1(21), FN1(13), FYN(3), GRB2(4), GRLF1(9), GSK3B(2), HGF(29), HRAS(1), IBSP(2), IGF1(5), IGF1R(10), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), JUN(1), KDR(30), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(14), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), MAP2K1(6), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MET(12), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLK(15), MYLK2(3), MYLPF(1), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PARVA(2), PARVB(1), PARVG(3), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(7), PRKCG(10), PTEN(8), PTK2(11), PXN(1), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF1(1), RELN(49), RHOA(1), ROCK1(10), ROCK2(4), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TLN1(13), TLN2(16), TNC(21), TNN(34), TNR(40), TNXB(14), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCL(2), VEGFA(1), VEGFC(11), VTN(2), VWF(13), ZYX(2) 128314883 1574 206 1536 500 202 521 378 235 235 3 0.971 1.000 1.000 179 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY7(7), ADCY8(22), ADCY9(3), ADORA2B(1), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), AGTR1(5), ATP2A1(3), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), ATP2B4(8), AVPR1A(6), AVPR1B(3), BDKRB1(1), BDKRB2(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CCKAR(7), CCKBR(11), CD38(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM5(3), CHRNA7(3), CYSLTR1(1), CYSLTR2(3), DRD1(3), EDNRB(6), EGFR(33), ERBB2(10), ERBB3(3), ERBB4(21), F2R(4), GNA11(1), GNAQ(2), GNAS(7), GRIN1(2), GRIN2A(26), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), GRPR(5), HRH1(6), HRH2(6), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), LHCGR(6), MYLK(15), MYLK2(3), NOS1(9), NOS3(2), NTSR1(5), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), PDE1A(8), PDE1B(6), PDE1C(17), PDGFRA(17), PDGFRB(8), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PLN(1), PPID(1), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(6), PTK2B(8), RYR1(51), RYR2(165), RYR3(53), SLC25A5(2), SLC25A6(5), SLC8A1(26), SLC8A2(3), SLC8A3(7), SPHK2(2), TACR1(3), TACR3(8), TNNC2(2), TRHR(4), TRPC1(9), VDAC3(1) 93388948 1285 205 1259 463 153 419 354 210 144 5 0.994 1.000 1.000 180 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(6), ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA2A(1), ADRA2B(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), C5AR1(4), CALCR(8), CALCRL(10), CCKAR(7), CCKBR(11), CGA(1), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CRHR1(1), CRHR2(2), CTSG(2), CYSLTR1(1), CYSLTR2(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), EDNRB(6), F2(5), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHB(1), FSHR(20), GABBR1(3), GABBR2(6), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GABRB1(11), GABRB2(3), GABRB3(18), GABRD(1), GABRE(3), GABRG1(14), GABRG2(10), GABRG3(10), GABRP(5), GABRQ(11), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GH1(2), GH2(5), GHR(5), GHRHR(5), GHSR(4), GIPR(2), GLP1R(1), GLP2R(9), GLRA1(5), GLRA2(10), GLRA3(2), GLRB(4), GNRHR(2), GPR156(6), GPR50(7), GPR63(4), GPR83(4), GRIA1(12), GRIA2(15), GRIA3(11), GRIA4(9), GRID1(15), GRID2(22), GRIK1(11), GRIK2(19), GRIK3(10), GRIK4(8), GRIK5(6), GRIN1(2), GRIN2A(26), GRIN2B(21), GRIN2C(3), GRIN2D(6), GRIN3A(19), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM6(7), GRM7(15), GRM8(19), GRPR(5), GZMA(4), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HRH4(4), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3), LEP(4), LEPR(13), LHB(1), LHCGR(6), LTB4R(2), MAS1(3), MC2R(2), MC3R(9), MC4R(1), MC5R(10), MCHR2(6), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPBWR1(4), NPBWR2(2), NPFFR2(11), NPY1R(9), NPY2R(6), NPY5R(9), NR3C1(3), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), P2RY1(5), P2RY10(10), P2RY14(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PPYR1(2), PRL(1), PRLHR(5), PRLR(9), PRSS1(10), PRSS3(1), PTAFR(2), PTGDR(3), PTGER2(2), PTGER3(3), PTGER4(7), PTGFR(6), PTGIR(2), PTH2R(8), RXFP1(11), RXFP2(4), SCTR(1), SSTR1(3), SSTR3(2), SSTR4(5), SSTR5(2), TAAR1(4), TAAR2(6), TAAR5(8), TAAR6(7), TAAR8(5), TAAR9(4), TACR1(3), TACR3(8), THRA(1), THRB(5), TRHR(4), TRPV1(4), TSHB(1), TSHR(10), UTS2R(1), VIPR2(4) 76220818 1270 199 1263 490 135 455 320 224 134 2 0.999 1.000 1.000 181 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(2), CHAD(1), COL11A1(66), COL11A2(7), COL17A1(9), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(34), COL4A1(16), COL4A2(15), COL4A4(13), COL4A6(17), COL5A1(18), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(34), COL6A6(24), COMP(2), DSC1(10), DSC2(7), DSC3(13), DSG1(16), DSG2(8), DSG3(16), DSG4(16), FN1(13), GJA1(6), GJA10(5), GJA4(1), GJA5(3), GJA8(7), GJA9(5), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GJC1(4), GJC2(1), GJD2(2), GJD4(3), IBSP(2), INA(1), ITGA6(5), ITGB4(4), KRT1(4), KRT10(2), KRT12(2), KRT13(5), KRT14(3), KRT15(4), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(7), KRT20(2), KRT23(2), KRT24(7), KRT25(5), KRT28(8), KRT3(2), KRT31(4), KRT32(4), KRT33A(3), KRT33B(3), KRT34(4), KRT35(4), KRT36(4), KRT37(1), KRT38(8), KRT39(4), KRT4(2), KRT40(3), KRT5(7), KRT6A(7), KRT6B(13), KRT6C(2), KRT7(5), KRT71(8), KRT72(5), KRT73(9), KRT74(5), KRT75(7), KRT76(3), KRT78(1), KRT79(3), KRT8(3), KRT81(2), KRT82(6), KRT83(2), KRT84(3), KRT85(5), KRT86(4), KRT9(2), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(14), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), LMNB1(2), LMNB2(2), NES(10), RELN(49), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(14), VIM(2), VTN(2), VWF(13) 85825536 1147 191 1139 386 139 399 288 144 174 3 0.994 1.000 1.000 182 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(23), APC2(2), AXIN1(3), AXIN2(2), BTRC(9), CACYBP(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND1(2), CCND2(1), CCND3(1), CER1(2), CHD8(13), CREBBP(4), CSNK1A1(1), CSNK1A1L(5), CSNK1E(5), CTNNB1(11), CUL1(6), CXXC4(3), DAAM1(3), DAAM2(4), DKK1(2), DKK2(4), DKK4(2), DVL1(1), DVL2(1), DVL3(5), EP300(2), FOSL1(3), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), JUN(1), LEF1(8), LRP5(5), LRP6(10), MAP3K7(5), MAPK10(5), MAPK8(3), MAPK9(6), MMP7(4), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKD1(5), NKD2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PORCN(3), PPARD(2), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRICKLE1(5), PRICKLE2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(10), ROCK2(4), RUVBL1(2), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(3), SFRP5(1), SKP1(2), SMAD2(2), SMAD3(3), SMAD4(8), SOX17(1), TBL1XR1(5), TCF7(1), TCF7L1(2), TCF7L2(3), TP53(128), VANGL1(3), VANGL2(8), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5) 55862718 608 191 582 143 90 136 179 80 123 0 0.00299 1.000 1.000 183 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), ABLIM1(5), ABLIM2(2), ABLIM3(8), ARHGEF12(11), CDC42(2), CDK5(1), CFL2(2), CXCL12(1), CXCR4(3), DCC(22), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(10), EPHA2(2), EPHA3(25), EPHA4(9), EPHA5(26), EPHA6(33), EPHA7(24), EPHA8(7), EPHB1(30), EPHB2(5), EPHB3(6), EPHB4(7), EPHB6(24), FES(1), FYN(3), GNAI1(3), GNAI3(1), GSK3B(2), HRAS(1), ITGB1(3), KRAS(60), L1CAM(15), LIMK2(1), LRRC4C(17), MAPK3(1), MET(12), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NGEF(4), NRAS(4), NRP1(4), NTN1(1), NTN4(5), NTNG1(13), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PLXNA1(8), PLXNA2(14), PLXNA3(8), PLXNB1(4), PLXNB2(8), PLXNB3(3), PLXNC1(11), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTK2(11), RAC2(1), RASA1(3), RGS3(9), RHOA(1), RHOD(1), ROBO1(14), ROBO2(21), ROBO3(12), ROCK1(10), ROCK2(4), SEMA3A(19), SEMA3B(2), SEMA3C(6), SEMA3D(20), SEMA3E(6), SEMA3F(3), SEMA3G(4), SEMA4A(3), SEMA4C(1), SEMA4D(5), SEMA4F(5), SEMA4G(3), SEMA5A(24), SEMA5B(9), SEMA6A(10), SEMA6B(5), SEMA6C(9), SEMA6D(21), SEMA7A(7), SLIT1(16), SLIT2(28), SLIT3(16), SRGAP1(9), SRGAP2(4), SRGAP3(11), UNC5A(5), UNC5B(8), UNC5C(11), UNC5D(17) 68212688 946 188 884 274 127 322 237 133 126 1 0.274 1.000 1.000 184 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CSNK1D(2), DRD1(3), DRD2(9), EGF(8), EGFR(33), GJA1(6), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAQ(2), GNAS(7), GRB2(4), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), HTR2A(3), HTR2B(2), HTR2C(5), ITPR1(11), ITPR2(25), ITPR3(6), KRAS(60), MAP2K1(6), MAP2K2(1), MAP3K2(5), MAPK3(1), MAPK7(5), NPR1(6), NPR2(2), NRAS(4), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), PRKX(3), RAF1(3), SOS1(12), SOS2(6), SRC(2), TJP1(10), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3C(12), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB4Q(12), TUBB8(7) 45586114 606 188 535 195 65 207 163 103 68 0 0.787 1.000 1.000 185 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), AMOTL1(7), ASH1L(22), CASK(3), CDC42(2), CDK4(2), CGN(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CSDA(2), CTNNA1(3), CTNNA2(29), CTNNA3(11), CTNNB1(11), CTTN(3), EPB41(1), EPB41L1(9), EPB41L2(9), EPB41L3(17), EXOC3(3), EXOC4(6), F11R(2), GNAI1(3), GNAI3(1), HCLS1(6), HRAS(1), IGSF5(3), INADL(25), JAM2(6), KRAS(60), LLGL1(1), LLGL2(2), MAGI1(16), MAGI2(15), MAGI3(4), MLLT4(4), MPDZ(7), MPP5(1), MRAS(1), MYH1(36), MYH10(6), MYH11(15), MYH13(18), MYH14(2), MYH15(15), MYH2(35), MYH3(11), MYH4(24), MYH6(22), MYH7(20), MYH7B(6), MYH8(29), MYH9(8), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLPF(1), NRAS(4), OCLN(1), PARD3(6), PARD6B(3), PPM1J(1), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP2R3A(1), PPP2R3B(4), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PTEN(8), RAB13(2), RAB3B(1), RHOA(1), RRAS(1), RRAS2(1), SPTAN1(12), SRC(2), SYMPK(7), TJAP1(2), TJP1(10), TJP2(4), TJP3(2), VAPA(1), YES1(3), ZAK(3) 66918380 774 186 709 247 113 266 200 108 86 1 0.845 1.000 1.000 186 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(2), ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), ATM(22), ATR(16), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC14A(7), CDC14B(1), CDC16(3), CDC20(3), CDC23(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC27(1), CDC6(1), CDC7(3), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2A(14), CDKN2D(1), CHEK1(6), CHEK2(2), CREBBP(4), CUL1(6), DBF4(3), E2F1(3), E2F3(1), EP300(2), ESPL1(4), FZR1(2), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PKMYT1(2), PLK1(3), PRKDC(23), PTTG1(1), PTTG2(2), RB1(13), RBL1(7), RBL2(2), SKP1(2), SKP2(4), SMAD2(2), SMAD3(3), SMAD4(8), SMC1A(4), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), TP53(128), WEE1(3), YWHAG(2) 47244990 493 183 470 92 59 111 146 72 105 0 0.000213 1.000 1.000 187 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD36(4), CD44(2), CD47(1), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(34), COL4A1(16), COL4A2(15), COL4A4(13), COL4A6(17), COL5A1(18), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(34), COL6A6(24), DAG1(2), FN1(13), FNDC1(14), FNDC3A(7), FNDC4(1), FNDC5(1), GP5(3), GP6(3), HMMR(4), HSPG2(17), IBSP(2), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(14), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), RELN(49), SDC1(5), SDC3(2), SV2A(5), SV2B(8), SV2C(11), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(14), VTN(2), VWF(13) 77840306 998 183 990 332 118 355 248 124 150 3 0.991 1.000 1.000 188 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), ANXA6(1), ARRB1(2), ARRB2(1), ATP1A4(15), ATP1B3(1), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1S(11), CACNB1(1), CALM1(2), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CASQ1(3), CASQ2(4), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), FXYD2(1), GJA1(6), GJA4(1), GJA5(3), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GNA11(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG2(4), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), ITPR1(11), ITPR2(25), ITPR3(6), KCNB1(16), KCNJ3(15), KCNJ5(1), MIB1(6), NME7(4), PEA15(3), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(3), RGS7(13), RGS9(5), RYR1(51), RYR2(165), RYR3(53), SLC8A1(26), SLC8A3(7), USP5(3) 65335303 941 181 933 333 116 313 262 134 112 4 0.970 1.000 1.000 189 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ATF4(1), CACNA1C(26), CACNA1D(17), CACNA1F(10), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(2), CGA(1), EGFR(33), ELK1(2), FSHB(1), GNA11(1), GNAQ(2), GNAS(7), GNRHR(2), GRB2(4), HBEGF(1), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), JUN(1), KRAS(60), LHB(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK9(6), MMP14(3), MMP2(13), NRAS(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLD1(9), PLD2(6), PRKACB(3), PRKACG(1), PRKCA(7), PRKCD(1), PRKX(3), PTK2B(8), RAF1(3), SOS1(12), SOS2(6), SRC(2) 44063493 551 180 479 157 75 176 147 84 69 0 0.306 1.000 1.000 190 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(2), ATM(22), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDAN1(2), CDC14A(7), CDC14B(1), CDC20(3), CDC25A(4), CDC25B(1), CDC25C(3), CDC6(1), CDC7(3), CDH1(5), CDK2(4), CDK4(2), CDKN1A(1), CDKN2A(14), CHEK1(6), CHEK2(2), DTX4(1), E2F1(3), E2F3(1), E2F6(3), EP300(2), ESPL1(4), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), HDAC8(2), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MPEG1(3), MPL(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PLK1(3), PRKDC(23), PTPRA(5), PTTG1(1), PTTG2(2), RB1(13), RBL1(7), SKP2(4), SMAD4(8), TBC1D8(3), TFDP1(3), TGFB1(2), TP53(128), WEE1(3) 38228573 443 179 420 83 54 109 117 64 99 0 0.000255 1.000 1.000 191 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(4), ACVR1B(5), ACVR2A(2), ACVR2B(4), AMH(1), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(1), BMPR1B(5), BMPR2(2), CCL13(2), CCL14(2), CCL15(3), CCL17(1), CCL18(1), CCL20(1), CCL22(1), CCL23(1), CCL25(1), CCL28(4), CCL3(1), CCL4(1), CCL7(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CD27(1), CD40LG(6), CNTF(1), CNTFR(3), CSF1(1), CSF1R(6), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(3), CX3CR1(5), CXCL1(2), CXCL12(1), CXCL16(1), CXCL5(1), CXCL6(4), CXCL9(3), CXCR3(1), CXCR4(3), CXCR6(1), EDA(2), EDA2R(2), EDAR(3), EGF(8), EGFR(33), EPO(3), EPOR(1), FAS(3), FASLG(3), FLT1(21), FLT3(10), FLT3LG(2), FLT4(13), GDF5(4), GH1(2), GH2(5), GHR(5), HGF(29), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL15(2), IL15RA(1), IL17A(4), IL17B(3), IL17RA(3), IL18R1(3), IL18RAP(8), IL19(1), IL1A(3), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL25(2), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), INHBA(15), INHBB(1), INHBC(1), INHBE(3), KDR(30), KIT(6), LEP(4), LEPR(13), LIF(2), LIFR(5), LTA(2), LTB(1), MET(12), MPL(2), NGFR(2), OSM(2), OSMR(5), PDGFB(1), PDGFRA(17), PDGFRB(8), PLEKHO2(2), PRL(1), PRLR(9), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(7), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(16), TSLP(3), VEGFA(1), VEGFC(11), XCL1(3), XCL2(5), XCR1(1) 61172083 706 179 689 225 66 228 180 139 93 0 0.883 1.000 1.000 192 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(10), ADCY8(22), ARAF(3), ATF4(1), BRAF(17), CACNA1C(26), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CREBBP(4), EP300(2), GNAQ(2), GRIA1(12), GRIA2(15), GRIN1(2), GRIN2A(26), GRIN2B(21), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), KRAS(60), MAP2K1(6), MAP2K2(1), MAPK3(1), NRAS(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R1A(2), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5) 34695332 458 179 395 126 53 168 114 70 53 0 0.221 1.000 1.000 193 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(10), ACACB(11), AKT2(2), AKT3(5), ARAF(3), BRAF(17), CALM1(2), CALML3(3), CBL(8), CBLB(5), CBLC(1), CRKL(2), ELK1(2), EXOC7(2), FASN(4), FBP2(1), FLOT1(2), FLOT2(1), FOXO1(3), G6PC(1), G6PC2(2), GCK(4), GRB2(4), GSK3B(2), GYS1(2), GYS2(3), HRAS(1), IKBKB(3), INPP5D(4), INSR(1), IRS1(15), IRS2(3), IRS4(17), KRAS(60), LIPE(2), MAP2K1(6), MAP2K2(1), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MKNK1(2), MKNK2(1), NRAS(4), PCK1(12), PCK2(3), PDE3A(13), PDE3B(9), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PKLR(11), PKM2(4), PPARGC1A(12), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R3A(12), PPP1R3B(1), PPP1R3C(1), PPP1R3D(4), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCI(7), PRKCZ(2), PRKX(3), PTPN1(1), PTPRF(4), PYGB(1), PYGL(3), PYGM(6), RAF1(3), RAPGEF1(1), RHEB(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOCS4(1), SORBS1(7), SOS1(12), SOS2(6), SREBF1(2), TSC1(9), TSC2(5) 55421435 522 179 455 166 78 166 141 77 60 0 0.627 1.000 1.000 194 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(17), CACNA1A(10), CRH(1), CRHR1(1), GNA11(1), GNA12(1), GNA13(5), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GNAZ(4), GRIA1(12), GRIA2(15), GRIA3(11), GRID2(22), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), IGF1(5), IGF1R(10), ITPR1(11), ITPR2(25), ITPR3(6), KRAS(60), LYN(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(6), NPR2(2), NRAS(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), RAF1(3), RYR1(51) 38142469 523 174 460 147 57 184 135 79 67 1 0.279 1.000 1.000 195 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(3), BID(1), BRAF(17), CASP3(4), CD244(6), CD48(3), FAS(3), FASLG(3), FCER1G(2), FCGR3A(6), FCGR3B(5), FYN(3), GRB2(4), GZMB(3), HCST(3), HLA-A(2), HLA-B(3), HLA-C(1), HLA-G(1), HRAS(1), ICAM2(2), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), ITGAL(20), ITGB2(2), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), KLRK1(2), KRAS(60), LAT(3), LCK(5), LCP2(6), MAP2K1(6), MAP2K2(1), MAPK3(1), NCR1(2), NCR3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NRAS(4), PAK1(5), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRF1(5), PRKCA(7), PRKCG(10), PTK2B(8), PTPN11(6), PTPN6(3), RAC2(1), RAF1(3), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SYK(3), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), ULBP3(1), VAV1(1), VAV2(3), VAV3(14), ZAP70(4) 39349757 485 171 417 129 60 160 126 87 52 0 0.136 1.000 1.000 196 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(1), ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ARRB1(2), ARRB2(1), ATF2(5), ATF4(1), ATP2A2(6), ATP2A3(4), CALCA(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN1(2), CORIN(12), CRH(1), CRHR1(1), DGKZ(3), ETS2(3), FOS(1), GABPA(1), GBA2(2), GJA1(6), GNAQ(2), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG2(4), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), GUCA2B(3), GUCY1A3(6), IGFBP1(3), IGFBP2(1), IGFBP3(2), IGFBP4(1), ITPR1(11), ITPR2(25), ITPR3(6), JUN(1), MIB1(6), MYL2(3), MYL4(1), MYLK2(3), NFKB1(3), NOS1(9), NOS3(2), OXT(1), OXTR(2), PDE4B(7), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(2), PLCG1(5), PLCG2(9), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RAMP2(1), RAMP3(2), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(3), RGS7(13), RGS9(5), RYR1(51), RYR2(165), RYR3(53), SLC8A1(26), SP1(1), TNXB(14), USP5(3) 60206161 736 171 732 274 81 240 206 113 93 3 0.998 1.000 1.000 197 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(2), ABL2(7), AKT2(2), AKT3(5), ARAF(3), BRAF(17), BTC(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(8), CBLB(5), CBLC(1), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(8), EGFR(33), ELK1(2), ERBB2(10), ERBB3(3), ERBB4(21), EREG(4), GAB1(2), GRB2(4), GSK3B(2), HBEGF(1), HRAS(1), JUN(1), KRAS(60), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), NCK1(3), NCK2(3), NRAS(4), NRG1(9), NRG2(2), NRG3(19), NRG4(1), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), RAF1(3), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), STAT5A(3), STAT5B(4), TGFA(1) 35438208 452 170 370 108 55 155 108 74 60 0 0.0393 1.000 1.000 198 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(3), CADM1(2), CADM3(5), CD2(3), CD22(6), CD226(8), CD274(3), CD276(1), CD28(1), CD34(4), CD4(3), CD40LG(6), CD58(1), CD6(4), CD80(4), CD86(6), CD8A(2), CD8B(3), CD99(3), CDH1(5), CDH15(5), CDH2(20), CDH3(3), CDH4(9), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CNTN1(20), CNTN2(9), CNTNAP1(5), CNTNAP2(40), CTLA4(1), ESAM(1), F11R(2), GLG1(9), HLA-A(2), HLA-B(3), HLA-C(1), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), ICAM2(2), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(19), ITGA6(5), ITGA8(24), ITGA9(2), ITGAL(20), ITGAM(14), ITGAV(9), ITGB1(3), ITGB2(2), ITGB7(1), ITGB8(5), JAM2(6), L1CAM(15), MADCAM1(2), MAG(5), MPZ(1), MPZL1(2), NCAM1(8), NCAM2(13), NEGR1(5), NEO1(13), NFASC(11), NLGN1(17), NLGN2(4), NLGN3(3), NRCAM(14), NRXN1(49), NRXN2(11), NRXN3(18), OCLN(1), PDCD1(1), PDCD1LG2(3), PTPRC(21), PTPRF(4), PTPRM(6), PVRL1(4), SDC1(5), SDC3(2), SELE(6), SELL(4), SELP(14), SELPLG(3), SIGLEC1(7), SPN(3), VCAM1(17), VCAN(34) 50938531 702 170 698 234 99 242 180 102 78 1 0.896 1.000 1.000 199 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT2(2), AKT3(5), BCL10(1), CARD11(17), CBL(8), CBLB(5), CBLC(1), CD28(1), CD3D(2), CD4(3), CD40LG(6), CD8A(2), CD8B(3), CDC42(2), CDK4(2), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(5), GRB2(4), HRAS(1), ICOS(2), IFNG(4), IKBKB(3), IL10(1), IL2(5), IL4(1), ITK(7), JUN(1), KRAS(60), LAT(3), LCK(5), LCP2(6), MALT1(6), MAP3K14(1), MAP3K8(2), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NRAS(4), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PDCD1(1), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCQ(4), PTPN6(3), PTPRC(21), RASGRP1(2), RHOA(1), SOS1(12), SOS2(6), TEC(5), VAV1(1), VAV2(3), VAV3(14), ZAP70(4) 35007230 418 168 356 112 50 147 114 51 56 0 0.239 1.000 1.000 200 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(5), BAX(1), BFAR(1), BTK(11), CAD(16), CASP10(6), CASP3(4), CASP8(4), CASP8AP2(10), CDK2AP1(1), CSNK1A1(1), DAXX(6), DEDD(2), DFFA(3), EGFR(33), EPHB2(5), FADD(1), FAF1(4), FAIM2(4), HSPB1(1), IL1A(3), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K5(12), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MET(12), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR0B2(1), PFN1(1), PFN2(3), PTPN13(11), RALBP1(1), RIPK1(4), ROCK1(10), SMPD1(2), TP53(128), TPX2(3), TRAF2(1), TUFM(2) 25343201 361 168 325 70 37 78 102 53 91 0 0.00273 1.000 1.000 201 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(9), AKT2(2), AKT3(5), APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CAPN2(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), CSF2RB(5), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(3), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL3(1), IL3RA(5), IRAK1(3), IRAK2(3), IRAK3(6), IRAK4(4), MAP3K14(1), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), NTRK1(12), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RIPK1(4), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TP53(128), TRAF2(1) 28957737 360 165 332 81 35 74 103 60 88 0 0.0351 1.000 1.000 202 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ARHGAP5(7), BCAR1(2), CD99(3), CDC42(2), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CTNNA1(3), CTNNA2(29), CTNNA3(11), CTNNB1(11), CTNND1(9), CXCL12(1), CXCR4(3), CYBB(7), ESAM(1), EZR(1), F11R(2), GNAI1(3), GNAI3(1), GRLF1(9), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), ITK(7), JAM2(6), MAPK11(1), MAPK14(1), MLLT4(4), MMP2(13), MMP9(10), MSN(1), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLPF(1), NCF1(1), NCF2(2), NCF4(2), NOX1(4), NOX3(5), OCLN(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), PTK2B(8), PTPN11(6), PXN(1), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(6), RHOA(1), RHOH(2), ROCK1(10), ROCK2(4), SIPA1(1), THY1(1), TXK(5), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCAM1(17), VCL(2) 42855518 480 165 473 148 60 151 135 76 58 0 0.645 1.000 1.000 203 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(22), CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2A(14), CDKN2D(1), CREB3L1(1), CREB3L3(1), CREB3L4(1), E2F1(3), E2F3(1), E2F6(3), GADD45A(1), GBA2(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MNAT1(2), MYT1(6), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLE(19), POLE2(1), PRIM1(3), RB1(13), RBL1(7), RPA2(1), TFDP1(3), TFDP2(2), TNXB(14), TP53(128), WEE1(3) 26673462 336 163 312 57 44 65 92 47 88 0 9.82e-05 1.000 1.000 204 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCBP2(2), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CCRL1(2), CCRL2(2), CHML(7), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CMKLR1(13), CNR1(4), CNR2(1), CX3CR1(5), CXCR3(1), CXCR4(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), EDNRB(6), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GPR17(3), GPR173(1), GPR174(8), GPR27(1), GPR37(5), GPR37L1(2), GPR4(5), GPR50(7), GPR6(2), GPR63(4), GPR77(1), GPR83(4), GPR85(8), GPR87(2), GRPR(5), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3), LHCGR(6), LTB4R(2), MAS1(3), MC3R(9), MC4R(1), MC5R(10), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPN1SW(3), OPN3(2), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OR10A5(9), OR11A1(3), OR12D3(1), OR1C1(14), OR1F1(3), OR1Q1(5), OR2H1(5), OR5V1(2), OR7A5(2), OR7C1(2), OR8B8(7), OXTR(2), P2RY1(5), P2RY10(10), P2RY12(4), P2RY14(1), P2RY6(1), PPYR1(2), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), RHO(1), RRH(2), SSTR1(3), SSTR3(2), SSTR4(5), SUCNR1(1), TRHR(4) 41762730 634 162 631 258 63 226 178 115 51 1 0.982 1.000 1.000 205 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(1), ACTN2(23), ACTN3(3), ACTN4(2), DMD(41), FAM48A(2), MYBPC1(6), MYBPC2(3), MYBPC3(5), MYH3(11), MYH6(22), MYH7(20), MYH8(29), MYL1(3), MYL2(3), MYL3(2), MYL4(1), MYL9(1), MYOM1(4), NEB(36), TMOD1(3), TNNC2(2), TNNI1(2), TNNI2(4), TNNI3(2), TNNT2(4), TNNT3(3), TPM1(1), TPM2(2), TPM3(3), TPM4(1), TTN(374), VIM(2) 47583223 625 161 619 214 63 194 176 121 62 9 1.000 1.000 1.000 206 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), AKAP1(4), AKAP10(1), AKAP11(8), AKAP12(5), AKAP3(7), AKAP4(7), AKAP5(1), AKAP6(16), AKAP7(1), AKAP9(23), ARHGEF1(2), CALM1(2), GNA11(1), GNA12(1), GNA13(5), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GNGT2(2), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(15), KRAS(60), NRAS(4), PDE1A(8), PDE1B(6), PDE1C(17), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKD3(5), RHOA(1), RRAS(1), SLC9A1(3), USP5(3) 40415981 439 159 381 133 36 175 113 62 53 0 0.770 1.000 1.000 207 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(17), CPEB1(5), EGFR(33), ERBB2(10), ERBB4(21), ETS1(7), ETS2(3), ETV6(3), FMN2(31), GRB2(4), KRAS(60), MAP2K1(6), MAPK3(1), NOTCH1(8), NOTCH2(26), NOTCH3(5), NOTCH4(23), PIWIL1(11), PIWIL2(6), PIWIL3(6), PIWIL4(4), RAF1(3), SOS1(12), SOS2(6), SPIRE1(5), SPIRE2(1) 18036956 317 159 240 62 30 130 70 53 33 1 0.0157 1.000 1.000 208 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(8), ATM(22), ATR(16), BAI1(10), BAX(1), BID(1), CASP3(4), CASP8(4), CASP9(3), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNG1(2), CD82(2), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN2A(14), CHEK1(6), CHEK2(2), EI24(1), FAS(3), GADD45A(1), GTSE1(3), IGF1(5), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(6), PTEN(8), RCHY1(1), RFWD2(3), RRM2(4), SERPINB5(6), SERPINE1(5), SESN2(2), THBS1(4), TNFRSF10B(1), TP53(128), TP53I3(2), TP73(4), TSC2(5), ZMAT3(1) 22606193 325 158 301 57 33 71 85 55 81 0 0.000863 1.000 1.000 209 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ACVR1B(5), ACVR1C(3), BAIAP2(2), CDC42(2), CDH1(5), CREBBP(4), CTNNA1(3), CTNNA2(29), CTNNA3(11), CTNNB1(11), CTNND1(9), EGFR(33), EP300(2), ERBB2(10), FARP2(3), FER(6), FGFR1(5), FYN(3), IGF1R(10), INSR(1), IQGAP1(5), LEF1(8), LMO7(10), MAP3K7(5), MAPK3(1), MET(12), MLLT4(4), PARD3(6), PTPN1(1), PTPN6(3), PTPRB(29), PTPRF(4), PTPRJ(5), PTPRM(6), PVRL1(4), PVRL4(3), RAC2(1), RHOA(1), SMAD2(2), SMAD3(3), SMAD4(8), SNAI1(3), SNAI2(4), SORBS1(7), SRC(2), SSX2IP(2), TCF7(1), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(2), TJP1(10), VCL(2), WAS(3), WASF1(8), WASF2(1), WASF3(4), WASL(5), YES1(3) 41251831 376 158 354 123 53 100 92 65 66 0 0.862 1.000 1.000 210 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(2), ACTN1(2), ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGEF6(9), ARHGEF7(6), BCAR1(2), BRAF(17), CDC42(2), CDKN2A(14), CSE1L(3), DOCK1(7), EPHB2(5), FYN(3), GRB2(4), GRB7(3), GRLF1(9), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), MAP2K4(3), MAP2K7(2), MAP3K11(7), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MRAS(1), MYLK(15), MYLK2(3), P4HB(4), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PIK3CA(11), PIK3CB(7), PKLR(11), PLCG1(5), PLCG2(9), PTEN(8), PTK2(11), RAF1(3), RALA(2), RHO(1), ROCK1(10), ROCK2(4), SHC1(2), SOS1(12), SOS2(6), SRC(2), TLN1(13), TLN2(16), VASP(3), WAS(3), ZYX(2) 42101650 435 156 424 121 68 114 123 65 65 0 0.217 1.000 1.000 211 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(13), AMY2A(4), AMY2B(16), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHX58(1), ENPP1(6), ENPP3(12), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), G6PC(1), G6PC2(2), GAA(2), GANC(1), GBA(3), GBA3(12), GBE1(2), GCK(4), GPI(3), GUSB(5), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), IFIH1(6), LYZL1(4), MGAM(30), MOV10L1(9), NUDT5(2), NUDT8(1), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SI(63), SKIV2L2(10), SMARCA2(10), SMARCA5(1), TREH(1), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B10(19), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), UXS1(4) 42941164 484 154 481 141 66 168 129 70 50 1 0.585 1.000 1.000 212 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT2(2), AKT3(5), BCL10(1), BLNK(1), BTK(11), CARD11(17), CD19(2), CD22(6), CD72(1), CD79B(1), CHUK(3), CR2(8), FCGR2B(2), FOS(1), GSK3B(2), HRAS(1), IKBKB(3), INPP5D(4), JUN(1), KRAS(60), LILRB3(1), LYN(4), MALT1(6), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NRAS(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTPN6(3), RAC2(1), RASGRP3(8), SYK(3), VAV1(1), VAV2(3), VAV3(14) 25646168 292 154 232 80 26 105 81 42 38 0 0.308 1.000 1.000 213 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB3L1(1), CREB3L2(4), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(11), DCT(7), DVL1(1), DVL2(1), DVL3(5), EDN1(1), EDNRB(6), EP300(2), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GSK3B(2), HRAS(1), KIT(6), KRAS(60), LEF1(8), MAP2K1(6), MAP2K2(1), MAPK3(1), MITF(1), NRAS(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), POMC(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), TCF7(1), TCF7L1(2), TCF7L2(3), TYR(14), TYRP1(4), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5) 37482033 427 154 369 141 54 142 123 60 48 0 0.697 1.000 1.000 214 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADSSL1(1), AK2(3), AK5(10), AK7(7), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(2), ATIC(3), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENPP3(12), ENTPD1(4), ENTPD2(2), ENTPD4(2), ENTPD6(3), FHIT(1), GART(4), GDA(6), GMPR(3), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NME6(1), NME7(4), NPR1(6), NPR2(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), NUDT5(2), NUDT9(2), PAPSS1(3), PAPSS2(4), PDE10A(16), PDE11A(11), PDE1A(8), PDE1C(17), PDE2A(5), PDE3B(9), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6D(1), PDE6G(2), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(3), PKLR(11), PKM2(4), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1), PPAT(5), PRIM1(3), PRIM2(10), PRPS1(3), PRPS1L1(2), PRPS2(2), PRUNE(5), RFC5(1), RRM1(5), RRM2(4), XDH(11) 56538039 561 152 556 194 75 160 170 89 67 0 0.928 1.000 1.000 215 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), CHPF(3), CHST1(10), CHST11(1), CHST12(3), CHST13(3), CHST2(4), CHST3(2), CHST6(3), CHSY1(2), DAD1(1), DDOST(1), DPAGT1(1), EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), FUT11(2), FUT8(4), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT13(15), GALNT14(10), GALNT2(3), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GANAB(3), GCNT1(4), GCNT3(3), GCNT4(3), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(1), HS6ST3(5), MAN1A2(9), MAN1B1(2), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(6), NDST1(2), NDST2(7), NDST3(8), NDST4(13), OGT(6), RPN2(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST6GALNAC1(3), STT3B(2), UST(1), WBSCR17(16), XYLT1(19) 37876371 385 150 382 147 63 109 111 61 40 1 0.991 1.000 1.000 216 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(5), BCAR1(2), CAPN10(4), CAPN11(9), CAPN2(3), CAPN3(6), CAPN5(10), CAPN6(10), CAPN7(5), CAPN9(6), CAV3(2), CDC42(2), DOCK1(7), FYN(3), GIT2(3), GRB2(4), ILK(1), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(5), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PDPK1(1), PIK3R2(1), PTK2(11), PXN(1), RAC2(1), RAP1B(1), RAPGEF1(1), RHO(1), ROCK1(10), ROCK2(4), SDCCAG8(6), SHC1(2), SHC3(4), SORBS1(7), SOS1(12), SRC(2), TLN1(13), TNS1(14), VASP(3), VAV2(3), VAV3(14), VCL(2), ZYX(2) 46314792 456 149 454 169 67 136 116 70 65 2 0.985 1.000 1.000 217 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT2(2), AKT3(5), CBL(8), CBLB(5), CBLC(1), CCND1(2), CCND2(1), CCND3(1), CNTF(1), CNTFR(3), CREBBP(4), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(2), EPO(3), EPOR(1), GH1(2), GH2(5), GHR(5), GRB2(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL13RA2(3), IL15(2), IL15RA(1), IL19(1), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), IRF9(2), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), LIF(2), LIFR(5), MPL(2), OSM(2), OSMR(5), PIAS1(2), PIAS2(5), PIAS3(5), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PRL(1), PRLR(9), PTPN11(6), PTPN6(3), SOCS4(1), SOCS5(2), SOS1(12), SOS2(6), SPRED1(1), SPRED2(2), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), STAM(6), STAM2(4), STAT1(4), STAT2(5), STAT3(8), STAT4(6), STAT5A(3), STAT5B(4), STAT6(2), TPO(16), TSLP(3), TYK2(2) 49993906 456 147 450 165 45 136 131 88 56 0 0.993 1.000 1.000 218 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(4), ACVR1B(5), ACVRL1(4), AURKB(1), BMPR1A(1), BMPR2(2), BUB1(4), CDIPT(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(3), CLK1(2), CLK2(7), CLK4(6), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(6), ITPKA(1), ITPKB(5), MAP3K10(1), MOS(2), NEK1(6), NEK3(4), OCRL(6), PIK3C2A(9), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PIM2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9), PLK3(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKG1(3), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KB1(2), STK11(21), TGFBR1(2), VRK1(2) 39126940 364 147 359 111 49 98 101 51 65 0 0.669 1.000 1.000 219 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(2), AKT3(5), CASP9(3), CDC42(2), HRAS(1), KDR(30), KRAS(60), MAP2K1(6), MAP2K2(1), MAPK11(1), MAPK14(1), MAPK3(1), MAPKAPK2(3), MAPKAPK3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NOS3(2), NRAS(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCA(7), PRKCG(10), PTGS2(4), PTK2(11), PXN(1), RAC2(1), RAF1(3), SH2D2A(7), SHC2(1), SPHK2(2), SRC(2), VEGFA(1) 24886346 307 146 246 80 38 115 76 50 28 0 0.145 1.000 1.000 220 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(12), ABCA10(12), ABCA12(21), ABCA13(43), ABCA2(6), ABCA3(6), ABCA4(21), ABCA5(7), ABCA6(10), ABCA7(6), ABCA8(16), ABCA9(11), ABCB1(20), ABCB10(9), ABCB11(15), ABCB4(17), ABCB5(27), ABCB6(3), ABCB7(3), ABCB8(5), ABCB9(3), ABCC1(7), ABCC10(3), ABCC11(17), ABCC12(18), ABCC2(5), ABCC3(7), ABCC4(8), ABCC5(11), ABCC6(3), ABCC8(11), ABCC9(25), ABCD1(1), ABCD2(9), ABCD3(5), ABCD4(2), ABCG1(3), ABCG2(5), ABCG4(6), ABCG5(10), ABCG8(6), CFTR(6), TAP2(7) 40968100 448 145 444 143 62 133 116 76 60 1 0.557 1.000 1.000 221 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(14), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(3), C3(5), C3AR1(5), C4BPA(6), C5(2), C5AR1(4), C6(14), C7(23), C8A(6), C8B(9), C9(10), CD46(1), CD55(2), CFB(4), CFH(23), CFI(7), CPB2(4), CR1(14), CR2(8), F10(3), F11(8), F12(1), F13A1(13), F13B(16), F2(5), F2R(4), F3(4), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(12), FGG(2), KLKB1(3), KNG1(3), MASP1(5), MASP2(2), MBL2(1), PLAT(6), PLAU(1), PLAUR(2), PLG(13), PROC(3), PROS1(13), SERPINA1(2), SERPINA5(7), SERPINC1(8), SERPIND1(1), SERPINE1(5), SERPING1(3), TFPI(1), THBD(1), VWF(13) 31291705 400 143 398 128 41 146 96 64 50 3 0.961 1.000 1.000 222 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALML3(3), CDIPT(1), CDS1(2), CDS2(3), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPP5D(4), INPPL1(6), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), OCRL(6), PI4KA(7), PI4KB(4), PIK3C2A(9), PIK3C2B(7), PIK3C2G(9), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PRKCA(7), PRKCG(10), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3) 43347410 400 142 395 120 54 120 108 54 63 1 0.553 1.000 1.000 223 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT2(2), AKT3(5), BTK(11), FCER1A(7), FCER1G(2), FYN(3), GAB2(1), GRB2(4), HRAS(1), IL13(1), IL3(1), IL4(1), INPP5D(4), KRAS(60), LAT(3), LCP2(6), LYN(4), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MS4A2(2), NRAS(4), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PRKCA(7), PRKCD(1), PRKCE(3), RAC2(1), RAF1(3), SOS1(12), SOS2(6), SYK(3), VAV1(1), VAV2(3), VAV3(14) 24935352 302 141 242 81 30 113 79 47 33 0 0.282 1.000 1.000 224 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), AK2(3), AK5(10), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(2), ATIC(3), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENPP3(12), ENTPD1(4), ENTPD2(2), FHIT(1), GART(4), GDA(6), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NPR1(6), NPR2(2), NT5E(2), NT5M(1), NUDT2(3), PAPSS1(3), PAPSS2(4), PDE1A(8), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6B(4), PDE6C(5), PDE6G(2), PDE7B(3), PDE8A(3), PDE9A(2), PFAS(3), PKLR(11), PKM2(4), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), PPAT(5), PRPS1(3), PRPS1L1(2), PRPS2(2), PRUNE(5), RRM1(5), RRM2(4) 44293638 432 140 429 149 64 112 130 71 55 0 0.878 1.000 1.000 225 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(11), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ADIPOR1(3), ADIPOR2(1), AKT2(2), AKT3(5), CAMKK1(2), CAMKK2(1), CD36(4), CHUK(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), G6PC(1), G6PC2(2), IKBKB(3), IRS1(15), IRS2(3), IRS4(17), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), MAPK10(5), MAPK8(3), MAPK9(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(12), PCK2(3), POMC(1), PPARA(1), PPARGC1A(12), PRKAA1(4), PRKAB1(3), PRKAG2(4), PRKAG3(4), PRKCQ(4), PTPN11(6), RXRA(1), RXRB(1), RXRG(11), STAT3(8), STK11(21), TNFRSF1B(1), TRAF2(1), TYK2(2) 28581032 278 139 276 99 41 80 60 48 49 0 0.934 1.000 1.000 226 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(22), CARM1(1), CTCFL(15), DOT1L(8), EED(4), EHMT1(8), EHMT2(1), EZH1(2), EZH2(8), FBXO11(2), HCFC1(10), HSF4(1), JMJD4(1), KDM6A(2), MEN1(4), MLL(12), MLL2(25), MLL3(55), MLL4(4), MLL5(3), NSD1(11), OGT(6), PAXIP1(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PRDM2(8), PRDM7(3), PRDM9(32), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), RBBP5(3), SATB1(6), SETD1A(8), SETD2(21), SETD7(1), SETD8(2), SETDB1(5), SETDB2(2), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(2), SUV39H2(3), SUV420H1(5), SUZ12(1), WHSC1(4), WHSC1L1(2) 40876042 347 138 345 95 50 99 100 40 54 4 0.347 1.000 1.000 227 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(4), ACVR1B(5), ACVR1C(3), ACVR2A(2), ACVR2B(4), ACVRL1(4), AMH(1), AMHR2(2), BMP2(1), BMP4(4), BMP5(4), BMP6(2), BMP7(4), BMP8A(1), BMPR1A(1), BMPR1B(5), BMPR2(2), CHRD(9), COMP(2), CREBBP(4), CUL1(6), DCN(1), EP300(2), FST(2), GDF5(4), GDF6(7), GDF7(1), ID3(1), IFNG(4), INHBA(15), INHBB(1), INHBC(1), INHBE(3), LEFTY1(3), LEFTY2(3), LTBP1(28), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), RBL1(7), RBL2(2), RHOA(1), ROCK1(10), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SKP1(2), SMAD1(3), SMAD2(2), SMAD3(3), SMAD4(8), SMAD5(2), SMAD9(1), SMURF1(3), SMURF2(2), SP1(1), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), ZFYVE16(1), ZFYVE9(5) 34157411 284 134 284 111 40 74 84 44 42 0 0.993 1.000 1.000 228 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(4), CD14(1), CD19(2), CD1A(8), CD1B(11), CD1C(9), CD1D(6), CD1E(12), CD2(3), CD22(6), CD33(10), CD34(4), CD36(4), CD38(3), CD3D(2), CD4(3), CD44(2), CD5(4), CD55(2), CD8A(2), CD8B(3), CR1(14), CR2(8), CSF1(1), CSF1R(6), CSF2RA(5), CSF3R(4), DNTT(3), EPO(3), EPOR(1), FCER2(1), FCGR1A(1), FLT3(10), FLT3LG(2), GP5(3), HLA-DRA(3), IL1A(3), IL1R1(1), IL1R2(4), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), ITGA1(9), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGAM(14), ITGB3(4), KIT(6), MME(8), MS4A1(4), TFRC(6), THPO(1), TPO(16) 28112498 331 133 329 116 42 125 79 50 35 0 0.946 1.000 1.000 229 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), CCKBR(11), CCR2(5), CCR3(2), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(17), CHRM2(17), CHRM3(13), CXCR3(1), EMR2(3), EMR3(5), F2R(4), FSHR(20), GHRHR(5), GNRHR(2), GPR116(5), GPR132(1), GPR133(8), GPR135(1), GPR143(1), GPR17(3), GPR18(2), GPR55(7), GPR56(6), GPR61(4), GPR77(1), GPR84(4), GRM1(26), GRPR(5), HRH4(4), LGR6(11), LPHN2(24), LPHN3(33), NTSR1(5), OR2M4(14), OR8G2(4), PTGFR(6), SMO(5), TAAR5(8), TSHR(10) 23021828 322 132 322 104 31 95 94 62 40 0 0.506 1.000 1.000 230 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BCL2(1), CABIN1(5), CALM1(2), CAMK2B(3), CAMK4(8), CD69(2), CDKN1A(1), CNR1(4), CREBBP(4), CTLA4(1), EGR2(2), EGR3(1), EP300(2), FCER1A(7), FCGR3A(6), FOS(1), FOSL1(3), GATA3(6), GATA4(4), GRLF1(9), GSK3B(2), HRAS(1), ICOS(2), IFNB1(4), IFNG(4), IL10(1), IL13(1), IL2(5), IL2RA(3), IL3(1), IL4(1), ITK(7), KPNA5(2), MAP2K7(2), MAPK14(1), MAPK8(3), MAPK9(6), MEF2A(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB2(6), NFKBIE(1), NUP214(18), OPRD1(1), P2RX7(5), PAK1(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PTPRC(21), SLA(1), SP1(1), SP3(4), TGFB1(2), TRAF2(1), TRPV6(8), VAV1(1), VAV2(3), VAV3(14), XPO5(3) 31344833 264 127 260 95 33 88 68 37 38 0 0.921 1.000 1.000 231 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT2(2), AKT3(5), CASP8(4), CCL3(1), CCL4(1), CD14(1), CD80(4), CD86(6), CHUK(3), CXCL9(3), FADD(1), FOS(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IKBKB(3), IKBKE(5), IL12A(3), IRAK1(3), IRAK4(4), IRF3(1), IRF7(1), JUN(1), LBP(5), LY96(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K7(5), MAP3K8(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), RIPK1(4), STAT1(4), TBK1(2), TLR1(4), TLR2(2), TLR4(31), TLR5(1), TLR6(6), TLR7(8), TLR8(6), TLR9(6), TOLLIP(1), TRAF3(3), TRAF6(4) 30930343 279 126 274 99 29 67 83 53 47 0 0.939 1.000 1.000 232 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(2), AKT3(5), ASAH1(2), BRAF(17), DAG1(2), DRD2(9), EGFR(33), EPHB2(5), GRB2(4), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PI3(1), PIK3CB(7), PITX2(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), RAF1(3), RGS20(5), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT3(8) 20242226 237 126 216 62 28 68 60 45 36 0 0.298 1.000 1.000 233 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), BDKRB2(1), CALM1(2), CHRM1(2), CHRNA1(7), FLT1(21), FLT4(13), KDR(30), NOS3(2), PDE2A(5), PDE3A(13), PDE3B(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKG1(3), PRKG2(7), RYR2(165), SLC7A1(3), SYT1(3), TNNI1(2) 14213572 304 124 300 85 32 110 71 49 39 3 0.460 1.000 1.000 234 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(4), CDC40(2), CLK2(7), CLK3(1), CLK4(6), COL2A1(7), CPSF1(6), CPSF2(5), CPSF3(3), CPSF4(2), CSTF1(1), CSTF2T(4), CSTF3(3), DDIT3(4), DDX1(5), DDX20(1), DHX15(4), DHX16(5), DHX38(9), DHX8(8), DHX9(3), DICER1(8), DNAJC8(2), FUS(1), GIPC1(2), LOC440563(7), METTL3(1), NCBP2(1), NONO(3), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(6), POLR2A(9), PPM1G(4), PRPF18(2), PRPF3(3), PRPF4(3), PRPF4B(6), PRPF8(6), PSKH1(2), PTBP1(2), PTBP2(8), RBM17(3), RBM5(3), RNGTT(4), RNMT(3), SF3A1(5), SF3A3(1), SF3B1(5), SF3B2(8), SF3B4(6), SF3B5(2), SF4(6), SFRS14(6), SFRS16(1), SFRS4(4), SFRS5(1), SFRS6(4), SFRS8(5), SNRPA(1), SNRPA1(1), SNRPB2(1), SNRPD1(1), SNRPD3(2), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(1), SRPK1(3), SRPK2(4), SRRM1(1), SUPT5H(5), TXNL4A(3), U2AF1(6), U2AF2(5), XRN2(5) 36465044 289 121 282 78 62 63 81 46 37 0 0.276 1.000 1.000 235 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(2), AKT3(5), CDC42(2), CDK2(4), CDKN1B(3), CDKN2A(14), CREB5(7), EBP(2), ERBB4(21), F2RL2(5), GAB1(2), GADD45A(1), GRB2(4), GSK3B(2), IGF1(5), IGFBP1(3), INPPL1(6), IRS1(15), IRS2(3), IRS4(17), MET(12), NOLC1(2), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PPP1R13B(2), PREX1(21), PTEN(8), PTK2(11), PTPN1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TSC1(9), TSC2(5), YWHAG(2) 26674607 283 119 278 81 45 85 72 38 43 0 0.413 1.000 1.000 236 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPPL1(6), IPMK(7), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), OCRL(6), PI4KA(7), PI4KB(4), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3) 25659221 230 118 226 76 29 69 63 33 36 0 0.793 1.000 1.000 237 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(5), AGTR2(2), ATP8A1(3), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CX3CR1(5), CXCR3(1), CXCR4(3), CXCR6(1), EDNRB(6), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GNRHR(2), GPR77(1), GRPR(5), LHCGR(6), MC2R(2), MC3R(9), MC4R(1), MC5R(10), NMBR(6), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), PPYR1(2), SSTR1(3), SSTR3(2), SSTR4(5), TAC4(1), TACR1(3), TACR3(8), TRHR(4), TSHR(10) 17948562 255 117 254 98 24 85 73 46 26 1 0.889 1.000 1.000 238 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(5), BRAF(17), CHUK(3), DAXX(6), ELK1(2), FOS(1), GRB2(4), HRAS(1), IKBKB(3), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(6), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP3K9(11), MAP4K1(5), MAP4K3(5), MAP4K5(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(5), MAPK8(3), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(3), NFKBIA(1), PAK1(5), PAK2(3), RAF1(3), RIPK1(4), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SP1(1), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1) 32984931 259 116 254 80 50 57 70 40 42 0 0.501 1.000 1.000 239 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(23), AR(4), ASAH1(2), BRAF(17), CAMP(2), CCL13(2), CCL15(3), DAG1(2), EGFR(33), GNA11(1), GNAI1(3), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CA(11), PIK3CD(1), PIK3R1(3), PITX2(4), PTX3(2), RAF1(3), SRC(2) 18495643 200 113 176 47 22 53 47 38 40 0 0.198 1.000 1.000 240 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(6), ADAM17(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), CASP3(4), CDC42(2), CHUK(3), CXCL1(2), EGFR(33), F11R(2), HBEGF(1), IGSF5(3), IKBKB(3), JAM2(6), JUN(1), LYN(4), MAP2K4(3), MAP3K14(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK8(3), MAPK9(6), MET(12), NFKB1(3), NFKB2(6), NFKBIA(1), NOD1(3), PAK1(5), PLCG1(5), PLCG2(9), PTPN11(6), PTPRZ1(36), SRC(2), TCIRG1(1), TJP1(10) 24116219 233 111 218 82 37 54 60 40 42 0 0.941 1.000 1.000 241 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGAP1(3), ARHGAP4(2), ARHGEF11(11), BTK(11), CDC42(2), CFL2(2), GDI1(3), GDI2(1), INPPL1(6), ITPR1(11), ITPR2(25), ITPR3(6), MYLK(15), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3CG(11), PIK3R1(3), PITX2(4), PPP1R13B(2), PTEN(8), RACGAP1(3), RHO(1), ROCK1(10), ROCK2(4), SAG(3), WASF1(8), WASL(5) 24267588 227 111 222 64 38 69 53 29 38 0 0.401 1.000 1.000 242 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(2), AKT3(5), BRAF(17), CAB39(2), DDIT4(2), EIF4B(5), FIGF(1), HIF1A(1), IGF1(5), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PRKAA1(4), RHEB(4), RICTOR(19), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), STK11(21), TSC1(9), TSC2(5), ULK1(3), ULK2(2), ULK3(1), VEGFA(1), VEGFC(11) 18484651 185 109 175 48 19 49 52 33 32 0 0.228 1.000 1.000 243 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(13), AMY2A(4), AMY2B(16), ENPP1(6), ENPP3(12), G6PC(1), GAA(2), GANAB(3), GBA3(12), GBE1(2), GCK(4), GPI(3), GUSB(5), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), MGAM(30), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), SI(63), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13), UXS1(4) 19815141 279 109 277 82 42 98 70 39 30 0 0.605 1.000 1.000 244 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(5), ARSD(3), CARM1(1), CYP11B1(10), CYP11B2(7), CYP19A1(3), HSD11B1(4), HSD11B2(1), HSD17B12(1), HSD17B2(3), HSD17B3(1), HSD17B7(1), HSD3B1(7), HSD3B2(13), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), SULT2B1(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B10(19), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), WBSCR22(1) 17412702 217 108 215 64 23 84 63 32 15 0 0.536 1.000 1.000 245 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADM(3), ACOX1(3), ACOX2(2), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ANGPTL4(1), APOA1(1), APOA5(3), APOC3(3), CD36(4), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP27A1(5), CYP4A11(4), CYP7A1(7), CYP8B1(2), EHHADH(8), FABP1(1), FABP2(1), FABP3(2), FABP5(1), FABP6(1), FADS2(1), GK(2), GK2(4), HMGCS2(5), ILK(1), LPL(5), ME1(1), MMP1(7), NR1H3(3), OLR1(3), PCK1(12), PCK2(3), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), PPARG(3), RXRA(1), RXRB(1), RXRG(11), SCP2(3), SLC27A1(3), SLC27A2(3), SLC27A4(3), SLC27A5(1), SLC27A6(11), SORBS1(7), UBC(10), UCP1(2) 22562683 215 108 213 63 35 70 46 38 26 0 0.421 1.000 1.000 246 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(2), CALM1(2), CALR(1), CAMK1(2), CAMK4(8), CREBBP(4), CSNK1A1(1), EDN1(1), ELSPBP1(4), F2(5), GATA4(4), GSK3B(2), HAND1(3), HAND2(3), HRAS(1), IGF1(5), LIF(2), MAP2K1(6), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(2), MYH2(35), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKX2-5(3), NPPA(1), PIK3CA(11), PIK3R1(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAF1(3), RPS6KB1(2), SYT1(3) 17444304 177 108 173 50 24 55 57 21 20 0 0.282 1.000 1.000 247 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(4), ACSS2(4), ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), G6PC2(2), GALM(1), GAPDH(3), GAPDHS(6), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGAM4(2), PGK1(5), PGK2(14), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6) 20068415 237 107 234 76 35 93 53 34 22 0 0.619 1.000 1.000 248 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ENTPD4(2), ENTPD6(3), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1), PRIM1(3), PRIM2(10), RFC5(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), TXNRD2(1), UCK2(2), UMPS(2), UPP1(6), UPP2(8), UPRT(4) 28076316 251 107 247 83 45 72 76 33 24 1 0.689 1.000 1.000 249 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(16), COL4A2(15), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), F10(3), F11(8), F12(1), F2(5), F2R(4), F5(23), F8(23), F9(8), FGA(9), FGB(12), FGG(2), KLKB1(3), PROC(3), PROS1(13), SERPINC1(8), SERPING1(3) 15473530 217 107 216 77 17 86 48 35 31 0 0.991 1.000 1.000 250 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AGK(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(1), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), GK(2), GK2(4), GLA(4), GPAM(3), LCT(30), LIPA(2), LIPC(6), LIPF(3), LIPG(2), LPL(5), MGLL(1), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PNPLA3(2), PPAP2B(2), PPAP2C(1) 20368176 242 106 242 65 24 83 72 30 32 1 0.232 1.000 1.000 251 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C1(2), AKR1C2(2), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHDH(1), EPHX1(2), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), MGST1(1), MGST3(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B10(19), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8) 19754685 246 106 243 78 26 99 62 34 25 0 0.770 1.000 1.000 252 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(2), AKT3(5), BCL2(1), BCR(3), BLNK(1), BTK(11), CD19(2), CD22(6), CR2(8), DAG1(2), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), INPP5D(4), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP4K1(5), MAPK3(1), NFATC1(3), NFATC2(8), NR0B2(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), PPP3CA(5), PPP3CB(1), PPP3CC(2), PTPRC(21), RAF1(3), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1) 25553194 204 106 199 60 24 58 54 34 34 0 0.440 1.000 1.000 253 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(5), ADCY4(6), ADCY6(10), ADCY8(22), CACNA1A(10), CACNA1B(15), GNAS(7), GNAT3(1), GNB1(2), GNB3(2), GNG3(2), GRM4(9), ITPR3(6), KCNB1(16), PDE1A(8), PLCB2(6), PRKACB(3), PRKACG(1), PRKX(3), SCNN1A(1), SCNN1B(3), SCNN1G(3), TAS1R1(2), TAS1R2(7), TAS1R3(3), TAS2R1(7), TAS2R10(1), TAS2R13(1), TAS2R14(3), TAS2R16(10), TAS2R3(2), TAS2R38(5), TAS2R39(5), TAS2R40(4), TAS2R41(3), TAS2R42(1), TAS2R46(2), TAS2R5(1), TAS2R50(4), TAS2R60(7), TAS2R9(1), TRPM5(1) 19798653 211 104 210 64 20 83 55 30 23 0 0.361 1.000 1.000 254 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), AFMID(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(3), AOC3(5), AOX1(14), ASMT(6), CARM1(1), CAT(3), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(6), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), INMT(5), KMO(4), KYNU(5), LCMT1(2), LCMT2(4), LNX1(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), NFX1(2), OGDH(1), OGDHL(11), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), TDO2(7), TPH1(11), TPH2(8), WARS(3), WARS2(9), WBSCR22(1) 20876098 218 103 213 74 21 59 69 33 35 1 0.814 1.000 1.000 255 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3C(12), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB4Q(12), TUBB8(7), WAS(3), WASL(5) 18035811 191 103 188 69 33 61 50 26 21 0 0.911 1.000 1.000 256 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3C(12), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB4Q(12), TUBB8(7), WAS(3), WASL(5) 18035811 191 103 188 69 33 61 50 26 21 0 0.911 1.000 1.000 257 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), AOX1(14), CARM1(1), DBH(2), DCT(7), DDC(6), ESCO1(7), ESCO2(2), FAH(1), GOT1(2), GOT2(3), GSTZ1(1), HGD(4), HPD(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SH3GLB1(1), TAT(4), TH(2), TPO(16), TYR(14), TYRP1(4), WBSCR22(1) 20516110 223 102 223 67 33 84 50 26 30 0 0.545 1.000 1.000 258 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(2), AKT3(5), BCR(3), BTK(11), CD19(2), CDKN2A(14), DAPP1(2), FLOT1(2), FLOT2(1), GAB1(2), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), NR0B2(1), PDK1(4), PIK3CA(11), PITX2(4), PLCG2(9), PPP1R13B(2), PREX1(21), PTEN(8), PTPRC(21), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SAG(3), SYK(3), TEC(5), VAV1(1) 19244931 194 102 189 45 22 53 54 32 33 0 0.101 1.000 1.000 259 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(5), ACTR2(2), ACTR3(1), ANGPTL2(4), CDC42(2), CFL2(2), FLNA(11), FLNC(19), FSCN1(3), FSCN3(8), GDI1(3), GDI2(1), MYH2(35), MYLK(15), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PFN1(1), PFN2(3), RHO(1), ROCK1(10), ROCK2(4), VASP(3), WASF1(8), WASL(5) 16505633 185 99 185 58 26 68 40 23 28 0 0.694 1.000 1.000 260 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(3), AOC3(5), AOX1(14), ASMT(6), CAT(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), DDC(6), EHHADH(8), GCDH(3), HADHA(3), KMO(4), KYNU(5), MAOA(3), MAOB(1), SDS(2), TDO2(7), TPH1(11), WARS(3), WARS2(9) 19017305 226 98 222 73 29 70 56 31 38 2 0.699 1.000 1.000 261 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(23), AXIN1(3), CCND1(2), CCND2(1), CCND3(1), CSNK1E(5), CTNNB1(11), DVL1(1), DVL2(1), DVL3(5), FBXW2(2), FOSL1(3), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), JUN(1), LDLR(5), MAPK10(5), MAPK9(6), PLAU(1), PPP2R5C(1), PPP2R5E(5), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), RHOA(1), SFRP4(3), TCF7(1), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2) 20636335 197 98 195 52 36 54 56 23 28 0 0.170 1.000 1.000 262 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(1), BMP4(4), BMP5(4), BMP6(2), BMP7(4), BMP8A(1), BTRC(9), CSNK1A1(1), CSNK1A1L(5), CSNK1D(2), CSNK1E(5), CSNK1G1(2), CSNK1G2(1), CSNK1G3(3), DHH(1), GAS1(1), GLI1(13), GLI2(10), GLI3(17), GSK3B(2), HHIP(1), IHH(1), LRP2(45), PRKACB(3), PRKACG(1), PRKX(3), PTCH1(8), PTCH2(2), SHH(4), SMO(5), STK36(5), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5), ZIC2(3) 21042352 218 97 216 62 47 63 61 29 17 1 0.292 1.000 1.000 263 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(6), ITPKA(1), ITPKB(5), OCRL(6), PIK3C2A(9), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9) 15515895 158 97 155 48 21 43 47 20 27 0 0.573 1.000 1.000 264 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRKL(2), DOCK1(7), ELK1(2), FOS(1), GAB1(2), GRB2(4), HGF(29), HRAS(1), ITGA1(9), ITGB1(3), JUN(1), MAP2K1(6), MAP2K2(1), MAP4K1(5), MAPK3(1), MAPK8(3), MET(12), PAK1(5), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), PTK2B(8), PTPN11(6), PXN(1), RAF1(3), RAP1A(2), RAP1B(1), RASA1(3), SOS1(12), SRC(2), STAT3(8) 15165983 177 97 172 46 22 45 37 45 28 0 0.405 1.000 1.000 265 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(23), ASAH1(2), CAMP(2), CAV3(2), DAG1(2), DLG4(3), EPHB2(5), GNAI1(3), GNAQ(2), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PITX2(4), PTX3(2), RHO(1), RYR1(51) 15931301 160 97 158 40 18 44 48 23 27 0 0.153 1.000 1.000 266 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(8), F12(1), F13B(16), F2(5), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(12), FGG(2), LPA(26), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5), VWF(13) 12094406 182 96 181 43 15 60 43 38 25 1 0.260 1.000 1.000 267 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6) 16820508 205 96 202 60 32 81 46 26 20 0 0.368 1.000 1.000 268 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6) 16820508 205 96 202 60 32 81 46 26 20 0 0.368 1.000 1.000 269 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(8), BAG4(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DAXX(6), DFFA(3), DFFB(2), FADD(1), GSN(3), LMNB1(2), LMNB2(2), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK8(3), MDM2(2), NFKB1(3), NFKBIA(1), NUMA1(6), PAK2(3), PRKCD(1), PRKDC(23), PSEN1(1), PSEN2(4), PTK2(11), RASA1(3), RB1(13), RIPK1(4), SPTAN1(12), TNFRSF1B(1), TRAF2(1) 24100647 172 96 172 58 28 41 42 22 39 0 0.920 1.000 1.000 270 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHFR(1), DHX58(1), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), FPGS(1), GCH1(4), GGH(4), IFIH1(6), MOV10L1(9), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SKIV2L2(10), SMARCA2(10), SMARCA5(1), SPR(1) 21726604 171 96 171 53 23 40 52 30 25 1 0.568 1.000 1.000 271 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(3), DAXX(6), EGF(8), EGFR(33), ETS1(7), ETS2(3), FOS(1), HOXA7(3), HRAS(1), IKBKB(3), JUN(1), MAP2K1(6), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(3), NFKBIA(1), PPP2CA(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), RAF1(3), RIPK1(4), SP1(1), TNFRSF1B(1), TRAF2(1) 16878445 152 96 138 55 19 37 35 32 29 0 0.946 1.000 1.000 272 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), GK(2), GLA(4), LCT(30), LIPC(6), LIPF(3), LIPG(2), LPL(5), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PPAP2B(2), PPAP2C(1) 16758907 210 94 210 55 20 74 60 26 30 0 0.221 1.000 1.000 273 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), ESCO1(7), ESCO2(2), ETNK1(1), ETNK2(1), GNPAT(3), GPAM(3), GPD1(2), GPD1L(6), GPD2(4), LCAT(1), LYPLA1(1), LYPLA2(1), MYST3(8), MYST4(8), NAT6(1), PCYT1A(2), PCYT1B(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(6), PNPLA3(2), PPAP2B(2), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(1) 22733746 207 93 207 60 28 57 61 31 29 1 0.464 1.000 1.000 274 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(7), CREBBP(4), DLL1(5), DLL3(3), DLL4(1), DTX1(4), DTX2(2), DTX3(4), DTX3L(2), DTX4(1), DVL1(1), DVL2(1), DVL3(5), EP300(2), HDAC1(3), HDAC2(8), HES1(1), JAG1(4), JAG2(2), LFNG(1), MAML1(5), MAML2(3), MAML3(6), NCOR2(13), NCSTN(4), NOTCH1(8), NOTCH2(26), NOTCH3(5), NOTCH4(23), NUMB(2), NUMBL(1), PSEN1(1), PSEN2(4), PSENEN(1), PTCRA(2), RBPJ(3), RBPJL(2), SNW1(2) 24025077 172 93 172 60 28 51 50 17 25 1 0.810 1.000 1.000 275 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(56), CDR1(4), DGKI(23), PIGK(2), RPL10(2), RPL11(1), RPL12(1), RPL14(1), RPL15(1), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(4), RPL35(1), RPL37(1), RPL3L(2), RPL4(5), RPL5(1), RPL6(3), RPL7(1), RPL7A(1), RPL8(1), RPLP0(3), RPLP2(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS15(1), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), RPSA(1), SLC36A2(3), UBC(10) 18271223 165 93 164 50 26 55 42 21 20 1 0.629 1.000 1.000 276 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CD28(1), CD3D(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(5), FBXW7(4), GRAP2(5), GRB2(4), ITK(7), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(6), NCK1(3), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PLCG1(5), PTPRC(21), RAF1(3), RASGRP1(2), RASGRP3(8), RASGRP4(2), SOS1(12), SOS2(6), VAV1(1), ZAP70(4) 19339966 179 92 179 51 27 60 44 21 27 0 0.420 1.000 1.000 277 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(33), ELK1(2), GNAS(7), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), IGF1R(10), ITGB1(3), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(2), PDGFRA(17), PPP2CA(1), PTPRR(8), RAF1(3), RPS6KA1(1), RPS6KA5(4), SHC1(2), SOS1(12), SRC(2), STAT3(8) 11376262 139 90 125 46 12 36 35 36 20 0 0.905 1.000 1.000 278 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(6), CALCR(8), CALCRL(10), CD97(4), CRHR1(1), CRHR2(2), ELTD1(20), EMR1(10), EMR2(3), GHRHR(5), GIPR(2), GLP1R(1), GLP2R(9), GPR64(7), LPHN1(3), LPHN2(24), LPHN3(33), SCTR(1), VIPR2(4) 9270607 153 90 153 49 9 52 35 37 20 0 0.750 1.000 1.000 279 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(3), APOA1(1), CD36(4), CITED2(2), CPT1B(5), CREBBP(4), EHHADH(8), EP300(2), FABP1(1), HSD17B4(5), JUN(1), LPL(5), MAPK3(1), ME1(1), NCOA1(5), NCOR1(10), NCOR2(13), NFKBIA(1), NR0B2(1), NR1H3(3), NR2F1(1), NRIP1(8), PDGFA(6), PIK3CA(11), PIK3R1(3), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PTGS2(4), RB1(13), RXRA(1), SP1(1), STAT5A(3), STAT5B(4) 21741260 151 90 146 51 24 38 41 19 29 0 0.796 1.000 1.000 280 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ITPA(1), NT5E(2), NT5M(1), NUDT2(3), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), UCK2(2), UMPS(2), UNG(5), UPP1(6) 19805523 190 90 188 57 41 42 58 27 21 1 0.353 1.000 1.000 281 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(2), AKT3(5), BRD4(6), CBL(8), CDC42(2), CDKN2A(14), F2RL2(5), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), IGFBP1(3), INPPL1(6), IRS1(15), IRS2(3), IRS4(17), LNPEP(1), MAPK3(1), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPYR1(2), PTEN(8), PTPN1(1), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SERPINB6(2), SHC1(2), SORBS1(7), SOS1(12), SOS2(6), YWHAG(2) 20447181 178 90 174 60 32 37 59 27 23 0 0.722 1.000 1.000 282 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(8), EGFR(33), ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), JUN(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3) 12854686 136 89 119 38 17 25 34 35 25 0 0.582 1.000 1.000 283 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(4), ALDOC(1), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GAPDHS(6), GCK(4), GOT1(2), GOT2(3), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), MDH1(2), MDH2(2), PC(1), PCK1(12), PDHA1(3), PDHA2(13), PDHX(4), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGK1(5), PGK2(14), PKLR(11), PKM2(4), TPI1(6) 14625772 169 89 166 55 32 55 39 25 18 0 0.524 1.000 1.000 284 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(10), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH4A1(3), ALDH9A1(3), AMD1(1), AOC2(3), AOC3(5), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), GATM(4), GLUD1(3), GOT1(2), GOT2(3), MAOA(3), MAOB(1), NOS1(9), NOS3(2), OAT(1), ODC1(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), P4HB(4), RARS(5), SMS(1) 15277277 154 87 153 56 22 42 45 26 19 0 0.887 1.000 1.000 285 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ACOX1(3), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP4A11(4), DCI(2), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HADHB(4), HSD17B4(5) 16841805 157 87 154 46 18 62 28 26 22 1 0.520 1.000 1.000 286 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), AKR1B10(7), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), HSD3B7(2), NSD1(11), OGDH(1), OGDHL(11), PLOD1(2), PLOD2(6), PLOD3(3), RDH11(2), SETD1A(8), SETD7(1), SETDB1(5), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(2), SUV39H2(3), TMLHE(2) 20037042 149 87 146 54 23 37 48 22 17 2 0.836 1.000 1.000 287 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CD3D(2), ELK1(2), FOS(1), FYN(3), GRB2(4), HRAS(1), JUN(1), LAT(3), LCK(5), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SYT1(3), VAV1(1), ZAP70(4) 16404415 136 87 131 40 24 31 45 17 19 0 0.406 1.000 1.000 288 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(11), CALM1(2), ELK1(2), FCER1A(7), FCER1G(2), FOS(1), GRB2(4), HRAS(1), JUN(1), LYN(4), MAP2K1(6), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PAK2(3), PIK3CA(11), PIK3R1(3), PLA2G4A(10), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1) 14773706 147 86 143 36 22 37 44 22 22 0 0.148 1.000 1.000 289 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CANX(2), CD4(3), CD8A(2), CD8B(3), CIITA(4), CTSB(1), CTSS(1), HLA-A(2), HLA-B(3), HLA-C(1), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), HSP90AA1(5), HSP90AB1(2), HSPA5(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR2DS4(2), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LGMN(4), LTA(2), NFYB(1), NFYC(2), PDIA3(2), PSME1(1), PSME2(1), RFX5(6), TAP2(7), TAPBP(2) 16155034 138 86 138 58 20 30 42 27 19 0 0.975 1.000 1.000 290 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(2), AKT3(5), ARHGEF11(11), BCL2(1), CDC42(2), DLG4(3), GNA13(5), LPA(26), MAP2K4(3), MAP3K1(4), MAP3K5(12), MAPK8(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PI3(1), PIK3CB(7), PLD1(9), PLD2(6), PLD3(1), PTK2(11), RDX(2), ROCK1(10), ROCK2(4), SERPINA4(9) 16867911 162 86 162 39 24 46 39 28 25 0 0.177 1.000 1.000 291 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(3), BLVRA(1), BLVRB(1), COX15(2), CP(6), CPOX(4), EARS2(2), EPRS(13), FECH(2), FTMT(4), GUSB(5), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B10(19), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8) 14639741 158 85 156 44 16 62 39 26 15 0 0.521 1.000 1.000 292 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), HRH1(6), HRH2(6), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3) 8817874 158 85 157 69 15 62 48 23 10 0 0.888 1.000 1.000 293 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(5), ATF2(5), CALM1(2), EGFR(33), ELK1(2), GNAQ(2), GRB2(4), HRAS(1), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PAK1(5), PRKCA(7), PTK2(11), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3) 11569309 134 84 120 35 24 35 21 30 24 0 0.381 1.000 1.000 294 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(11), ACAT1(1), ACAT2(1), ACOT12(4), ACSS1(4), ACSS2(4), ACYP2(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK1(12), PCK2(3), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4) 16098013 149 84 148 50 27 43 40 21 18 0 0.720 1.000 1.000 295 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(1), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EARS2(2), EPRS(13), GAD1(5), GAD2(9), GCLC(8), GCLM(1), GFPT1(4), GFPT2(6), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), GMPS(8), GOT1(2), GOT2(3), GPT2(3), GSR(1), GSS(3), NADSYN1(1), NAGK(1), PPAT(5), QARS(2) 13623439 157 83 156 44 21 46 39 31 19 1 0.471 1.000 1.000 296 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(2), AKT3(5), BCR(3), BLNK(1), BTK(11), CD19(2), DAG1(2), EPHB2(5), GRB2(4), ITPKA(1), ITPKB(5), LYN(4), MAP2K1(6), MAP2K2(1), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1) 18092603 132 83 129 39 14 29 41 28 20 0 0.419 1.000 1.000 297 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(1), ALOX15(4), ALOX15B(2), ALOX5(5), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP2U1(2), CYP4A11(4), CYP4F2(5), CYP4F3(12), DHRS4(1), EPHX2(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6) 13383676 144 82 143 46 23 42 40 21 17 1 0.585 1.000 1.000 298 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ASAH1(2), BRAF(17), CAMP(2), CREB5(7), CREBBP(4), CRKL(2), DAG1(2), EGR1(2), EGR2(2), EGR3(1), EGR4(2), ELK1(2), FRS2(2), GNAQ(2), JUN(1), MAP1B(11), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), NTRK1(12), OPN1LW(3), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PTPN11(6), RPS6KA3(1), SHC1(2), SRC(2), TH(2) 17853527 141 82 131 45 21 37 43 18 22 0 0.557 1.000 1.000 299 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(3), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT13(15), GALNT14(10), GALNT2(3), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GCNT1(4), GCNT3(3), GCNT4(3), OGT(6), ST3GAL1(3), ST3GAL2(3), ST6GALNAC1(3), WBSCR17(16) 11092302 140 81 139 52 30 35 32 28 15 0 0.942 1.000 1.000 300 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN2(3), CAPNS2(2), CXCR3(1), EGF(8), EGFR(33), HRAS(1), ITGA1(9), ITGB1(3), MAPK3(1), MYL2(3), MYLK(15), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTK2(11), PXN(1), TLN1(13) 11288326 120 81 106 34 12 32 20 32 24 0 0.639 1.000 1.000 301 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), AOX1(14), DBH(2), DCT(7), DDC(6), FAH(1), GOT1(2), GOT2(3), GSTZ1(1), HGD(4), HPD(2), MAOA(3), MAOB(1), TAT(4), TH(2), TPO(16), TYR(14) 10944826 149 81 149 46 19 64 26 19 21 0 0.602 1.000 1.000 302 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(1), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), ELAVL1(3), FLT1(21), FLT4(13), HIF1A(1), HRAS(1), KDR(30), NOS3(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PXN(1), SHC1(2), VHL(1) 11744952 129 81 125 31 18 41 39 16 15 0 0.150 1.000 1.000 303 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(10), ACY3(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), AMDHD1(3), AOC2(3), AOC3(5), ASPA(2), CARM1(1), CNDP1(5), DDC(6), FTCD(3), HAL(2), HARS(2), HARS2(3), HDC(7), HNMT(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), PRPS1(3), PRPS2(2), UROC1(9), WBSCR22(1) 13689849 134 80 134 39 24 34 46 18 12 0 0.214 1.000 1.000 304 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT2(2), AKT3(5), BTK(11), CDKN2A(14), DAPP1(2), GRB2(4), GSK3B(2), IARS(9), IGFBP1(3), INPP5D(4), PDK1(4), PIK3CA(11), PPP1R13B(2), PTEN(8), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TEC(5), YWHAG(2) 12467676 121 80 117 37 9 25 44 24 19 0 0.738 1.000 1.000 305 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(3), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), JUN(1), LY96(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), PPARA(1), TLR10(6), TLR2(2), TLR4(31), TLR6(6), TLR7(8), TLR9(6), TOLLIP(1), TRAF6(4) 12531338 111 80 110 42 12 32 25 17 25 0 0.951 1.000 1.000 306 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(4), APC(23), ATF2(5), AXIN1(3), BMP10(7), BMP2(1), BMP4(4), BMP5(4), BMP7(4), BMPR1A(1), BMPR2(2), CHRD(9), CTNNB1(11), DVL1(1), FZD1(3), GATA4(4), GSK3B(2), MAP3K7(5), MEF2C(2), MYL2(3), NKX2-5(3), NPPA(1), RFC1(6), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(12), WNT1(3) 12563856 138 79 136 41 18 41 34 22 23 0 0.685 1.000 1.000 307 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(10), AGXT(3), AGXT2(8), AKR1B10(7), ALAS1(3), AMT(1), AOC2(3), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), HSD3B7(2), MAOA(3), MAOB(1), PHGDH(3), PSAT1(2), PSPH(5), RDH11(2), SARDH(5), SARS(2), SDS(2), SHMT1(2), SHMT2(2), TARS(5), TARS2(9) 14882710 130 79 129 42 23 43 34 19 11 0 0.553 1.000 1.000 308 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), DLG4(3), GRIN1(2), GRIN2A(26), GRIN2B(21), GRIN2C(3), GRIN2D(6), NOS1(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), SYT1(3) 8824973 102 79 101 43 16 29 33 12 12 0 0.948 1.000 1.000 309 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(1), AOC2(3), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CPT1B(5), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), MAOA(3), MAOB(1), PLCB2(6), PLCG1(5), PLCG2(9), PSPH(5), SARDH(5), SARS(2), SHMT1(2), SHMT2(2), TARS(5) 14591193 128 78 128 37 23 39 35 23 8 0 0.347 1.000 1.000 310 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(14), AUH(1), BCAT1(1), BCAT2(1), BCKDHB(5), DBT(10), DLD(6), EHHADH(8), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(4), HMGCS1(5), HMGCS2(5), HSD17B4(5), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2) 14806911 136 78 134 43 9 43 35 19 27 3 0.757 1.000 1.000 311 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), JUN(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3) 11969601 118 78 115 34 16 23 37 25 17 0 0.508 1.000 1.000 312 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(2), AKT3(5), ANKRD6(1), APC(23), AXIN1(3), AXIN2(2), CER1(2), CSNK1A1(1), CTNNB1(11), DACT1(12), DKK1(2), DKK2(4), DKK4(2), DVL1(1), FSTL1(3), GSK3B(2), LRP1(20), MVP(3), NKD1(5), NKD2(3), PSEN1(1), PTPRA(5), SENP2(3), SFRP1(1), TSHB(1) 13926635 118 78 116 33 11 36 38 13 20 0 0.495 1.000 1.000 313 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(11), CALM1(2), CD79B(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), JUN(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1) 13125135 116 77 115 33 21 28 35 17 15 0 0.307 1.000 1.000 314 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(8), EGFR(33), GRB2(4), HRAS(1), MAP2K1(6), MAPK3(1), PTPRB(29), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), SRC(2) 8608110 123 77 109 37 17 29 22 35 20 0 0.690 1.000 1.000 315 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(3), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), CLC(1), CPT1B(5), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), ETNK1(1), GNPAT(3), GPD1(2), GPD2(4), LCAT(1), LGALS13(2), LYPLA1(1), LYPLA2(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB2(6), PLCG1(5), PLCG2(9), PPAP2B(2), PPAP2C(1) 17365757 147 76 147 44 18 35 46 28 20 0 0.500 1.000 1.000 316 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(14), GABBR1(3), GPRC5A(1), GPRC5B(7), GPRC5C(1), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM7(15), GRM8(19) 7178692 122 76 122 41 11 37 44 21 9 0 0.515 1.000 1.000 317 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(10), CALM1(2), ELK1(2), FOS(1), GNAI1(3), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), JUN(1), MAP2K1(6), MAPK3(1), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RAF1(3), RPS6KA3(1), SYT1(3) 11996852 108 76 107 31 19 28 33 12 16 0 0.363 1.000 1.000 318 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(4), ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1B10(7), AKR1C4(1), AKR1D1(5), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), HSD3B7(2), LIPA(2), RDH11(2), SLC27A5(1), SOAT1(7), SRD5A1(3), SRD5A2(3) 10932231 133 76 132 43 12 53 31 20 16 1 0.653 1.000 1.000 319 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACAT1(1), ACAT2(1), ACYP2(1), ADH5(4), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK1(12), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4) 12747514 135 76 134 32 23 39 38 16 19 0 0.126 1.000 1.000 320 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP2(7), CASP3(4), CASP8(4), DFFA(3), DFFB(2), FADD(1), JUN(1), LMNB1(2), LMNB2(2), MADD(13), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), RB1(13), RIPK1(4), SPTAN1(12), TRAF2(1) 13602600 116 76 116 29 26 24 25 16 25 0 0.296 1.000 1.000 321 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CAMK1(2), ELK1(2), FPR1(4), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PAK1(5), PIK3C2G(9), PLCB1(18), PPP3CA(5), PPP3CB(1), PPP3CC(2), RAF1(3), SYT1(3) 13249024 117 75 116 35 22 35 32 8 20 0 0.445 1.000 1.000 322 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EPRS(13), GAD1(5), GAD2(9), GCLC(8), GCLM(1), GFPT1(4), GLS(3), GLS2(2), GLUD1(3), GLUL(2), GMPS(8), GOT1(2), GOT2(3), GPT2(3), GSS(3), NADSYN1(1), PPAT(5), QARS(2) 11439237 141 75 140 40 19 40 38 26 17 1 0.512 1.000 1.000 323 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(21), AR(4), ESR1(1), ESR2(3), HNF4A(5), NPM1(2), NR0B1(5), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(3), NR1I2(2), NR1I3(5), NR2C2(2), NR2E1(7), NR2F1(1), NR2F2(2), NR3C1(3), NR4A1(2), NR4A2(7), NR5A1(2), NR5A2(5), PGR(6), PPARA(1), PPARD(2), PPARG(3), RARA(3), RARB(3), RARG(1), ROR1(4), RORA(5), RORC(2), RXRA(1), RXRB(1), RXRG(11), THRA(1), THRB(5), VDR(1) 14429519 140 75 140 69 30 45 33 19 13 0 0.998 1.000 1.000 324 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(6), AADAC(3), ABAT(4), ACAT1(1), ACAT2(1), ACSM1(6), AKR1B10(7), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH7A1(1), ALDH9A1(3), BDH2(1), DDHD1(3), EHHADH(8), GAD1(5), GAD2(9), HADH(4), HADHA(3), HMGCS1(5), HMGCS2(5), HSD17B4(5), HSD3B7(2), ILVBL(1), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), PLA1A(4), PPME1(3), PRDX6(3), RDH11(2) 13949077 135 74 133 42 19 40 33 20 20 3 0.628 1.000 1.000 325 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(4), ARRB2(1), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(5), CLCA2(12), CLCA4(12), CNGA3(9), CNGA4(7), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(17), PRKACB(3), PRKACG(1), PRKG1(3), PRKG2(7), PRKX(3) 10497589 113 74 113 38 19 43 18 14 19 0 0.817 1.000 1.000 326 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(2), C6(14), C7(23), IL1A(3), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELP(14), SELPLG(3), VCAM1(17) 8572844 125 74 124 37 15 44 32 21 13 0 0.682 1.000 1.000 327 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(22), BMPR1B(5), CCND2(1), CDK4(2), CDKN1B(3), DAZL(2), DMC1(1), EGR1(2), ESR2(3), FSHR(20), GJA4(1), LHCGR(6), MLH1(5), MSH5(4), NCOR1(10), NR5A1(2), NRIP1(8), PGR(6), PRLR(9), PTGER2(2), SMPD1(2), VDR(1), ZP2(2) 12067613 119 74 118 38 13 32 40 18 16 0 0.735 1.000 1.000 328 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(8), BAX(1), BCL2(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CD40LG(6), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(3), IKBKE(5), LTA(2), MCL1(1), NFKB1(3), NFKBIA(1), NGFR(2), NR3C1(3), NTRK1(12), PTPN13(11), RIPK1(4), SFRS2IP(12), TFG(1), TNFRSF1B(1), TRAF2(1), TRAF3(3), TRAF6(4) 15176746 131 73 129 43 15 40 31 24 21 0 0.808 1.000 1.000 329 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(7), B4GALT1(1), B4GALT2(2), G6PC(1), G6PC2(2), GAA(2), GALE(1), GALK2(2), GALT(2), GANC(1), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), HSD3B7(2), LCT(30), MGAM(30), PFKL(2), PFKM(5), PFKP(3), PGM1(2), PGM3(4), RDH11(2), UGP2(1) 13429476 136 73 135 40 28 38 42 20 8 0 0.267 1.000 1.000 330 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(7), ATP4B(1), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), COX15(2), COX4I1(1), COX5B(1), COX6B1(1), COX6B2(1), COX7B2(1), COX8A(1), COX8C(1), CYC1(2), LHPP(2), NDUFA10(2), NDUFA11(1), NDUFA12(2), NDUFA13(4), NDUFA4(1), NDUFA8(3), NDUFA9(5), NDUFB11(1), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(7), NDUFS2(6), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFS8(1), NDUFV1(3), PPA1(1), SDHA(4), SDHB(1), SDHD(1), TCIRG1(1), UQCRB(4), UQCRC2(4), UQCRFS1(2), UQCRQ(1) 19192261 147 73 147 72 28 31 43 24 21 0 0.999 1.000 1.000 331 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(4), CARS(1), CARS2(1), DARS2(3), EARS2(2), EPRS(13), FARS2(1), FARSA(2), FARSB(3), GARS(4), HARS(2), HARS2(3), IARS(9), IARS2(7), KARS(4), LARS(7), LARS2(2), MARS(3), MARS2(8), MTFMT(1), NARS(3), NARS2(3), PARS2(1), QARS(2), RARS(5), RARS2(2), SARS(2), TARS(5), TARS2(9), VARS(6), VARS2(8), WARS(3), WARS2(9), YARS(1), YARS2(2) 18699453 142 73 141 39 21 44 39 22 16 0 0.359 1.000 1.000 332 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), BCR(3), CAPNS2(2), CRKL(2), FYN(3), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), JUN(1), MAP2K1(6), MAP2K2(1), MAPK3(1), MAPK8(3), PPP1R12B(5), PTK2(11), PXN(1), RAF1(3), RAP1A(2), ROCK1(10), SHC1(2), SOS1(12), SRC(2), TLN1(13), VCL(2), ZYX(2) 16248466 138 73 136 53 28 38 21 34 17 0 0.922 1.000 1.000 333 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(5), CDC42(2), DAXX(6), DDIT3(4), ELK1(2), GRB2(4), HRAS(1), HSPB1(1), HSPB2(1), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), PLA2G4A(10), RIPK1(4), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1) 12674463 118 73 118 32 17 28 31 25 17 0 0.410 1.000 1.000 334 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDK5(1), F2(5), FYN(3), GNA11(1), GNAI1(3), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(8), MYLK(15), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), SYT1(3) 14373185 130 72 129 45 23 36 28 23 20 0 0.793 1.000 1.000 335 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(2), FBP2(1), G6PC(1), GAA(2), GALE(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), LCT(30), MGAM(30), PFKM(5), PFKP(3), PGM1(2), PGM3(4) 11299547 123 72 122 36 25 34 37 19 8 0 0.274 1.000 1.000 336 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), DCXR(1), GUSB(5), RPE(2), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B10(19), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), XYLB(3) 9469379 122 72 120 34 10 50 30 20 12 0 0.571 1.000 1.000 337 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(7), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), FUK(3), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), HSD3B7(2), KHK(2), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PFKFB1(6), PFKFB2(3), PFKFB3(5), PFKFB4(5), PFKL(2), PFKM(5), PFKP(3), PGM2(5), PHPT1(1), PMM1(1), RDH11(2), SORD(2), TPI1(6), TSTA3(1) 12992086 124 72 122 37 23 36 32 22 11 0 0.293 1.000 1.000 338 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(3), CDK2(4), CDT1(2), DIAPH2(7), GMNN(1), MCM10(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), PRIM1(3), RFC1(6), RFC2(2), RFC3(1), RFC4(1), RFC5(1), RPA2(1), RPA4(5), UBC(10) 17523538 131 71 130 33 34 28 42 14 13 0 0.110 1.000 1.000 339 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CFLAR(1), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAF1(4), JUN(1), LMNB1(2), LMNB2(2), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), PTPN13(11), RB1(13), SPTAN1(12) 14378223 120 71 120 42 24 26 29 13 28 0 0.916 1.000 1.000 340 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(1), ANGPTL2(4), DAG1(2), DGKA(5), GCA(1), ITGA9(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAPK3(1), NR1I3(5), PAK1(5), PDE3A(13), PDE3B(9), PI3(1), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PSME1(1), RIPK3(4), SGCB(1), VASP(3) 16948061 138 71 134 29 24 35 35 21 23 0 0.0449 1.000 1.000 341 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(2), AKT3(5), GRB2(4), IARS(9), IL2RG(3), IL4(1), IL4R(5), INPP5D(4), JAK1(8), JAK2(4), JAK3(5), NR0B2(1), PI3(1), PIK3CA(11), PPP1R13B(2), RPS6KB1(2), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT6(2), TYK2(2) 12721179 102 71 99 33 8 27 35 21 11 0 0.698 1.000 1.000 342 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(5), ARSB(1), ARSD(3), CYP11B1(10), CYP11B2(7), HSD11B1(4), HSD11B2(1), HSD17B2(3), HSD17B3(1), HSD3B1(7), HSD3B2(13), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13) 9448311 120 70 119 39 10 49 30 21 10 0 0.725 1.000 1.000 343 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ASL(3), ASS1(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), EPRS(13), GATM(4), GLUD1(3), GLUD2(5), GOT1(2), GOT2(3), LAP3(1), NOS1(9), NOS3(2), OAT(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), PARS2(1), PYCR2(1), RARS(5), RARS2(2) 12373786 120 70 119 45 15 36 35 20 14 0 0.942 1.000 1.000 344 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), DAD1(1), DDOST(1), DHDDS(1), DOLPP1(3), DPAGT1(1), DPM1(1), FUT8(4), GANAB(3), MAN1A2(9), MAN1B1(2), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(6), RFT1(4), RPN2(4), STT3B(2) 14680503 118 70 118 37 17 37 35 17 12 0 0.647 1.000 1.000 345 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALNT1(4), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(4), PIGZ(1), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST3GAL6(3), ST6GALNAC3(8), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4) 16714939 112 70 110 48 26 21 37 20 8 0 0.940 1.000 1.000 346 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADHA(3), PLOD1(2), PLOD2(6), PLOD3(3), SDS(2), SHMT1(2), SHMT2(2), TMLHE(2) 12828351 106 70 104 31 15 29 33 14 13 2 0.456 1.000 1.000 347 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(10), ARHGEF1(2), F2(5), F2R(4), F2RL3(2), GNA12(1), GNA13(5), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), MAP3K7(5), PIK3CA(11), PIK3R1(3), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2B(8), ROCK1(10) 8952755 105 70 102 25 16 32 29 10 18 0 0.200 1.000 1.000 348 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(3), CDK5(1), CHN1(4), MAP3K1(4), MYL2(3), MYLK(15), NCF2(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLD1(9), PPP1R12B(5), RALBP1(1), RPS6KB1(2), TRIO(15), VAV1(1), WASF1(8) 12037385 109 70 105 29 13 29 35 14 18 0 0.348 1.000 1.000 349 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(6), EGF(8), EGFR(33), GRB2(4), MET(12), PDGFRA(17), PRKCA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(2), SRC(2) 6663213 101 69 87 32 12 25 18 26 20 0 0.817 1.000 1.000 350 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA1(1), FUCA2(1), GBA(3), GUSB(5), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(5), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(1), NEU1(1), NEU3(3), NEU4(6), SPAM1(12) 11948533 96 69 96 35 10 34 31 12 9 0 0.809 1.000 1.000 351 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(3), ARHGAP4(2), ARHGAP5(7), ARHGAP6(6), ARHGEF1(2), ARHGEF11(11), ARHGEF5(4), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), BAIAP2(2), DIAPH1(4), GSN(3), MYL2(3), MYLK(15), OPHN1(7), PFN1(1), PIP5K1A(5), PIP5K1B(7), PPP1R12B(5), ROCK1(10), SRC(2), TLN1(13), VCL(2) 15730697 123 69 123 38 24 35 28 16 20 0 0.627 1.000 1.000 352 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(1), ACP5(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), PON1(3) 10113327 115 68 114 41 17 30 30 17 20 1 0.730 1.000 1.000 353 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(10), ADC(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AMD1(1), AOC2(3), AOC3(5), ARG1(1), ASL(3), ASS1(3), CPS1(39), GATM(4), MAOA(3), MAOB(1), ODC1(1), OTC(5), SAT1(1), SMS(1), SRM(2) 10196683 105 68 104 37 12 29 29 21 14 0 0.809 1.000 1.000 354 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), DDC(6), EPX(7), ESCO1(7), ESCO2(2), GOT1(2), GOT2(3), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRDX6(3), SH3GLB1(1), TAT(4), TPO(16) 11768310 110 68 110 39 16 35 27 19 13 0 0.813 1.000 1.000 355 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX15(4), ALOX5(5), CYP4F2(5), CYP4F3(12), EPX(7), GGT1(1), LPO(4), LTA4H(1), MPO(4), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6), TPO(16) 9543117 114 68 114 34 13 28 32 25 16 0 0.526 1.000 1.000 356 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT2(2), AKT3(5), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PIK3CB(7), PITX2(4), PLD1(9), PLD2(6), PLD3(1) 15490934 114 68 113 30 17 32 32 15 18 0 0.203 1.000 1.000 357 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(7), EEF1B2(2), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(2), EIF1AX(1), EIF2AK1(6), EIF2AK2(5), EIF2AK3(6), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), EIF5(1), EIF5B(10), GSPT2(3), PABPC1(3), PABPC3(12), PAIP1(4) 15141938 110 68 110 27 15 34 37 13 11 0 0.268 1.000 1.000 358 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(6), POLA2(2), POLB(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLG(10), POLG2(1), POLI(2), POLK(3), POLL(2), POLM(6), POLQ(17), PRIM1(3), PRIM2(10), REV1(4), REV3L(13), RFC5(1) 14134109 109 67 106 26 22 21 40 16 10 0 0.199 1.000 1.000 359 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(4), ABAT(4), ACY3(2), ADSSL1(1), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), ASRGL1(1), ASS1(3), CAD(16), CRAT(1), DARS2(3), DDO(3), DLAT(5), DLD(6), GAD1(5), GAD2(9), GOT1(2), GOT2(3), GPT2(3), NARS(3), NARS2(3), PC(1), PDHA1(3), PDHA2(13) 13044756 114 66 114 41 22 30 35 17 10 0 0.723 1.000 1.000 360 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(3), ASAH1(2), B4GALT6(3), CERK(3), DEGS1(3), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SGMS1(1), SGMS2(3), SGPP1(1), SMPD1(2), SMPD2(1), SMPD3(1), SMPD4(2), SPHK2(2), SPTLC1(1), SPTLC2(1), UGT8(1) 12407907 95 66 94 30 13 33 31 10 8 0 0.484 1.000 1.000 361 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(5), F2R(4), F2RL3(2), GNAI1(3), GNB1(2), GNGT1(2), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), PLA2G4A(10), PLCB1(18), PRKCA(7), PTGS1(5), PTK2(11), RAF1(3), SRC(2), SYK(3), TBXAS1(6) 8377736 103 66 103 26 13 32 20 18 20 0 0.408 1.000 1.000 362 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(10), ACADM(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(3), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(9), HADHA(3), MLYCD(4), SDS(2), SMS(1) 9987148 115 65 114 38 19 38 26 16 14 2 0.706 1.000 1.000 363 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(8), CARM1(1), CCND1(2), CREBBP(4), EP300(2), ERCC3(5), ESR1(1), GRIP1(6), GTF2A1(3), GTF2E1(6), GTF2F1(1), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), MEF2C(2), NCOR2(13), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(9) 15866265 108 65 107 30 24 25 34 14 11 0 0.289 1.000 1.000 364 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(7), DIAPH1(4), FYN(3), GSN(3), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), MYL2(3), MYLK(15), PFN1(1), PIK3CA(11), PIK3R1(3), PTK2(11), PXN(1), RAF1(3), ROCK1(10), SHC1(2), SRC(2), TLN1(13) 12848503 112 65 108 31 17 28 23 27 17 0 0.459 1.000 1.000 365 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), ASRGL1(1), CA1(2), CA12(1), CA13(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), HAL(2) 7318840 90 65 89 38 10 29 23 19 9 0 0.982 1.000 1.000 366 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(5), ADCY3(5), ADCY9(3), ARF3(1), ARF4(2), ARF5(1), ARL4D(3), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ERO1L(2), GNAS(7), PDIA4(3), PLCG1(5), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(5), SEC61B(1), SEC61G(1), TRIM23(2) 12707439 100 65 99 39 18 26 27 16 13 0 0.908 1.000 1.000 367 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOX1(14), BCAT1(1), BCKDHB(5), EHHADH(8), HADHA(3), HADHB(4), HIBADH(1), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2), SDS(2) 12378366 104 65 103 37 9 32 28 12 21 2 0.863 1.000 1.000 368 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(10), ASAH1(2), GNAI1(3), GNB1(2), GNGT1(2), ITGAV(9), ITGB3(4), MAPK3(1), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCB1(18), PRKCA(7), PTK2(11), SMPD1(2), SMPD2(1), SRC(2) 9425640 111 64 108 34 15 36 29 13 18 0 0.612 1.000 1.000 369 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(17), CREB5(7), DUSP6(3), DUSP9(2), EEF2K(2), EIF4E(3), GRB2(4), MAP2K1(6), MAP2K2(1), MAP3K8(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), SHC1(2), SOS1(12), SOS2(6), TRAF3(3) 10209278 90 64 85 30 9 23 29 17 12 0 0.720 1.000 1.000 370 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(2), AGTR1(5), AGTR2(2), CMA1(6), COL4A1(16), COL4A2(15), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), REN(1) 8864361 108 62 108 51 8 52 24 11 13 0 1.000 1.000 1.000 371 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(6), ABAT(4), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH9A1(3), EHHADH(8), GAD1(5), GAD2(9), HADHA(3), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), SDHB(1), SDS(2) 8839629 95 62 94 31 14 28 25 12 14 2 0.704 1.000 1.000 372 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(10), ACADM(3), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(3), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(9), HADHA(3), HIBCH(4), MLYCD(4), SMS(1), SRM(2) 9297629 108 62 107 34 17 34 26 16 13 2 0.588 1.000 1.000 373 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2F1(1), GTF2H1(4), GTF2H3(1), GTF2I(4), GTF2IRD1(5), TAF1(9), TAF10(1), TAF1L(25), TAF2(6), TAF4(4), TAF4B(5), TAF5L(4), TAF6(2), TAF7(2), TAF7L(3), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(3) 12389816 96 62 95 28 16 19 31 14 16 0 0.563 1.000 1.000 374 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), BTRC(9), CDC16(3), CDC20(3), CDC23(1), CDC27(1), CUL1(6), CUL2(6), CUL3(7), FBXW7(4), FZR1(2), ITCH(6), SKP1(2), SKP2(4), SMURF1(3), SMURF2(2), TCEB1(1), UBA1(1), UBE2D2(1), UBE2D3(3), UBE2D4(3), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(3), WWP2(3) 13918391 92 62 91 24 19 16 26 17 14 0 0.326 1.000 1.000 375 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(4), HRAS(1), JAK2(4), JUN(1), MAP2K1(6), MAPK3(1), MPL(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), THPO(1) 10285764 86 62 83 25 11 17 25 19 14 0 0.567 1.000 1.000 376 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(4), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), SRD5A1(3), SRD5A2(3) 7989352 113 61 112 36 11 47 24 16 15 0 0.649 1.000 1.000 377 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(16), COL4A2(15), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), P4HB(4), SLC23A2(4), SLC2A3(6) 8821309 103 61 103 45 11 48 20 11 13 0 0.993 1.000 1.000 378 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(10), ACACB(11), ACADM(3), ACAT1(1), ACAT2(1), ACSS1(4), ACSS2(4), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), EHHADH(8), HADHA(3), HIBCH(4), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SUCLG1(2), SUCLG2(2) 13612676 108 60 107 48 21 31 25 12 18 1 0.986 1.000 1.000 379 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2(1), CBL(8), CFLAR(1), CRKL(2), E2F1(3), FOS(1), GRB2(4), HRAS(1), IL2RA(3), IL2RB(5), IL2RG(3), IRS1(15), JAK1(8), JAK3(5), MAPK3(1), NMI(1), PIK3CA(11), PIK3R1(3), PTPN6(3), RAF1(3), RPS6KB1(2), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3) 12429891 108 60 104 36 23 18 32 23 12 0 0.537 1.000 1.000 380 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(2), CA12(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUL(2), HAL(2) 6542301 83 60 82 34 10 24 22 18 9 0 0.967 1.000 1.000 381 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ATP7A(14), ATP7B(11), COX4I1(1), COX5B(1), COX6B1(1), COX8A(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3), SDHA(4), SDHB(1), SHMT1(2), UQCRB(4), UQCRFS1(2) 13158111 114 60 114 51 24 34 25 17 14 0 0.985 1.000 1.000 382 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), DDC(6), EPX(7), GOT1(2), GOT2(3), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TAT(4), TPO(16) 7565702 85 60 85 30 12 25 22 17 9 0 0.722 1.000 1.000 383 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(2), AKT3(5), BCL2(1), GRB2(4), GSK3B(2), IL4R(5), IRS1(15), IRS2(3), JAK1(8), JAK3(5), MAP4K1(5), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPP1R13B(2), RAF1(3), SHC1(2), SOS1(12), SOS2(6), STAT6(2) 12566375 102 60 99 37 16 20 32 21 13 0 0.764 1.000 1.000 384 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), MYL2(3), NOX1(4), PIK3C2G(9), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2(11), RAF1(3), ROCK2(4) 8767494 87 59 87 24 14 25 20 11 17 0 0.596 1.000 1.000 385 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(5), CALM1(2), CAMK1(2), HDAC5(2), IGF1(5), IGF1R(10), INSR(1), MAP2K6(1), MAPK14(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5), NFATC1(3), NFATC2(8), PIK3CA(11), PIK3R1(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYT1(3) 11979906 81 59 77 23 9 27 22 9 14 0 0.375 1.000 1.000 386 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(3), ANXA4(3), ANXA5(2), ANXA6(1), CYP11A1(1), EDN1(1), EDNRB(6), HPGD(1), HSD11B1(4), HSD11B2(1), PLA2G4A(10), PRL(1), PTGDR(3), PTGDS(2), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6) 7115488 80 59 80 30 12 22 21 11 14 0 0.904 1.000 1.000 387 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), GHR(5), IRS1(15), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(3), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PRKCA(7), PTEN(8), RPS6KB1(2) 9649373 91 58 87 32 15 21 33 12 10 0 0.814 1.000 1.000 388 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(5), F2R(4), F3(4), F5(23), F7(2), FGA(9), FGB(12), FGG(2), PROC(3), PROS1(13), SERPINC1(8), TFPI(1) 5624927 89 58 88 27 10 36 19 10 13 1 0.771 1.000 1.000 389 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GPHN(3), NSF(3), SRC(2), UBQLN1(5) 4109634 84 58 81 26 12 33 14 16 9 0 0.759 1.000 1.000 390 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(4), ACO2(1), CLYBL(5), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), OGDHL(11), PC(1), PCK1(12), PCK2(3), SDHA(4), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2) 10204698 79 58 79 38 14 13 22 14 16 0 0.976 1.000 1.000 391 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(2), FOS(1), GRB2(4), HRAS(1), IGF1(5), IGF1R(10), IRS1(15), JUN(1), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PTPN11(6), RAF1(3), RASA1(3), SHC1(2), SOS1(12) 8481244 89 58 85 24 16 21 25 16 11 0 0.326 1.000 1.000 392 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(5), GRB2(4), HRAS(1), INSR(1), IRS1(15), JAK2(4), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(1), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4) 11358400 93 57 90 30 18 19 26 20 10 0 0.569 1.000 1.000 393 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(1), BLVRB(1), CP(6), CPOX(4), EPRS(13), FECH(2), GUSB(5), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13) 9435487 92 57 91 27 7 34 22 17 12 0 0.640 1.000 1.000 394 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(10), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), GNAS(7), GRB2(4), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RPS6KA1(1), RPS6KA5(4), SOS1(12) 9983942 82 56 79 32 11 21 24 15 11 0 0.933 1.000 1.000 395 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), SELE(6), SELL(4), SELP(14) 5528060 84 56 84 31 9 30 25 13 7 0 0.918 1.000 1.000 396 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(7), ARHGEF1(2), GNA12(1), GNA13(5), GNAQ(2), GNB1(2), GNGT1(2), MYL2(3), MYLK(15), PLCB1(18), PPP1R12B(5), PRKCA(7), ROCK1(10) 7129686 79 56 79 20 10 28 18 8 15 0 0.477 1.000 1.000 397 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(11), DLG4(3), EPHB2(5), F2(5), F2RL1(1), F2RL2(5), F2RL3(2), JUN(1), MAPK7(5), MAPK8(3), MYEF2(4), PLD1(9), PLD2(6), PLD3(1), PTK2(11), RAF1(3), RASAL1(7), SRC(2), TEC(5), VAV1(1) 9471669 90 56 90 20 12 23 29 13 13 0 0.106 1.000 1.000 398 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), CAPNS2(2), ITGA1(9), ITGB1(3), ITGB3(4), PTK2(11), PXN(1), SPTAN1(12), SRC(2), TLN1(13) 9819062 89 56 88 35 18 26 12 22 11 0 0.927 1.000 1.000 399 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(7), AGT(2), AGTR2(2), EDN1(1), EDNRB(6), EGF(8), EGFR(33), FOS(1), HRAS(1), JUN(1), NFKB1(3), PLCG1(5), PRKCA(7) 7025262 77 55 63 24 11 18 15 20 13 0 0.803 1.000 1.000 400 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), CTNNA1(3), CTNNA2(29), CTNNB1(11), PTK2(11), PXN(1), SRC(2), VCL(2) 6565659 89 55 86 24 13 32 15 18 11 0 0.380 1.000 1.000 401 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(13), F2(5), F2R(4), FGA(9), FGB(12), FGG(2), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5) 4602900 80 55 79 27 6 36 19 12 7 0 0.890 1.000 1.000 402 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(10), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), AOC2(3), AOC3(5), ASPA(2), CNDP1(5), DDC(6), HAL(2), HARS(2), HDC(7), HNMT(2), MAOA(3), MAOB(1), PRPS1(3), PRPS2(2) 8440940 88 55 88 28 16 25 22 16 9 0 0.486 1.000 1.000 403 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(9), CYP2C9(3), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), HADHA(3), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1) 10627890 83 55 82 26 12 26 20 14 10 1 0.615 1.000 1.000 404 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(2), EIF4A2(4), EIF4B(5), EIF4E(3), EIF4G1(8), EIF4G3(13), MKNK1(2), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2), TSC1(9), TSC2(5) 9543117 79 55 74 23 7 21 31 11 9 0 0.532 1.000 1.000 405 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(10), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), LDHA(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2) 11345347 95 55 94 34 17 27 24 9 17 1 0.857 1.000 1.000 406 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CALM1(2), CRKL(2), GNAQ(2), GRB2(4), HRAS(1), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(5), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3) 9781964 86 55 86 26 22 25 16 11 12 0 0.453 1.000 1.000 407 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(5), BCR(3), BLNK(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), JUN(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK3(1), MAPK8IP3(4), PAPPA(12), RPS6KA1(1), RPS6KA3(1), SHC1(2), SOS1(12), SYK(3), VAV1(1), VAV2(3), VAV3(14) 11049708 86 55 86 34 9 24 20 19 14 0 0.934 1.000 1.000 408 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(3), ASAH1(2), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(1), SPTLC2(1) 8402010 70 54 69 20 9 26 25 5 5 0 0.349 1.000 1.000 409 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2H1(4), ILK(1), MNAT1(2), POLR1A(8), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR3B(13), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(2), TAF7(2), TAF9(2) 12033034 91 54 89 31 17 22 31 12 9 0 0.741 1.000 1.000 410 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(23), CDH1(5), CREBBP(4), EP300(2), MAP2K1(6), MAP3K7(5), MAPK3(1), SKIL(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2) 8789936 68 54 68 16 3 19 14 16 16 0 0.470 1.000 1.000 411 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4) 7926835 75 53 75 25 6 26 23 6 14 0 0.787 1.000 1.000 412 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4) 7926835 75 53 75 25 6 26 23 6 14 0 0.787 1.000 1.000 413 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GPX1(1), PRKCE(3) 2730825 70 53 68 24 7 33 12 13 5 0 0.883 1.000 1.000 414 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), GCK(4), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), KHK(2), PFKFB1(6), PFKFB3(5), PFKFB4(5), PFKM(5), PFKP(3), PMM1(1), SORD(2), TPI1(6) 8314532 87 53 85 26 18 25 21 15 8 0 0.322 1.000 1.000 415 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(3), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(4), JUN(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), RAF1(3), SOS1(12), STAT1(4), STAT5A(3), STAT5B(4) 9611359 74 53 71 20 10 11 23 16 14 0 0.306 1.000 1.000 416 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), GLCE(4), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(1), HS6ST3(5), NDST1(2), NDST2(7), NDST3(8), NDST4(13) 7153731 78 53 77 36 8 24 28 9 8 1 0.984 1.000 1.000 417 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(3), IFNB1(4), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL1RN(1), IRAK1(3), IRAK2(3), IRAK3(6), JUN(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), TGFB1(2), TGFB2(8), TGFB3(1), TOLLIP(1), TRAF6(4) 10174928 74 53 73 33 10 19 16 14 15 0 0.986 1.000 1.000 418 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(4), EP300(2), FYN(3), IL2RG(3), IL7R(7), JAK1(8), JAK3(5), LCK(5), NMI(1), PIK3CA(11), PIK3R1(3), PTK2B(8), STAT5A(3), STAT5B(4) 9665403 68 53 64 24 9 14 19 16 10 0 0.812 1.000 1.000 419 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(5), C5(2), C6(14), C7(23), C8A(6), C8B(9), C9(10), MASP1(5) 7218767 82 52 81 31 12 32 16 13 9 0 0.950 1.000 1.000 420 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3C2G(9), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PTK2B(8), PXN(1), RAF1(3) 9569910 84 52 81 19 15 23 21 11 14 0 0.127 1.000 1.000 421 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1) 8604904 88 52 88 27 7 45 12 13 11 0 0.752 1.000 1.000 422 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 ELK1(2), FOS(1), GRB2(4), HRAS(1), IL6R(8), JAK1(8), JAK2(4), JAK3(5), JUN(1), MAP2K1(6), MAPK3(1), PTPN11(6), RAF1(3), SHC1(2), SOS1(12), STAT3(8) 8241252 72 52 71 21 9 15 19 22 7 0 0.525 1.000 1.000 423 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(3), FADD(1), IKBKB(3), IL1A(3), IL1R1(1), IRAK1(3), MAP3K1(4), MAP3K14(1), MAP3K7(5), MYD88(3), NFKB1(3), NFKBIA(1), RIPK1(4), TLR4(31), TNFRSF1B(1), TRAF6(4) 8407048 71 52 70 27 8 18 20 11 14 0 0.887 1.000 1.000 424 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CDC42(2), CREB5(7), DUSP10(6), EEF2K(2), EIF4E(3), ELK1(2), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K10(1), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAPK11(1), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MKNK1(2), MKNK2(1), MYEF2(4), NFKB1(3), NR2C2(2), TRAF6(4) 11449542 91 52 90 28 20 24 23 11 13 0 0.589 1.000 1.000 425 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFAT5(6), PDE6A(9), PDE6B(4), PDE6C(5), PDE6D(1), PDE6G(2), SLC6A13(4), TF(4) 12435387 93 52 92 27 15 31 17 17 13 0 0.493 1.000 1.000 426 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(8), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DFFA(3), DFFB(2), FADD(1), GAS2(1), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1), TRAF2(1) 11580988 70 51 70 34 12 14 19 10 15 0 0.994 1.000 1.000 427 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(4), ALDOC(1), DERA(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKL(2), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(2), RPE(2), RPIA(5), TKT(2), TKTL1(10), TKTL2(12) 8405445 73 51 72 24 13 19 17 14 10 0 0.626 1.000 1.000 428 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GUSB(5), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(5), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), NAGLU(1), SPAM1(12) 7051597 67 51 67 23 7 24 20 8 8 0 0.745 1.000 1.000 429 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(7), ALOX15(4), ALOX5(5), CYP1A2(2), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), RDH11(2) 8223161 87 51 87 35 20 32 18 8 8 1 0.903 1.000 1.000 430 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(10), AOC2(3), AOC3(5), CES1(3), CES7(9), DDHD1(3), ESCO1(7), ESCO2(2), LIPA(2), MYST3(8), MYST4(8), NAT6(1), PLA1A(4), PNPLA3(2), PPME1(3), PRDX6(3), SH3GLB1(1) 8709557 77 51 77 21 11 26 17 13 10 0 0.504 1.000 1.000 431 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(2), FOS(1), GRB2(4), HRAS(1), INSR(1), IRS1(15), JUN(1), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PTPN11(6), RAF1(3), RASA1(3), SHC1(2), SOS1(12) 8739785 75 51 71 22 14 14 23 17 7 0 0.431 1.000 1.000 432 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(1), DLAT(5), DLD(6), DLST(2), FH(7), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), PC(1), PDHA1(3), PDHA2(13), PDHX(4), PDK1(4), PDK2(2), PDK3(2), PDP2(1), SDHA(4), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2) 9740515 74 51 74 34 13 21 18 11 11 0 0.966 1.000 1.000 433 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK5(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), SYT1(3), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4) 11610987 72 51 68 26 12 12 28 8 12 0 0.656 1.000 1.000 434 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CDKN1A(1), GNAQ(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SP1(1), SP3(4), SYT1(3) 7188768 62 50 61 18 12 18 19 6 7 0 0.376 1.000 1.000 435 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCL4(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CD28(1), CD4(3), CXCR3(1), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL4(1), IL4R(5), TGFB1(2), TGFB2(8), TGFB3(1) 6867481 75 50 74 24 7 21 20 13 14 0 0.527 1.000 1.000 436 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(15), FYN(3), LRP8(3), RELN(49), VLDLR(2) 4832816 73 50 72 27 4 26 17 16 10 0 0.963 1.000 1.000 437 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(14), CR2(8), FCGR2B(2), HLA-DRA(3), ITGAL(20), ITGB2(2), PTPRC(21) 5287839 74 49 74 23 8 29 15 8 14 0 0.793 1.000 1.000 438 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(5), C5(2), C6(14), C7(23), C8A(6), C9(10), MASP1(5), MASP2(2), MBL2(1) 7411356 76 49 75 33 12 28 15 12 9 0 0.987 1.000 1.000 439 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), MTFMT(1), MTR(11), SRM(2), TAT(4) 7191974 67 49 67 20 13 18 21 8 6 1 0.446 1.000 1.000 440 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6) 7070604 57 49 57 15 7 21 20 6 3 0 0.323 1.000 1.000 441 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AGPS(3), ENPP2(11), ENPP6(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(6), PPAP2B(2), PPAP2C(1) 8004237 77 49 77 25 12 28 19 8 10 0 0.718 1.000 1.000 442 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(3), ATG7(1), BECN1(1), GABARAPL1(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNG(4), PIK3C3(7), PIK3R4(9), PRKAA1(4), ULK1(3), ULK2(2), ULK3(1) 7295711 68 49 68 23 6 25 18 14 5 0 0.863 1.000 1.000 443 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CHUK(3), EGR2(2), EGR3(1), GNAQ(2), MAP3K1(4), NFATC1(3), NFATC2(8), NFKB1(3), NFKBIA(1), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SYT1(3), VIP(1), VIPR2(4) 9592581 62 49 61 17 10 18 17 3 14 0 0.369 1.000 1.000 444 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1) 8089883 75 48 74 26 15 16 25 13 6 0 0.733 1.000 1.000 445 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(10), ACE2(3), AGT(2), AGTR1(5), AGTR2(2), ANPEP(4), CMA1(6), CPA3(6), CTSA(1), CTSG(2), ENPEP(8), LNPEP(1), MAS1(3), MME(8), NLN(5), REN(1), THOP1(2) 7310825 69 48 69 33 6 24 24 6 9 0 0.991 1.000 1.000 446 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(12), APOA1(1), APOA4(3), APOC2(1), APOC3(3), APOE(1), CETP(2), CYP7A1(7), DGAT1(2), HMGCR(4), LCAT(1), LDLR(5), LIPC(6), LPL(5), LRP1(20), SOAT1(7) 9394267 80 48 79 33 17 19 19 18 6 1 0.920 1.000 1.000 447 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), EPRS(13), FARS2(1), GARS(4), HARS(2), IARS(9), KARS(4), LARS(7), LARS2(2), MARS(3), MARS2(8), NARS(3), QARS(2), RARS(5), SARS(2), TARS(5), WARS(3), WARS2(9), YARS(1) 11020854 85 47 85 26 11 29 21 17 7 0 0.709 1.000 1.000 448 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(5), C5(2), C6(14), C7(23), C8A(6), C9(10) 6089110 68 47 67 28 12 23 13 12 8 0 0.969 1.000 1.000 449 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(6), DDX20(1), E2F1(3), ETS1(7), ETS2(3), FOS(1), HDAC2(8), HDAC5(2), HRAS(1), JUN(1), NCOR2(13), RBL1(7), RBL2(2), SIN3A(6) 8949778 62 47 62 25 6 11 22 12 11 0 0.918 1.000 1.000 450 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(4), HEXA(1), LCT(30), SLC33A1(2), ST3GAL1(3), ST3GAL2(3), ST6GALNAC3(8), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4) 5647369 62 47 62 19 11 14 24 7 6 0 0.504 1.000 1.000 451 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(2), FOS(1), GRB2(4), HRAS(1), IL2(5), IL2RA(3), IL2RB(5), IL2RG(3), JAK1(8), JAK3(5), JUN(1), LCK(5), MAP2K1(6), MAPK3(1), MAPK8(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3) 8085303 80 47 78 25 13 18 18 21 10 0 0.567 1.000 1.000 452 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(7), ABCC2(5), ABCG2(5), BCHE(14), CES1(3), CES2(1), CYP3A4(1), CYP3A5(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5) 7820350 67 47 66 32 12 26 12 10 7 0 0.975 1.000 1.000 453 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), GATM(4), GLUD1(3), OAT(1), ODC1(1), OTC(5), SMS(1) 5990411 65 47 64 24 8 17 17 13 10 0 0.874 1.000 1.000 454 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(8), DBH(2), DDC(6), GAD1(5), GAD2(9), HDC(7), MAOA(3), PAH(3), SLC18A3(8), TH(2), TPH1(11) 4997467 67 46 67 23 14 15 13 16 9 0 0.711 1.000 1.000 455 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(1), BTG1(1), CBX3(2), CLOCK(1), CRY1(3), CRY2(2), DAZAP2(1), ETV6(3), GFRA1(8), GSTM3(1), GSTP1(2), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(6), NCKAP1(4), NCOA4(4), NR1D2(2), PER1(3), PER2(4), PPP1R3C(1), PPP2CB(3), PSMA4(1), PURA(1), SF3A3(1), SUMO3(1), TOB1(1), UCP3(1), UGP2(1), VAPA(1), ZFR(5) 12668509 73 46 73 31 14 23 23 4 9 0 0.972 1.000 1.000 456 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(2), CD80(4), CD86(6), CTLA4(1), GRB2(4), HLA-DRA(3), ICOS(2), IL2(5), ITK(7), LCK(5), PIK3CA(11), PIK3R1(3), PTPN11(6) 4378480 60 46 55 17 4 16 19 11 10 0 0.627 1.000 1.000 457 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(1), CBS(1), CTH(1), GGT1(1), LCMT1(2), LCMT2(4), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SCLY(2), SEPHS1(4), WBSCR22(1) 8575363 73 46 73 21 18 16 29 3 7 0 0.254 1.000 1.000 458 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(14), CD38(3), ENPP1(6), ENPP3(12), NADK(2), NADSYN1(1), NMNAT1(1), NMNAT2(3), NMNAT3(1), NNMT(5), NNT(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(2) 7433340 65 46 65 27 7 24 16 11 7 0 0.949 1.000 1.000 459 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(2), CASP1(2), CASP3(4), CASP7(1), CASP8(4), GAPDH(3), INSR(1), ITCH(6), MAGI1(16), MAGI2(15), RERE(10), WWP1(3), WWP2(3) 8282472 74 46 73 22 16 24 18 8 8 0 0.518 1.000 1.000 460 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(10), BAX(1), BCL2(1), CSF2RB(5), IGF1(5), IGF1R(10), IL3(1), IL3RA(5), KIT(6), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 7509597 70 45 67 25 8 21 24 7 10 0 0.699 1.000 1.000 461 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(3), GALNT2(3), GALNT3(4), GALNT4(4), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GCNT1(4), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), WBSCR17(16) 4952583 59 45 59 30 16 10 18 12 3 0 0.983 1.000 1.000 462 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(1), GUSB(5), RPE(2), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13) 6090026 64 45 63 22 6 21 15 12 10 0 0.777 1.000 1.000 463 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), PON1(3), PON3(5) 6216434 54 44 54 28 5 11 19 9 10 0 0.974 1.000 1.000 464 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(4), HRAS(1), IGF1R(10), IRS1(15), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), RAF1(3), SHC1(2), SOS1(12) 6468334 68 44 65 19 13 17 17 15 6 0 0.378 1.000 1.000 465 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(2), ITGB1(3), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LAT(3), MAP2K1(6), MAPK3(1), PAK1(5), PIK3CA(11), PIK3R1(3), PTK2B(8), PTPN6(3), SYK(3), VAV1(1) 6399176 61 44 58 16 12 9 18 13 9 0 0.250 1.000 1.000 466 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(4), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), CAD(16), CRAT(1), DDO(3), GAD1(5), GAD2(9), GOT1(2), GOT2(3), GPT2(3), NARS(3), PC(1) 8995349 70 43 70 30 15 16 20 12 7 0 0.895 1.000 1.000 467 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(1), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), PC(1), PCK1(12), SDHA(4), SDHB(1), SUCLG1(2), SUCLG2(2) 7035338 56 43 56 23 12 11 12 9 12 0 0.867 1.000 1.000 468 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(2), AP2M1(5), BTK(11), EEA1(6), GSK3B(2), LYN(4), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PLCG1(5), PRKCE(3), PRKCZ(2), RAB5A(1), RPS6KB1(2), VAV2(3) 8585210 57 43 56 19 10 11 19 11 6 0 0.648 1.000 1.000 469 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(2), C6(14), C7(23), C8A(6), C9(10) 4363824 60 42 59 19 12 23 10 8 7 0 0.802 1.000 1.000 470 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(8), BIRC2(2), BIRC3(3), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), LMNB1(2), LMNB2(2), PRF1(5) 6681762 61 42 61 20 8 19 13 11 10 0 0.806 1.000 1.000 471 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), RB1(13), SP1(1) 6670312 51 42 48 14 4 12 11 7 17 0 0.626 1.000 1.000 472 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(7), GBA(3), GBA3(12), LPO(4), MPO(4), PRDX6(3), TPO(16) 2867996 49 42 49 17 4 16 15 7 7 0 0.728 1.000 1.000 473 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22(2), IL22RA2(2), JAK1(8), JAK2(4), JAK3(5), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), TYK2(2) 6383833 46 42 46 17 3 8 9 16 10 0 0.854 1.000 1.000 474 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM1(2), CAPN2(3), CAPNS2(2), EP300(2), HDAC1(3), HDAC2(8), MEF2D(1), NFATC1(3), NFATC2(8), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SYT1(3) 8365370 55 42 54 18 9 19 15 4 8 0 0.621 1.000 1.000 475 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(11), AP2A1(2), AP2M1(5), BIN1(1), CALM1(2), DNM1(5), EPN1(5), EPS15(3), PICALM(4), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(3) 7450057 56 42 55 18 6 21 12 8 9 0 0.852 1.000 1.000 476 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(8), JAK1(8), JAK2(4), JAK3(5), PIAS3(5), PTPRU(10), REG1A(9), SRC(2), STAT3(8) 5302724 59 42 58 18 9 18 12 13 7 0 0.604 1.000 1.000 477 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(2), EPO(3), EPOR(1), FOS(1), GRB2(4), HRAS(1), JAK2(4), JUN(1), MAP2K1(6), MAPK3(1), MAPK8(3), PLCG1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4) 7393494 59 41 59 19 10 13 15 14 7 0 0.550 1.000 1.000 478 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(33), ERBB3(3), NRG1(9) 3545378 53 41 38 18 7 9 9 14 14 0 0.874 1.000 1.000 479 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELE(6), SELL(4) 4197341 56 41 56 22 7 19 15 8 7 0 0.937 1.000 1.000 480 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), CDKN1B(3), GRB2(4), ILK(1), ITGB1(3), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), SHC1(2), SOS1(12) 6648557 64 41 60 16 6 16 18 14 10 0 0.421 1.000 1.000 481 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(2), AKT3(5), BPNT1(3), GRB2(4), ILK(1), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PTEN(8), PTK2B(8), RBL2(2), SHC1(2), SOS1(12) 7004194 64 41 60 22 10 16 20 12 6 0 0.770 1.000 1.000 482 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(5), CHUK(3), IFNG(4), IKBKB(3), IL2(5), IL4(1), JUN(1), MAP3K1(4), MAP3K5(12), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), TNFRSF9(4), TNFSF9(1), TRAF2(1) 6665503 53 40 52 14 7 11 14 5 16 0 0.489 1.000 1.000 483 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(4), HRAS(1), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), NTRK1(12), PIK3CA(11), PIK3R1(3), PLCG1(5), RPS6KA1(1), SHC1(2) 6552835 51 40 47 16 8 9 17 10 7 0 0.526 1.000 1.000 484 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACAT2(1), ACOT11(2), ACYP2(1), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), GCDH(3), HADHA(3), ITGB1BP3(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1) 8925504 59 40 57 16 7 18 16 8 9 1 0.483 1.000 1.000 485 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16) 4053300 49 40 49 15 6 15 12 10 6 0 0.544 1.000 1.000 486 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(3), CREBBP(4), EP300(2), IKBKB(3), MAP2K3(6), MAP2K6(1), MAP3K14(1), MAP3K7(5), MAPK11(1), MAPK14(1), MYD88(3), NFKB1(3), NFKBIA(1), NR3C1(3), TGFBR1(2), TGFBR2(2), TLR2(2) 10176531 43 40 43 22 3 9 13 5 13 0 0.990 1.000 1.000 487 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), NCK1(3), NCKAP1(4), NTRK1(12), PIR(2), PSMA7(1), WASF1(8), WASF2(1), WASF3(4), WASL(5) 5269061 53 39 52 14 3 15 13 8 14 0 0.627 1.000 1.000 488 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), HRAS(1), JUN(1), MAP2K1(6), MAPK3(1), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7), RAF1(3) 5298373 45 39 45 14 9 10 13 5 8 0 0.513 1.000 1.000 489 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(4), ALOX15B(2), ALOX5(5), DPEP1(4), GGT1(1), LTA4H(1), PLA2G2A(3), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6) 5174942 46 39 46 13 6 6 16 11 7 0 0.399 1.000 1.000 490 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(2), CXCR3(1), ETV5(8), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), JAK2(4), JUN(1), MAP2K6(1), MAPK14(1), MAPK8(3), STAT4(6), TYK2(2) 6409710 55 39 55 21 3 15 16 8 13 0 0.889 1.000 1.000 491 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(4), MAP2K1(6), MAPK3(1), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4) 6077431 55 39 55 19 7 12 15 14 7 0 0.657 1.000 1.000 492 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(6), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(8), NCOR2(13), POLR2A(9), RARA(3), RXRA(1) 8569867 62 39 61 21 17 18 12 11 4 0 0.684 1.000 1.000 493 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(7), CHUK(3), IKBKB(3), JUN(1), LTA(2), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TRAF2(1) 8338119 46 39 46 20 5 15 9 4 13 0 0.965 1.000 1.000 494 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3D(2), CD4(3), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1) 3887962 53 39 53 20 8 19 10 6 10 0 0.856 1.000 1.000 495 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNB1(4), CHRNG(1), MUSK(9), PIK3CA(11), PIK3R1(3), PTK2(11), PTK2B(8), RAPSN(1), SRC(2), TERT(4) 5591493 54 38 51 16 12 13 14 10 5 0 0.383 1.000 1.000 496 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), WASL(5) 4601984 52 38 49 17 6 14 18 7 7 0 0.831 1.000 1.000 497 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(10), CREM(2), FHL5(5), FSHB(1), FSHR(20), GNAS(7), XPO1(3) 3263708 48 38 48 21 4 15 13 9 7 0 0.983 1.000 1.000 498 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(4), PGAP1(4), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGW(1), PIGX(4), PIGZ(1) 8254534 51 38 50 16 9 9 20 10 3 0 0.483 1.000 1.000 499 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), MTHFR(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16) 3991928 46 38 46 16 6 14 13 7 6 0 0.699 1.000 1.000 500 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(10), CCNB1(1), CDC25C(3), GNAI1(3), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAPK3(1), MYT1(6), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RPS6KA1(1), SRC(2) 7030758 55 38 55 23 7 13 14 8 13 0 0.939 1.000 1.000 501 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PPP2CA(1), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 5262878 45 37 45 18 5 14 13 5 8 0 0.907 1.000 1.000 502 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), FDPS(1), GGCX(4), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1), TM7SF2(5), VKORC1(1) 6685197 51 37 50 19 5 18 15 9 4 0 0.805 1.000 1.000 503 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(14), CD38(3), ENPP1(6), ENPP3(12), NADSYN1(1), NMNAT1(1), NMNAT2(3), NNMT(5), NNT(4), NT5E(2), NT5M(1), QPRT(2) 5010520 54 37 54 20 7 21 11 10 5 0 0.855 1.000 1.000 504 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3D(2), CD8A(2), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1) 3704762 52 37 52 20 8 18 10 6 10 0 0.860 1.000 1.000 505 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(39), GLS(3), GLUD1(3), GOT1(2) 2677697 51 37 50 17 6 11 15 11 8 0 0.797 1.000 1.000 506 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(4), GFPT1(4), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), PGM3(4), RENBP(3), UAP1(6) 5809272 53 36 53 15 13 14 11 9 6 0 0.423 1.000 1.000 507 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13) 3251113 53 36 53 21 5 22 13 7 6 0 0.860 1.000 1.000 508 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13) 3251113 53 36 53 21 5 22 13 7 6 0 0.860 1.000 1.000 509 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(10), ADRB2(2), GNAS(7), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAP2B(1) 5052427 46 36 46 19 3 17 12 5 9 0 0.927 1.000 1.000 510 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(3), CDC42(2), CHUK(3), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), RAF1(3), RALA(2), RALBP1(1), RHOA(1) 6558789 43 36 40 15 7 9 11 9 7 0 0.697 1.000 1.000 511 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(6), HLA-DRA(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL2RA(3), IL4(1), IL4R(5) 4359702 55 36 53 19 8 12 17 8 10 0 0.662 1.000 1.000 512 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1) 5179980 45 35 45 14 10 8 20 4 3 0 0.407 1.000 1.000 513 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(2), RPL10L(9), RPL11(1), RPL12(1), RPL14(1), RPL19(2), RPL21(1), RPL23A(2), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(4), RPL35(1), RPL36A(1), RPL37(1), RPL3L(2), RPL6(3), RPL7(1), RPL8(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPSA(1) 7966223 48 35 48 15 10 13 9 7 9 0 0.653 1.000 1.000 514 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(4), IL2RG(3), IL4(1), IL4R(5), IRS1(15), JAK1(8), JAK3(5), RPS6KB1(2), SHC1(2), STAT6(2) 5098914 47 35 47 20 10 10 13 12 2 0 0.867 1.000 1.000 515 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(8), JAK2(4), JAK3(5), PIAS1(2), PIAS3(5), PTPRU(10), REG1A(9), SOAT1(7) 4808771 50 35 49 16 6 18 9 10 6 1 0.736 1.000 1.000 516 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), BIRC3(3), CASP3(4), CASP8(4), CFLAR(1), FADD(1), JUN(1), MAP2K4(3), MAP3K3(4), MAP3K7(5), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(4), TNFRSF1B(1), TRAF2(1) 9372512 49 35 49 18 10 9 14 5 11 0 0.768 1.000 1.000 517 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), ANXA1(2), CALM1(2), GNAS(7), GNB1(2), GNGT1(2), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3CA(11), PIK3R1(3), SYT1(3) 6143154 43 34 40 18 4 12 15 4 8 0 0.920 1.000 1.000 518 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(20), ITGAM(14), ITGB2(2), SELE(6), SELL(4) 3617742 48 34 48 21 8 16 14 5 5 0 0.907 1.000 1.000 519 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(2), RPE(2), RPIA(5), TAL1(3), TKT(2) 7050223 51 34 50 18 11 11 12 12 5 0 0.725 1.000 1.000 520 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(10), CD44(2), CSF1(1), FCGR3A(6), IL6R(8), SELL(4), SPN(3), TGFB1(2), TGFB2(8), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1) 4599007 48 34 48 15 7 15 11 9 6 0 0.613 1.000 1.000 521 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(4), CNR2(1), DNMT1(5), MTNR1A(5), MTNR1B(6), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2) 3896206 43 34 43 18 7 13 12 8 3 0 0.796 1.000 1.000 522 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), PGD(2) 6155749 53 33 53 13 6 17 19 4 6 1 0.238 1.000 1.000 523 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(7), LEP(4), LEPR(13), PRKAA1(4), PRKAB1(3), PRKAG2(4) 4972735 45 33 45 13 7 19 7 7 5 0 0.712 1.000 1.000 524 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(3), GH1(2), GHR(5), HRAS(1), IGF1(5), IGF1R(10), PIK3CA(11), PIK3R1(3), SHC1(2), SOD2(1), SOD3(1) 4524353 44 33 41 16 4 15 11 6 8 0 0.839 1.000 1.000 525 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(3), ACSL1(8), ACSL3(3), ACSL4(2), CPT1A(7), CPT2(2), DCI(2), EHHADH(8), HADHA(3), PECR(1), SCP2(3), SLC25A20(2) 5754541 44 33 43 15 6 16 6 9 6 1 0.768 1.000 1.000 526 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(2), CD4(3), FYN(3), HLA-DRA(3), LCK(5), PTPRC(21), ZAP70(4) 3126308 41 33 40 12 3 16 10 4 8 0 0.732 1.000 1.000 527 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), AMT(1), ATIC(3), DHFR(1), FTCD(3), GART(4), MTFMT(1), MTHFD1(1), MTHFD1L(4), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2) 6542530 40 32 40 20 10 14 7 3 5 1 0.966 1.000 1.000 528 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(3), IL10(1), IL10RA(4), IL10RB(2), IL1A(3), JAK1(8), STAT1(4), STAT3(8), STAT5A(3) 4199402 38 32 38 13 1 7 11 11 8 0 0.760 1.000 1.000 529 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(3), CD3D(2), CD4(3), CXCR3(1), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), JAK2(4), STAT4(6), TYK2(2) 5062961 44 32 44 18 3 11 13 7 10 0 0.890 1.000 1.000 530 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), HDAC5(2), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PPARA(1), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYT1(3) 7036483 40 32 39 17 4 14 9 7 6 0 0.920 1.000 1.000 531 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(8), CHKA(1), PCYT1A(2), PDHA1(3), PDHA2(13), SLC18A3(8) 2406790 38 31 38 13 8 8 11 6 5 0 0.556 1.000 1.000 532 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(1), CASP8(4), FADD(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFKB1(3), NSMAF(2), RAF1(3), RIPK1(4), SMPD1(2), TRAF2(1) 7064879 39 31 39 14 8 6 14 5 6 0 0.639 1.000 1.000 533 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(10), ADRB2(2), CFTR(6), GNAS(7), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SLC9A3R1(1) 4478782 38 31 38 16 3 12 12 5 6 0 0.904 1.000 1.000 534 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL13(1), IL4(1), MAF(1), MAP2K3(6), MAPK14(1), NFATC1(3), NFATC2(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 4203753 39 31 38 13 4 16 8 2 9 0 0.618 1.000 1.000 535 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(8), BCL2(1), CASP3(4), CASP9(3), DAXX(6), FAS(3), FASLG(3), HSPB1(1), HSPB2(1), IL1A(3), MAPKAPK2(3), MAPKAPK3(1) 3892084 41 31 41 16 5 10 8 11 7 0 0.895 1.000 1.000 536 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(5), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(1), FUT8(4), MAN1B1(2), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), RPN2(4) 6863359 41 31 41 11 8 11 11 6 5 0 0.344 1.000 1.000 537 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(3), CHUK(3), GH1(2), GHR(5), NFKB1(3), NFKBIA(1), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1) 4800756 33 30 30 17 2 8 12 4 7 0 0.987 1.000 1.000 538 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(8), ARHGAP5(7), CASP1(2), CASP10(6), CASP3(4), CASP8(4), CASP9(3), GZMB(3), JUN(1), PRF1(5) 4422677 43 30 43 12 5 11 9 11 7 0 0.632 1.000 1.000 539 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(4), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(5), PKLR(11), TPI1(6) 3205771 38 30 37 15 5 13 11 4 5 0 0.766 1.000 1.000 540 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(11), FASN(4), MCAT(1), OLAH(7), OXSM(5) 5490275 38 30 38 21 6 15 12 2 3 0 0.983 1.000 1.000 541 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(1), CTH(1), GOT1(2), GOT2(3), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), SDS(2), SULT1B1(8), SULT1C2(2), SULT1C4(1), SULT4A1(3) 4337260 37 30 37 17 6 15 7 7 2 0 0.966 1.000 1.000 542 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1) 4872662 42 30 42 13 10 7 19 3 3 0 0.436 1.000 1.000 543 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(10), CHST2(4), CHST6(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2) 4290773 39 30 38 22 12 6 12 4 5 0 0.968 1.000 1.000 544 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR2(1), SEC22B(5), SNAP23(1), SNAP25(4), STX11(1), STX12(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(8), STX3(3), STX7(2), STX8(3), TSNARE1(1), VTI1A(1) 5810875 41 30 40 18 7 9 8 8 9 0 0.957 1.000 1.000 545 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(3), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TNFRSF1B(1), TRAF2(1), TRAF3(3) 7701270 33 30 33 17 2 7 13 4 7 0 0.977 1.000 1.000 546 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CCL4(1), CCR5(1), CXCL12(1), CXCR4(3), FOS(1), GNAQ(2), JUN(1), MAPK14(1), MAPK8(3), PLCG1(5), PRKCA(7), PTK2B(8), SYT1(3) 4713049 39 29 39 17 10 12 10 1 6 0 0.842 1.000 1.000 547 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), HMGCS1(5), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1) 4565802 34 29 33 13 2 13 10 7 1 1 0.845 1.000 1.000 548 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), AMT(1), ATIC(3), DHFR(1), GART(4), MTHFD1(1), MTHFD1L(4), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2) 6166512 36 29 36 18 9 13 5 3 5 1 0.963 1.000 1.000 549 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(2), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7) 2821738 31 29 31 11 6 10 9 0 6 0 0.770 1.000 1.000 550 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(2), GNB1(2), GNGT1(2), HTR2C(5), PLCB1(18), TUB(3) 2457628 34 29 34 10 5 14 9 0 6 0 0.575 1.000 1.000 551 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), NAT1(3), NAT2(2), XDH(11) 2737695 30 28 30 10 1 11 9 3 6 0 0.507 1.000 1.000 552 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), ST3GAL6(3), ST8SIA1(2) 5541571 32 28 31 19 7 6 10 6 3 0 0.980 1.000 1.000 553 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1) 4631296 38 28 37 16 8 8 12 6 4 0 0.873 1.000 1.000 554 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(8), UBE2A(4), UBE2D2(1), UBE2D3(3), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(8) 3617742 37 28 36 14 9 10 4 7 7 0 0.810 1.000 1.000 555 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(4), TGDS(2) 4028339 40 27 40 16 12 10 9 7 2 0 0.735 1.000 1.000 556 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2) 4694500 34 27 34 13 4 8 9 5 8 0 0.889 1.000 1.000 557 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(20), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5) 2782808 33 27 33 12 3 13 6 5 6 0 0.850 1.000 1.000 558 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(2), GZMB(3), HLA-A(2), ITGAL(20), ITGB2(2), PRF1(5) 3004022 35 26 35 14 5 8 10 6 6 0 0.773 1.000 1.000 559 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(2), FOS(1), JUN(1), MAPK3(1), OPRK1(5), POLR2A(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 4408021 31 26 31 10 6 9 9 3 4 0 0.590 1.000 1.000 560 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(1), CYP11B2(7), CYP17A1(3), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13) 2393737 41 26 41 15 7 17 8 6 3 0 0.689 1.000 1.000 561 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(8), BAX(1), BCL10(1), BCL2(1), BCL2L11(2), BID(1), CASP8AP2(10), CASP9(3), CES1(3) 3918877 30 26 30 15 4 10 8 5 3 0 0.982 1.000 1.000 562 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(8), JAK2(4), JAK3(5), MAPK3(1), STAT3(8), TYK2(2) 4066582 28 26 28 13 3 5 7 9 4 0 0.938 1.000 1.000 563 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(3), ARFGAP3(2), ARFGEF2(6), CLTB(1), COPA(10), GBF1(7), GPLD1(4), KDELR1(1), KDELR2(1), KDELR3(5) 5529892 40 25 40 10 6 16 7 5 6 0 0.488 1.000 1.000 564 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREBBP(4), EP300(2), NCOA3(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RARA(3), RXRA(1) 7131289 31 25 31 11 4 11 9 3 4 0 0.756 1.000 1.000 565 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19) 2303740 29 25 29 12 7 3 13 4 2 0 0.623 1.000 1.000 566 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(1), EPO(3), FLT3(10), IGF1(5), IL1A(3), IL3(1), TGFB1(2), TGFB2(8), TGFB3(1) 2810059 34 25 34 12 4 12 4 8 6 0 0.755 1.000 1.000 567 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19) 2303740 29 25 29 12 7 3 13 4 2 0 0.623 1.000 1.000 568 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(6), FADS2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1) 3505761 38 25 38 15 10 13 6 7 2 0 0.864 1.000 1.000 569 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1) 5698207 37 25 37 12 5 13 6 8 5 0 0.717 1.000 1.000 570 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), FDXR(2), SHMT1(2) 5516610 35 25 35 13 10 7 9 7 2 0 0.685 1.000 1.000 571 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(3), FOSL2(1), IFNAR2(2), IFNB1(4), MAPK8(3), NFKB1(3), TNFRSF11A(7), TNFSF11(1), TRAF6(4) 3820407 29 25 28 11 6 6 6 4 7 0 0.842 1.000 1.000 572 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), PGM1(2), PGM3(4), TGDS(2) 3534386 37 25 37 15 10 10 9 6 2 0 0.779 1.000 1.000 573 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(1), FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST8SIA1(2) 3668122 27 24 27 14 7 2 11 6 1 0 0.935 1.000 1.000 574 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(1), AFMID(2), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(4), MTHFD2(1) 4599007 31 24 31 11 6 12 5 3 5 0 0.715 1.000 1.000 575 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3) 2394195 33 24 33 13 4 8 8 5 8 0 0.856 1.000 1.000 576 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(7), GNB1(2), GNGT1(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7) 3291875 32 23 32 12 7 10 10 1 4 0 0.838 1.000 1.000 577 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2) 5182499 33 23 33 13 10 7 7 7 2 0 0.757 1.000 1.000 578 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CAMKK1(2), CAMKK2(1), SYT1(3) 3999256 26 23 26 10 2 12 3 5 4 0 0.825 1.000 1.000 579 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2) 5182499 33 23 33 13 10 7 7 7 2 0 0.757 1.000 1.000 580 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST8SIA1(2) 3455839 27 23 27 13 7 2 10 6 2 0 0.886 1.000 1.000 581 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(2), LPL(5), NCOA1(5), NCOA2(6), PPARG(3), RXRA(1) 6362994 26 23 26 15 3 10 6 4 3 0 0.990 1.000 1.000 582 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(3), CREBBP(4), EP300(2), FADD(1), HDAC3(1), IKBKB(3), NFKB1(3), NFKBIA(1), RIPK1(4), TNFRSF1B(1), TRAF6(4) 7715697 27 23 26 17 5 4 7 3 8 0 0.993 1.000 1.000 583 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2) 5182499 33 23 33 13 10 7 7 7 2 0 0.757 1.000 1.000 584 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(10), AGT(2), AGTR1(5), AGTR2(2), BDKRB2(1), KNG1(3), NOS3(2), REN(1) 3453091 26 22 26 17 2 10 10 2 2 0 0.992 1.000 1.000 585 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NQO2(2), PMVK(1), SC5DL(3), SQLE(1), VKORC1(1) 3835979 27 22 26 13 3 10 7 5 2 0 0.927 1.000 1.000 586 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(3), IKBKAP(5), IKBKB(3), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), TRAF3(3), TRAF6(4) 6216892 27 22 26 16 4 3 11 2 7 0 0.988 1.000 1.000 587 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(3), GPR109B(1), GPR171(1), GPR18(2), GPR34(3), GPR39(2), GPR45(3), GPR65(8), GPR75(2) 3348438 26 22 25 13 1 5 10 7 3 0 0.932 1.000 1.000 588 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(8), HADH(4), HADHA(3), HSD17B4(5), SIRT1(1), SIRT2(2), SIRT7(3), VNN2(4) 4077574 30 22 28 10 1 12 6 3 7 1 0.856 1.000 1.000 589 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(2), ESR1(1), GREB1(14), HSPB1(1), HSPB2(1), MTA1(1), MTA3(3), PDZK1(2), TUBA8(1) 3783767 28 22 28 11 6 7 11 3 1 0 0.631 1.000 1.000 590 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(3), CHST11(1), CHST12(3), CHST13(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SULT2B1(1), SUOX(5) 3174169 28 21 28 10 2 9 10 5 2 0 0.733 1.000 1.000 591 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(1), CRY1(3), CRY2(2), CSNK1D(2), CSNK1E(5), NPAS2(1), NR1D1(3), PER1(3), PER2(4), PER3(1) 5916673 27 21 27 12 8 9 8 0 2 0 0.854 1.000 1.000 592 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(10), AOC2(3), AOC3(5), CES1(3), ESD(1) 2085274 22 20 22 10 3 9 6 2 2 0 0.862 1.000 1.000 593 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PRKAR1A(1) 2243513 22 19 22 13 2 6 7 3 4 0 0.981 1.000 1.000 594 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), UGDH(4) 2946314 24 19 24 11 3 7 8 4 2 0 0.848 1.000 1.000 595 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(3), ACOX3(6), ELOVL2(4), ELOVL6(1), FADS2(1), FASN(4), HADHA(3), HSD17B12(1), PECR(1) 4953499 24 19 24 13 4 6 8 4 1 1 0.910 1.000 1.000 596 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), GRB2(4), PRKCA(7), PTPRA(5), SRC(2) 3158597 27 19 27 10 6 10 5 4 2 0 0.772 1.000 1.000 597 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(1), GSS(3), NFKB1(3), NOX1(4), XDH(11) 3426069 23 18 23 10 3 7 8 2 3 0 0.838 1.000 1.000 598 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(2), COPS5(1), EDN1(1), EP300(2), EPO(3), HIF1A(1), JUN(1), LDHA(3), NOS3(2), P4HB(4), VHL(1) 5899498 23 18 23 15 2 8 4 2 6 1 0.999 1.000 1.000 599 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(5), CAPNS2(2), CDK5(1), CSNK1A1(1), CSNK1D(2), GSK3B(2), MAPT(8), PPP2CA(1) 3277448 22 18 22 12 4 9 5 3 1 0 0.948 1.000 1.000 600 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), CKM(1), EIF4E(3), LDHA(3), LDHB(2), LDHC(5), MAPK14(1), NCL(4) 3040891 23 18 23 10 4 5 7 3 4 0 0.872 1.000 1.000 601 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(3), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), TNFRSF13B(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4) 5003421 23 18 22 15 5 2 8 2 6 0 0.989 1.000 1.000 602 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(9), APOBEC1(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1) 2524038 19 17 19 10 5 7 4 1 2 0 0.948 1.000 1.000 603 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(1), EPO(3), EPOR(1), GRIN1(2), HIF1A(1), JAK2(4), NFKB1(3), NFKBIA(1), SOD2(1) 4383747 19 16 19 14 2 7 4 2 4 0 0.997 1.000 1.000 604 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(3), GOT1(2), GOT2(3), PAH(3), TAT(4), YARS(1), YARS2(2) 2995549 21 16 21 10 6 9 4 1 1 0 0.874 1.000 1.000 605 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(4), NR1I3(5), PTGS1(5), PTGS2(4) 1823069 20 15 20 10 5 4 6 3 2 0 0.891 1.000 1.000 606 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), GOT1(2), GOT2(3), LDHA(3), LDHB(2), LDHC(5) 2352288 17 14 17 11 5 4 4 2 2 0 0.980 1.000 1.000 607 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(1), FH(7), IDH2(2), MDH1(2), OGDH(1), SDHA(4) 3216534 18 13 18 14 5 4 4 3 2 0 0.987 1.000 1.000 608 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO3(2), FARS2(1), GOT1(2), GOT2(3), PAH(3), TAT(4), YARS(1) 2843951 19 13 19 10 5 9 3 2 0 0 0.915 1.000 1.000 609 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(4), SDHA(4), SDHB(1), SDHD(1) 2269619 13 11 13 14 2 1 8 1 1 0 1.000 1.000 1.000 610 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY6(1) 2030772 12 11 12 11 2 1 5 2 2 0 0.979 1.000 1.000 611 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(2), ESR1(1), MAPK3(1), PELP1(2), SRC(2) 5057923 12 10 12 6 4 1 5 0 2 0 0.777 1.000 1.000 612 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT3(2), ST3GAL3(1) 1754827 6 6 6 4 3 0 2 1 0 0 0.872 1.000 1.000 613 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), MST1(1), MST1R(4) 2269848 6 6 6 8 1 2 3 0 0 0 0.998 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 628834 5 5 5 4 0 1 0 4 0 0 0.964 1.000 1.000 615 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 248236 1 1 1 3 1 0 0 0 0 0 0.998 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 718144 1 1 1 2 0 0 0 1 0 0 0.990 1.000 1.000