rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(4), IL12A(3), IL2(5) 1033019 14 12 13 1 2 7 2 2 1 0 0.149 0.228 1.000 2 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(4), COQ5(5), COQ6(3), COQ7(1), NDUFA12(2), NDUFA13(4), NDUFB11(1) 1380412 20 14 20 2 5 5 5 1 4 0 0.0820 0.297 1.000 3 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(3), CDK2(4), CDKN1B(3), CUL1(6), E2F1(3), NEDD8(2), SKP2(4), TFDP1(3), UBE2M(1) 2352746 29 22 29 4 5 6 10 6 2 0 0.0820 0.339 1.000 4 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(7), SNAP25(4), STX1A(3) 1118665 16 13 16 3 5 3 5 1 2 0 0.203 0.342 1.000 5 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(9), CYP2C9(3) 690893 12 11 12 3 2 3 3 2 2 0 0.540 0.389 1.000 6 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NFS1(4), PHPT1(1), TPK1(5) 2218323 25 20 25 3 1 9 6 7 1 1 0.150 0.532 1.000 7 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), FBXW7(4), TFDP1(3) 2268932 24 18 24 2 5 6 8 5 0 0 0.0354 0.580 1.000 8 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(6) 566088 6 5 6 0 0 3 2 1 0 0 0.237 0.597 1.000 9 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(9), BCMO1(4) 1334612 16 14 16 3 2 4 5 1 4 0 0.329 0.628 1.000 10 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2), ALDOB(4), ALDOC(1), TPI1(6) 1340337 13 10 13 0 0 5 4 2 2 0 0.0430 0.713 1.000 11 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(2) 390674 2 2 2 1 0 0 1 1 0 0 0.860 0.760 1.000 12 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 173582 1 1 1 3 0 0 0 0 1 0 0.995 0.765 1.000 13 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(3), GRIA2(15), PPP1R1B(1) 1325681 20 19 20 8 1 6 5 1 7 0 0.779 0.857 1.000 14 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(3), MMP2(13), MMP9(10), RECK(6), TIMP1(1), TIMP4(1) 2582662 35 26 35 6 3 6 15 6 5 0 0.106 0.871 1.000 15 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(3), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PGK1(5), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(2), TPI1(6) 6166283 65 42 64 7 10 19 16 10 10 0 0.00257 0.875 1.000 16 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(1), HGD(4) 772188 6 5 6 1 1 3 0 0 2 0 0.479 0.897 1.000 17 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(22), ATR(16), CDC25C(3), CHEK1(6), CHEK2(2) 5229444 49 38 48 5 2 13 17 10 7 0 0.0550 0.898 1.000 18 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), TGDS(2), UGDH(4), UXS1(4) 1340337 13 12 13 3 1 3 5 1 3 0 0.590 0.903 1.000 19 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), HADH(4), HADHA(3), HADHB(4), HSD17B4(5), MECR(1), PPT1(2), PPT2(7) 2924330 30 23 28 5 4 5 9 3 8 1 0.129 0.914 1.000 20 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(3), TAT(4) 902718 9 8 9 3 4 3 1 1 0 0 0.595 0.918 1.000 21 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(2), CCNE1(3), CDC34(1), CDK2(4), CUL1(6), E2F1(3), SKP2(4), TFDP1(3) 2348395 26 20 26 5 6 7 8 5 0 0 0.200 0.923 1.000 22 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL16(9), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2) 3410955 36 29 35 5 2 15 11 6 2 0 0.0670 0.927 1.000 23 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), SPCS1(1), SPCS3(1) 1063476 7 7 7 2 0 1 3 2 1 0 0.615 0.941 1.000 24 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), TGDS(2), UGDH(4), UGP2(1), UXS1(4) 1699180 14 12 14 3 2 3 5 1 3 0 0.522 0.947 1.000 25 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(3), CSF1(1), HLA-DRA(3), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL15(2), IL1A(3), IL2(5), IL3(1), IL4(1), LTA(2), PDGFA(6), TGFB1(2), TGFB2(8), TGFB3(1) 4545421 51 39 50 9 4 17 13 10 7 0 0.0994 0.955 1.000 26 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), ACAT2(1), OXCT1(4) 1160343 6 5 6 2 1 1 1 1 1 1 0.778 0.984 1.000 27 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 524181 2 1 2 0 1 1 0 0 0 0 0.608 0.986 1.000 28 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(3), CD80(4), HLA-DRA(3), IL10(1), IL2(5), IL4(1) 1359344 18 16 17 5 0 8 4 3 3 0 0.674 0.991 1.000 29 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(3), HLA-DRA(3) 809744 7 7 7 3 0 2 3 1 1 0 0.821 0.993 1.000 30 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(8), HADHA(3), SDS(2) 1650174 13 11 12 4 1 5 3 1 2 1 0.726 0.993 1.000 31 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(4), ACAT1(1), ACAT2(1), EHHADH(8), HADHA(3), HADHB(4), SDS(2) 2851966 23 19 22 5 1 6 8 2 5 1 0.406 0.994 1.000 32 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLS2(2), GLUD1(3), GLUD2(5) 1555597 13 12 13 4 1 4 6 2 0 0 0.636 0.994 1.000 33 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(1) 581889 1 1 1 1 0 0 1 0 0 0 0.956 0.995 1.000 34 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 4 GGT1(1), SHMT1(2), SHMT2(2) 1134008 5 5 5 2 3 0 2 0 0 0 0.567 0.995 1.000 35 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(4), CD3D(2), CD4(3), CD58(1), CD8A(2), IL3(1) 2134738 16 13 16 4 3 2 6 2 3 0 0.329 0.996 1.000 36 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(5), CSAD(3), GAD1(5), GAD2(9), GGT1(1) 1941004 23 19 23 6 5 3 6 6 3 0 0.434 0.997 1.000 37 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(4), CASP8(4), CFLAR(1), PDE6D(1) 1316521 11 7 11 5 4 0 4 1 2 0 0.793 0.998 1.000 38 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3D(2), CD4(3) 1101948 7 7 7 6 0 2 2 1 2 0 0.969 0.999 1.000 39 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(3), ACAT1(1), HADHA(3) 1846885 7 7 7 5 0 0 1 2 3 1 0.971 0.999 1.000 40 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACAT2(1), ACYP2(1), EHHADH(8), GCDH(3), HADHA(3), SDHB(1), SDS(2) 2671972 20 17 18 5 1 5 9 1 3 1 0.530 0.999 1.000 41 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 22 ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), GOT1(2), GOT2(3), GPT2(3), MDH1(2), MDH2(2), ME1(1), ME3(2), PGK1(5), PGK2(14), PKLR(11), PKM2(4), RPE(2), RPIA(5), TKT(2), TKTL1(10), TPI1(6) 6460777 82 55 81 14 12 25 18 14 13 0 0.0198 0.999 1.000 42 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(2), IFNG(4), IL2(5), IL2RA(3), IL4(1), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(12), TOB1(1), TOB2(3) 3648199 47 35 45 10 6 19 8 7 7 0 0.279 0.999 1.000 43 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(1), FMOD(2), KERA(3), LUM(6) 1242783 18 15 18 5 2 5 3 6 2 0 0.587 0.999 1.000 44 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CHEK1(6), MYT1(6), WEE1(3) 4733659 45 34 44 8 2 12 11 10 10 0 0.253 0.999 1.000 45 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(1) 1101032 5 5 5 3 0 2 2 0 1 0 0.873 0.999 1.000 46 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(4), IFNGR1(3), IFNGR2(3), JAK1(8), JAK2(4), STAT1(4) 2833188 26 23 26 6 4 4 8 5 5 0 0.380 0.999 1.000 47 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 4 DDC(6), GOT1(2), GOT2(3), TAT(4) 1245073 15 13 15 5 5 4 1 3 2 0 0.604 0.999 1.000 48 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF3(1), CCND1(2), CDK2(4), CDK4(2), CDKN1A(1), CDKN1B(3), E2F1(3), MDM2(2), NXT1(1), PRB1(2) 2444804 21 14 21 5 7 6 3 2 3 0 0.340 0.999 1.000 49 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), DHFR(1), FPGS(1), GCH1(4), GGH(4), SPR(1) 2288626 25 20 25 7 2 2 8 6 7 0 0.518 0.999 1.000 50 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2) 1931157 41 26 41 11 2 29 3 4 3 0 0.600 1.000 1.000 51 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(7), SNCA(3), SNCAIP(4), UBE2E2(1), UBE2G2(1), UBE2L6(1) 2197713 22 19 22 5 2 11 6 2 1 0 0.431 1.000 1.000 52 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(14), PNPO(1), PSAT1(2) 1669868 17 15 17 7 2 7 2 2 4 0 0.863 1.000 1.000 53 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(5), BCKDK(2), CBS(1), CTH(1), MUT(6) 1685440 15 13 15 9 2 5 3 1 4 0 0.963 1.000 1.000 54 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(4), JAK1(8), PTPRU(10), REG1A(9), STAT1(4), STAT2(5), TYK2(2) 4318711 42 33 41 8 4 13 8 10 7 0 0.202 1.000 1.000 55 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(5), HDC(7), TH(2), TPH1(11) 2096495 27 17 27 8 7 6 5 6 3 0 0.577 1.000 1.000 56 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(5), PRKCA(7), PTK2B(8) 2300534 20 16 20 5 8 6 5 1 0 0 0.369 1.000 1.000 57 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 6 EPHX2(1), HSD3B7(2), RDH11(2) 1449570 5 5 5 2 0 3 2 0 0 0 0.796 1.000 1.000 58 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(2), IFNB1(4), JAK1(8), STAT1(4), STAT2(5), TYK2(2) 3732929 25 23 25 5 1 4 6 8 6 0 0.418 1.000 1.000 59 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(2), BFAR(1), CAMP(2), CREB5(7), RAF1(3), SNX13(3), SRC(2) 3428130 20 12 20 4 6 6 4 2 2 0 0.310 1.000 1.000 60 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), HPRT1(1), IMPDH1(4), MTHFD2(1), POLB(2), POLD1(2), POLG(10), PRPS2(2), RRM1(5), SRM(2) 4356954 30 21 30 5 11 3 9 4 3 0 0.0746 1.000 1.000 61 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(1), CRY1(3), CRY2(2), CSNK1E(5), PER1(3) 2947917 16 11 16 3 7 3 5 0 1 0 0.215 1.000 1.000 62 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3) 2760595 31 24 31 9 5 10 9 4 3 0 0.452 1.000 1.000 63 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3) 2760595 31 24 31 9 5 10 9 4 3 0 0.452 1.000 1.000 64 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2), HLA-DRA(3), IL3(1) 1035309 6 6 6 3 0 1 3 2 0 0 0.878 1.000 1.000 65 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(11), GNA12(1), PRKACB(3), PRKACG(1), PRKAR2A(1) 3484922 17 13 17 3 2 5 6 2 2 0 0.274 1.000 1.000 66 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(6), ANKRD1(6), CYR61(1), DUSP14(1), EIF4E(3), HBEGF(1), IFNG(4), IFRD1(1), IL1A(3), IL1R1(1), MYOG(1), NR4A3(2), WDR1(2) 3770714 32 24 32 7 6 7 13 4 2 0 0.233 1.000 1.000 67 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(2), PON1(3), PON3(5), RDH11(2) 2890209 20 18 20 5 1 7 7 4 1 0 0.406 1.000 1.000 68 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(1), FUT1(2), FUT3(2), ST3GAL3(1), ST3GAL4(2) 2472284 14 10 14 4 4 4 4 1 1 0 0.471 1.000 1.000 69 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), GGPS1(1), IDI1(1), SQLE(1) 1470867 6 6 6 4 0 3 2 0 1 0 0.922 1.000 1.000 70 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(6), EGF(8), EGFR(33), RAB5A(1), TF(4), TFRC(6) 4416036 58 40 44 12 4 15 10 17 12 0 0.464 1.000 1.000 71 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(4), FADD(1), RIPK1(4), TNFRSF1B(1), TRAF2(1) 2916544 15 12 15 3 1 2 7 2 3 0 0.382 1.000 1.000 72 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(3), MAX(3), SP1(1), SP3(4), WT1(8) 2139776 19 18 19 8 1 7 4 3 4 0 0.891 1.000 1.000 73 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(2), CREBBP(4), DFFA(3), DFFB(2), GZMA(4), GZMB(3), HMGB2(4), PRF1(5), SET(1) 3651634 29 21 29 6 5 9 7 4 4 0 0.336 1.000 1.000 74 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(3), GLUD1(3), OAT(1) 1919478 11 10 11 4 2 1 6 1 1 0 0.672 1.000 1.000 75 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(1), FXYD2(1), JUN(1), MAFG(1), MAPK14(1), MAPK8(3), NFE2L2(5), PRKCA(7) 2664186 20 17 20 7 5 4 5 1 5 0 0.734 1.000 1.000 76 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(4), CD36(4), FOS(1), FYN(3), JUN(1), MAPK14(1), THBS1(4) 2528847 18 12 17 5 5 4 2 3 4 0 0.583 1.000 1.000 77 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(4), CASP7(1), DFFA(3), DFFB(2), GZMB(3), HMGB2(4), TOP2A(6), TOP2B(4) 3305615 27 18 26 6 8 6 4 5 4 0 0.461 1.000 1.000 78 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(2), CCNA2(4), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1B(3), E2F1(3), PRB1(2) 2919979 25 18 25 7 6 6 7 3 3 0 0.401 1.000 1.000 79 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(4), LPL(5), NR3C1(3), PPARG(3), RXRA(1) 1996193 16 15 16 8 1 6 3 3 3 0 0.943 1.000 1.000 80 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDC25A(4), CDC25B(1), CDC25C(3), CDK7(3), MNAT1(2), SHH(4), XPO1(3) 3034937 22 18 22 5 1 7 6 5 3 0 0.484 1.000 1.000 81 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(4), HRAS(1), PTK2B(8), SHC1(2), SOS1(12), SRC(2) 3031273 29 19 29 8 8 8 5 7 1 0 0.438 1.000 1.000 82 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(7), APC(23), AXIN1(3), BTRC(9), CTNNB1(11), DLL1(5), DVL1(1), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(1), WNT1(3) 7428531 76 52 73 12 10 18 24 10 14 0 0.0331 1.000 1.000 83 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), ACAT2(1), BDH2(1), HMGCS1(5), HMGCS2(5), OXCT1(4) 2479383 17 12 17 5 1 5 4 3 2 2 0.676 1.000 1.000 84 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(1), LDLR(5), LPL(5) 1832916 12 12 12 6 1 3 3 3 2 0 0.922 1.000 1.000 85 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB4A(2), RAB5A(1) 1469493 7 7 7 3 0 2 1 3 1 0 0.895 1.000 1.000 86 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(9), LARS(7), LARS2(2), PDHA1(3), PDHA2(13) 3442557 35 28 35 9 3 11 8 8 5 0 0.572 1.000 1.000 87 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), WASF1(8), WASL(5) 2788991 28 22 28 9 1 9 9 3 6 0 0.847 1.000 1.000 88 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 8 ACP1(2), ACP2(1), ACP5(3), ACPP(7), ENPP1(6), FLAD1(3) 2355494 22 20 22 9 0 4 10 5 3 0 0.788 1.000 1.000 89 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(2), PRKCA(7), TGM2(3) 1714523 16 14 16 5 4 5 4 2 1 0 0.577 1.000 1.000 90 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(2), HRAS(1), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NGFR(2), RAF1(3) 2857691 21 18 21 6 3 6 5 5 2 0 0.397 1.000 1.000 91 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(5), SRP19(1), SRP54(2), SRP68(2), SRP72(2), SRPR(4) 2570754 17 11 16 9 3 5 6 0 3 0 0.967 1.000 1.000 92 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST6GALNAC4(1), ST8SIA1(2) 1949706 11 11 11 8 3 0 6 0 2 0 0.935 1.000 1.000 93 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(5), LDLR(5), MBTPS1(6), MBTPS2(2), SCAP(4), SREBF1(2), SREBF2(1) 4127496 25 20 25 6 3 4 10 4 3 1 0.303 1.000 1.000 94 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(7), KARS(4) 1625442 14 10 14 6 3 4 3 3 1 0 0.883 1.000 1.000 95 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(3), CD8A(2), CSF1(1), EPO(3), IL2(5), IL3(1), IL4(1) 2063748 16 14 15 5 0 8 4 2 2 0 0.592 1.000 1.000 96 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(16), HSD17B2(3), HSD17B3(1), HSD17B4(5), HSD17B7(1), HSD3B1(7), HSD3B2(13) 2802273 49 36 48 13 6 17 12 7 6 1 0.460 1.000 1.000 97 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(3), FUT1(2), FUT9(7), GCNT2(2), ST8SIA1(2) 2110693 17 17 16 9 3 3 5 4 2 0 0.912 1.000 1.000 98 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), NFYC(2), SP1(1), SP3(4) 1674448 8 7 8 5 1 1 2 3 1 0 0.916 1.000 1.000 99 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(3), CPOX(4), FECH(2), HMBS(3), PPOX(3) 2627546 17 12 17 5 4 4 4 3 2 0 0.551 1.000 1.000 100 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), CD4(3), HLA-DRA(3), IL4(1), IL5RA(5) 1824443 14 14 14 5 0 4 6 3 1 0 0.754 1.000 1.000 101 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(7), DLL1(5), FURIN(7), NOTCH1(8), PSEN1(1) 3239434 28 22 28 8 7 6 5 3 7 0 0.539 1.000 1.000 102 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(33), MAP2K1(6), MAP3K1(4), MAPK14(1), NCOR2(13), RARA(3), RXRA(1), THRA(1), THRB(5) 5922398 75 52 61 18 8 14 14 22 17 0 0.404 1.000 1.000 103 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(18), RANGAP1(2) 2892499 20 14 20 8 5 7 4 1 2 1 0.870 1.000 1.000 104 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(1), CHEK1(6), NEK1(6), WEE1(3) 2473429 24 19 24 8 1 9 6 6 2 0 0.827 1.000 1.000 105 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(6), EIF2AK4(6), EIF2B5(3), EIF2S3(2), EIF5(1), GSK3B(2), PPP1CA(2) 3996966 22 15 22 5 4 10 5 1 2 0 0.533 1.000 1.000 106 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), KARS(4) 2393279 22 17 22 8 5 7 4 4 2 0 0.833 1.000 1.000 107 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(3), DNAJC3(3), MAP3K14(1), NFKB1(3), NFKBIA(1) 3084859 11 10 11 7 1 1 5 0 4 0 0.967 1.000 1.000 108 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(22), CDC25A(4), CDC25B(1), CDC25C(3), CDK2(4), CDK4(2), CHEK1(6), MYT1(6), WEE1(3) 5156164 51 35 50 10 7 13 11 10 10 0 0.216 1.000 1.000 109 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(4), IFNGR1(3), JAK1(8), JAK2(4), PLA2G2A(3), PTPRU(10), REG1A(9), STAT1(4) 3982997 45 35 44 10 5 14 9 9 8 0 0.313 1.000 1.000 110 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CSNK1D(2), DRD1(3), DRD2(9), GRM1(26), PLCB1(18), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 5549128 80 61 79 18 11 27 28 3 11 0 0.120 1.000 1.000 111 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(1), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2), SDHB(1) 3049364 21 18 21 6 2 6 5 4 4 0 0.593 1.000 1.000 112 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SUOX(5) 2092144 20 18 20 7 2 6 7 4 1 0 0.740 1.000 1.000 113 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(5), NR0B2(1), NR1H3(3), NR1H4(5), RXRA(1) 1876884 16 13 16 6 1 3 7 4 1 0 0.742 1.000 1.000 114 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(3), EIF2S3(2), EIF4E(3), GSK3B(2), IGF1(5), IGF1R(10), INPPL1(6), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2) 6777484 59 37 55 11 10 18 18 5 8 0 0.0983 1.000 1.000 115 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(2), AKT3(5), CDKN1A(1), ELK1(2), GRB2(4), HRAS(1), MAP2K1(6), MAP2K2(1), NGFR(2), NTRK1(12), PIK3CA(11), PIK3CD(1), SHC1(2), SOS1(12) 5622866 62 47 58 14 4 17 18 15 8 0 0.200 1.000 1.000 116 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMD14(2), RPN2(4), UBE2A(4), UBE3A(8) 4451531 31 22 31 7 6 8 8 6 3 0 0.255 1.000 1.000 117 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2) 3607666 23 22 23 7 1 5 6 7 4 0 0.683 1.000 1.000 118 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA2(3), IL4R(5), JAK1(8), JAK2(4), TYK2(2) 3607666 23 22 23 7 1 5 6 7 4 0 0.683 1.000 1.000 119 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(30), PGM1(2), PYGL(3), PYGM(6), TPI1(6), TREH(1) 4612976 53 40 53 12 8 20 19 3 3 0 0.144 1.000 1.000 120 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(3), CPO(3), FECH(2), GATA1(2), HBB(4), HMBS(3) 2723039 19 14 19 7 3 10 2 2 2 0 0.757 1.000 1.000 121 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2) 2714337 23 17 22 8 8 1 9 2 3 0 0.487 1.000 1.000 122 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(5), BMPR2(2) 2163363 13 10 13 6 3 2 4 3 1 0 0.883 1.000 1.000 123 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(2), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5) 2119166 14 11 14 6 1 5 4 3 1 0 0.795 1.000 1.000 124 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(1), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(4), MTHFD2(1) 4388785 29 23 29 9 6 10 5 3 5 0 0.569 1.000 1.000 125 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), GSR(1), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), OPLAH(5), TXNDC12(1) 7431279 71 43 71 14 9 21 26 7 7 1 0.0419 1.000 1.000 126 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17) 5740343 54 37 53 12 16 5 20 7 6 0 0.114 1.000 1.000 127 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), SDS(2) 4179479 44 33 43 12 6 15 12 5 5 1 0.403 1.000 1.000 128 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMC2(2), PSMD1(4), PSMD11(5), PSMD12(4), PSMD13(2), PSMD2(3), PSMD6(1) 5480886 34 24 34 8 8 10 9 4 3 0 0.233 1.000 1.000 129 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(23), AXIN1(3), CCND1(2), CD14(1), CTNNB1(11), DVL1(1), FZD1(3), GJA1(6), GNAI1(3), GSK3B(2), IRAK1(3), LBP(5), LEF1(8), LY96(1), MYD88(3), NFKB1(3), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), TLR4(31), TOLLIP(1), WNT1(3) 10579800 129 81 124 24 13 32 42 18 24 0 0.0338 1.000 1.000 130 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(4), ACO2(1), ACSS1(4), ACSS2(4), FH(7), IDH1(2), IDH2(2), MDH1(2), MDH2(2) 4555955 30 23 30 9 5 7 7 6 5 0 0.505 1.000 1.000 131 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GUSB(5), HEXA(1), IDS(3), IDUA(2), LCT(30), NAGLU(1) 4924874 43 37 43 11 5 14 13 4 7 0 0.372 1.000 1.000 132 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(3), B3GAT3(1), CHPF(3), CHST11(1), CHST12(3), CHST13(3), CHST3(2), CHSY1(2), DSE(10), UST(1), XYLT1(19) 4717629 49 42 49 12 4 12 20 8 5 0 0.188 1.000 1.000 133 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(4), HRAS(1), KLK2(4), NTRK1(12), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), SHC1(2), SOS1(12) 5335700 61 47 57 15 9 17 18 10 7 0 0.308 1.000 1.000 134 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(23), AXIN1(3), BTRC(9), CCND1(2), CREBBP(4), CSNK1A1(1), CSNK1D(2), CTNNB1(11), DVL1(1), FZD1(3), GSK3B(2), HDAC1(3), MAP3K7(5), PPARD(2), PPP2CA(1), TLE1(3), WNT1(3) 10187065 78 54 75 14 11 19 25 10 13 0 0.0579 1.000 1.000 135 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(11), PIK3R1(3), PLCB1(18), PLCG1(5), PRKCA(7), VAV1(1) 4363824 45 38 42 11 7 12 17 2 7 0 0.365 1.000 1.000 136 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(1), PSMA6(3), PSMA7(1), PSMB4(4), PSMB5(1), PSMB6(1), PSMB9(1) 3000587 14 9 14 7 4 4 4 1 1 0 0.811 1.000 1.000 137 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), CS(1), MDH1(2), ME1(1), PC(1), PDHA1(3), SLC25A11(2) 3167986 12 11 12 6 3 2 3 3 1 0 0.823 1.000 1.000 138 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(1), CTH(1), GGT1(1), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), PAPSS1(3), PAPSS2(4), SCLY(2), SEPHS1(4) 4248179 36 25 36 10 9 10 10 2 5 0 0.357 1.000 1.000 139 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS(9), IARS2(7), ILVBL(1), LARS(7), LARS2(2), PDHA1(3), PDHA2(13), VARS(6), VARS2(8) 6351773 58 43 58 14 8 16 14 11 9 0 0.305 1.000 1.000 140 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(20), ABCB11(15), ABCB4(17), ABCC1(7), ABCC3(7), GSTP1(2) 4930599 68 52 67 20 6 18 22 10 12 0 0.477 1.000 1.000 141 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(4), CHIT1(4), CMAS(3), CYB5R1(1), GFPT1(4), GFPT2(6), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), NAGK(1), NANS(2), NPL(3), PGM3(4), PHPT1(1), RENBP(3), UAP1(6) 9867381 87 58 87 19 15 23 17 22 10 0 0.135 1.000 1.000 142 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(23), AXIN1(3), CREBBP(4), CTNNB1(11), DVL1(1), EP300(2), FZD1(3), GSK3B(2), HDAC1(3), LDB1(1), LEF1(8), PITX2(4), TRRAP(24), WNT1(3) 11428703 92 56 90 16 17 19 27 13 16 0 0.0195 1.000 1.000 143 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(4), CD2(3), CD33(10), CD5(4), IFNB1(4), IFNG(4), IL10(1), IL12A(3), IL13(1), IL3(1), IL4(1), ITGAX(20), TLR2(2), TLR4(31), TLR7(8), TLR9(6) 6388184 103 69 103 28 9 35 24 19 15 1 0.325 1.000 1.000 144 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), E2F1(3), RBL1(7), TFDP1(3) 4756330 45 31 45 12 8 15 11 7 4 0 0.412 1.000 1.000 145 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(23), MAP2(17), PPP1CA(2), PPP2CA(1), PRKACB(3), PRKACG(1), PRKAR2A(1), PRKCE(3) 6259028 51 40 51 11 2 22 13 9 5 0 0.627 1.000 1.000 146 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), ITPKA(1), PDE1A(8), PDE1B(6), PLCB1(18), PLCB2(6), PRL(1), TRH(1), VIP(1) 3826590 46 37 46 13 7 14 13 3 9 0 0.505 1.000 1.000 147 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 ELK1(2), FOS(1), GRB2(4), HRAS(1), JUN(1), KLK2(4), MAP2K1(6), MAPK3(1), MAPK8(3), NGFR(2), PIK3CA(11), PIK3R1(3), PLCG1(5), RAF1(3), SHC1(2), SOS1(12) 6555125 61 45 58 16 9 16 19 12 5 0 0.327 1.000 1.000 148 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(23), ASAH1(2), CAMP(2), CASP3(4), CERK(3), CREB5(7), DAG1(2), EPHB2(5), FOS(1), GNAQ(2), ITPKA(1), ITPKB(5), JUN(1), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6) 9859137 85 58 85 19 12 19 25 10 19 0 0.175 1.000 1.000 149 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(2), E2F1(3), MDM2(2), PIK3CA(11), PIK3R1(3), POLR1A(8), POLR1B(10), POLR1D(2), TBX2(1), TWIST1(1) 5898582 43 29 39 11 8 8 17 6 4 0 0.270 1.000 1.000 150 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6) 5739656 52 45 52 14 6 19 20 4 3 0 0.404 1.000 1.000 151 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(10), GLI3(17), GSK3B(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SHH(4), SMO(5) 5808356 55 44 55 15 14 17 9 6 9 0 0.360 1.000 1.000 152 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(8), ATM(22), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1A(1), E2F1(3), GADD45A(1), MDM2(2), PCNA(1) 5352417 51 38 50 13 8 13 10 10 10 0 0.439 1.000 1.000 153 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(8), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), PRF1(5), SCAP(4), SREBF1(2), SREBF2(1) 6305515 51 36 51 13 7 11 12 10 11 0 0.352 1.000 1.000 154 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 11 BCAT1(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCS(1) 4178105 44 32 44 13 4 13 12 7 7 1 0.532 1.000 1.000 155 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(2), ATM(22), BRCA1(8), CDKN1A(1), CHEK1(6), CHEK2(2), GADD45A(1), JUN(1), MAPK8(3), MDM2(2), MRE11A(6), NFKB1(3), NFKBIA(1), RAD50(3), RAD51(1), RBBP8(3), TP73(4) 9990125 69 50 68 14 7 19 22 10 11 0 0.260 1.000 1.000 156 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), MTR(11) 6019952 59 43 59 16 10 16 19 7 6 1 0.329 1.000 1.000 157 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3) 4584351 65 39 65 20 5 37 9 8 6 0 0.646 1.000 1.000 158 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 ABI2(3), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), APC(23), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(11), ARHGEF4(4), ARHGEF6(9), ARHGEF7(6), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), ARPC5(1), BAIAP2(2), BCAR1(2), BDKRB1(1), BDKRB2(1), CD14(1), CDC42(2), CFL2(2), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CRKL(2), CYFIP1(7), CYFIP2(8), DIAPH1(4), DIAPH2(7), DIAPH3(6), DOCK1(7), EGF(8), EGFR(33), EZR(1), F2(5), F2R(4), FGD1(2), FGD3(6), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FN1(13), GNA12(1), GNA13(5), GNG12(2), GRLF1(9), GSN(3), HRAS(1), IQGAP1(5), IQGAP2(13), IQGAP3(6), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LIMK2(1), MAP2K1(6), MAP2K2(1), MAPK3(1), MOS(2), MRAS(1), MSN(1), MYH10(6), MYH14(2), MYH9(8), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLK(15), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(12), NRAS(4), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PFN1(1), PFN2(3), PFN4(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(11), PXN(1), RAC2(1), RAF1(3), RDX(2), RHOA(1), ROCK1(10), ROCK2(4), RRAS(1), RRAS2(1), SCIN(4), SLC9A1(3), SOS1(12), SOS2(6), SSH1(4), SSH2(4), SSH3(2), TIAM1(19), TIAM2(11), TMSL3(1), VAV1(1), VAV2(3), VAV3(14), VCL(2), WAS(3), WASF1(8), WASF2(1), WASL(5) 94893249 936 207 916 302 130 267 242 163 132 2 0.888 1.000 1.000 159 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY7(7), ADCY8(22), ADCY9(3), ADORA2B(1), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), AGTR1(5), ATP2A1(3), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), ATP2B4(8), AVPR1A(6), AVPR1B(3), BDKRB1(1), BDKRB2(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CCKAR(7), CCKBR(11), CD38(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM5(3), CHRNA7(3), CYSLTR1(1), CYSLTR2(3), DRD1(3), EDNRB(6), EGFR(33), ERBB2(10), ERBB3(3), ERBB4(21), F2R(4), GNA11(1), GNAQ(2), GNAS(7), GRIN1(2), GRIN2A(26), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), GRPR(5), HRH1(6), HRH2(6), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), LHCGR(6), MYLK(15), MYLK2(3), NOS1(9), NOS3(2), NTSR1(5), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), PDE1A(8), PDE1B(6), PDE1C(17), PDGFRA(17), PDGFRB(8), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PLN(1), PPID(1), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(6), PTK2B(8), RYR1(51), RYR2(165), RYR3(53), SLC25A5(2), SLC25A6(5), SLC8A1(26), SLC8A2(3), SLC8A3(7), SPHK2(2), TACR1(3), TACR3(8), TNNC2(2), TRHR(4), TRPC1(9), VDAC3(1) 93388948 1285 205 1259 463 153 419 354 210 144 5 0.994 1.000 1.000 160 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), ARHGAP5(7), BCAR1(2), BCL2(1), BIRC2(2), BIRC3(3), CAPN2(3), CAV3(2), CCND1(2), CCND2(1), CCND3(1), CDC42(2), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(34), COL4A1(16), COL4A2(15), COL4A4(13), COL4A6(17), COL5A1(18), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(34), COL6A6(24), COMP(2), CRKL(2), CTNNB1(11), DIAPH1(4), DOCK1(7), EGF(8), EGFR(33), ELK1(2), ERBB2(10), FARP2(3), FIGF(1), FLNA(11), FLNB(12), FLNC(19), FLT1(21), FN1(13), FYN(3), GRB2(4), GRLF1(9), GSK3B(2), HRAS(1), IBSP(2), IGF1(5), IGF1R(10), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), JUN(1), KDR(30), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(14), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), MAP2K1(6), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MET(12), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLK(15), MYLK2(3), MYLPF(1), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PARVA(2), PARVB(1), PARVG(3), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PIP5K1C(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(7), PRKCG(10), PTEN(8), PTK2(11), PXN(1), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF1(1), RELN(49), RHOA(1), ROCK1(10), ROCK2(4), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TLN1(13), TLN2(16), TNC(21), TNN(34), TNR(40), TNXB(14), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCL(2), VEGFA(1), VEGFC(11), VTN(2), VWF(13), ZYX(2) 127296291 1528 205 1495 495 201 499 373 221 231 3 0.985 1.000 1.000 161 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(6), ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA2A(1), ADRA2B(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), C5AR1(4), CALCR(8), CALCRL(10), CCKAR(7), CCKBR(11), CGA(1), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CRHR1(1), CRHR2(2), CTSG(2), CYSLTR1(1), CYSLTR2(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), EDNRB(6), F2(5), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHB(1), FSHR(20), GABBR1(3), GABBR2(6), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GABRB1(11), GABRB2(3), GABRD(1), GABRE(3), GABRG1(14), GABRG2(10), GABRG3(10), GABRP(5), GABRQ(11), GABRR1(6), GABRR2(5), GALR1(3), GALR2(1), GH1(2), GH2(5), GHR(5), GHRHR(5), GHSR(4), GIPR(2), GLP1R(1), GLP2R(9), GLRA1(5), GLRA2(10), GLRA3(2), GLRB(4), GNRHR(2), GPR156(6), GPR50(7), GPR63(4), GPR83(4), GRIA1(12), GRIA2(15), GRIA3(11), GRIA4(9), GRID1(15), GRID2(22), GRIK1(11), GRIK2(19), GRIK3(10), GRIK4(8), GRIK5(6), GRIN1(2), GRIN2A(26), GRIN2B(21), GRIN2C(3), GRIN2D(6), GRIN3A(19), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM6(7), GRM7(15), GRM8(19), GRPR(5), GZMA(4), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HRH4(4), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3), LEP(4), LEPR(13), LHB(1), LHCGR(6), LTB4R(2), MAS1(3), MC2R(2), MC3R(9), MC4R(1), MC5R(10), MCHR2(6), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPBWR1(4), NPBWR2(2), NPY1R(9), NPY2R(6), NPY5R(9), NR3C1(3), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(4), P2RX3(3), P2RX4(1), P2RX5(4), P2RX7(5), P2RY1(5), P2RY14(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PPYR1(2), PRL(1), PRLHR(5), PRLR(9), PRSS1(10), PRSS3(1), PTAFR(2), PTGDR(3), PTGER2(2), PTGER3(3), PTGER4(7), PTGFR(6), PTGIR(2), PTH2R(8), RXFP1(11), RXFP2(4), SCTR(1), SSTR1(3), SSTR3(2), SSTR4(5), SSTR5(2), TAAR1(4), TAAR2(6), TAAR5(8), TAAR6(7), TAAR8(5), TAAR9(4), TACR1(3), TACR3(8), THRA(1), THRB(5), TRHR(4), TRPV1(4), TSHB(1), TSHR(10), UTS2R(1), VIPR2(4) 75308940 1231 198 1225 487 129 446 307 217 130 2 1.000 1.000 1.000 162 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 243 ACVR1B(5), ACVR1C(3), AKT2(2), AKT3(5), ARRB1(2), ARRB2(1), ATF2(5), ATF4(1), BDNF(1), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1F(10), CACNA1G(10), CACNA1H(10), CACNA1I(7), CACNA1S(11), CACNA2D1(19), CACNA2D2(1), CACNA2D3(14), CACNA2D4(6), CACNB1(1), CACNB2(7), CACNB4(1), CACNG1(1), CACNG2(1), CACNG3(7), CACNG4(2), CACNG5(6), CACNG6(3), CACNG7(1), CACNG8(2), CASP3(4), CD14(1), CDC25B(1), CDC42(2), CHUK(3), CRKL(2), DAXX(6), DDIT3(4), DUSP10(6), DUSP14(1), DUSP16(2), DUSP2(1), DUSP6(3), DUSP7(2), DUSP8(1), DUSP9(2), EGF(8), EGFR(33), ELK1(2), ELK4(4), FAS(3), FASLG(3), FGF1(1), FGF10(2), FGF12(4), FGF13(6), FGF18(1), FGF19(2), FGF20(1), FGF21(2), FGF23(4), FGF3(1), FGF4(2), FGF5(2), FGF9(1), FGFR1(5), FGFR2(8), FGFR3(2), FGFR4(3), FLNA(11), FLNB(12), FLNC(19), FOS(1), GADD45A(1), GNA12(1), GNG12(2), GRB2(4), HRAS(1), IKBKB(3), IL1A(3), IL1R1(1), IL1R2(4), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K12(6), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP4K1(5), MAP4K3(5), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAPT(8), MAX(3), MEF2C(2), MKNK1(2), MKNK2(1), MOS(2), MRAS(1), NF1(30), NFATC2(8), NFATC4(8), NFKB1(3), NFKB2(6), NR4A1(2), NRAS(4), NTF3(7), NTRK1(12), NTRK2(9), PAK1(5), PAK2(3), PDGFA(6), PDGFB(1), PDGFRA(17), PDGFRB(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PPM1B(4), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PPP5C(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PTPN5(4), PTPRR(8), RAC2(1), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF2(10), RASA1(3), RASA2(3), RASGRF1(1), RASGRF2(14), RASGRP1(2), RASGRP3(8), RASGRP4(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(5), RRAS(1), RRAS2(1), SOS1(12), SOS2(6), STK4(4), STMN1(1), TAOK1(1), TAOK2(6), TAOK3(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TRAF2(1), TRAF6(4), ZAK(3) 98008336 957 197 935 307 148 233 261 169 141 5 0.728 1.000 1.000 163 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(2), CHAD(1), COL11A1(66), COL11A2(7), COL17A1(9), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(34), COL4A1(16), COL4A2(15), COL4A4(13), COL4A6(17), COL5A1(18), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(34), COL6A6(24), COMP(2), DSC1(10), DSC2(7), DSC3(13), DSG1(16), DSG2(8), DSG3(16), DSG4(16), FN1(13), GJA1(6), GJA10(5), GJA4(1), GJA5(3), GJA8(7), GJA9(5), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GJC1(4), GJC2(1), GJD2(2), GJD4(3), IBSP(2), INA(1), ITGA6(5), ITGB4(4), KRT1(4), KRT10(2), KRT12(2), KRT13(5), KRT14(3), KRT15(4), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(7), KRT20(2), KRT23(2), KRT24(7), KRT25(5), KRT28(8), KRT3(2), KRT31(4), KRT32(4), KRT33A(3), KRT33B(3), KRT34(4), KRT35(4), KRT36(4), KRT37(1), KRT38(8), KRT39(4), KRT4(2), KRT40(3), KRT5(7), KRT6A(7), KRT6B(13), KRT6C(2), KRT7(5), KRT71(8), KRT72(5), KRT73(9), KRT74(5), KRT75(7), KRT76(3), KRT78(1), KRT79(3), KRT8(3), KRT81(2), KRT82(6), KRT83(2), KRT84(3), KRT85(5), KRT86(4), KRT9(2), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(14), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), LMNB1(2), LMNB2(2), NES(10), RELN(49), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(14), VIM(2), VTN(2), VWF(13) 85825536 1147 191 1139 386 139 399 288 144 174 3 0.994 1.000 1.000 164 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD36(4), CD44(2), CD47(1), CHAD(1), COL11A1(66), COL11A2(7), COL1A1(4), COL1A2(19), COL2A1(7), COL3A1(34), COL4A1(16), COL4A2(15), COL4A4(13), COL4A6(17), COL5A1(18), COL5A2(30), COL5A3(12), COL6A1(4), COL6A2(3), COL6A3(34), COL6A6(24), DAG1(2), FN1(13), FNDC1(14), FNDC3A(7), FNDC4(1), FNDC5(1), GP5(3), GP6(3), HMMR(4), HSPG2(17), IBSP(2), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAV(9), ITGB1(3), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), LAMA1(36), LAMA2(33), LAMA3(25), LAMA4(15), LAMA5(14), LAMB1(21), LAMB2(13), LAMB3(8), LAMB4(23), LAMC1(14), LAMC2(9), LAMC3(13), RELN(49), SDC1(5), SDC3(2), SV2A(5), SV2B(8), SV2C(11), THBS1(4), THBS2(16), THBS3(6), THBS4(5), TNC(21), TNN(34), TNR(40), TNXB(14), VTN(2), VWF(13) 77840306 998 183 990 332 118 355 248 124 150 3 0.991 1.000 1.000 165 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 121 ABL1(2), ABLIM1(5), ABLIM2(2), ABLIM3(8), ARHGEF12(11), CDC42(2), CDK5(1), CFL2(2), CXCL12(1), CXCR4(3), DCC(22), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(10), EPHA2(2), EPHA3(25), EPHA4(9), EPHA5(26), EPHA8(7), EPHB2(5), EPHB3(6), EPHB4(7), EPHB6(24), FES(1), FYN(3), GNAI1(3), GNAI3(1), GSK3B(2), HRAS(1), ITGB1(3), L1CAM(15), LIMK2(1), LRRC4C(17), MAPK3(1), MET(12), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NGEF(4), NRAS(4), NRP1(4), NTN1(1), NTN4(5), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PLXNA1(8), PLXNA2(14), PLXNA3(8), PLXNB1(4), PLXNB2(8), PLXNB3(3), PLXNC1(11), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTK2(11), RAC2(1), RASA1(3), RGS3(9), RHOA(1), RHOD(1), ROBO1(14), ROBO2(21), ROBO3(12), ROCK1(10), ROCK2(4), SEMA3B(2), SEMA3C(6), SEMA3D(20), SEMA3E(6), SEMA3F(3), SEMA3G(4), SEMA4A(3), SEMA4C(1), SEMA4D(5), SEMA4F(5), SEMA4G(3), SEMA5A(24), SEMA5B(9), SEMA6A(10), SEMA6B(5), SEMA6C(9), SEMA6D(21), SEMA7A(7), SLIT1(16), SLIT2(28), SLIT3(16), SRGAP1(9), SRGAP2(4), SRGAP3(11), UNC5A(5), UNC5B(8), UNC5C(11), UNC5D(17) 64966613 767 181 760 261 111 230 199 112 114 1 0.928 1.000 1.000 166 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRB2(2), ADRB3(3), ANXA6(1), ARRB1(2), ARRB2(1), ATP1A4(15), ATP1B3(1), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(11), CACNA1A(10), CACNA1B(15), CACNA1C(26), CACNA1D(17), CACNA1E(50), CACNA1S(11), CACNB1(1), CALM1(2), CALR(1), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CASQ1(3), CASQ2(4), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), FXYD2(1), GJA1(6), GJA4(1), GJA5(3), GJB1(3), GJB3(1), GJB4(4), GJB5(3), GJB6(1), GNA11(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), ITPR1(11), ITPR2(25), ITPR3(6), KCNB1(16), KCNJ3(15), KCNJ5(1), MIB1(6), NME7(4), PEA15(3), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(3), RGS9(5), RYR1(51), RYR2(165), RYR3(53), SLC8A1(26), SLC8A3(7), USP5(3) 64933179 924 180 917 331 115 305 260 133 107 4 0.977 1.000 1.000 167 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 248 ACVR1(4), ACVR1B(5), ACVR2A(2), ACVR2B(4), AMH(1), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(1), BMPR1B(5), BMPR2(2), CCL13(2), CCL14(2), CCL15(3), CCL17(1), CCL18(1), CCL20(1), CCL22(1), CCL23(1), CCL25(1), CCL28(4), CCL3(1), CCL4(1), CCL7(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CD27(1), CD40LG(6), CNTF(1), CNTFR(3), CSF1(1), CSF1R(6), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(3), CX3CR1(5), CXCL1(2), CXCL12(1), CXCL16(1), CXCL5(1), CXCL6(4), CXCL9(3), CXCR3(1), CXCR4(3), CXCR6(1), EDA(2), EDA2R(2), EDAR(3), EGF(8), EGFR(33), EPO(3), EPOR(1), FAS(3), FASLG(3), FLT1(21), FLT3(10), FLT3LG(2), FLT4(13), GDF5(4), GH1(2), GH2(5), GHR(5), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL15(2), IL15RA(1), IL17A(4), IL17B(3), IL17RA(3), IL18R1(3), IL18RAP(8), IL19(1), IL1A(3), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL25(2), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), INHBB(1), INHBC(1), INHBE(3), KDR(30), KIT(6), LEP(4), LEPR(13), LIF(2), LIFR(5), LTA(2), LTB(1), MET(12), MPL(2), NGFR(2), OSM(2), OSMR(5), PDGFB(1), PDGFRA(17), PDGFRB(8), PLEKHO2(2), PRL(1), PRLR(9), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(7), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(16), TSLP(3), VEGFA(1), VEGFC(11), XCL1(3), XCL2(5), XCR1(1) 60369209 662 177 645 218 64 209 171 128 90 0 0.931 1.000 1.000 168 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), AKT2(2), AKT3(5), AMOTL1(7), ASH1L(22), CASK(3), CDC42(2), CDK4(2), CGN(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CSDA(2), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTTN(3), EPB41(1), EPB41L1(9), EPB41L2(9), EPB41L3(17), EXOC3(3), EXOC4(6), F11R(2), GNAI1(3), GNAI3(1), HCLS1(6), HRAS(1), IGSF5(3), INADL(25), JAM2(6), LLGL1(1), LLGL2(2), MAGI1(16), MAGI2(15), MAGI3(4), MLLT4(4), MPDZ(7), MPP5(1), MRAS(1), MYH1(36), MYH10(6), MYH11(15), MYH13(18), MYH14(2), MYH15(15), MYH2(35), MYH3(11), MYH4(24), MYH6(22), MYH7(20), MYH7B(6), MYH8(29), MYH9(8), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLPF(1), NRAS(4), OCLN(1), PARD3(6), PARD6B(3), PPM1J(1), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP2R3A(1), PPP2R3B(4), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PTEN(8), RAB13(2), RAB3B(1), RHOA(1), RRAS(1), RRAS2(1), SPTAN1(12), SRC(2), SYMPK(7), TJAP1(2), TJP1(10), TJP2(4), TJP3(2), VAPA(1), YES1(3), ZAK(3) 66166115 685 173 674 242 111 208 183 102 80 1 0.981 1.000 1.000 169 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(4), ACTA2(1), ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ARRB1(2), ARRB2(1), ATF2(5), ATF4(1), ATP2A2(6), ATP2A3(4), CALCA(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN1(2), CORIN(12), CRH(1), CRHR1(1), DGKZ(3), ETS2(3), FOS(1), GABPA(1), GBA2(2), GJA1(6), GNAQ(2), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GRK4(6), GRK5(8), GRK6(1), GUCA2B(3), GUCY1A3(6), IGFBP1(3), IGFBP2(1), IGFBP3(2), IGFBP4(1), ITPR1(11), ITPR2(25), ITPR3(6), JUN(1), MIB1(6), MYL2(3), MYL4(1), MYLK2(3), NFKB1(3), NOS1(9), NOS3(2), OXT(1), OXTR(2), PDE4B(7), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(2), PLCG1(5), PLCG2(9), PRKACB(3), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), RAMP2(1), RAMP3(2), RGS1(7), RGS11(1), RGS16(1), RGS18(5), RGS2(1), RGS20(5), RGS3(9), RGS4(4), RGS5(5), RGS6(3), RGS9(5), RYR1(51), RYR2(165), RYR3(53), SLC8A1(26), SP1(1), TNXB(14), USP5(3) 59804037 719 170 716 272 80 232 204 112 88 3 0.999 1.000 1.000 170 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CSNK1D(2), DRD1(3), DRD2(9), EGF(8), EGFR(33), GJA1(6), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAQ(2), GNAS(7), GRB2(4), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), HTR2A(3), HTR2B(2), HTR2C(5), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAP2K2(1), MAP3K2(5), MAPK3(1), MAPK7(5), NPR1(6), NPR2(2), NRAS(4), PDGFA(6), PDGFB(1), PDGFD(4), PDGFRA(17), PDGFRB(8), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), PRKX(3), RAF1(3), SOS1(12), SOS2(6), SRC(2), TJP1(10), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB8(7) 44864306 522 169 505 192 61 151 146 98 66 0 0.987 1.000 1.000 171 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ATF4(1), CACNA1C(26), CACNA1D(17), CACNA1F(10), CACNA1S(11), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(2), CGA(1), EGFR(33), ELK1(2), FSHB(1), GNA11(1), GNAQ(2), GNAS(7), GNRHR(2), GRB2(4), HBEGF(1), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), JUN(1), LHB(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK7(5), MAPK8(3), MAPK9(6), MMP14(3), MMP2(13), NRAS(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLD1(9), PLD2(6), PRKACB(3), PRKACG(1), PRKCA(7), PRKCD(1), PRKX(3), PTK2B(8), RAF1(3), SOS1(12), SOS2(6), SRC(2) 43901590 491 169 473 157 75 129 137 81 69 0 0.732 1.000 1.000 172 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 ALCAM(3), CADM1(2), CADM3(5), CD2(3), CD22(6), CD274(3), CD276(1), CD28(1), CD34(4), CD4(3), CD40LG(6), CD58(1), CD6(4), CD80(4), CD86(6), CD8A(2), CD8B(3), CD99(3), CDH1(5), CDH15(5), CDH2(20), CDH3(3), CDH4(9), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CNTN1(20), CNTN2(9), CNTNAP1(5), CNTNAP2(40), CTLA4(1), ESAM(1), F11R(2), GLG1(9), HLA-A(2), HLA-B(3), HLA-C(1), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), ICAM2(2), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(19), ITGA6(5), ITGA8(24), ITGA9(2), ITGAL(20), ITGAM(14), ITGAV(9), ITGB1(3), ITGB2(2), ITGB7(1), ITGB8(5), JAM2(6), L1CAM(15), MADCAM1(2), MAG(5), MPZ(1), MPZL1(2), NCAM1(8), NCAM2(13), NEGR1(5), NEO1(13), NFASC(11), NLGN2(4), NLGN3(3), NRCAM(14), NRXN2(11), NRXN3(18), OCLN(1), PDCD1(1), PDCD1LG2(3), PTPRC(21), PTPRF(4), PTPRM(6), PVRL1(4), SDC1(5), SDC3(2), SELE(6), SELL(4), SELP(14), SELPLG(3), SIGLEC1(7), SPN(3), VCAM1(17), VCAN(34) 49077677 628 165 625 224 88 213 164 92 70 1 0.977 1.000 1.000 173 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(23), APC2(2), AXIN1(3), AXIN2(2), BTRC(9), CACYBP(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND1(2), CCND2(1), CCND3(1), CER1(2), CHD8(13), CREBBP(4), CSNK1A1(1), CSNK1A1L(5), CSNK1E(5), CTNNB1(11), CUL1(6), CXXC4(3), DAAM1(3), DAAM2(4), DKK1(2), DKK2(4), DKK4(2), DVL1(1), DVL2(1), DVL3(5), EP300(2), FOSL1(3), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), JUN(1), LEF1(8), LRP5(5), LRP6(10), MAP3K7(5), MAPK10(5), MAPK8(3), MAPK9(6), MMP7(4), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKD1(5), NKD2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PORCN(3), PPARD(2), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRICKLE1(5), PRICKLE2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(10), ROCK2(4), RUVBL1(2), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(3), SFRP5(1), SKP1(2), SMAD2(2), SMAD3(3), SMAD4(8), SOX17(1), TBL1XR1(5), TCF7(1), TCF7L1(2), TCF7L2(3), VANGL1(3), VANGL2(8), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5) 55574636 480 164 476 141 82 114 148 62 74 0 0.265 1.000 1.000 174 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ARHGAP5(7), BCAR1(2), CD99(3), CDC42(2), CDH5(7), CLDN1(3), CLDN10(1), CLDN11(3), CLDN14(4), CLDN15(1), CLDN16(3), CLDN17(7), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(2), CLDN8(5), CLDN9(2), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTNND1(9), CXCL12(1), CXCR4(3), CYBB(7), ESAM(1), EZR(1), F11R(2), GNAI1(3), GNAI3(1), GRLF1(9), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), ITK(7), JAM2(6), MAPK11(1), MAPK14(1), MLLT4(4), MMP2(13), MMP9(10), MSN(1), MYL2(3), MYL5(1), MYL7(3), MYL9(1), MYLPF(1), NCF1(1), NCF2(2), NCF4(2), NOX1(4), NOX3(5), OCLN(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), PTK2B(8), PTPN11(6), PXN(1), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(6), RHOA(1), RHOH(2), ROCK1(10), ROCK2(4), SIPA1(1), THY1(1), TXK(5), VASP(3), VAV1(1), VAV2(3), VAV3(14), VCAM1(17), VCL(2) 42265156 451 162 444 143 58 140 128 73 52 0 0.722 1.000 1.000 175 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(1), ACTN2(23), ACTN3(3), ACTN4(2), DMD(41), FAM48A(2), MYBPC1(6), MYBPC2(3), MYBPC3(5), MYH3(11), MYH6(22), MYH7(20), MYH8(29), MYL1(3), MYL2(3), MYL3(2), MYL4(1), MYL9(1), MYOM1(4), NEB(36), TMOD1(3), TNNC2(2), TNNI1(2), TNNI2(4), TNNI3(2), TNNT2(4), TNNT3(3), TPM1(1), TPM2(2), TPM3(3), TPM4(1), TTN(374), VIM(2) 47583223 625 161 619 214 63 194 176 121 62 9 1.000 1.000 1.000 176 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(10), ACACB(11), AKT2(2), AKT3(5), ARAF(3), CALM1(2), CALML3(3), CBL(8), CBLB(5), CBLC(1), CRKL(2), ELK1(2), EXOC7(2), FASN(4), FBP2(1), FLOT1(2), FLOT2(1), FOXO1(3), G6PC(1), G6PC2(2), GCK(4), GRB2(4), GSK3B(2), GYS1(2), GYS2(3), HRAS(1), IKBKB(3), INPP5D(4), INSR(1), IRS1(15), IRS2(3), IRS4(17), LIPE(2), MAP2K1(6), MAP2K2(1), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), MKNK1(2), MKNK2(1), NRAS(4), PCK1(12), PCK2(3), PDE3A(13), PDE3B(9), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PHKA1(4), PHKA2(10), PHKB(7), PHKG1(1), PHKG2(3), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PKLR(11), PKM2(4), PPARGC1A(12), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R3A(12), PPP1R3B(1), PPP1R3C(1), PPP1R3D(4), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCI(7), PRKCZ(2), PRKX(3), PTPN1(1), PTPRF(4), PYGB(1), PYGL(3), PYGM(6), RAF1(3), RAPGEF1(1), RHEB(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOCS4(1), SORBS1(7), SOS1(12), SOS2(6), SREBF1(2), TSC1(9), TSC2(5) 54748633 445 160 437 165 77 112 129 69 58 0 0.956 1.000 1.000 177 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA1(1), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), AGTR1(5), AGTR2(2), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCBP2(2), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CCRL1(2), CCRL2(2), CHML(7), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), CNR1(4), CNR2(1), CX3CR1(5), CXCR3(1), CXCR4(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), EDNRB(6), F2R(4), F2RL1(1), F2RL2(5), F2RL3(2), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GPR17(3), GPR173(1), GPR27(1), GPR37(5), GPR37L1(2), GPR4(5), GPR50(7), GPR6(2), GPR63(4), GPR77(1), GPR83(4), GPR85(8), GPR87(2), GRPR(5), HCRTR1(1), HCRTR2(13), HRH1(6), HRH2(6), HRH3(1), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3), LHCGR(6), LTB4R(2), MAS1(3), MC3R(9), MC4R(1), MC5R(10), MLNR(1), MTNR1A(5), MTNR1B(6), NMBR(6), NMUR1(4), NMUR2(11), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPN1SW(3), OPN3(2), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OR10A5(9), OR11A1(3), OR12D3(1), OR1C1(14), OR1F1(3), OR1Q1(5), OR2H1(5), OR5V1(2), OR7A5(2), OR7C1(2), OR8B8(7), OXTR(2), P2RY1(5), P2RY12(4), P2RY14(1), P2RY6(1), PPYR1(2), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), RHO(1), RRH(2), SSTR1(3), SSTR3(2), SSTR4(5), SUCNR1(1), TRHR(4) 41040693 603 159 601 254 60 217 167 108 50 1 0.994 1.000 1.000 178 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(3), CACNA1A(10), CRH(1), CRHR1(1), GNA11(1), GNA12(1), GNA13(5), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GNAZ(4), GRIA1(12), GRIA2(15), GRIA3(11), GRID2(22), GRM1(26), GRM5(13), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), HRAS(1), IGF1(5), IGF1R(10), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP2K1(6), MAP2K2(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(6), NPR2(2), NRAS(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), PRKCA(7), PRKCG(10), PRKG1(3), PRKG2(7), RAF1(3), RYR1(51) 37469667 446 157 442 146 56 130 123 71 65 1 0.795 1.000 1.000 179 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(2), ACTG1(2), ACTN1(2), ACTN2(23), ACTN3(3), ACTN4(2), ACVR1B(5), ACVR1C(3), BAIAP2(2), CDC42(2), CDH1(5), CREBBP(4), CTNNA1(3), CTNNA3(11), CTNNB1(11), CTNND1(9), EGFR(33), EP300(2), ERBB2(10), FARP2(3), FER(6), FGFR1(5), FYN(3), IGF1R(10), INSR(1), IQGAP1(5), LEF1(8), LMO7(10), MAP3K7(5), MAPK3(1), MET(12), MLLT4(4), PARD3(6), PTPN1(1), PTPN6(3), PTPRB(29), PTPRF(4), PTPRJ(5), PTPRM(6), PVRL1(4), PVRL4(3), RAC2(1), RHOA(1), SMAD2(2), SMAD3(3), SMAD4(8), SNAI1(3), SNAI2(4), SORBS1(7), SRC(2), SSX2IP(2), TCF7(1), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(2), TJP1(10), VCL(2), WAS(3), WASF1(8), WASF2(1), WASF3(4), WASL(5), YES1(3) 40661469 347 156 325 118 51 89 85 62 60 0 0.909 1.000 1.000 180 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(10), ADCY8(22), ARAF(3), ATF4(1), CACNA1C(26), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CREBBP(4), EP300(2), GNAQ(2), GRIA1(12), GRIA2(15), GRIN1(2), GRIN2A(26), GRIN2B(21), GRIN2C(3), GRIN2D(6), GRM1(26), GRM5(13), HRAS(1), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAP2K2(1), MAPK3(1), NRAS(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PPP1CA(2), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R1A(2), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5) 34022530 381 156 377 125 52 114 102 62 51 0 0.764 1.000 1.000 181 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(2), ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), ADSSL1(1), AK2(3), AK5(10), AK7(7), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(2), ATIC(3), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENTPD1(4), ENTPD2(2), ENTPD4(2), ENTPD6(3), FHIT(1), GART(4), GDA(6), GMPR(3), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NME6(1), NME7(4), NPR1(6), NPR2(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), NUDT5(2), NUDT9(2), PAPSS1(3), PAPSS2(4), PDE10A(16), PDE11A(11), PDE1A(8), PDE1C(17), PDE2A(5), PDE3B(9), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6D(1), PDE6G(2), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PDE9A(2), PFAS(3), PKLR(11), PKM2(4), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1), PPAT(5), PRIM1(3), PRPS1(3), PRPS1L1(2), PRPS2(2), PRUNE(5), RFC5(1), RRM1(5), RRM2(4), XDH(11) 55583796 539 150 536 193 72 151 161 89 66 0 0.965 1.000 1.000 182 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(2), ACTN1(2), ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGEF6(9), ARHGEF7(6), BCAR1(2), CDC42(2), CSE1L(3), DOCK1(7), EPHB2(5), FYN(3), GRB2(4), GRB7(3), GRLF1(9), ILK(1), ITGA1(9), ITGA10(7), ITGA11(10), ITGA2(11), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), MAP2K4(3), MAP2K7(2), MAP3K11(7), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MRAS(1), MYLK(15), MYLK2(3), P4HB(4), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PIK3CA(11), PIK3CB(7), PKLR(11), PLCG1(5), PLCG2(9), PTEN(8), PTK2(11), RAF1(3), RALA(2), RHO(1), ROCK1(10), ROCK2(4), SHC1(2), SOS1(12), SOS2(6), SRC(2), TLN1(13), TLN2(16), VASP(3), WAS(3), ZYX(2) 41364728 404 150 398 119 67 106 117 56 58 0 0.358 1.000 1.000 183 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(1), ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), CHPF(3), CHST1(10), CHST11(1), CHST12(3), CHST13(3), CHST2(4), CHST3(2), CHST6(3), CHSY1(2), DAD1(1), DDOST(1), DPAGT1(1), EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), FUT11(2), FUT8(4), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT14(10), GALNT2(3), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GANAB(3), GCNT1(4), GCNT3(3), GCNT4(3), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(1), HS6ST3(5), MAN1A2(9), MAN1B1(2), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(6), NDST1(2), NDST2(7), NDST3(8), NDST4(13), OGT(6), RPN2(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST6GALNAC1(3), STT3B(2), UST(1), WBSCR17(16), XYLT1(19) 37483636 370 149 367 146 61 104 109 57 38 1 0.995 1.000 1.000 184 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(5), BCAR1(2), CAPN10(4), CAPN11(9), CAPN2(3), CAPN3(6), CAPN5(10), CAPN6(10), CAPN7(5), CAPN9(6), CAV3(2), CDC42(2), DOCK1(7), FYN(3), GIT2(3), GRB2(4), ILK(1), ITGA10(7), ITGA11(10), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGA7(2), ITGA8(24), ITGA9(2), ITGAD(17), ITGAE(9), ITGAL(20), ITGAM(14), ITGAV(9), ITGAX(20), ITGB1(3), ITGB2(2), ITGB3(4), ITGB4(4), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(5), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(5), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PDPK1(1), PIK3R2(1), PTK2(11), PXN(1), RAC2(1), RAP1B(1), RAPGEF1(1), RHO(1), ROCK1(10), ROCK2(4), SDCCAG8(6), SHC1(2), SHC3(4), SORBS1(7), SOS1(12), SRC(2), TLN1(13), TNS1(14), VASP(3), VAV2(3), VAV3(14), VCL(2), ZYX(2) 46314792 456 149 454 169 67 136 116 70 65 2 0.985 1.000 1.000 185 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT2(2), AKT3(5), CBL(8), CBLB(5), CBLC(1), CCND1(2), CCND2(1), CCND3(1), CNTF(1), CNTFR(3), CREBBP(4), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(2), EPO(3), EPOR(1), GH1(2), GH2(5), GHR(5), GRB2(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), IFNW1(1), IL10(1), IL10RA(4), IL10RB(2), IL12A(3), IL12RB1(3), IL12RB2(12), IL13(1), IL13RA2(3), IL15(2), IL15RA(1), IL19(1), IL2(5), IL20RA(3), IL21(1), IL21R(9), IL22(2), IL22RA2(2), IL23R(1), IL24(3), IL28B(2), IL28RA(4), IL2RA(3), IL2RB(5), IL2RG(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), IRF9(2), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), LIF(2), LIFR(5), MPL(2), OSM(2), OSMR(5), PIAS1(2), PIAS2(5), PIAS3(5), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PRL(1), PRLR(9), PTPN11(6), PTPN6(3), SOCS4(1), SOCS5(2), SOS1(12), SOS2(6), SPRED1(1), SPRED2(2), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), STAM(6), STAM2(4), STAT1(4), STAT2(5), STAT3(8), STAT4(6), STAT5A(3), STAT5B(4), STAT6(2), TPO(16), TSLP(3), TYK2(2) 49993906 456 147 450 165 45 136 131 88 56 0 0.993 1.000 1.000 186 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT2(2), AKT3(5), BCL10(1), CARD11(17), CBL(8), CBLB(5), CBLC(1), CD28(1), CD3D(2), CD4(3), CD40LG(6), CD8A(2), CD8B(3), CDC42(2), CDK4(2), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(5), GRB2(4), HRAS(1), ICOS(2), IFNG(4), IKBKB(3), IL10(1), IL2(5), IL4(1), ITK(7), JUN(1), LAT(3), LCK(5), LCP2(6), MALT1(6), MAP3K14(1), MAP3K8(2), NCK1(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NRAS(4), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PDCD1(1), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCQ(4), PTPN6(3), PTPRC(21), RASGRP1(2), RHOA(1), SOS1(12), SOS2(6), TEC(5), VAV1(1), VAV2(3), VAV3(14), ZAP70(4) 34845327 358 146 350 112 50 100 104 48 56 0 0.679 1.000 1.000 187 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(12), ABCA10(12), ABCA12(21), ABCA13(43), ABCA2(6), ABCA3(6), ABCA4(21), ABCA5(7), ABCA6(10), ABCA7(6), ABCA8(16), ABCA9(11), ABCB1(20), ABCB10(9), ABCB11(15), ABCB4(17), ABCB5(27), ABCB6(3), ABCB7(3), ABCB8(5), ABCB9(3), ABCC1(7), ABCC10(3), ABCC11(17), ABCC12(18), ABCC2(5), ABCC3(7), ABCC4(8), ABCC5(11), ABCC6(3), ABCC8(11), ABCC9(25), ABCD1(1), ABCD2(9), ABCD3(5), ABCD4(2), ABCG1(3), ABCG2(5), ABCG4(6), ABCG5(10), ABCG8(6), CFTR(6), TAP2(7) 40968100 448 145 444 143 62 133 116 76 60 1 0.557 1.000 1.000 188 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 77 AGL(13), AMY2A(4), AMY2B(16), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHX58(1), ENPP1(6), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), G6PC(1), G6PC2(2), GAA(2), GANC(1), GBA(3), GBE1(2), GCK(4), GPI(3), GUSB(5), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), IFIH1(6), LYZL1(4), MGAM(30), MOV10L1(9), NUDT5(2), NUDT8(1), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SI(63), SKIV2L2(10), SMARCA2(10), SMARCA5(1), TREH(1), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), UXS1(4) 41295570 441 144 438 136 59 153 117 66 45 1 0.748 1.000 1.000 189 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALML3(3), CDIPT(1), CDS1(2), CDS2(3), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPP5D(4), INPPL1(6), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), OCRL(6), PI4KA(7), PI4KB(4), PIK3C2A(9), PIK3C2B(7), PIK3C2G(9), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PRKCA(7), PRKCG(10), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3) 43347410 400 142 395 120 54 120 108 54 63 1 0.553 1.000 1.000 190 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(3), BID(1), CASP3(4), CD244(6), CD48(3), FAS(3), FASLG(3), FCER1G(2), FCGR3A(6), FCGR3B(5), FYN(3), GRB2(4), GZMB(3), HCST(3), HLA-A(2), HLA-B(3), HLA-C(1), HLA-G(1), HRAS(1), ICAM2(2), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IFNG(4), IFNGR1(3), IFNGR2(3), ITGAL(20), ITGB2(2), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), KLRK1(2), LAT(3), LCK(5), LCP2(6), MAP2K1(6), MAP2K2(1), MAPK3(1), NCR1(2), NCR3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NRAS(4), PAK1(5), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRF1(5), PRKCA(7), PRKCG(10), PTK2B(8), PTPN11(6), PTPN6(3), RAC2(1), RAF1(3), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SYK(3), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), ULBP3(1), VAV1(1), VAV2(3), VAV3(14), ZAP70(4) 38676955 408 142 399 128 59 106 114 79 50 0 0.614 1.000 1.000 191 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(2), ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), ATM(22), ATR(16), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC14A(7), CDC14B(1), CDC16(3), CDC20(3), CDC23(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC27(1), CDC6(1), CDC7(3), CDK2(4), CDK4(2), CDK6(3), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), CHEK1(6), CHEK2(2), CREBBP(4), CUL1(6), DBF4(3), E2F1(3), E2F3(1), EP300(2), ESPL1(4), FZR1(2), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PKMYT1(2), PLK1(3), PRKDC(23), PTTG1(1), PTTG2(2), RBL1(7), RBL2(2), SKP1(2), SKP2(4), SMAD2(2), SMAD3(3), SMAD4(8), SMC1A(4), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), WEE1(3), YWHAG(2) 46104799 338 141 337 88 51 86 110 49 42 0 0.174 1.000 1.000 192 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(4), ACVR1B(5), ACVRL1(4), AURKB(1), BMPR1A(1), BMPR2(2), BUB1(4), CDIPT(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(3), CLK1(2), CLK2(7), CLK4(6), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(6), ITPKA(1), ITPKB(5), MAP3K10(1), MOS(2), NEK1(6), NEK3(4), OCRL(6), PIK3C2A(9), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PIM2(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9), PLK3(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKG1(3), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KB1(2), TGFBR1(2), VRK1(2) 38927710 343 140 339 111 49 94 99 47 54 0 0.806 1.000 1.000 193 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(2), ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), AK2(3), AK5(10), ALLC(6), AMPD1(6), AMPD2(3), AMPD3(2), ATIC(3), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), CANT1(3), DCK(2), DGUOK(2), ENPP1(6), ENTPD1(4), ENTPD2(2), FHIT(1), GART(4), GDA(6), GMPS(8), GUCY1A2(7), GUCY1A3(6), GUCY1B3(5), GUCY2C(7), GUCY2D(1), GUCY2F(12), GUK1(2), HPRT1(1), IMPDH1(4), IMPDH2(1), ITPA(1), NPR1(6), NPR2(2), NT5E(2), NT5M(1), NUDT2(3), PAPSS1(3), PAPSS2(4), PDE1A(8), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE5A(1), PDE6B(4), PDE6C(5), PDE6G(2), PDE7B(3), PDE8A(3), PDE9A(2), PFAS(3), PKLR(11), PKM2(4), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), PPAT(5), PRPS1(3), PRPS1L1(2), PRPS2(2), PRUNE(5), RRM1(5), RRM2(4) 43677170 420 140 417 148 61 108 126 71 54 0 0.913 1.000 1.000 194 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(2), ABL2(7), AKT2(2), AKT3(5), ARAF(3), BTC(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(8), CBLB(5), CBLC(1), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(8), EGFR(33), ELK1(2), ERBB2(10), ERBB3(3), ERBB4(21), EREG(4), GAB1(2), GRB2(4), GSK3B(2), HBEGF(1), HRAS(1), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK9(6), NCK1(3), NCK2(3), NRAS(4), NRG1(9), NRG2(2), NRG4(1), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG1(5), PLCG2(9), PRKCA(7), PRKCG(10), PTK2(11), RAF1(3), RPS6KB1(2), RPS6KB2(2), SHC1(2), SHC2(1), SHC3(4), SHC4(4), SOS1(12), SOS2(6), SRC(2), STAT5A(3), STAT5B(4), TGFA(1) 34326413 356 139 333 105 53 96 88 62 57 0 0.500 1.000 1.000 195 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(14), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(2), C1QC(3), C1R(1), C1S(1), C2(3), C3(5), C3AR1(5), C4BPA(6), C5(2), C5AR1(4), C6(14), C8A(6), C8B(9), C9(10), CD46(1), CD55(2), CFB(4), CFH(23), CFI(7), CPB2(4), CR1(14), CR2(8), F10(3), F11(8), F12(1), F13A1(13), F13B(16), F2(5), F2R(4), F3(4), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(12), FGG(2), KLKB1(3), KNG1(3), MASP1(5), MASP2(2), MBL2(1), PLAT(6), PLAU(1), PLAUR(2), PLG(13), PROC(3), PROS1(13), SERPINA1(2), SERPINA5(7), SERPINC1(8), SERPIND1(1), SERPINE1(5), SERPING1(3), TFPI(1), THBD(1), VWF(13) 30740044 377 139 376 126 35 137 95 58 49 3 0.983 1.000 1.000 196 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(22), CARM1(1), CTCFL(15), DOT1L(8), EED(4), EHMT1(8), EHMT2(1), EZH1(2), EZH2(8), FBXO11(2), HCFC1(10), HSF4(1), JMJD4(1), KDM6A(2), MEN1(4), MLL(12), MLL2(25), MLL3(55), MLL4(4), MLL5(3), NSD1(11), OGT(6), PAXIP1(3), PPP1CA(2), PPP1CB(1), PPP1CC(1), PRDM2(8), PRDM7(3), PRDM9(32), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), RBBP5(3), SATB1(6), SETD1A(8), SETD2(21), SETD7(1), SETD8(2), SETDB1(5), SETDB2(2), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(2), SUV39H2(3), SUV420H1(5), SUZ12(1), WHSC1(4), WHSC1L1(2) 40876042 347 138 345 95 50 99 100 40 54 4 0.347 1.000 1.000 197 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), AKAP1(4), AKAP10(1), AKAP11(8), AKAP12(5), AKAP3(7), AKAP4(7), AKAP5(1), AKAP6(16), AKAP7(1), AKAP9(23), ARHGEF1(2), CALM1(2), GNA11(1), GNA12(1), GNA13(5), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(4), GNB1(2), GNB3(2), GNB5(1), GNG12(2), GNG3(2), GNG4(1), GNGT1(2), GNGT2(2), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(15), NRAS(4), PDE1A(8), PDE1B(6), PDE1C(17), PDE4A(4), PDE4B(7), PDE4C(2), PDE4D(4), PDE7A(2), PDE7B(3), PDE8A(3), PDE8B(5), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), PRKD3(5), RHOA(1), RRAS(1), SLC9A1(3), USP5(3) 40254078 379 137 375 133 36 128 103 59 53 0 0.976 1.000 1.000 198 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(4), CD14(1), CD19(2), CD1A(8), CD1B(11), CD1C(9), CD1D(6), CD1E(12), CD2(3), CD22(6), CD33(10), CD34(4), CD36(4), CD38(3), CD3D(2), CD4(3), CD44(2), CD5(4), CD55(2), CD8A(2), CD8B(3), CR1(14), CR2(8), CSF1(1), CSF1R(6), CSF2RA(5), CSF3R(4), DNTT(3), EPO(3), EPOR(1), FCER2(1), FCGR1A(1), FLT3(10), FLT3LG(2), GP5(3), HLA-DRA(3), IL1A(3), IL1R1(1), IL1R2(4), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(5), IL5RA(5), IL6R(8), IL7R(7), IL9R(5), ITGA1(9), ITGA2(11), ITGA2B(3), ITGA3(5), ITGA4(19), ITGA5(6), ITGA6(5), ITGAM(14), ITGB3(4), KIT(6), MME(8), MS4A1(4), TFRC(6), THPO(1), TPO(16) 28112498 331 133 329 116 42 125 79 50 35 0 0.946 1.000 1.000 199 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), CCKBR(11), CCR2(5), CCR3(2), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(17), CHRM2(17), CHRM3(13), CXCR3(1), EMR2(3), EMR3(5), F2R(4), FSHR(20), GHRHR(5), GNRHR(2), GPR116(5), GPR132(1), GPR133(8), GPR135(1), GPR143(1), GPR17(3), GPR18(2), GPR55(7), GPR56(6), GPR61(4), GPR77(1), GPR84(4), GRM1(26), GRPR(5), HRH4(4), LGR6(11), LPHN2(24), LPHN3(33), NTSR1(5), OR2M4(14), OR8G2(4), PTGFR(6), SMO(5), TAAR5(8), TSHR(10) 23021828 322 132 322 104 31 95 94 62 40 0 0.506 1.000 1.000 200 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(10), ADCY2(16), ADCY3(5), ADCY4(6), ADCY5(12), ADCY6(10), ADCY7(7), ADCY8(22), ADCY9(3), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB3L1(1), CREB3L2(4), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(11), DCT(7), DVL1(1), DVL2(1), DVL3(5), EDN1(1), EDNRB(6), EP300(2), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD4(5), FZD5(1), FZD7(3), FZD9(2), GNAI1(3), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(7), GSK3B(2), HRAS(1), KIT(6), LEF1(8), MAP2K1(6), MAP2K2(1), MAPK3(1), MITF(1), NRAS(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), POMC(1), PRKACB(3), PRKACG(1), PRKCA(7), PRKCG(10), PRKX(3), RAF1(3), TCF7(1), TCF7L1(2), TCF7L2(3), TYRP1(4), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5) 36951440 353 132 349 139 52 89 111 55 46 0 0.977 1.000 1.000 201 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 87 ACVR1(4), ACVR1B(5), ACVR1C(3), ACVR2A(2), ACVR2B(4), ACVRL1(4), AMH(1), AMHR2(2), BMP2(1), BMP4(4), BMP5(4), BMP6(2), BMP7(4), BMP8A(1), BMPR1A(1), BMPR1B(5), BMPR2(2), CHRD(9), COMP(2), CREBBP(4), CUL1(6), DCN(1), EP300(2), FST(2), GDF5(4), GDF6(7), GDF7(1), ID3(1), IFNG(4), INHBB(1), INHBC(1), INHBE(3), LEFTY1(3), LEFTY2(3), LTBP1(28), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(3), PPP2R2A(4), PPP2R2B(5), PPP2R2C(3), RBL1(7), RBL2(2), RHOA(1), ROCK1(10), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SKP1(2), SMAD1(3), SMAD2(2), SMAD3(3), SMAD4(8), SMAD5(2), SMAD9(1), SMURF1(3), SMURF2(2), SP1(1), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), THBS1(4), THBS2(16), THBS3(6), THBS4(5), ZFYVE16(1), ZFYVE9(5) 33862230 269 129 269 108 38 70 78 42 41 0 0.996 1.000 1.000 202 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(11), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ADIPOR1(3), ADIPOR2(1), AKT2(2), AKT3(5), CAMKK1(2), CAMKK2(1), CD36(4), CHUK(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), G6PC(1), G6PC2(2), IKBKB(3), IRS1(15), IRS2(3), IRS4(17), JAK1(8), JAK2(4), JAK3(5), LEP(4), LEPR(13), MAPK10(5), MAPK8(3), MAPK9(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(12), PCK2(3), POMC(1), PPARA(1), PPARGC1A(12), PRKAA1(4), PRKAB1(3), PRKAG2(4), PRKAG3(4), PRKCQ(4), PTPN11(6), RXRA(1), RXRB(1), RXRG(11), STAT3(8), TNFRSF1B(1), TRAF2(1), TYK2(2) 28381802 257 128 256 99 41 76 58 44 38 0 0.978 1.000 1.000 203 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BCL2(1), CABIN1(5), CALM1(2), CAMK2B(3), CAMK4(8), CD69(2), CDKN1A(1), CNR1(4), CREBBP(4), CTLA4(1), EGR2(2), EGR3(1), EP300(2), FCER1A(7), FCGR3A(6), FOS(1), FOSL1(3), GATA3(6), GATA4(4), GRLF1(9), GSK3B(2), HRAS(1), ICOS(2), IFNB1(4), IFNG(4), IL10(1), IL13(1), IL2(5), IL2RA(3), IL3(1), IL4(1), ITK(7), KPNA5(2), MAP2K7(2), MAPK14(1), MAPK8(3), MAPK9(6), MEF2A(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(3), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB2(6), NFKBIE(1), NUP214(18), OPRD1(1), P2RX7(5), PAK1(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PTPRC(21), SLA(1), SP1(1), SP3(4), TGFB1(2), TRAF2(1), TRPV6(8), VAV1(1), VAV2(3), VAV3(14), XPO5(3) 31344833 264 127 260 95 33 88 68 37 38 0 0.921 1.000 1.000 204 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(2), ATM(22), BUB1(4), BUB1B(8), BUB3(1), CCNA1(2), CCNA2(4), CCNB1(1), CCNB2(1), CCNB3(13), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDAN1(2), CDC14A(7), CDC14B(1), CDC20(3), CDC25A(4), CDC25B(1), CDC25C(3), CDC6(1), CDC7(3), CDH1(5), CDK2(4), CDK4(2), CDKN1A(1), CHEK1(6), CHEK2(2), DTX4(1), E2F1(3), E2F3(1), E2F6(3), EP300(2), ESPL1(4), GADD45A(1), GSK3B(2), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), HDAC8(2), MAD1L1(5), MAD2L1(3), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MPEG1(3), MPL(2), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), PLK1(3), PRKDC(23), PTPRA(5), PTTG1(1), PTTG2(2), RBL1(7), SKP2(4), SMAD4(8), TBC1D8(3), TFDP1(3), TGFB1(2), WEE1(3) 37088382 288 127 287 79 46 84 81 41 36 0 0.256 1.000 1.000 205 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT2(2), AKT3(5), CASP8(4), CCL3(1), CCL4(1), CD14(1), CD80(4), CD86(6), CHUK(3), CXCL9(3), FADD(1), FOS(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNAR2(2), IFNB1(4), IKBKB(3), IKBKE(5), IL12A(3), IRAK1(3), IRAK4(4), IRF3(1), IRF7(1), JUN(1), LBP(5), LY96(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K7(5), MAP3K8(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), RIPK1(4), STAT1(4), TBK1(2), TLR1(4), TLR2(2), TLR4(31), TLR5(1), TLR6(6), TLR7(8), TLR8(6), TLR9(6), TOLLIP(1), TRAF3(3), TRAF6(4) 30930343 279 126 274 99 29 67 83 53 47 0 0.939 1.000 1.000 206 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), BDKRB2(1), CALM1(2), CHRM1(2), CHRNA1(7), FLT1(21), FLT4(13), KDR(30), NOS3(2), PDE2A(5), PDE3A(13), PDE3B(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKG1(3), PRKG2(7), RYR2(165), SLC7A1(3), SYT1(3), TNNI1(2) 14213572 304 124 300 85 32 110 71 49 39 3 0.460 1.000 1.000 207 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(5), BAX(1), BFAR(1), BTK(11), CAD(16), CASP10(6), CASP3(4), CASP8(4), CASP8AP2(10), CDK2AP1(1), CSNK1A1(1), DAXX(6), DEDD(2), DFFA(3), EGFR(33), EPHB2(5), FADD(1), FAF1(4), FAIM2(4), HSPB1(1), IL1A(3), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K5(12), MAPK10(5), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MET(12), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR0B2(1), PFN1(1), PFN2(3), PTPN13(11), RALBP1(1), RIPK1(4), ROCK1(10), SMPD1(2), TPX2(3), TRAF2(1), TUFM(2) 25055119 233 123 219 68 29 56 71 35 42 0 0.565 1.000 1.000 208 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT2(2), AKT3(5), BCL10(1), BLNK(1), BTK(11), CARD11(17), CD19(2), CD22(6), CD72(1), CD79B(1), CHUK(3), CR2(8), FCGR2B(2), FOS(1), GSK3B(2), HRAS(1), IKBKB(3), INPP5D(4), JUN(1), LILRB3(1), LYN(4), MALT1(6), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NRAS(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PTPN6(3), RAC2(1), RASGRP3(8), SYK(3), VAV1(1), VAV2(3), VAV3(14) 25484265 232 122 226 80 26 58 71 39 38 0 0.834 1.000 1.000 209 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 CPEB1(5), EGFR(33), ERBB2(10), ERBB4(21), ETS1(7), ETS2(3), ETV6(3), FMN2(31), GRB2(4), MAP2K1(6), MAPK3(1), NOTCH1(8), NOTCH2(26), NOTCH3(5), NOTCH4(23), PIWIL1(11), PIWIL2(6), PIWIL3(6), PIWIL4(4), RAF1(3), SOS1(12), SOS2(6), SPIRE1(5), SPIRE2(1) 17364154 240 121 222 61 29 76 58 45 31 1 0.341 1.000 1.000 210 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(1), IMPA2(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPP5B(2), INPPL1(6), IPMK(7), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), OCRL(6), PI4KA(7), PI4KB(4), PIK3C3(7), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIP4K2A(5), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(7), PIP5K1C(3), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCD3(2), PLCD4(3), PLCE1(14), PLCG1(5), PLCG2(9), PLCZ1(3), PTEN(8), PTPMT1(1), SYNJ1(4), SYNJ2(3) 25659221 230 118 226 76 29 69 63 33 36 0 0.793 1.000 1.000 211 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(4), CDC40(2), CLK2(7), CLK3(1), CLK4(6), COL2A1(7), CPSF1(6), CPSF2(5), CPSF3(3), CPSF4(2), CSTF1(1), CSTF2T(4), CSTF3(3), DDIT3(4), DDX1(5), DDX20(1), DHX15(4), DHX16(5), DHX38(9), DHX8(8), DHX9(3), DICER1(8), DNAJC8(2), FUS(1), GIPC1(2), METTL3(1), NCBP2(1), NONO(3), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(6), POLR2A(9), PPM1G(4), PRPF18(2), PRPF3(3), PRPF4(3), PRPF4B(6), PRPF8(6), PSKH1(2), PTBP1(2), PTBP2(8), RBM17(3), RBM5(3), RNGTT(4), RNMT(3), SF3A1(5), SF3A3(1), SF3B1(5), SF3B2(8), SF3B4(6), SF3B5(2), SF4(6), SFRS14(6), SFRS16(1), SFRS4(4), SFRS5(1), SFRS6(4), SFRS8(5), SNRPA(1), SNRPA1(1), SNRPB2(1), SNRPD1(1), SNRPD3(2), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(1), SRPK1(3), SRPK2(4), SRRM1(1), SUPT5H(5), TXNL4A(3), U2AF1(6), U2AF2(5), XRN2(5) 36262150 282 118 275 77 62 62 77 45 36 0 0.304 1.000 1.000 212 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(9), AKT2(2), AKT3(5), APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CAPN2(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), CSF2RB(5), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(3), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL3(1), IL3RA(5), IRAK1(3), IRAK2(3), IRAK3(6), IRAK4(4), MAP3K14(1), MYD88(3), NFKB1(3), NFKB2(6), NFKBIA(1), NTRK1(12), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RIPK1(4), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(1), TRAF2(1) 28669655 232 117 226 79 27 52 72 42 39 0 0.870 1.000 1.000 213 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(5), AGTR2(2), ATP8A1(3), AVPR1A(6), AVPR1B(3), AVPR2(4), BDKRB1(1), BDKRB2(1), BRS3(8), C3AR1(5), CCKAR(7), CCKBR(11), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CCR6(2), CCR8(6), CX3CR1(5), CXCR3(1), CXCR4(3), CXCR6(1), EDNRB(6), FPR1(4), FSHR(20), GALR1(3), GALR2(1), GALT(2), GHSR(4), GNB2L1(2), GNRHR(2), GPR77(1), GRPR(5), LHCGR(6), MC2R(2), MC3R(9), MC4R(1), MC5R(10), NMBR(6), NPY1R(9), NPY2R(6), NPY5R(9), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(5), OPRL1(5), OPRM1(4), OXTR(2), PPYR1(2), SSTR1(3), SSTR3(2), SSTR4(5), TAC4(1), TACR1(3), TACR3(8), TRHR(4), TSHR(10) 17948562 255 117 254 98 24 85 73 46 26 1 0.889 1.000 1.000 214 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT2(2), AKT3(5), ASAH1(2), DAG1(2), DRD2(9), EGFR(33), EPHB2(5), GRB2(4), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PI3(1), PIK3CB(7), PITX2(4), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), RAF1(3), RGS20(5), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT3(8) 19731327 220 117 204 61 27 61 58 40 34 0 0.436 1.000 1.000 215 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT2(2), AKT3(5), CASP9(3), CDC42(2), HRAS(1), KDR(30), MAP2K1(6), MAP2K2(1), MAPK11(1), MAPK14(1), MAPK3(1), MAPKAPK2(3), MAPKAPK3(1), NFAT5(6), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NOS3(2), NRAS(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PPP3R1(3), PPP3R2(2), PRKCA(7), PRKCG(10), PTGS2(4), PTK2(11), PXN(1), RAC2(1), RAF1(3), SH2D2A(7), SHC2(1), SPHK2(2), SRC(2), VEGFA(1) 24724443 247 116 240 80 38 68 66 47 28 0 0.658 1.000 1.000 216 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT2(2), AKT3(5), CDC42(2), CDK2(4), CDKN1B(3), CREB5(7), EBP(2), ERBB4(21), F2RL2(5), GAB1(2), GADD45A(1), GRB2(4), GSK3B(2), IGF1(5), IGFBP1(3), INPPL1(6), IRS1(15), IRS2(3), IRS4(17), MET(12), NOLC1(2), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PPP1R13B(2), PREX1(21), PTEN(8), PTK2(11), PTPN1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TSC1(9), TSC2(5), YWHAG(2) 26448584 269 113 264 80 45 84 68 34 38 0 0.493 1.000 1.000 217 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(6), ADAM17(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), CASP3(4), CDC42(2), CHUK(3), CXCL1(2), EGFR(33), F11R(2), HBEGF(1), IGSF5(3), IKBKB(3), JAM2(6), JUN(1), LYN(4), MAP2K4(3), MAP3K14(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK8(3), MAPK9(6), MET(12), NFKB1(3), NFKB2(6), NFKBIA(1), NOD1(3), PAK1(5), PLCG1(5), PLCG2(9), PTPN11(6), PTPRZ1(36), SRC(2), TCIRG1(1), TJP1(10) 24116219 233 111 218 82 37 54 60 40 42 0 0.941 1.000 1.000 218 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(1), AKT2(2), AKT3(5), ANGPTL2(4), ARHGAP1(3), ARHGAP4(2), ARHGEF11(11), BTK(11), CDC42(2), CFL2(2), GDI1(3), GDI2(1), INPPL1(6), ITPR1(11), ITPR2(25), ITPR3(6), MYLK(15), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3CG(11), PIK3R1(3), PITX2(4), PPP1R13B(2), PTEN(8), RACGAP1(3), RHO(1), ROCK1(10), ROCK2(4), SAG(3), WASF1(8), WASL(5) 24267588 227 111 222 64 38 69 53 29 38 0 0.401 1.000 1.000 219 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT2(2), AKT3(5), BTK(11), FCER1A(7), FCER1G(2), FYN(3), GAB2(1), GRB2(4), HRAS(1), IL13(1), IL3(1), IL4(1), INPP5D(4), LAT(3), LCP2(6), LYN(4), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(6), MS4A2(2), NRAS(4), PDK1(4), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCG1(5), PLCG2(9), PRKCA(7), PRKCD(1), PRKCE(3), RAC2(1), RAF1(3), SOS1(12), SOS2(6), SYK(3), VAV1(1), VAV2(3), VAV3(14) 24773449 242 109 236 81 30 66 69 44 33 0 0.811 1.000 1.000 220 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADM(3), ACOX1(3), ACOX2(2), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADIPOQ(4), ANGPTL4(1), APOA1(1), APOA5(3), APOC3(3), CD36(4), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP27A1(5), CYP4A11(4), CYP7A1(7), CYP8B1(2), EHHADH(8), FABP1(1), FABP2(1), FABP3(2), FABP5(1), FABP6(1), FADS2(1), GK(2), GK2(4), HMGCS2(5), ILK(1), LPL(5), ME1(1), MMP1(7), NR1H3(3), OLR1(3), PCK1(12), PCK2(3), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), PPARG(3), RXRA(1), RXRB(1), RXRG(11), SCP2(3), SLC27A1(3), SLC27A2(3), SLC27A4(3), SLC27A5(1), SLC27A6(11), SORBS1(7), UBC(10), UCP1(2) 22562683 215 108 213 63 35 70 46 38 26 0 0.421 1.000 1.000 221 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(5), CHUK(3), DAXX(6), ELK1(2), FOS(1), GRB2(4), HRAS(1), IKBKB(3), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(6), MAP3K13(7), MAP3K14(1), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K6(1), MAP3K7(5), MAP3K8(2), MAP3K9(11), MAP4K1(5), MAP4K3(5), MAP4K5(1), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(5), MAPK8(3), MAPK9(6), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(3), NFKBIA(1), PAK1(5), PAK2(3), RAF1(3), RIPK1(4), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(2), SHC1(2), SP1(1), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1) 32474032 242 108 242 79 49 50 68 35 40 0 0.639 1.000 1.000 222 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(2), CALM1(2), CALR(1), CAMK1(2), CAMK4(8), CREBBP(4), CSNK1A1(1), EDN1(1), ELSPBP1(4), F2(5), GATA4(4), GSK3B(2), HAND1(3), HAND2(3), HRAS(1), IGF1(5), LIF(2), MAP2K1(6), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(2), MYH2(35), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NKX2-5(3), NPPA(1), PIK3CA(11), PIK3R1(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAF1(3), RPS6KB1(2), SYT1(3) 17444304 177 108 173 50 24 55 57 21 20 0 0.282 1.000 1.000 223 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(4), ACSS2(4), ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), G6PC2(2), GALM(1), GAPDH(3), GAPDHS(6), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGAM4(2), PGK1(5), PGK2(14), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6) 20068415 237 107 234 76 35 93 53 34 22 0 0.619 1.000 1.000 224 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(16), COL4A2(15), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), F10(3), F11(8), F12(1), F2(5), F2R(4), F5(23), F8(23), F9(8), FGA(9), FGB(12), FGG(2), KLKB1(3), PROC(3), PROS1(13), SERPINC1(8), SERPING1(3) 15473530 217 107 216 77 17 86 48 35 31 0 0.991 1.000 1.000 225 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AGK(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(1), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), GK(2), GK2(4), GLA(4), GPAM(3), LCT(30), LIPA(2), LIPC(6), LIPF(3), LIPG(2), LPL(5), MGLL(1), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PNPLA3(2), PPAP2B(2), PPAP2C(1) 20368176 242 106 242 65 24 83 72 30 32 1 0.232 1.000 1.000 226 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(2), AKT3(5), BCL2(1), BCR(3), BLNK(1), BTK(11), CD19(2), CD22(6), CR2(8), DAG1(2), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), INPP5D(4), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), MAP4K1(5), MAPK3(1), NFATC1(3), NFATC2(8), NR0B2(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), PPP3CA(5), PPP3CB(1), PPP3CC(2), PTPRC(21), RAF1(3), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1) 25553194 204 106 199 60 24 58 54 34 34 0 0.440 1.000 1.000 227 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 APC(23), AR(4), ASAH1(2), CAMP(2), CCL13(2), CCL15(3), DAG1(2), EGFR(33), GNA11(1), GNAI1(3), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CA(11), PIK3CD(1), PIK3R1(3), PITX2(4), PTX3(2), RAF1(3), SRC(2) 17984744 183 105 164 46 21 46 45 33 38 0 0.329 1.000 1.000 228 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ENTPD4(2), ENTPD6(3), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT2(3), PNPT1(5), POLA1(6), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1), PRIM1(3), RFC5(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), TXNRD2(1), UCK2(2), UMPS(2), UPP1(6), UPP2(8), UPRT(4) 27738541 241 104 239 83 45 67 71 33 24 1 0.779 1.000 1.000 229 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), AFMID(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(3), AOC3(5), AOX1(14), ASMT(6), CARM1(1), CAT(3), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(6), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), INMT(5), KMO(4), KYNU(5), LCMT1(2), LCMT2(4), LNX1(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), NFX1(2), OGDH(1), OGDHL(11), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), TDO2(7), TPH1(11), TPH2(8), WARS(3), WARS2(9), WBSCR22(1) 20876098 218 103 213 74 21 59 69 33 35 1 0.814 1.000 1.000 230 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 39 AGL(13), AMY2A(4), AMY2B(16), ENPP1(6), G6PC(1), GAA(2), GANAB(3), GBE1(2), GCK(4), GPI(3), GUSB(5), GYS1(2), GYS2(3), HK1(3), HK2(9), HK3(12), MGAM(30), PGM1(2), PGM3(4), PYGB(1), PYGL(3), PYGM(6), SI(63), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13), UXS1(4) 18900744 255 102 253 79 38 90 63 38 26 0 0.709 1.000 1.000 231 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(1), AKR1D1(5), ARSD(3), CARM1(1), CYP11B1(10), CYP11B2(7), CYP19A1(3), HSD11B1(4), HSD11B2(1), HSD17B12(1), HSD17B2(3), HSD17B3(1), HSD17B7(1), HSD3B1(7), HSD3B2(13), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), SULT2B1(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), WBSCR22(1) 16681505 198 101 196 62 20 77 58 29 14 0 0.674 1.000 1.000 232 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 67 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C1(2), AKR1C2(2), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHDH(1), EPHX1(2), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), MGST1(1), MGST3(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8) 19023488 227 101 224 76 23 92 57 31 24 0 0.862 1.000 1.000 233 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(5), ADCY4(6), ADCY6(10), ADCY8(22), CACNA1A(10), CACNA1B(15), GNAS(7), GNAT3(1), GNB1(2), GNB3(2), GNG3(2), GRM4(9), ITPR3(6), KCNB1(16), PDE1A(8), PLCB2(6), PRKACB(3), PRKACG(1), PRKX(3), SCNN1A(1), SCNN1B(3), SCNN1G(3), TAS1R1(2), TAS1R2(7), TAS1R3(3), TAS2R10(1), TAS2R13(1), TAS2R14(3), TAS2R16(10), TAS2R3(2), TAS2R38(5), TAS2R39(5), TAS2R40(4), TAS2R41(3), TAS2R42(1), TAS2R46(2), TAS2R5(1), TAS2R50(4), TAS2R60(7), TAS2R9(1), TRPM5(1) 19591637 204 101 203 64 19 79 55 29 22 0 0.449 1.000 1.000 234 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), AOX1(14), CARM1(1), DBH(2), DCT(7), DDC(6), ESCO1(7), ESCO2(2), FAH(1), GOT1(2), GOT2(3), GSTZ1(1), HGD(4), HPD(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SH3GLB1(1), TAT(4), TH(2), TPO(16), TYRP1(4), WBSCR22(1) 20147420 209 99 209 65 31 78 48 24 28 0 0.626 1.000 1.000 235 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(5), ACTR2(2), ACTR3(1), ANGPTL2(4), CDC42(2), CFL2(2), FLNA(11), FLNC(19), FSCN1(3), FSCN3(8), GDI1(3), GDI2(1), MYH2(35), MYLK(15), MYLK2(3), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PFN1(1), PFN2(3), RHO(1), ROCK1(10), ROCK2(4), VASP(3), WASF1(8), WASL(5) 16505633 185 99 185 58 26 68 40 23 28 0 0.694 1.000 1.000 236 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(10), ACAT1(1), ACAT2(1), ACMSD(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(3), AOC3(5), AOX1(14), ASMT(6), CAT(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), DDC(6), EHHADH(8), GCDH(3), HADHA(3), KMO(4), KYNU(5), MAOA(3), MAOB(1), SDS(2), TDO2(7), TPH1(11), WARS(3), WARS2(9) 19017305 226 98 222 73 29 70 56 31 38 2 0.699 1.000 1.000 237 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(23), AXIN1(3), CCND1(2), CCND2(1), CCND3(1), CSNK1E(5), CTNNB1(11), DVL1(1), DVL2(1), DVL3(5), FBXW2(2), FOSL1(3), FZD1(3), FZD10(7), FZD2(3), FZD3(4), FZD5(1), FZD7(3), FZD9(2), GSK3B(2), JUN(1), LDLR(5), MAPK10(5), MAPK9(6), PLAU(1), PPP2R5C(1), PPP2R5E(5), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCI(7), PRKCQ(4), PRKCZ(2), PRKD1(16), RHOA(1), SFRP4(3), TCF7(1), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2) 20636335 197 98 195 52 36 54 56 23 28 0 0.170 1.000 1.000 238 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(1), BMP4(4), BMP5(4), BMP6(2), BMP7(4), BMP8A(1), BTRC(9), CSNK1A1(1), CSNK1A1L(5), CSNK1D(2), CSNK1E(5), CSNK1G1(2), CSNK1G2(1), CSNK1G3(3), DHH(1), GAS1(1), GLI1(13), GLI2(10), GLI3(17), GSK3B(2), HHIP(1), IHH(1), LRP2(45), PRKACB(3), PRKACG(1), PRKX(3), PTCH1(8), PTCH2(2), SHH(4), SMO(5), STK36(5), WNT1(3), WNT10A(4), WNT10B(2), WNT11(2), WNT16(2), WNT2(4), WNT2B(2), WNT3A(4), WNT4(1), WNT5A(1), WNT5B(3), WNT6(1), WNT7A(6), WNT7B(2), WNT8A(3), WNT8B(2), WNT9A(2), WNT9B(5), ZIC2(3) 21042352 218 97 216 62 47 63 61 29 17 1 0.292 1.000 1.000 239 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(3), INPP4A(5), INPP4B(14), INPP5A(3), INPPL1(6), ITPKA(1), ITPKB(5), OCRL(6), PIK3C2A(9), PIK3C2B(7), PIK3C2G(9), PIK3CA(11), PIK3CB(7), PIK3CG(11), PLCB1(18), PLCB2(6), PLCB3(4), PLCB4(16), PLCD1(2), PLCG1(5), PLCG2(9) 15515895 158 97 155 48 21 43 47 20 27 0 0.573 1.000 1.000 240 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(23), ASAH1(2), CAMP(2), CAV3(2), DAG1(2), DLG4(3), EPHB2(5), GNAI1(3), GNAQ(2), ITPR1(11), ITPR2(25), ITPR3(6), KCNJ3(15), KCNJ5(1), PITX2(4), PTX3(2), RHO(1), RYR1(51) 15931301 160 97 158 40 18 44 48 23 27 0 0.153 1.000 1.000 241 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(8), F12(1), F13B(16), F2(5), F5(23), F7(2), F8(23), F9(8), FGA(9), FGB(12), FGG(2), LPA(26), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5), VWF(13) 12094406 182 96 181 43 15 60 43 38 25 1 0.260 1.000 1.000 242 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6) 16820508 205 96 202 60 32 81 46 26 20 0 0.368 1.000 1.000 243 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP2(1), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), ALDOA(2), ALDOB(4), ALDOC(1), BPGM(2), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GCK(4), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), PDHA1(3), PDHA2(13), PFKM(5), PFKP(3), PGAM1(1), PGK1(5), PGM1(2), PGM3(4), PKLR(11), PKM2(4), TPI1(6) 16820508 205 96 202 60 32 81 46 26 20 0 0.368 1.000 1.000 244 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), ASCC3(10), ATP13A2(5), DDX18(3), DDX19A(1), DDX23(8), DDX4(6), DDX41(1), DDX47(1), DDX50(6), DDX52(3), DDX54(2), DDX55(1), DDX56(1), DHFR(1), DHX58(1), ENTPD7(3), EP400(14), ERCC2(3), ERCC3(5), FPGS(1), GCH1(4), GGH(4), IFIH1(6), MOV10L1(9), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(8), RAD54L(1), RUVBL2(3), SETX(17), SKIV2L2(10), SMARCA2(10), SMARCA5(1), SPR(1) 21726604 171 96 171 53 23 40 52 30 25 1 0.568 1.000 1.000 245 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(8), ATM(22), ATR(16), BAI1(10), BAX(1), BID(1), CASP3(4), CASP8(4), CASP9(3), CCNB1(1), CCNB2(1), CCNB3(13), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNG1(2), CD82(2), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CHEK1(6), CHEK2(2), EI24(1), FAS(3), GADD45A(1), GTSE1(3), IGF1(5), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(6), PTEN(8), RCHY1(1), RFWD2(3), RRM2(4), SERPINB5(6), SERPINE1(5), SESN2(2), THBS1(4), TNFRSF10B(1), TP53I3(2), TP73(4), TSC2(5), ZMAT3(1) 22092088 183 96 181 54 25 48 50 33 27 0 0.573 1.000 1.000 246 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(3), DAXX(6), EGF(8), EGFR(33), ETS1(7), ETS2(3), FOS(1), HOXA7(3), HRAS(1), IKBKB(3), JUN(1), MAP2K1(6), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(3), NFKBIA(1), PPP2CA(1), PRKCA(7), PRKCD(1), PRKCE(3), PRKCG(10), PRKCH(2), PRKCQ(4), RAF1(3), RIPK1(4), SP1(1), TNFRSF1B(1), TRAF2(1) 16878445 152 96 138 55 19 37 35 32 29 0 0.946 1.000 1.000 247 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT2(2), AKT3(5), BCR(3), BTK(11), CD19(2), DAPP1(2), FLOT1(2), FLOT2(1), GAB1(2), ITPR1(11), ITPR2(25), ITPR3(6), LYN(4), NR0B2(1), PDK1(4), PIK3CA(11), PITX2(4), PLCG2(9), PPP1R13B(2), PREX1(21), PTEN(8), PTPRC(21), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SAG(3), SYK(3), TEC(5), VAV1(1) 19018908 180 96 175 44 22 52 50 28 28 0 0.147 1.000 1.000 248 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), GK(2), GLA(4), LCT(30), LIPC(6), LIPF(3), LIPG(2), LPL(5), PNLIP(8), PNLIPRP1(7), PNLIPRP2(7), PPAP2B(2), PPAP2C(1) 16758907 210 94 210 55 20 74 60 26 30 0 0.221 1.000 1.000 249 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB8(7), WAS(3), WASL(5) 17475906 167 94 164 66 29 52 43 24 19 0 0.974 1.000 1.000 250 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(2), ACTG1(2), ARHGEF2(6), ARPC5(1), CD14(1), CDC42(2), CDH1(5), CLDN1(3), CTNNB1(11), CTTN(3), EZR(1), FYN(3), HCLS1(6), ITGB1(3), KRT18(1), LY96(1), NCK1(3), NCK2(3), NCL(4), OCLN(1), PRKCA(7), RHOA(1), ROCK1(10), ROCK2(4), TLR4(31), TLR5(1), TUBA1A(3), TUBA1B(1), TUBA1C(3), TUBA3D(9), TUBA3E(2), TUBA4A(3), TUBA8(1), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB4(5), TUBB8(7), WAS(3), WASL(5) 17475906 167 94 164 66 29 52 43 24 19 0 0.974 1.000 1.000 251 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(22), CCNA1(2), CCNB1(1), CCND1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(1), CDC25A(4), CDK2(4), CDK4(2), CDK7(3), CDKN1A(1), CDKN1B(3), CDKN2D(1), CREB3L1(1), CREB3L3(1), CREB3L4(1), E2F1(3), E2F3(1), E2F6(3), GADD45A(1), GBA2(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), MDM2(2), MNAT1(2), MYT1(6), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLE(19), POLE2(1), PRIM1(3), RBL1(7), RPA2(1), TFDP1(3), TFDP2(2), TNXB(14), WEE1(3) 25533271 181 93 179 53 36 40 56 24 25 0 0.368 1.000 1.000 252 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKI(23), DGKZ(3), ESCO1(7), ESCO2(2), ETNK1(1), ETNK2(1), GNPAT(3), GPAM(3), GPD1(2), GPD1L(6), GPD2(4), LCAT(1), LYPLA1(1), LYPLA2(1), MYST3(8), MYST4(8), NAT6(1), PCYT1A(2), PCYT1B(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(6), PNPLA3(2), PPAP2B(2), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(1) 22733746 207 93 207 60 28 57 61 31 29 1 0.464 1.000 1.000 253 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(7), CREBBP(4), DLL1(5), DLL3(3), DLL4(1), DTX1(4), DTX2(2), DTX3(4), DTX3L(2), DTX4(1), DVL1(1), DVL2(1), DVL3(5), EP300(2), HDAC1(3), HDAC2(8), HES1(1), JAG1(4), JAG2(2), LFNG(1), MAML1(5), MAML2(3), MAML3(6), NCOR2(13), NCSTN(4), NOTCH1(8), NOTCH2(26), NOTCH3(5), NOTCH4(23), NUMB(2), NUMBL(1), PSEN1(1), PSEN2(4), PSENEN(1), PTCRA(2), RBPJ(3), RBPJL(2), SNW1(2) 24025077 172 93 172 60 28 51 50 17 25 1 0.810 1.000 1.000 254 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(56), CDR1(4), DGKI(23), PIGK(2), RPL10(2), RPL11(1), RPL12(1), RPL14(1), RPL15(1), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(4), RPL35(1), RPL37(1), RPL3L(2), RPL4(5), RPL5(1), RPL6(3), RPL7(1), RPL7A(1), RPL8(1), RPLP0(3), RPLP2(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS15(1), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), RPSA(1), SLC36A2(3), UBC(10) 18271223 165 93 164 50 26 55 42 21 20 1 0.629 1.000 1.000 255 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CD28(1), CD3D(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(5), FBXW7(4), GRAP2(5), GRB2(4), ITK(7), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(6), NCK1(3), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PAK1(5), PAK2(3), PAK3(7), PAK7(19), PLCG1(5), PTPRC(21), RAF1(3), RASGRP1(2), RASGRP3(8), RASGRP4(2), SOS1(12), SOS2(6), VAV1(1), ZAP70(4) 19339966 179 92 179 51 27 60 44 21 27 0 0.420 1.000 1.000 256 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(2), APAF1(8), BAG4(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DAXX(6), DFFA(3), DFFB(2), FADD(1), GSN(3), LMNB1(2), LMNB2(2), MAP2K7(2), MAP3K1(4), MAP3K14(1), MAP3K5(12), MAPK8(3), MDM2(2), NFKB1(3), NFKBIA(1), NUMA1(6), PAK2(3), PRKCD(1), PRKDC(23), PSEN1(1), PSEN2(4), PTK2(11), RASA1(3), RIPK1(4), SPTAN1(12), TNFRSF1B(1), TRAF2(1) 23474561 159 91 159 57 28 39 41 21 30 0 0.947 1.000 1.000 257 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(33), ELK1(2), GNAS(7), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), IGF1R(10), ITGB1(3), KLK2(4), MAP2K1(6), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(2), PDGFRA(17), PPP2CA(1), PTPRR(8), RAF1(3), RPS6KA1(1), RPS6KA5(4), SHC1(2), SOS1(12), SRC(2), STAT3(8) 11376262 139 90 125 46 12 36 35 36 20 0 0.905 1.000 1.000 258 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT2(2), AKT3(5), CAB39(2), DDIT4(2), EIF4B(5), FIGF(1), HIF1A(1), IGF1(5), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(11), PIK3CB(7), PIK3CD(1), PIK3CG(11), PIK3R1(3), PIK3R2(1), PIK3R3(2), PIK3R5(8), PRKAA1(4), RHEB(4), RICTOR(19), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), TSC1(9), TSC2(5), ULK1(3), ULK2(2), ULK3(1), VEGFA(1), VEGFC(11) 17774522 147 90 143 47 18 38 48 24 19 0 0.614 1.000 1.000 259 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(16), CANT1(3), CTPS(5), CTPS2(5), DCK(2), DCTD(5), DHODH(1), DPYD(12), DPYS(10), DTYMK(2), ENTPD1(4), ITPA(1), NT5E(2), NT5M(1), NUDT2(3), POLB(2), POLD1(2), POLD2(2), POLE(19), POLG(10), POLL(2), POLQ(17), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), RRM1(5), RRM2(4), TK2(1), TXNRD1(1), UCK2(2), UMPS(2), UNG(5), UPP1(6) 19805523 190 90 188 57 41 42 58 27 21 1 0.353 1.000 1.000 260 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(8), EGFR(33), ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), JUN(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3) 12854686 136 89 119 38 17 25 34 35 25 0 0.582 1.000 1.000 261 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(4), ALDOC(1), DLAT(5), DLD(6), ENO1(3), ENO3(2), FBP2(1), G6PC(1), GAPDH(3), GAPDHS(6), GCK(4), GOT1(2), GOT2(3), GPI(3), HK1(3), HK2(9), HK3(12), LDHA(3), LDHB(2), LDHC(5), MDH1(2), MDH2(2), PC(1), PCK1(12), PDHA1(3), PDHA2(13), PDHX(4), PFKL(2), PFKM(5), PFKP(3), PGAM1(1), PGAM2(1), PGK1(5), PGK2(14), PKLR(11), PKM2(4), TPI1(6) 14625772 169 89 166 55 32 55 39 25 18 0 0.524 1.000 1.000 262 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(10), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH4A1(3), ALDH9A1(3), AMD1(1), AOC2(3), AOC3(5), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), GATM(4), GLUD1(3), GOT1(2), GOT2(3), MAOA(3), MAOB(1), NOS1(9), NOS3(2), OAT(1), ODC1(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), P4HB(4), RARS(5), SMS(1) 15277277 154 87 153 56 22 42 45 26 19 0 0.887 1.000 1.000 263 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ACOX1(3), ACOX3(6), ACSL1(8), ACSL3(3), ACSL4(2), ACSL5(1), ACSL6(7), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1A(7), CPT1B(5), CPT1C(6), CPT2(2), CYP4A11(4), DCI(2), EHHADH(8), GCDH(3), HADH(4), HADHA(3), HADHB(4), HSD17B4(5) 16841805 157 87 154 46 18 62 28 26 22 1 0.520 1.000 1.000 264 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CD3D(2), ELK1(2), FOS(1), FYN(3), GRB2(4), HRAS(1), JUN(1), LAT(3), LCK(5), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SYT1(3), VAV1(1), ZAP70(4) 16404415 136 87 131 40 24 31 45 17 19 0 0.406 1.000 1.000 265 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(11), CALM1(2), ELK1(2), FCER1A(7), FCER1G(2), FOS(1), GRB2(4), HRAS(1), JUN(1), LYN(4), MAP2K1(6), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PAK2(3), PIK3CA(11), PIK3R1(3), PLA2G4A(10), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1) 14773706 147 86 143 36 22 37 44 22 22 0 0.148 1.000 1.000 266 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CANX(2), CD4(3), CD8A(2), CD8B(3), CIITA(4), CTSB(1), CTSS(1), HLA-A(2), HLA-B(3), HLA-C(1), HLA-DMA(2), HLA-DMB(1), HLA-DOA(2), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(3), HLA-G(1), HSP90AA1(5), HSP90AB1(2), HSPA5(4), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(1), KIR2DS4(2), KIR3DL1(10), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LGMN(4), LTA(2), NFYB(1), NFYC(2), PDIA3(2), PSME1(1), PSME2(1), RFX5(6), TAP2(7), TAPBP(2) 16155034 138 86 138 58 20 30 42 27 19 0 0.975 1.000 1.000 267 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(2), AKT3(5), ARHGEF11(11), BCL2(1), CDC42(2), DLG4(3), GNA13(5), LPA(26), MAP2K4(3), MAP3K1(4), MAP3K5(12), MAPK8(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PI3(1), PIK3CB(7), PLD1(9), PLD2(6), PLD3(1), PTK2(11), RDX(2), ROCK1(10), ROCK2(4), SERPINA4(9) 16867911 162 86 162 39 24 46 39 28 25 0 0.177 1.000 1.000 268 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADH(4), HADHA(3), HSD17B4(5), HSD3B7(2), NSD1(11), OGDH(1), OGDHL(11), PLOD1(2), PLOD2(6), PLOD3(3), RDH11(2), SETD1A(8), SETD7(1), SETDB1(5), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(2), SUV39H2(3), TMLHE(2) 19810103 142 85 139 53 20 35 46 22 17 2 0.880 1.000 1.000 269 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(4), CRKL(2), DOCK1(7), ELK1(2), FOS(1), GAB1(2), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), JUN(1), MAP2K1(6), MAP2K2(1), MAP4K1(5), MAPK3(1), MAPK8(3), MET(12), PAK1(5), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), PTK2B(8), PTPN11(6), PXN(1), RAF1(3), RAP1A(2), RAP1B(1), RASA1(3), SOS1(12), SRC(2), STAT3(8) 14658290 148 85 143 42 22 30 34 36 26 0 0.523 1.000 1.000 270 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(4), ADRA1D(2), ADRA2A(1), ADRA2C(3), ADRB2(2), ADRB3(3), CHRM1(2), CHRM2(17), CHRM3(13), CHRM4(2), CHRM5(3), DRD1(3), DRD2(9), DRD3(9), DRD5(8), HRH1(6), HRH2(6), HTR1A(13), HTR1B(5), HTR1D(1), HTR1E(9), HTR1F(4), HTR2A(3), HTR2B(2), HTR2C(5), HTR5A(11), HTR6(5), HTR7(3) 8817874 158 85 157 69 15 62 48 23 10 0 0.888 1.000 1.000 271 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(3), APOA1(1), CD36(4), CITED2(2), CPT1B(5), CREBBP(4), EHHADH(8), EP300(2), FABP1(1), HSD17B4(5), JUN(1), LPL(5), MAPK3(1), ME1(1), NCOA1(5), NCOR1(10), NCOR2(13), NFKBIA(1), NR0B2(1), NR1H3(3), NR2F1(1), NRIP1(8), PDGFA(6), PIK3CA(11), PIK3R1(3), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), PTGS2(4), RXRA(1), SP1(1), STAT5A(3), STAT5B(4) 21115174 138 85 133 50 24 36 40 18 20 0 0.849 1.000 1.000 272 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 ATF2(5), CDC42(2), DLD(6), DUSP10(6), DUSP8(1), GAB1(2), GADD45A(1), GCK(4), IL1R1(1), JUN(1), MAP2K4(3), MAP2K7(2), MAP3K1(4), MAP3K10(1), MAP3K11(7), MAP3K12(6), MAP3K13(7), MAP3K2(5), MAP3K3(4), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK10(5), MAPK7(5), MAPK8(3), MAPK9(6), MYEF2(4), NFATC3(10), NR2C2(2), PAPPA(12), SHC1(2), TRAF6(4), ZAK(3) 16997983 166 85 165 46 40 37 47 25 17 0 0.322 1.000 1.000 273 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(5), ATF2(5), CALM1(2), EGFR(33), ELK1(2), GNAQ(2), GRB2(4), HRAS(1), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PAK1(5), PRKCA(7), PTK2(11), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3) 11569309 134 84 120 35 24 35 21 30 24 0 0.381 1.000 1.000 274 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(11), ACAT1(1), ACAT2(1), ACOT12(4), ACSS1(4), ACSS2(4), ACYP2(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK1(12), PCK2(3), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4) 16098013 149 84 148 50 27 43 40 21 18 0 0.720 1.000 1.000 275 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(1), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EARS2(2), EPRS(13), GAD1(5), GAD2(9), GCLC(8), GCLM(1), GFPT1(4), GFPT2(6), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), GMPS(8), GOT1(2), GOT2(3), GPT2(3), GSR(1), GSS(3), NADSYN1(1), NAGK(1), PPAT(5), QARS(2) 13623439 157 83 156 44 21 46 39 31 19 1 0.471 1.000 1.000 276 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(2), AKT3(5), BCR(3), BLNK(1), BTK(11), CD19(2), DAG1(2), EPHB2(5), GRB2(4), ITPKA(1), ITPKB(5), LYN(4), MAP2K1(6), MAP2K2(1), NFAT5(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SYK(3), VAV1(1) 18092603 132 83 129 39 14 29 41 28 20 0 0.419 1.000 1.000 277 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(1), ALOX15(4), ALOX15B(2), ALOX5(5), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP2U1(2), CYP4A11(4), CYP4F2(5), CYP4F3(12), DHRS4(1), EPHX2(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GPX6(3), GPX7(3), LTA4H(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6) 13383676 144 82 143 46 23 42 40 21 17 1 0.585 1.000 1.000 278 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN2(3), CAPNS2(2), CXCR3(1), EGF(8), EGFR(33), HRAS(1), ITGA1(9), ITGB1(3), MAPK3(1), MYL2(3), MYLK(15), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTK2(11), PXN(1), TLN1(13) 11288326 120 81 106 34 12 32 20 32 24 0 0.639 1.000 1.000 279 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT2(2), AKT3(5), BRD4(6), CBL(8), CDC42(2), F2RL2(5), FLOT1(2), FLOT2(1), GRB2(4), GSK3B(2), IGFBP1(3), INPPL1(6), IRS1(15), IRS2(3), IRS4(17), LNPEP(1), MAPK3(1), PARD3(6), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPYR1(2), PTEN(8), PTPN1(1), RAF1(3), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SERPINB6(2), SHC1(2), SORBS1(7), SOS1(12), SOS2(6), YWHAG(2) 20221158 164 81 160 59 32 36 55 23 18 0 0.802 1.000 1.000 280 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(1), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), ELAVL1(3), FLT1(21), FLT4(13), HIF1A(1), HRAS(1), KDR(30), NOS3(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PXN(1), SHC1(2), VHL(1) 11744952 129 81 125 31 18 41 39 16 15 0 0.150 1.000 1.000 281 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 ADCYAP1R1(6), CALCR(8), CALCRL(10), CD97(4), CRHR1(1), CRHR2(2), EMR1(10), EMR2(3), GHRHR(5), GIPR(2), GLP1R(1), GLP2R(9), GPR64(7), LPHN1(3), LPHN2(24), LPHN3(33), SCTR(1), VIPR2(4) 8788104 133 80 133 49 9 48 31 29 16 0 0.922 1.000 1.000 282 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(10), ACY3(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH7A1(1), ALDH9A1(3), AMDHD1(3), AOC2(3), AOC3(5), ASPA(2), CARM1(1), CNDP1(5), DDC(6), FTCD(3), HAL(2), HARS(2), HARS2(3), HDC(7), HNMT(2), LCMT1(2), LCMT2(4), MAOA(3), MAOB(1), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), PRPS1(3), PRPS2(2), UROC1(9), WBSCR22(1) 13689849 134 80 134 39 24 34 46 18 12 0 0.214 1.000 1.000 283 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(3), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), JUN(1), LY96(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), PPARA(1), TLR10(6), TLR2(2), TLR4(31), TLR6(6), TLR7(8), TLR9(6), TOLLIP(1), TRAF6(4) 12531338 111 80 110 42 12 32 25 17 25 0 0.951 1.000 1.000 284 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(4), APC(23), ATF2(5), AXIN1(3), BMP10(7), BMP2(1), BMP4(4), BMP5(4), BMP7(4), BMPR1A(1), BMPR2(2), CHRD(9), CTNNB1(11), DVL1(1), FZD1(3), GATA4(4), GSK3B(2), MAP3K7(5), MEF2C(2), MYL2(3), NKX2-5(3), NPPA(1), RFC1(6), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2), TGFBR3(12), WNT1(3) 12563856 138 79 136 41 18 41 34 22 23 0 0.685 1.000 1.000 285 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), DLG4(3), GRIN1(2), GRIN2A(26), GRIN2B(21), GRIN2C(3), GRIN2D(6), NOS1(9), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), SYT1(3) 8824973 102 79 101 43 16 29 33 12 12 0 0.948 1.000 1.000 286 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(1), AOC2(3), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CPT1B(5), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), MAOA(3), MAOB(1), PLCB2(6), PLCG1(5), PLCG2(9), PSPH(5), SARDH(5), SARS(2), SHMT1(2), SHMT2(2), TARS(5) 14591193 128 78 128 37 23 39 35 23 8 0 0.347 1.000 1.000 287 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(14), AUH(1), BCAT1(1), BCAT2(1), BCKDHB(5), DBT(10), DLD(6), EHHADH(8), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(4), HMGCS1(5), HMGCS2(5), HSD17B4(5), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2) 14806911 136 78 134 43 9 43 35 19 27 3 0.757 1.000 1.000 288 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(2), FOS(1), GRB2(4), HRAS(1), JAK1(8), JUN(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3) 11969601 118 78 115 34 16 23 37 25 17 0 0.508 1.000 1.000 289 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT2(2), AKT3(5), ANKRD6(1), APC(23), AXIN1(3), AXIN2(2), CER1(2), CSNK1A1(1), CTNNB1(11), DACT1(12), DKK1(2), DKK2(4), DKK4(2), DVL1(1), FSTL1(3), GSK3B(2), LRP1(20), MVP(3), NKD1(5), NKD2(3), PSEN1(1), PTPRA(5), SENP2(3), SFRP1(1), TSHB(1) 13926635 118 78 116 33 11 36 38 13 20 0 0.495 1.000 1.000 290 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(11), CALM1(2), CD79B(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), JUN(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), RAF1(3), SHC1(2), SOS1(12), SYK(3), SYT1(3), VAV1(1) 13125135 116 77 115 33 21 28 35 17 15 0 0.307 1.000 1.000 291 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(2), ALAS1(3), BLVRA(1), BLVRB(1), COX15(2), CP(6), CPOX(4), EARS2(2), EPRS(13), FECH(2), FTMT(4), GUSB(5), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8) 13908544 139 77 137 42 13 55 34 23 14 0 0.685 1.000 1.000 292 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(8), EGFR(33), GRB2(4), HRAS(1), MAP2K1(6), MAPK3(1), PTPRB(29), RAF1(3), RASA1(3), SHC1(2), SOS1(12), SPRY1(1), SPRY2(2), SPRY3(5), SPRY4(3), SRC(2) 8608110 123 77 109 37 17 29 22 35 20 0 0.690 1.000 1.000 293 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(3), CDIPT(1), CDS1(2), CDS2(3), CHAT(8), CHKA(1), CHKB(2), CLC(1), CPT1B(5), DGKA(5), DGKB(15), DGKD(3), DGKE(5), DGKG(7), DGKH(5), DGKZ(3), ETNK1(1), GNPAT(3), GPD1(2), GPD2(4), LCAT(1), LGALS13(2), LYPLA1(1), LYPLA2(1), PAFAH2(1), PCYT1A(2), PCYT1B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLCB2(6), PLCG1(5), PLCG2(9), PPAP2B(2), PPAP2C(1) 17365757 147 76 147 44 18 35 46 28 20 0 0.500 1.000 1.000 294 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(14), GABBR1(3), GPRC5A(1), GPRC5B(7), GPRC5C(1), GRM1(26), GRM2(5), GRM3(9), GRM4(9), GRM5(13), GRM7(15), GRM8(19) 7178692 122 76 122 41 11 37 44 21 9 0 0.515 1.000 1.000 295 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(10), CALM1(2), ELK1(2), FOS(1), GNAI1(3), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), JUN(1), MAP2K1(6), MAPK3(1), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RAF1(3), RPS6KA3(1), SYT1(3) 11996852 108 76 107 31 19 28 33 12 16 0 0.363 1.000 1.000 296 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACAT1(1), ACAT2(1), ACYP2(1), ADH5(4), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), DLAT(5), DLD(6), GLO1(1), GRHPR(1), HAGH(1), HAGHL(1), LDHA(3), LDHB(2), LDHC(5), LDHD(2), MDH1(2), MDH2(2), ME1(1), ME2(7), ME3(2), PC(1), PCK1(12), PDHA1(3), PDHA2(13), PKLR(11), PKM2(4) 12747514 135 76 134 32 23 39 38 16 19 0 0.126 1.000 1.000 297 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CAMK1(2), ELK1(2), FPR1(4), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), NFKB1(3), NFKBIA(1), PAK1(5), PIK3C2G(9), PLCB1(18), PPP3CA(5), PPP3CB(1), PPP3CC(2), RAF1(3), SYT1(3) 13249024 117 75 116 35 22 35 32 8 20 0 0.445 1.000 1.000 298 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(3), ALDH5A1(2), CAD(16), CPS1(39), EPRS(13), GAD1(5), GAD2(9), GCLC(8), GCLM(1), GFPT1(4), GLS(3), GLS2(2), GLUD1(3), GLUL(2), GMPS(8), GOT1(2), GOT2(3), GPT2(3), GSS(3), NADSYN1(1), PPAT(5), QARS(2) 11439237 141 75 140 40 19 40 38 26 17 1 0.512 1.000 1.000 299 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B3GNT6(3), B4GALT5(3), C1GALT1(2), C1GALT1C1(2), GALNT1(3), GALNT10(3), GALNT11(2), GALNT12(4), GALNT14(10), GALNT2(3), GALNT3(4), GALNT4(4), GALNT5(6), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GALNTL1(4), GALNTL2(6), GALNTL4(6), GALNTL5(5), GCNT1(4), GCNT3(3), GCNT4(3), OGT(6), ST3GAL1(3), ST3GAL2(3), ST6GALNAC1(3), WBSCR17(16) 10699567 125 75 124 51 28 30 30 24 13 0 0.974 1.000 1.000 300 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(21), AR(4), ESR1(1), ESR2(3), HNF4A(5), NPM1(2), NR0B1(5), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(3), NR1I2(2), NR1I3(5), NR2C2(2), NR2E1(7), NR2F1(1), NR2F2(2), NR3C1(3), NR4A1(2), NR4A2(7), NR5A1(2), NR5A2(5), PGR(6), PPARA(1), PPARD(2), PPARG(3), RARA(3), RARB(3), RARG(1), ROR1(4), RORA(5), RORC(2), RXRA(1), RXRB(1), RXRG(11), THRA(1), THRB(5), VDR(1) 14429519 140 75 140 69 30 45 33 19 13 0 0.998 1.000 1.000 301 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(10), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), AOX1(14), DBH(2), DCT(7), DDC(6), FAH(1), GOT1(2), GOT2(3), GSTZ1(1), HGD(4), HPD(2), MAOA(3), MAOB(1), TAT(4), TH(2), TPO(16) 10576136 135 75 135 44 17 58 24 17 19 0 0.705 1.000 1.000 302 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(8), BAX(1), BCL2(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(3), BIRC5(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CHUK(3), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(3), GZMB(3), HELLS(1), IKBKB(3), IRF1(1), IRF2(1), IRF3(1), IRF4(3), IRF6(5), IRF7(1), JUN(1), LTA(2), MAP2K4(3), MAP3K1(4), MAPK10(5), MDM2(2), NFKB1(3), NFKBIA(1), NFKBIE(1), PLEKHG5(5), PRF1(5), RIPK1(4), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFSF10(1), TP73(4), TRAF2(1), TRAF3(3) 19619575 134 74 134 43 15 37 33 21 28 0 0.773 1.000 1.000 303 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(10), AGXT(3), AGXT2(8), ALAS1(3), AMT(1), AOC2(3), AOC3(5), BHMT(6), CBS(1), CHKA(1), CHKB(2), CTH(1), DAO(1), DLD(6), DMGDH(4), GARS(4), GATM(4), GCAT(4), GLDC(11), HSD3B7(2), MAOA(3), MAOB(1), PHGDH(3), PSAT1(2), PSPH(5), RDH11(2), SARDH(5), SARS(2), SDS(2), SHMT1(2), SHMT2(2), TARS(5), TARS2(9) 14655771 123 74 122 41 20 41 32 19 11 0 0.634 1.000 1.000 304 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(4), ARRB2(1), CALM1(2), CALML3(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(5), CLCA2(12), CLCA4(12), CNGA3(9), CNGA4(7), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(17), PRKACB(3), PRKACG(1), PRKG1(3), PRKG2(7), PRKX(3) 10497589 113 74 113 38 19 43 18 14 19 0 0.817 1.000 1.000 305 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(22), BMPR1B(5), CCND2(1), CDK4(2), CDKN1B(3), DAZL(2), DMC1(1), EGR1(2), ESR2(3), FSHR(20), GJA4(1), LHCGR(6), MLH1(5), MSH5(4), NCOR1(10), NR5A1(2), NRIP1(8), PGR(6), PRLR(9), PTGER2(2), SMPD1(2), VDR(1), ZP2(2) 12067613 119 74 118 38 13 32 40 18 16 0 0.735 1.000 1.000 306 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 ASAH1(2), CAMP(2), CREB5(7), CREBBP(4), CRKL(2), DAG1(2), EGR1(2), EGR2(2), EGR3(1), EGR4(2), ELK1(2), FRS2(2), GNAQ(2), JUN(1), MAP1B(11), MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), NTRK1(12), OPN1LW(3), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PTPN11(6), RPS6KA3(1), SHC1(2), SRC(2), TH(2) 17342628 124 74 119 44 20 30 41 13 20 0 0.734 1.000 1.000 307 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(8), BAX(1), BCL2(1), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CD40LG(6), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAS(3), FASLG(3), IKBKE(5), LTA(2), MCL1(1), NFKB1(3), NFKBIA(1), NGFR(2), NR3C1(3), NTRK1(12), PTPN13(11), RIPK1(4), SFRS2IP(12), TFG(1), TNFRSF1B(1), TRAF2(1), TRAF3(3), TRAF6(4) 15176746 131 73 129 43 15 40 31 24 21 0 0.808 1.000 1.000 308 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(7), ATP4B(1), ATP5A1(3), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP5G3(2), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), COX15(2), COX4I1(1), COX5B(1), COX6B1(1), COX6B2(1), COX7B2(1), COX8A(1), COX8C(1), CYC1(2), LHPP(2), NDUFA10(2), NDUFA11(1), NDUFA12(2), NDUFA13(4), NDUFA4(1), NDUFA8(3), NDUFA9(5), NDUFB11(1), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(7), NDUFS2(6), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFS8(1), NDUFV1(3), PPA1(1), SDHA(4), SDHB(1), SDHD(1), TCIRG1(1), UQCRB(4), UQCRC2(4), UQCRFS1(2), UQCRQ(1) 19192261 147 73 147 72 28 31 43 24 21 0 0.999 1.000 1.000 309 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(4), CARS(1), CARS2(1), DARS2(3), EARS2(2), EPRS(13), FARS2(1), FARSA(2), FARSB(3), GARS(4), HARS(2), HARS2(3), IARS(9), IARS2(7), KARS(4), LARS(7), LARS2(2), MARS(3), MARS2(8), MTFMT(1), NARS(3), NARS2(3), PARS2(1), QARS(2), RARS(5), RARS2(2), SARS(2), TARS(5), TARS2(9), VARS(6), VARS2(8), WARS(3), WARS2(9), YARS(1), YARS2(2) 18699453 142 73 141 39 21 44 39 22 16 0 0.359 1.000 1.000 310 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), BCR(3), CAPNS2(2), CRKL(2), FYN(3), GRB2(4), HRAS(1), ITGA1(9), ITGB1(3), JUN(1), MAP2K1(6), MAP2K2(1), MAPK3(1), MAPK8(3), PPP1R12B(5), PTK2(11), PXN(1), RAF1(3), RAP1A(2), ROCK1(10), SHC1(2), SOS1(12), SRC(2), TLN1(13), VCL(2), ZYX(2) 16248466 138 73 136 53 28 38 21 34 17 0 0.922 1.000 1.000 311 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(5), CDC42(2), DAXX(6), DDIT3(4), ELK1(2), GRB2(4), HRAS(1), HSPB1(1), HSPB2(1), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K5(12), MAP3K7(5), MAP3K9(11), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MKNK1(2), PLA2G4A(10), RIPK1(4), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TRAF2(1) 12674463 118 73 118 32 17 28 31 25 17 0 0.410 1.000 1.000 312 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(2), CALM1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDK5(1), F2(5), FYN(3), GNA11(1), GNAI1(3), GNB1(2), GNGT1(2), GRB2(4), HRAS(1), JAK2(4), MAP2K1(6), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(8), MYLK(15), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), SYT1(3) 14373185 130 72 129 45 23 36 28 23 20 0 0.793 1.000 1.000 313 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(2), FBP2(1), G6PC(1), GAA(2), GALE(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), LCT(30), MGAM(30), PFKM(5), PFKP(3), PGM1(2), PGM3(4) 11299547 123 72 122 36 25 34 37 19 8 0 0.274 1.000 1.000 314 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 AKR1B1(2), B4GALT1(1), B4GALT2(2), G6PC(1), G6PC2(2), GAA(2), GALE(1), GALK2(2), GALT(2), GANC(1), GCK(4), GLA(4), HK1(3), HK2(9), HK3(12), HSD3B7(2), LCT(30), MGAM(30), PFKL(2), PFKM(5), PFKP(3), PGM1(2), PGM3(4), RDH11(2), UGP2(1) 13202537 129 72 128 39 25 36 40 20 8 0 0.331 1.000 1.000 315 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 44 AACS(6), AADAC(3), ABAT(4), ACAT1(1), ACAT2(1), ACSM1(6), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH7A1(1), ALDH9A1(3), BDH2(1), DDHD1(3), EHHADH(8), GAD1(5), GAD2(9), HADH(4), HADHA(3), HMGCS1(5), HMGCS2(5), HSD17B4(5), HSD3B7(2), ILVBL(1), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), PLA1A(4), PPME1(3), PRDX6(3), RDH11(2) 13722138 128 72 126 41 16 38 31 20 20 3 0.703 1.000 1.000 316 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(3), CDK2(4), CDT1(2), DIAPH2(7), GMNN(1), MCM10(2), MCM2(6), MCM3(5), MCM4(6), MCM5(3), MCM6(10), MCM7(4), NACA(1), ORC1L(4), ORC2L(4), ORC3L(1), ORC4L(1), ORC5L(5), ORC6L(1), PCNA(1), POLA2(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), PRIM1(3), RFC1(6), RFC2(2), RFC3(1), RFC4(1), RFC5(1), RPA2(1), RPA4(5), UBC(10) 17523538 131 71 130 33 34 28 42 14 13 0 0.110 1.000 1.000 317 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA2(4), ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), HSD3B7(2), LIPA(2), RDH11(2), SLC27A5(1), SOAT1(7), SRD5A1(3), SRD5A2(3) 10705292 126 71 125 42 9 51 29 20 16 1 0.728 1.000 1.000 318 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(1), ANGPTL2(4), DAG1(2), DGKA(5), GCA(1), ITGA9(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), MAP2K1(6), MAPK3(1), NR1I3(5), PAK1(5), PDE3A(13), PDE3B(9), PI3(1), PIK3C2G(9), PIK3CA(11), PIK3CD(1), PIK3R1(3), PSME1(1), RIPK3(4), SGCB(1), VASP(3) 16948061 138 71 134 29 24 35 35 21 23 0 0.0449 1.000 1.000 319 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(2), AKT3(5), GRB2(4), IARS(9), IL2RG(3), IL4(1), IL4R(5), INPP5D(4), JAK1(8), JAK2(4), JAK3(5), NR0B2(1), PI3(1), PIK3CA(11), PPP1R13B(2), RPS6KB1(2), SERPINA4(9), SHC1(2), SOS1(12), SOS2(6), SRC(2), STAT6(2), TYK2(2) 12721179 102 71 99 33 8 27 35 21 11 0 0.698 1.000 1.000 320 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(5), ARSB(1), ARSD(3), CYP11B1(10), CYP11B2(7), HSD11B1(4), HSD11B2(1), HSD17B2(3), HSD17B3(1), HSD3B1(7), HSD3B2(13), SRD5A1(3), SRD5A2(3), STS(5), SULT1E1(1), SULT2A1(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13) 9448311 120 70 119 39 10 49 30 21 10 0 0.725 1.000 1.000 321 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ASL(3), ASS1(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), DAO(1), EPRS(13), GATM(4), GLUD1(3), GLUD2(5), GOT1(2), GOT2(3), LAP3(1), NOS1(9), NOS3(2), OAT(1), OTC(5), P4HA1(3), P4HA2(2), P4HA3(2), PARS2(1), PYCR2(1), RARS(5), RARS2(2) 12373786 120 70 119 45 15 36 35 20 14 0 0.942 1.000 1.000 322 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(9), ALG10B(6), ALG12(2), ALG13(9), ALG14(2), ALG2(5), ALG3(5), ALG8(2), ALG9(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), DAD1(1), DDOST(1), DHDDS(1), DOLPP1(3), DPAGT1(1), DPM1(1), FUT8(4), GANAB(3), MAN1A2(9), MAN1B1(2), MAN1C1(2), MAN2A1(11), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), MGAT5B(6), RFT1(4), RPN2(4), STT3B(2) 14680503 118 70 118 37 17 37 35 17 12 0 0.647 1.000 1.000 323 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(8), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BBOX1(3), DLST(2), DOT1L(8), EHHADH(8), EHMT1(8), EHMT2(1), GCDH(3), HADHA(3), PLOD1(2), PLOD2(6), PLOD3(3), SDS(2), SHMT1(2), SHMT2(2), TMLHE(2) 12828351 106 70 104 31 15 29 33 14 13 2 0.456 1.000 1.000 324 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(10), ARHGEF1(2), F2(5), F2R(4), F2RL3(2), GNA12(1), GNA13(5), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), MAP3K7(5), PIK3CA(11), PIK3R1(3), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2B(8), ROCK1(10) 8952755 105 70 102 25 16 32 29 10 18 0 0.200 1.000 1.000 325 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(3), CDK5(1), CHN1(4), MAP3K1(4), MYL2(3), MYLK(15), NCF2(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLD1(9), PPP1R12B(5), RALBP1(1), RPS6KB1(2), TRIO(15), VAV1(1), WASF1(8) 12037385 109 70 105 29 13 29 35 14 18 0 0.348 1.000 1.000 326 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(6), EGF(8), EGFR(33), GRB2(4), MET(12), PDGFRA(17), PRKCA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(2), SRC(2) 6663213 101 69 87 32 12 25 18 26 20 0 0.817 1.000 1.000 327 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA1(1), FUCA2(1), GBA(3), GUSB(5), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(5), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(1), NEU1(1), NEU3(3), NEU4(6), SPAM1(12) 11948533 96 69 96 35 10 34 31 12 9 0 0.809 1.000 1.000 328 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(3), ARHGAP4(2), ARHGAP5(7), ARHGAP6(6), ARHGEF1(2), ARHGEF11(11), ARHGEF5(4), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), BAIAP2(2), DIAPH1(4), GSN(3), MYL2(3), MYLK(15), OPHN1(7), PFN1(1), PIP5K1A(5), PIP5K1B(7), PPP1R12B(5), ROCK1(10), SRC(2), TLN1(13), VCL(2) 15730697 123 69 123 38 24 35 28 16 20 0 0.627 1.000 1.000 329 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(2), AKT2(2), AKT3(5), BTK(11), DAPP1(2), GRB2(4), GSK3B(2), IARS(9), IGFBP1(3), INPP5D(4), PDK1(4), PIK3CA(11), PPP1R13B(2), PTEN(8), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), RPS6KB1(2), SHC1(2), SOS1(12), SOS2(6), TEC(5), YWHAG(2) 12241653 107 69 103 36 9 24 40 20 14 0 0.833 1.000 1.000 330 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(22), ATR(16), BRCA1(8), CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(6), CHEK2(2), EP300(2), GADD45A(1), MDM2(2), MYT1(6), PRKDC(23), RPS6KA1(1), WEE1(3) 14339293 104 68 103 21 8 30 30 17 19 0 0.228 1.000 1.000 331 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(1), ACP5(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CYP19A1(3), CYP1A1(6), CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), CYP2B6(8), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A5(1), CYP3A7(4), CYP4B1(8), CYP4F8(5), CYP51A1(3), PON1(3) 10113327 115 68 114 41 17 30 30 17 20 1 0.730 1.000 1.000 332 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), FUK(3), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), HSD3B7(2), KHK(2), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PFKFB1(6), PFKFB2(3), PFKFB3(5), PFKFB4(5), PFKL(2), PFKM(5), PFKP(3), PGM2(5), PHPT1(1), PMM1(1), RDH11(2), SORD(2), TPI1(6), TSTA3(1) 12765147 117 68 115 36 20 34 30 22 11 0 0.365 1.000 1.000 333 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(10), ADC(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AMD1(1), AOC2(3), AOC3(5), ARG1(1), ASL(3), ASS1(3), CPS1(39), GATM(4), MAOA(3), MAOB(1), ODC1(1), OTC(5), SAT1(1), SMS(1), SRM(2) 10196683 105 68 104 37 12 29 29 21 14 0 0.809 1.000 1.000 334 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), DDC(6), EPX(7), ESCO1(7), ESCO2(2), GOT1(2), GOT2(3), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), PRDX6(3), SH3GLB1(1), TAT(4), TPO(16) 11768310 110 68 110 39 16 35 27 19 13 0 0.813 1.000 1.000 335 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 ABO(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALNT1(4), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(4), PIGZ(1), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2), ST3GAL6(3), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4) 16502885 104 68 102 47 25 20 35 17 7 0 0.964 1.000 1.000 336 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX15(4), ALOX5(5), CYP4F2(5), CYP4F3(12), EPX(7), GGT1(1), LPO(4), LTA4H(1), MPO(4), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6), TPO(16) 9543117 114 68 114 34 13 28 32 25 16 0 0.526 1.000 1.000 337 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT2(2), AKT3(5), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PDK1(4), PHKA2(10), PIK3CB(7), PITX2(4), PLD1(9), PLD2(6), PLD3(1) 15490934 114 68 113 30 17 32 32 15 18 0 0.203 1.000 1.000 338 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(22), ATR(16), BRCA1(8), BRCA2(16), CHEK1(6), CHEK2(2), FANCA(5), FANCC(1), FANCD2(3), FANCE(3), FANCF(2), FANCG(4), HUS1(2), MRE11A(6), RAD1(5), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TREX1(1) 14899885 110 67 109 26 7 33 33 20 17 0 0.484 1.000 1.000 339 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 BAG4(1), CASP2(7), CASP3(4), CASP8(4), DFFA(3), DFFB(2), FADD(1), JUN(1), LMNB1(2), LMNB2(2), MADD(13), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), RIPK1(4), SPTAN1(12), TRAF2(1) 12976514 103 67 103 28 26 22 24 15 16 0 0.375 1.000 1.000 340 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(4), ABAT(4), ACY3(2), ADSSL1(1), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), ASRGL1(1), ASS1(3), CAD(16), CRAT(1), DARS2(3), DDO(3), DLAT(5), DLD(6), GAD1(5), GAD2(9), GOT1(2), GOT2(3), GPT2(3), NARS(3), NARS2(3), PC(1), PDHA1(3), PDHA2(13) 13044756 114 66 114 41 22 30 35 17 10 0 0.723 1.000 1.000 341 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(3), ASAH1(2), B4GALT6(3), CERK(3), DEGS1(3), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SGMS1(1), SGMS2(3), SGPP1(1), SMPD1(2), SMPD2(1), SMPD3(1), SMPD4(2), SPHK2(2), SPTLC1(1), SPTLC2(1), UGT8(1) 12407907 95 66 94 30 13 33 31 10 8 0 0.484 1.000 1.000 342 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(5), F2R(4), F2RL3(2), GNAI1(3), GNB1(2), GNGT1(2), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), PLA2G4A(10), PLCB1(18), PRKCA(7), PTGS1(5), PTK2(11), RAF1(3), SRC(2), SYK(3), TBXAS1(6) 8377736 103 66 103 26 13 32 20 18 20 0 0.408 1.000 1.000 343 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(10), ACADM(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOC2(3), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(9), HADHA(3), MLYCD(4), SDS(2), SMS(1) 9987148 115 65 114 38 19 38 26 16 14 2 0.706 1.000 1.000 344 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(8), CARM1(1), CCND1(2), CREBBP(4), EP300(2), ERCC3(5), ESR1(1), GRIP1(6), GTF2A1(3), GTF2E1(6), GTF2F1(1), HDAC1(3), HDAC2(8), HDAC3(1), HDAC4(11), HDAC5(2), HDAC6(5), MEF2C(2), NCOR2(13), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(9) 15866265 108 65 107 30 24 25 34 14 11 0 0.289 1.000 1.000 345 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(7), DIAPH1(4), FYN(3), GSN(3), HRAS(1), ITGA1(9), ITGB1(3), MAP2K1(6), MAPK3(1), MYL2(3), MYLK(15), PFN1(1), PIK3CA(11), PIK3R1(3), PTK2(11), PXN(1), RAF1(3), ROCK1(10), SHC1(2), SRC(2), TLN1(13) 12848503 112 65 108 31 17 28 23 27 17 0 0.459 1.000 1.000 346 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), ASRGL1(1), CA1(2), CA12(1), CA13(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUD2(5), GLUL(2), HAL(2) 7318840 90 65 89 38 10 29 23 19 9 0 0.982 1.000 1.000 347 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(5), ADCY3(5), ADCY9(3), ARF3(1), ARF4(2), ARF5(1), ARL4D(3), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(4), ATP6V1A(4), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ERO1L(2), GNAS(7), PDIA4(3), PLCG1(5), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(5), SEC61B(1), SEC61G(1), TRIM23(2) 12707439 100 65 99 39 18 26 27 16 13 0 0.908 1.000 1.000 348 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(4), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), AOX1(14), BCAT1(1), BCKDHB(5), EHHADH(8), HADHA(3), HADHB(4), HIBADH(1), IVD(3), MCCC1(2), MCCC2(3), MCEE(1), MUT(6), OXCT1(4), PCCA(5), PCCB(2), SDS(2) 12378366 104 65 103 37 9 32 28 12 21 2 0.863 1.000 1.000 349 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(10), ASAH1(2), GNAI1(3), GNB1(2), GNGT1(2), ITGAV(9), ITGB3(4), MAPK3(1), PDGFA(6), PDGFRA(17), PIK3CA(11), PIK3R1(3), PLCB1(18), PRKCA(7), PTK2(11), SMPD1(2), SMPD2(1), SRC(2) 9425640 111 64 108 34 15 36 29 13 18 0 0.612 1.000 1.000 350 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CFLAR(1), DAXX(6), DFFA(3), DFFB(2), FADD(1), FAF1(4), JUN(1), LMNB1(2), LMNB2(2), MAP2K4(3), MAP3K1(4), MAP3K7(5), MAPK8(3), PAK1(5), PAK2(3), PRKDC(23), PTPN13(11), SPTAN1(12) 13752137 107 64 107 41 24 24 28 12 19 0 0.947 1.000 1.000 351 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(5), C5(2), C6(14), IL1A(3), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELP(14), SELPLG(3), VCAM1(17) 8021183 102 64 102 35 9 35 31 15 12 0 0.872 1.000 1.000 352 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(2), ATM(22), ATR(16), CCNA1(2), CCND1(2), CCNE1(3), CDC25A(4), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), DHFR(1), E2F1(3), GSK3B(2), HDAC1(3), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(8), TGFB3(1) 9329002 91 63 90 24 10 30 23 15 13 0 0.511 1.000 1.000 353 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(2), DCXR(1), GUSB(5), RPE(2), UGDH(4), UGP2(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2A1(3), UGT2A3(6), UGT2B11(11), UGT2B15(6), UGT2B28(8), UGT2B4(13), UGT2B7(8), XYLB(3) 8738182 103 63 101 32 7 43 25 17 11 0 0.750 1.000 1.000 354 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(2), AGTR1(5), AGTR2(2), CMA1(6), COL4A1(16), COL4A2(15), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), REN(1) 8864361 108 62 108 51 8 52 24 11 13 0 1.000 1.000 1.000 355 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(6), ABAT(4), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH5A1(2), ALDH9A1(3), EHHADH(8), GAD1(5), GAD2(9), HADHA(3), L2HGDH(2), OXCT1(4), PDHA1(3), PDHA2(13), SDHB(1), SDS(2) 8839629 95 62 94 31 14 28 25 12 14 2 0.704 1.000 1.000 356 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(10), ACADM(3), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(3), AOC3(5), CNDP1(5), DPYD(12), DPYS(10), EHHADH(8), GAD1(5), GAD2(9), HADHA(3), HIBCH(4), MLYCD(4), SMS(1), SRM(2) 9297629 108 62 107 34 17 34 26 16 13 2 0.588 1.000 1.000 357 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2F1(1), GTF2H1(4), GTF2H3(1), GTF2I(4), GTF2IRD1(5), TAF1(9), TAF10(1), TAF1L(25), TAF2(6), TAF4(4), TAF4B(5), TAF5L(4), TAF6(2), TAF7(2), TAF7L(3), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(3) 12389816 96 62 95 28 16 19 31 14 16 0 0.563 1.000 1.000 358 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(6), POLA2(2), POLB(2), POLD1(2), POLD2(2), POLD3(3), POLE(19), POLE2(1), POLG(10), POLG2(1), POLI(2), POLK(3), POLL(2), POLM(6), POLQ(17), PRIM1(3), REV1(4), REV3L(13), RFC5(1) 13796334 99 62 98 26 22 16 35 16 10 0 0.319 1.000 1.000 359 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(3), ANAPC7(4), BTRC(9), CDC16(3), CDC20(3), CDC23(1), CDC27(1), CUL1(6), CUL2(6), CUL3(7), FBXW7(4), FZR1(2), ITCH(6), SKP1(2), SKP2(4), SMURF1(3), SMURF2(2), TCEB1(1), UBA1(1), UBE2D2(1), UBE2D3(3), UBE2D4(3), UBE2E2(1), UBE2E3(1), VHL(1), WWP1(3), WWP2(3) 13918391 92 62 91 24 19 16 26 17 14 0 0.326 1.000 1.000 360 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(4), HRAS(1), JAK2(4), JUN(1), MAP2K1(6), MAPK3(1), MPL(2), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), RAF1(3), RASA1(3), SHC1(2), SOS1(12), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), THPO(1) 10285764 86 62 83 25 11 17 25 19 14 0 0.567 1.000 1.000 361 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(4), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH6(8), ADH7(4), ADHFE1(2), AKR1C4(1), AKR1D1(5), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), BAAT(5), CEL(4), CYP27A1(5), CYP7A1(7), HADHB(4), SRD5A1(3), SRD5A2(3) 7989352 113 61 112 36 11 47 24 16 15 0 0.649 1.000 1.000 362 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 BCL2(1), EGFR(33), IGF1R(10), POLR2A(9), PPP2CA(1), PRKCA(7), TEP1(22), TERF1(1), TERT(4), TNKS(3), XRCC5(6) 8768410 97 61 83 32 18 21 18 19 21 0 0.766 1.000 1.000 363 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(16), COL4A2(15), COL4A3(5), COL4A4(13), COL4A5(23), COL4A6(17), P4HB(4), SLC23A2(4), SLC2A3(6) 8821309 103 61 103 45 11 48 20 11 13 0 0.993 1.000 1.000 364 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(10), ACACB(11), ACADM(3), ACAT1(1), ACAT2(1), ACSS1(4), ACSS2(4), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), EHHADH(8), HADHA(3), HIBCH(4), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SUCLG1(2), SUCLG2(2) 13612676 108 60 107 48 21 31 25 12 18 1 0.986 1.000 1.000 365 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2(1), CBL(8), CFLAR(1), CRKL(2), E2F1(3), FOS(1), GRB2(4), HRAS(1), IL2RA(3), IL2RB(5), IL2RG(3), IRS1(15), JAK1(8), JAK3(5), MAPK3(1), NMI(1), PIK3CA(11), PIK3R1(3), PTPN6(3), RAF1(3), RPS6KB1(2), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3) 12429891 108 60 104 36 23 18 32 23 12 0 0.537 1.000 1.000 366 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(2), CA12(1), CA14(2), CA2(2), CA3(4), CA4(5), CA5A(4), CA5B(1), CA6(1), CA8(2), CA9(3), CPS1(39), CTH(1), GLS(3), GLS2(2), GLUD1(3), GLUL(2), HAL(2) 6542301 83 60 82 34 10 24 22 18 9 0 0.967 1.000 1.000 367 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), ATP7A(14), ATP7B(11), COX4I1(1), COX5B(1), COX6B1(1), COX8A(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3), SDHA(4), SDHB(1), SHMT1(2), UQCRB(4), UQCRFS1(2) 13158111 114 60 114 51 24 34 25 17 14 0 0.985 1.000 1.000 368 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(10), ALDH1A3(2), ALDH3A1(2), ALDH3B2(4), AOC2(3), AOC3(5), DDC(6), EPX(7), GOT1(2), GOT2(3), HPD(2), LPO(4), MAOA(3), MAOB(1), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TAT(4), TPO(16) 7565702 85 60 85 30 12 25 22 17 9 0 0.722 1.000 1.000 369 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(2), AKT3(5), BCL2(1), GRB2(4), GSK3B(2), IL4R(5), IRS1(15), IRS2(3), JAK1(8), JAK3(5), MAP4K1(5), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PIK3R1(3), PPP1R13B(2), RAF1(3), SHC1(2), SOS1(12), SOS2(6), STAT6(2) 12566375 102 60 99 37 16 20 32 21 13 0 0.764 1.000 1.000 370 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1A2(7), EEF1B2(2), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(2), EIF1AX(1), EIF2AK1(6), EIF2AK2(5), EIF2AK3(6), EIF2B1(1), EIF2B2(2), EIF2B3(3), EIF2B4(3), EIF2B5(3), EIF2S3(2), EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), EIF5(1), EIF5B(10), GSPT2(3), PABPC1(3), PAIP1(4) 14706838 98 60 98 26 14 29 36 8 11 0 0.377 1.000 1.000 371 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), GNAQ(2), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), MYL2(3), NOX1(4), PIK3C2G(9), PLCB1(18), PPP1R12B(5), PRKCA(7), PTK2(11), RAF1(3), ROCK2(4) 8767494 87 59 87 24 14 25 20 11 17 0 0.596 1.000 1.000 372 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(5), CALM1(2), CAMK1(2), HDAC5(2), IGF1(5), IGF1R(10), INSR(1), MAP2K6(1), MAPK14(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5), NFATC1(3), NFATC2(8), PIK3CA(11), PIK3R1(3), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYT1(3) 11979906 81 59 77 23 9 27 22 9 14 0 0.375 1.000 1.000 373 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(3), ANXA4(3), ANXA5(2), ANXA6(1), CYP11A1(1), EDN1(1), EDNRB(6), HPGD(1), HSD11B1(4), HSD11B2(1), PLA2G4A(10), PRL(1), PTGDR(3), PTGDS(2), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6) 7115488 80 59 80 30 12 22 21 11 14 0 0.904 1.000 1.000 374 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(2), EIF4A2(4), EIF4E(3), EIF4G1(8), EIF4G3(13), GHR(5), IRS1(15), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(3), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PRKCA(7), PTEN(8), RPS6KB1(2) 9649373 91 58 87 32 15 21 33 12 10 0 0.814 1.000 1.000 375 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(5), F2R(4), F3(4), F5(23), F7(2), FGA(9), FGB(12), FGG(2), PROC(3), PROS1(13), SERPINC1(8), TFPI(1) 5624927 89 58 88 27 10 36 19 10 13 1 0.771 1.000 1.000 376 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GPHN(3), NSF(3), SRC(2), UBQLN1(5) 4109634 84 58 81 26 12 33 14 16 9 0 0.759 1.000 1.000 377 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(4), ACO2(1), CLYBL(5), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), OGDHL(11), PC(1), PCK1(12), PCK2(3), SDHA(4), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2) 10204698 79 58 79 38 14 13 22 14 16 0 0.976 1.000 1.000 378 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(2), FOS(1), GRB2(4), HRAS(1), IGF1(5), IGF1R(10), IRS1(15), JUN(1), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PTPN11(6), RAF1(3), RASA1(3), SHC1(2), SOS1(12) 8481244 89 58 85 24 16 21 25 16 11 0 0.326 1.000 1.000 379 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(5), GRB2(4), HRAS(1), INSR(1), IRS1(15), JAK2(4), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(1), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4) 11358400 93 57 90 30 18 19 26 20 10 0 0.569 1.000 1.000 380 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(1), BLVRB(1), CP(6), CPOX(4), EPRS(13), FECH(2), GUSB(5), HMBS(3), HMOX1(3), PPOX(3), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13) 9435487 92 57 91 27 7 34 22 17 12 0 0.640 1.000 1.000 381 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(10), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), GNAS(7), GRB2(4), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7), RPS6KA1(1), RPS6KA5(4), SOS1(12) 9983942 82 56 79 32 11 21 24 15 11 0 0.933 1.000 1.000 382 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGA4(19), ITGAL(20), ITGAM(14), ITGB1(3), ITGB2(2), SELE(6), SELL(4), SELP(14) 5528060 84 56 84 31 9 30 25 13 7 0 0.918 1.000 1.000 383 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(7), ARHGEF1(2), GNA12(1), GNA13(5), GNAQ(2), GNB1(2), GNGT1(2), MYL2(3), MYLK(15), PLCB1(18), PPP1R12B(5), PRKCA(7), ROCK1(10) 7129686 79 56 79 20 10 28 18 8 15 0 0.477 1.000 1.000 384 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(11), DLG4(3), EPHB2(5), F2(5), F2RL1(1), F2RL2(5), F2RL3(2), JUN(1), MAPK7(5), MAPK8(3), MYEF2(4), PLD1(9), PLD2(6), PLD3(1), PTK2(11), RAF1(3), RASAL1(7), SRC(2), TEC(5), VAV1(1) 9471669 90 56 90 20 12 23 29 13 13 0 0.106 1.000 1.000 385 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(2), ACTN2(23), ACTN3(3), CAPNS2(2), ITGA1(9), ITGB1(3), ITGB3(4), PTK2(11), PXN(1), SPTAN1(12), SRC(2), TLN1(13) 9819062 89 56 88 35 18 26 12 22 11 0 0.927 1.000 1.000 386 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(7), AGT(2), AGTR2(2), EDN1(1), EDNRB(6), EGF(8), EGFR(33), FOS(1), HRAS(1), JUN(1), NFKB1(3), PLCG1(5), PRKCA(7) 7025262 77 55 63 24 11 18 15 20 13 0 0.803 1.000 1.000 387 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(13), F2(5), F2R(4), FGA(9), FGB(12), FGG(2), PLAT(6), PLAU(1), PLG(13), SERPINB2(6), SERPINE1(5) 4602900 80 55 79 27 6 36 19 12 7 0 0.890 1.000 1.000 388 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(10), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH3B2(4), ALDH9A1(3), AOC2(3), AOC3(5), ASPA(2), CNDP1(5), DDC(6), HAL(2), HARS(2), HDC(7), HNMT(2), MAOA(3), MAOB(1), PRPS1(3), PRPS2(2) 8440940 88 55 88 28 16 25 22 16 9 0 0.486 1.000 1.000 389 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(9), CYP2C9(3), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), HADHA(3), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1) 10627890 83 55 82 26 12 26 20 14 10 1 0.615 1.000 1.000 390 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(2), EIF4A2(4), EIF4B(5), EIF4E(3), EIF4G1(8), EIF4G3(13), MKNK1(2), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1), PTEN(8), RPS6KB1(2), TSC1(9), TSC2(5) 9543117 79 55 74 23 7 21 31 11 9 0 0.532 1.000 1.000 391 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(10), ACADM(3), ACAT1(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH9A1(3), EHHADH(8), HADHA(3), LDHA(3), LDHB(2), LDHC(5), MCEE(1), MLYCD(4), MUT(6), PCCA(5), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2) 11345347 95 55 94 34 17 27 24 9 17 1 0.857 1.000 1.000 392 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CALM1(2), CRKL(2), GNAQ(2), GRB2(4), HRAS(1), JUN(1), MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K4(3), MAP3K1(4), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(5), PLCG1(5), PRKCA(7), PTK2B(8), RAF1(3), SHC1(2), SOS1(12), SRC(2), SYT1(3) 9781964 86 55 86 26 22 25 16 11 12 0 0.453 1.000 1.000 393 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(5), BCR(3), BLNK(1), ELK1(2), FOS(1), GRB2(4), HRAS(1), JUN(1), LYN(4), MAP2K1(6), MAP3K1(4), MAPK3(1), MAPK8IP3(4), PAPPA(12), RPS6KA1(1), RPS6KA3(1), SHC1(2), SOS1(12), SYK(3), VAV1(1), VAV2(3), VAV3(14) 11049708 86 55 86 34 9 24 20 19 14 0 0.934 1.000 1.000 394 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(7), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), FADD(1), FAS(3), FASLG(3), GZMB(3), JUN(1), MAP2K4(3), MAP3K1(4), MAP3K14(1), MAPK10(5), MCL1(1), MDM2(2), NFKB1(3), NFKBIA(1), PARP1(2), PRF1(5), RIPK1(4), TNFRSF1B(1), TNFSF10(1), TRAF2(1) 12612862 81 54 81 30 9 23 17 16 16 0 0.911 1.000 1.000 395 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSD(3), ASAH1(2), GAL3ST1(3), GALC(5), GBA(3), GLA(4), LCT(30), NEU1(1), NEU3(3), NEU4(6), PPAP2B(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(1), SPTLC2(1) 8402010 70 54 69 20 9 26 25 5 5 0 0.349 1.000 1.000 396 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(6), GTF2E2(2), GTF2H1(4), ILK(1), MNAT1(2), POLR1A(8), POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR3B(13), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(2), TAF7(2), TAF9(2) 12033034 91 54 89 31 17 22 31 12 9 0 0.741 1.000 1.000 397 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(23), CDH1(5), CREBBP(4), EP300(2), MAP2K1(6), MAP3K7(5), MAPK3(1), SKIL(7), TGFB1(2), TGFB2(8), TGFB3(1), TGFBR1(2), TGFBR2(2) 8789936 68 54 68 16 3 19 14 16 16 0 0.470 1.000 1.000 398 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4) 7926835 75 53 75 25 6 26 23 6 14 0 0.787 1.000 1.000 399 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 APAF1(8), ATM(22), BAX(1), BCL2(1), BID(1), CASP3(4), CASP6(1), CASP7(1), CASP9(3), PRKCA(7), PTK2(11), PXN(1), STAT1(4), TLN1(13) 9164809 78 53 77 27 10 20 16 15 17 0 0.831 1.000 1.000 400 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(2), CD4(3), CREBBP(4), GNAS(7), GNB1(2), GNGT1(2), HLA-DRA(3), LCK(5), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PTPRC(21), ZAP70(4) 7926835 75 53 75 25 6 26 23 6 14 0 0.787 1.000 1.000 401 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(8), GABRA2(14), GABRA3(8), GABRA4(10), GABRA5(14), GABRA6(12), GPX1(1), PRKCE(3) 2730825 70 53 68 24 7 33 12 13 5 0 0.883 1.000 1.000 402 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), FPGT(2), GCK(4), GMDS(6), GMPPA(5), GMPPB(1), HK1(3), HK2(9), HK3(12), KHK(2), PFKFB1(6), PFKFB3(5), PFKFB4(5), PFKM(5), PFKP(3), PMM1(1), SORD(2), TPI1(6) 8314532 87 53 85 26 18 25 21 15 8 0 0.322 1.000 1.000 403 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(3), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(4), JUN(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), RAF1(3), SOS1(12), STAT1(4), STAT5A(3), STAT5B(4) 9611359 74 53 71 20 10 11 23 16 14 0 0.306 1.000 1.000 404 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(7), EXTL1(3), EXTL3(5), GLCE(4), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(1), HS6ST3(5), NDST1(2), NDST2(7), NDST3(8), NDST4(13) 7153731 78 53 77 36 8 24 28 9 8 1 0.984 1.000 1.000 405 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(3), IFNB1(4), IKBKB(3), IL1A(3), IL1R1(1), IL1RAP(2), IL1RN(1), IRAK1(3), IRAK2(3), IRAK3(6), JUN(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(5), MAPK14(1), MAPK8(3), MYD88(3), NFKB1(3), NFKBIA(1), TGFB1(2), TGFB2(8), TGFB3(1), TOLLIP(1), TRAF6(4) 10174928 74 53 73 33 10 19 16 14 15 0 0.986 1.000 1.000 406 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(4), EP300(2), FYN(3), IL2RG(3), IL7R(7), JAK1(8), JAK3(5), LCK(5), NMI(1), PIK3CA(11), PIK3R1(3), PTK2B(8), STAT5A(3), STAT5B(4) 9665403 68 53 64 24 9 14 19 16 10 0 0.812 1.000 1.000 407 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(2), GNB1(2), GNGT1(2), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3C2G(9), PIK3CA(11), PIK3R1(3), PLCG1(5), PRKCA(7), PTK2(11), PTK2B(8), PXN(1), RAF1(3) 9569910 84 52 81 19 15 23 21 11 14 0 0.127 1.000 1.000 408 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(3), ADH1A(6), ADH1B(9), ADH1C(7), ADH4(5), ADH5(4), ADH6(8), ADH7(4), ADHFE1(2), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1) 8604904 88 52 88 27 7 45 12 13 11 0 0.752 1.000 1.000 409 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 ELK1(2), FOS(1), GRB2(4), HRAS(1), IL6R(8), JAK1(8), JAK2(4), JAK3(5), JUN(1), MAP2K1(6), MAPK3(1), PTPN11(6), RAF1(3), SHC1(2), SOS1(12), STAT3(8) 8241252 72 52 71 21 9 15 19 22 7 0 0.525 1.000 1.000 410 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(3), FADD(1), IKBKB(3), IL1A(3), IL1R1(1), IRAK1(3), MAP3K1(4), MAP3K14(1), MAP3K7(5), MYD88(3), NFKB1(3), NFKBIA(1), RIPK1(4), TLR4(31), TNFRSF1B(1), TRAF6(4) 8407048 71 52 70 27 8 18 20 11 14 0 0.887 1.000 1.000 411 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 CDC42(2), CREB5(7), DUSP10(6), EEF2K(2), EIF4E(3), ELK1(2), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K10(1), MAP3K4(14), MAP3K5(12), MAP3K7(5), MAPK11(1), MAPK14(1), MAPKAPK2(3), MAPKAPK5(3), MKNK1(2), MKNK2(1), MYEF2(4), NFKB1(3), NR2C2(2), TRAF6(4) 11449542 91 52 90 28 20 24 23 11 13 0 0.589 1.000 1.000 412 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(5), ITPR1(11), ITPR2(25), ITPR3(6), NFAT5(6), PDE6A(9), PDE6B(4), PDE6C(5), PDE6D(1), PDE6G(2), SLC6A13(4), TF(4) 12435387 93 52 92 27 15 31 17 17 13 0 0.493 1.000 1.000 413 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(8), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP10(6), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(3), DFFA(3), DFFB(2), FADD(1), GAS2(1), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1), TRAF2(1) 11580988 70 51 70 34 12 14 19 10 15 0 0.994 1.000 1.000 414 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GUSB(5), HEXA(1), HGSNAT(4), HPSE(1), HPSE2(5), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(30), NAGLU(1), SPAM1(12) 7051597 67 51 67 23 7 24 20 8 8 0 0.745 1.000 1.000 415 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(10), AOC2(3), AOC3(5), CES1(3), CES7(9), DDHD1(3), ESCO1(7), ESCO2(2), LIPA(2), MYST3(8), MYST4(8), NAT6(1), PLA1A(4), PNPLA3(2), PPME1(3), PRDX6(3), SH3GLB1(1) 8709557 77 51 77 21 11 26 17 13 10 0 0.504 1.000 1.000 416 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(2), FOS(1), GRB2(4), HRAS(1), INSR(1), IRS1(15), JUN(1), MAP2K1(6), MAPK3(1), MAPK8(3), PIK3CA(11), PIK3R1(3), PTPN11(6), RAF1(3), RASA1(3), SHC1(2), SOS1(12) 8739785 75 51 71 22 14 14 23 17 7 0 0.431 1.000 1.000 417 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(1), DLAT(5), DLD(6), DLST(2), FH(7), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), OGDH(1), PC(1), PDHA1(3), PDHA2(13), PDHX(4), PDK1(4), PDK2(2), PDK3(2), PDP2(1), SDHA(4), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(2) 9740515 74 51 74 34 13 21 18 11 11 0 0.966 1.000 1.000 418 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(3), MAP2K7(2), MAPK10(5), MAPK11(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(4), MAPK8IP3(4), MAPK9(6), MAPKAPK5(3), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), PIK3CA(11), PIK3CD(1), PIK3R1(3), SYT1(3), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4) 11610987 72 51 68 26 12 12 28 8 12 0 0.656 1.000 1.000 419 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CDKN1A(1), GNAQ(2), NFATC1(3), NFATC2(8), NFATC3(10), NFATC4(8), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SP1(1), SP3(4), SYT1(3) 7188768 62 50 61 18 12 18 19 6 7 0 0.376 1.000 1.000 420 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCL4(1), CCR1(2), CCR2(5), CCR3(2), CCR4(2), CCR5(1), CD28(1), CD4(3), CXCR3(1), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL4(1), IL4R(5), TGFB1(2), TGFB2(8), TGFB3(1) 6867481 75 50 74 24 7 21 20 13 14 0 0.527 1.000 1.000 421 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(15), FYN(3), LRP8(3), RELN(49), VLDLR(2) 4832816 73 50 72 27 4 26 17 16 10 0 0.963 1.000 1.000 422 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(14), CR2(8), FCGR2B(2), HLA-DRA(3), ITGAL(20), ITGB2(2), PTPRC(21) 5287839 74 49 74 23 8 29 15 8 14 0 0.793 1.000 1.000 423 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), BHMT(6), CBS(1), CTH(1), DNMT1(5), DNMT3A(11), DNMT3B(4), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), MTFMT(1), MTR(11), SRM(2), TAT(4) 7191974 67 49 67 20 13 18 21 8 6 1 0.446 1.000 1.000 424 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(30), MAN2B1(2), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(1), NEU3(3), NEU4(6) 7070604 57 49 57 15 7 21 20 6 3 0 0.323 1.000 1.000 425 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(1), AGPS(3), ENPP2(11), ENPP6(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), PLD1(9), PLD2(6), PPAP2B(2), PPAP2C(1) 8004237 77 49 77 25 12 28 19 8 10 0 0.718 1.000 1.000 426 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(3), ATG7(1), BECN1(1), GABARAPL1(1), IFNA10(4), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(3), IFNA21(3), IFNA4(3), IFNA5(1), IFNA6(2), IFNA7(5), IFNA8(1), IFNG(4), PIK3C3(7), PIK3R4(9), PRKAA1(4), ULK1(3), ULK2(2), ULK3(1) 7295711 68 49 68 23 6 25 18 14 5 0 0.863 1.000 1.000 427 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB5(7), DUSP6(3), DUSP9(2), EEF2K(2), EIF4E(3), GRB2(4), MAP2K1(6), MAP2K2(1), MAP3K8(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(7), RPS6KA3(1), SHC1(2), SOS1(12), SOS2(6), TRAF3(3) 9698379 73 49 73 29 8 16 27 12 10 0 0.887 1.000 1.000 428 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CHUK(3), EGR2(2), EGR3(1), GNAQ(2), MAP3K1(4), NFATC1(3), NFATC2(8), NFKB1(3), NFKBIA(1), PLCG1(5), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SYT1(3), VIP(1), VIPR2(4) 9592581 62 49 61 17 10 18 17 3 14 0 0.369 1.000 1.000 429 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(8), POLR1B(10), POLR1D(2), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(12), POLR3B(13), POLR3G(1), POLR3H(1) 8089883 75 48 74 26 15 16 25 13 6 0 0.733 1.000 1.000 430 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(10), ACE2(3), AGT(2), AGTR1(5), AGTR2(2), ANPEP(4), CMA1(6), CPA3(6), CTSA(1), CTSG(2), ENPEP(8), LNPEP(1), MAS1(3), MME(8), NLN(5), REN(1), THOP1(2) 7310825 69 48 69 33 6 24 24 6 9 0 0.991 1.000 1.000 431 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(12), APOA1(1), APOA4(3), APOC2(1), APOC3(3), APOE(1), CETP(2), CYP7A1(7), DGAT1(2), HMGCR(4), LCAT(1), LDLR(5), LIPC(6), LPL(5), LRP1(20), SOAT1(7) 9394267 80 48 79 33 17 19 19 18 6 1 0.920 1.000 1.000 432 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), EPRS(13), FARS2(1), GARS(4), HARS(2), IARS(9), KARS(4), LARS(7), LARS2(2), MARS(3), MARS2(8), NARS(3), QARS(2), RARS(5), SARS(2), TARS(5), WARS(3), WARS2(9), YARS(1) 11020854 85 47 85 26 11 29 21 17 7 0 0.709 1.000 1.000 433 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(4), EPHA4(9), FYN(3), ITGA1(9), ITGB1(3), L1CAM(15), LYN(4), RAP1B(1), SELP(14) 4715339 62 47 60 18 8 15 14 19 6 0 0.709 1.000 1.000 434 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(6), DDX20(1), E2F1(3), ETS1(7), ETS2(3), FOS(1), HDAC2(8), HDAC5(2), HRAS(1), JUN(1), NCOR2(13), RBL1(7), RBL2(2), SIN3A(6) 8949778 62 47 62 25 6 11 22 12 11 0 0.918 1.000 1.000 435 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(2), FOS(1), GRB2(4), HRAS(1), IL2(5), IL2RA(3), IL2RB(5), IL2RG(3), JAK1(8), JAK3(5), JUN(1), LCK(5), MAP2K1(6), MAPK3(1), MAPK8(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4), SYK(3) 8085303 80 47 78 25 13 18 18 21 10 0 0.567 1.000 1.000 436 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(20), ATM(22), BAX(1), CDKN1A(1), CPB2(4), CSNK1A1(1), CSNK1D(2), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NQO1(3) 6884198 63 47 61 16 9 18 14 9 13 0 0.521 1.000 1.000 437 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ASL(3), CKM(1), CKMT1A(2), CKMT1B(1), CKMT2(2), CPS1(39), GATM(4), GLUD1(3), OAT(1), ODC1(1), OTC(5), SMS(1) 5990411 65 47 64 24 8 17 17 13 10 0 0.874 1.000 1.000 438 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(8), DBH(2), DDC(6), GAD1(5), GAD2(9), HDC(7), MAOA(3), PAH(3), SLC18A3(8), TH(2), TPH1(11) 4997467 67 46 67 23 14 15 13 16 9 0 0.711 1.000 1.000 439 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(1), BTG1(1), CBX3(2), CLOCK(1), CRY1(3), CRY2(2), DAZAP2(1), ETV6(3), GFRA1(8), GSTM3(1), GSTP1(2), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(6), NCKAP1(4), NCOA4(4), NR1D2(2), PER1(3), PER2(4), PPP1R3C(1), PPP2CB(3), PSMA4(1), PURA(1), SF3A3(1), SUMO3(1), TOB1(1), UCP3(1), UGP2(1), VAPA(1), ZFR(5) 12668509 73 46 73 31 14 23 23 4 9 0 0.972 1.000 1.000 440 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(2), CD80(4), CD86(6), CTLA4(1), GRB2(4), HLA-DRA(3), ICOS(2), IL2(5), ITK(7), LCK(5), PIK3CA(11), PIK3R1(3), PTPN11(6) 4378480 60 46 55 17 4 16 19 11 10 0 0.627 1.000 1.000 441 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(1), CBS(1), CTH(1), GGT1(1), LCMT1(2), LCMT2(4), MARS(3), MARS2(8), MAT1A(4), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), SCLY(2), SEPHS1(4), WBSCR22(1) 8575363 73 46 73 21 18 16 29 3 7 0 0.254 1.000 1.000 442 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 ALOX15(4), ALOX5(5), CYP1A2(2), CYP2C18(4), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2E1(4), CYP2J2(8), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), HSD3B7(2), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1), RDH11(2) 7996222 80 46 80 34 17 30 16 8 8 1 0.943 1.000 1.000 443 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(2), CASP1(2), CASP3(4), CASP7(1), CASP8(4), GAPDH(3), INSR(1), ITCH(6), MAGI1(16), MAGI2(15), RERE(10), WWP1(3), WWP2(3) 8282472 74 46 73 22 16 24 18 8 8 0 0.518 1.000 1.000 444 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(10), BAX(1), BCL2(1), CSF2RB(5), IGF1(5), IGF1R(10), IL3(1), IL3RA(5), KIT(6), PIK3CA(11), PIK3R1(3), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 7509597 70 45 67 25 8 21 24 7 10 0 0.699 1.000 1.000 445 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(3), GALNT2(3), GALNT3(4), GALNT4(4), GALNT6(2), GALNT7(5), GALNT8(6), GALNT9(1), GCNT1(4), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), WBSCR17(16) 4952583 59 45 59 30 16 10 18 12 3 0 0.983 1.000 1.000 446 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(1), GUSB(5), RPE(2), UCHL1(1), UGDH(4), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5), UGT2B15(6), UGT2B4(13) 6090026 64 45 63 22 6 21 15 12 10 0 0.777 1.000 1.000 447 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ALPI(5), ALPL(2), ALPP(4), ALPPL2(3), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(4), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), PON1(3), PON3(5) 6216434 54 44 54 28 5 11 19 9 10 0 0.974 1.000 1.000 448 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(4), HRAS(1), IGF1R(10), IRS1(15), MAP2K1(6), MAPK3(1), PIK3CA(11), PIK3R1(3), RAF1(3), SHC1(2), SOS1(12) 6468334 68 44 65 19 13 17 17 15 6 0 0.378 1.000 1.000 449 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(2), ITGB1(3), KLRC1(3), KLRC2(3), KLRC3(3), KLRD1(2), LAT(3), MAP2K1(6), MAPK3(1), PAK1(5), PIK3CA(11), PIK3R1(3), PTK2B(8), PTPN6(3), SYK(3), VAV1(1) 6399176 61 44 58 16 12 9 18 13 9 0 0.250 1.000 1.000 450 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(4), AGXT(3), AGXT2(8), ASL(3), ASNS(3), ASPA(2), CAD(16), CRAT(1), DDO(3), GAD1(5), GAD2(9), GOT1(2), GOT2(3), GPT2(3), NARS(3), PC(1) 8995349 70 43 70 30 15 16 20 12 7 0 0.895 1.000 1.000 451 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(1), CS(1), DLD(6), DLST(2), FH(7), IDH1(2), IDH2(2), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(2), MDH2(2), PC(1), PCK1(12), SDHA(4), SDHB(1), SUCLG1(2), SUCLG2(2) 7035338 56 43 56 23 12 11 12 9 12 0 0.867 1.000 1.000 452 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B4GALNT1(4), HEXA(1), LCT(30), SLC33A1(2), ST3GAL1(3), ST3GAL2(3), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(4) 5435315 54 43 54 18 10 13 22 4 5 0 0.615 1.000 1.000 453 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(2), AP2M1(5), BTK(11), EEA1(6), GSK3B(2), LYN(4), PDPK1(1), PFKL(2), PFKM(5), PFKP(3), PLCG1(5), PRKCE(3), PRKCZ(2), RAB5A(1), RPS6KB1(2), VAV2(3) 8585210 57 43 56 19 10 11 19 11 6 0 0.648 1.000 1.000 454 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(8), BIRC2(2), BIRC3(3), CASP1(2), CASP10(6), CASP2(7), CASP3(4), CASP4(3), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2), GZMB(3), LMNB1(2), LMNB2(2), PRF1(5) 6681762 61 42 61 20 8 19 13 11 10 0 0.806 1.000 1.000 455 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(5), C5(2), C6(14), C8A(6), C8B(9), C9(10), MASP1(5) 6667106 59 42 59 29 6 23 15 7 8 0 0.995 1.000 1.000 456 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 25 ALDOA(2), ALDOB(4), ALDOC(1), DERA(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKL(2), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(2), RPE(2), RPIA(5), TKT(2), TKTL1(10) 7973780 61 42 60 23 12 12 15 14 8 0 0.785 1.000 1.000 457 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22(2), IL22RA2(2), JAK1(8), JAK2(4), JAK3(5), STAT1(4), STAT3(8), STAT5A(3), STAT5B(4), TYK2(2) 6383833 46 42 46 17 3 8 9 16 10 0 0.854 1.000 1.000 458 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM1(2), CAPN2(3), CAPNS2(2), EP300(2), HDAC1(3), HDAC2(8), MEF2D(1), NFATC1(3), NFATC2(8), PPP3CA(5), PPP3CB(1), PPP3CC(2), PRKCA(7), SYT1(3) 8365370 55 42 54 18 9 19 15 4 8 0 0.621 1.000 1.000 459 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(11), AP2A1(2), AP2M1(5), BIN1(1), CALM1(2), DNM1(5), EPN1(5), EPS15(3), PICALM(4), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(3) 7450057 56 42 55 18 6 21 12 8 9 0 0.852 1.000 1.000 460 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(8), JAK1(8), JAK2(4), JAK3(5), PIAS3(5), PTPRU(10), REG1A(9), SRC(2), STAT3(8) 5302724 59 42 58 18 9 18 12 13 7 0 0.604 1.000 1.000 461 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(2), EPO(3), EPOR(1), FOS(1), GRB2(4), HRAS(1), JAK2(4), JUN(1), MAP2K1(6), MAPK3(1), MAPK8(3), PLCG1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4) 7393494 59 41 59 19 10 13 15 14 7 0 0.550 1.000 1.000 462 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(33), ERBB3(3), NRG1(9) 3545378 53 41 38 18 7 9 9 14 14 0 0.874 1.000 1.000 463 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGA4(19), ITGAL(20), ITGB1(3), ITGB2(2), SELE(6), SELL(4) 4197341 56 41 56 22 7 19 15 8 7 0 0.937 1.000 1.000 464 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), CDKN1B(3), GRB2(4), ILK(1), ITGB1(3), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(11), PIK3R1(3), PTEN(8), PTK2(11), SHC1(2), SOS1(12) 6648557 64 41 60 16 6 16 18 14 10 0 0.421 1.000 1.000 465 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(2), AKT3(5), BPNT1(3), GRB2(4), ILK(1), MAPK3(1), PDK1(4), PIK3CA(11), PIK3CD(1), PTEN(8), PTK2B(8), RBL2(2), SHC1(2), SOS1(12) 7004194 64 41 60 22 10 16 20 12 6 0 0.770 1.000 1.000 466 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(5), CHUK(3), IFNG(4), IKBKB(3), IL2(5), IL4(1), JUN(1), MAP3K1(4), MAP3K5(12), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), TNFRSF9(4), TNFSF9(1), TRAF2(1) 6665503 53 40 52 14 7 11 14 5 16 0 0.489 1.000 1.000 467 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(2), ACTN2(23), ACTN3(3), BCAR1(2), CTNNA1(3), CTNNB1(11), PTK2(11), PXN(1), SRC(2), VCL(2) 5975297 60 40 57 19 11 21 8 15 5 0 0.589 1.000 1.000 468 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(4), HRAS(1), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), NTRK1(12), PIK3CA(11), PIK3R1(3), PLCG1(5), RPS6KA1(1), SHC1(2) 6552835 51 40 47 16 8 9 17 10 7 0 0.526 1.000 1.000 469 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACAT2(1), ACOT11(2), ACYP2(1), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), EHHADH(8), ESCO1(7), ESCO2(2), GCDH(3), HADHA(3), ITGB1BP3(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1), YOD1(1) 8925504 59 40 57 16 7 18 16 8 9 1 0.483 1.000 1.000 470 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16) 4053300 49 40 49 15 6 15 12 10 6 0 0.544 1.000 1.000 471 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(3), CREBBP(4), EP300(2), IKBKB(3), MAP2K3(6), MAP2K6(1), MAP3K14(1), MAP3K7(5), MAPK11(1), MAPK14(1), MYD88(3), NFKB1(3), NFKBIA(1), NR3C1(3), TGFBR1(2), TGFBR2(2), TLR2(2) 10176531 43 40 43 22 3 9 13 5 13 0 0.990 1.000 1.000 472 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), NCK1(3), NCKAP1(4), NTRK1(12), PIR(2), PSMA7(1), WASF1(8), WASF2(1), WASF3(4), WASL(5) 5269061 53 39 52 14 3 15 13 8 14 0 0.627 1.000 1.000 473 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), HRAS(1), JUN(1), MAP2K1(6), MAPK3(1), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7), RAF1(3) 5298373 45 39 45 14 9 10 13 5 8 0 0.513 1.000 1.000 474 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(4), ALOX15B(2), ALOX5(5), DPEP1(4), GGT1(1), LTA4H(1), PLA2G2A(3), PLA2G6(1), PTGDS(2), PTGIS(5), PTGS1(5), PTGS2(4), TBXAS1(6) 5174942 46 39 46 13 6 6 16 11 7 0 0.399 1.000 1.000 475 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(2), CXCR3(1), ETV5(8), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), JAK2(4), JUN(1), MAP2K6(1), MAPK14(1), MAPK8(3), STAT4(6), TYK2(2) 6409710 55 39 55 21 3 15 16 8 13 0 0.889 1.000 1.000 476 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(4), MAP2K1(6), MAPK3(1), PTPN6(3), RAF1(3), SHC1(2), SOS1(12), STAT5A(3), STAT5B(4) 6077431 55 39 55 19 7 12 15 14 7 0 0.657 1.000 1.000 477 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(6), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(8), NCOR2(13), POLR2A(9), RARA(3), RXRA(1) 8569867 62 39 61 21 17 18 12 11 4 0 0.684 1.000 1.000 478 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(7), CHUK(3), IKBKB(3), JUN(1), LTA(2), MAP2K3(6), MAP2K4(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TRAF2(1) 8338119 46 39 46 20 5 15 9 4 13 0 0.965 1.000 1.000 479 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3D(2), CD4(3), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1) 3887962 53 39 53 20 8 19 10 6 10 0 0.856 1.000 1.000 480 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNB1(4), CHRNG(1), MUSK(9), PIK3CA(11), PIK3R1(3), PTK2(11), PTK2B(8), RAPSN(1), SRC(2), TERT(4) 5591493 54 38 51 16 12 13 14 10 5 0 0.383 1.000 1.000 481 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC2(1), ARPC3(2), CDC42(2), PAK1(5), PDGFRA(17), PIK3CA(11), PIK3R1(3), WASL(5) 4601984 52 38 49 17 6 14 18 7 7 0 0.831 1.000 1.000 482 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(10), CREM(2), FHL5(5), FSHB(1), FSHR(20), GNAS(7), XPO1(3) 3263708 48 38 48 21 4 15 13 9 7 0 0.983 1.000 1.000 483 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(4), PGAP1(4), PIGB(1), PIGC(2), PIGG(7), PIGK(2), PIGL(2), PIGM(5), PIGN(2), PIGO(7), PIGP(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGW(1), PIGX(4), PIGZ(1) 8254534 51 38 50 16 9 9 20 10 3 0 0.483 1.000 1.000 484 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(4), CAT(3), EPX(7), LPO(4), MPO(4), MTHFR(1), PRDX6(3), SHMT1(2), SHMT2(2), TPO(16) 3991928 46 38 46 16 6 14 13 7 6 0 0.699 1.000 1.000 485 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(14), CD38(3), ENPP1(6), NADK(2), NADSYN1(1), NMNAT1(1), NMNAT2(3), NMNAT3(1), NNMT(5), NNT(4), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(2) 6816872 53 38 53 26 4 20 12 11 6 0 0.986 1.000 1.000 486 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(10), CCNB1(1), CDC25C(3), GNAI1(3), GNAS(7), GNB1(2), GNGT1(2), HRAS(1), MAPK3(1), MYT1(6), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RPS6KA1(1), SRC(2) 7030758 55 38 55 23 7 13 14 8 13 0 0.939 1.000 1.000 487 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PPP2CA(1), PRKAA1(4), PRKAB1(3), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 5262878 45 37 45 18 5 14 13 5 8 0 0.907 1.000 1.000 488 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), FDPS(1), GGCX(4), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1), TM7SF2(5), VKORC1(1) 6685197 51 37 50 19 5 18 15 9 4 0 0.805 1.000 1.000 489 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 15 BCAT1(1), BCAT2(1), COASY(5), DPYD(12), DPYS(10), ENPP1(6), ILVBL(1), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCDC(1), PPCS(1), VNN1(4) 5324250 51 37 51 16 4 14 16 9 7 1 0.585 1.000 1.000 490 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(7), ABCC2(5), ABCG2(5), CES1(3), CES2(1), CYP3A4(1), CYP3A5(1), UGT1A1(4), UGT1A10(5), UGT1A3(3), UGT1A4(2), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A8(1), UGT1A9(5) 7403341 53 37 52 30 11 22 8 8 4 0 0.991 1.000 1.000 491 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3D(2), CD8A(2), ITGAL(20), ITGB2(2), PTPRC(21), THY1(1) 3704762 52 37 52 20 8 18 10 6 10 0 0.860 1.000 1.000 492 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(39), GLS(3), GLUD1(3), GOT1(2) 2677697 51 37 50 17 6 11 15 11 8 0 0.797 1.000 1.000 493 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(4), GFPT1(4), GNE(1), GNPDA1(1), GNPDA2(2), HEXA(1), HK1(3), HK2(9), HK3(12), PGM3(4), RENBP(3), UAP1(6) 5809272 53 36 53 15 13 14 11 9 6 0 0.423 1.000 1.000 494 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13) 3251113 53 36 53 21 5 22 13 7 6 0 0.860 1.000 1.000 495 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(5), C5(2), C6(14), C8A(6), C9(10), MASP1(5), MASP2(2), MBL2(1) 6859695 53 36 53 31 6 19 14 6 8 0 0.999 1.000 1.000 496 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(5), CYP11A1(1), CYP11B1(10), CYP11B2(7), CYP17A1(3), CYP21A2(1), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13) 3251113 53 36 53 21 5 22 13 7 6 0 0.860 1.000 1.000 497 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(10), ADRB2(2), GNAS(7), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RAP2B(1) 5052427 46 36 46 19 3 17 12 5 9 0 0.927 1.000 1.000 498 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(3), CDC42(2), CHUK(3), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(6), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), RAF1(3), RALA(2), RALBP1(1), RHOA(1) 6558789 43 36 40 15 7 9 11 9 7 0 0.697 1.000 1.000 499 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(6), HLA-DRA(3), IFNG(4), IFNGR1(3), IFNGR2(3), IL12A(3), IL12RB1(3), IL12RB2(12), IL18R1(3), IL2(5), IL2RA(3), IL4(1), IL4R(5) 4359702 55 36 53 19 8 12 17 8 10 0 0.662 1.000 1.000 500 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1) 5179980 45 35 45 14 10 8 20 4 3 0 0.407 1.000 1.000 501 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(4), IL2RG(3), IL4(1), IL4R(5), IRS1(15), JAK1(8), JAK3(5), RPS6KB1(2), SHC1(2), STAT6(2) 5098914 47 35 47 20 10 10 13 12 2 0 0.867 1.000 1.000 502 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(4), DAXX(6), HRAS(1), PAX3(6), PML(7), RARA(3), SIRT1(1), SP100(9), TNFRSF1B(1) 5708054 38 35 38 12 6 6 15 6 5 0 0.558 1.000 1.000 503 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(3), E2F1(3), HRAS(1), MAPK3(1), NFKB1(3), NFKBIA(1), PAK1(5), PIK3CA(11), PIK3R1(3), RAF1(3), TFDP1(3) 6326125 52 35 49 15 15 12 14 6 5 0 0.350 1.000 1.000 504 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(8), JAK2(4), JAK3(5), PIAS1(2), PIAS3(5), PTPRU(10), REG1A(9), SOAT1(7) 4808771 50 35 49 16 6 18 9 10 6 1 0.736 1.000 1.000 505 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), BIRC3(3), CASP3(4), CASP8(4), CFLAR(1), FADD(1), JUN(1), MAP2K4(3), MAP3K3(4), MAP3K7(5), NFKB1(3), NFKB2(6), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(4), TNFRSF1B(1), TRAF2(1) 9372512 49 35 49 18 10 9 14 5 11 0 0.768 1.000 1.000 506 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(1), C1QB(2), C1R(1), C1S(1), C2(3), C3(5), C5(2), C6(14), C8A(6), C9(10) 5537449 45 34 45 26 6 14 12 6 7 0 0.998 1.000 1.000 507 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), ANXA1(2), CALM1(2), GNAS(7), GNB1(2), GNGT1(2), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3CA(11), PIK3R1(3), SYT1(3) 6143154 43 34 40 18 4 12 15 4 8 0 0.920 1.000 1.000 508 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 14 ACP1(2), ACP2(1), ACP5(3), ACP6(3), ACPP(7), ENPP1(6), FLAD1(3), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(6), PHPT1(1) 4208104 41 34 41 13 1 9 16 11 4 0 0.628 1.000 1.000 509 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(20), ITGAM(14), ITGB2(2), SELE(6), SELL(4) 3617742 48 34 48 21 8 16 14 5 5 0 0.907 1.000 1.000 510 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(4), ALDOC(1), FBP2(1), G6PD(2), GPI(3), H6PD(3), PFKM(5), PFKP(3), PGD(2), PGM1(2), PGM3(4), PRPS1(3), PRPS1L1(2), PRPS2(2), RPE(2), RPIA(5), TAL1(3), TKT(2) 7050223 51 34 50 18 11 11 12 12 5 0 0.725 1.000 1.000 511 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(10), CD44(2), CSF1(1), FCGR3A(6), IL6R(8), SELL(4), SPN(3), TGFB1(2), TGFB2(8), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1) 4599007 48 34 48 15 7 15 11 9 6 0 0.613 1.000 1.000 512 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(4), CNR2(1), DNMT1(5), MTNR1A(5), MTNR1B(6), PTAFR(2), PTGDR(3), PTGER2(2), PTGER4(7), PTGFR(6), PTGIR(2) 3896206 43 34 43 18 7 13 12 8 3 0 0.796 1.000 1.000 513 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(4), G6PD(2), GCLC(8), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(4), GSS(3), GSTA1(1), GSTA2(3), GSTA3(2), GSTA4(1), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTZ1(1), IDH1(2), IDH2(2), MGST1(1), MGST3(3), PGD(2) 6155749 53 33 53 13 6 17 19 4 6 1 0.238 1.000 1.000 514 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(7), LEP(4), LEPR(13), PRKAA1(4), PRKAB1(3), PRKAG2(4) 4972735 45 33 45 13 7 19 7 7 5 0 0.712 1.000 1.000 515 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(3), GH1(2), GHR(5), HRAS(1), IGF1(5), IGF1R(10), PIK3CA(11), PIK3R1(3), SHC1(2), SOD2(1), SOD3(1) 4524353 44 33 41 16 4 15 11 6 8 0 0.839 1.000 1.000 516 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(3), ACSL1(8), ACSL3(3), ACSL4(2), CPT1A(7), CPT2(2), DCI(2), EHHADH(8), HADHA(3), PECR(1), SCP2(3), SLC25A20(2) 5754541 44 33 43 15 6 16 6 9 6 1 0.768 1.000 1.000 517 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(2), CD4(3), FYN(3), HLA-DRA(3), LCK(5), PTPRC(21), ZAP70(4) 3126308 41 33 40 12 3 16 10 4 8 0 0.732 1.000 1.000 518 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), AMT(1), ATIC(3), DHFR(1), FTCD(3), GART(4), MTFMT(1), MTHFD1(1), MTHFD1L(4), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2) 6542530 40 32 40 20 10 14 7 3 5 1 0.966 1.000 1.000 519 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 6 EPX(7), GBA(3), LPO(4), MPO(4), PRDX6(3), TPO(16) 2570067 37 32 37 15 3 12 12 6 4 0 0.813 1.000 1.000 520 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(3), IL10(1), IL10RA(4), IL10RB(2), IL1A(3), JAK1(8), STAT1(4), STAT3(8), STAT5A(3) 4199402 38 32 38 13 1 7 11 11 8 0 0.760 1.000 1.000 521 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(3), CD3D(2), CD4(3), CXCR3(1), IFNG(4), IL12A(3), IL12RB1(3), IL12RB2(12), JAK2(4), STAT4(6), TYK2(2) 5062961 44 32 44 18 3 11 13 7 10 0 0.890 1.000 1.000 522 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), HDAC5(2), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), PPARA(1), PPP3CA(5), PPP3CB(1), PPP3CC(2), SYT1(3) 7036483 40 32 39 17 4 14 9 7 6 0 0.920 1.000 1.000 523 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 8 EPX(7), LPO(4), MPO(4), PRDX1(2), PRDX2(1), PRDX5(1), PRDX6(3), TPO(16) 2630981 38 32 38 12 3 11 11 9 4 0 0.593 1.000 1.000 524 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 IFNG(4), IFNGR1(3), IFNGR2(3), IKBKB(3), JAK2(4), LIN7A(2), NFKB1(3), NFKBIA(1), TNFRSF1B(1), USH1C(4), WT1(8) 5418140 36 32 36 13 7 11 9 2 7 0 0.718 1.000 1.000 525 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(8), CHKA(1), PCYT1A(2), PDHA1(3), PDHA2(13), SLC18A3(8) 2406790 38 31 38 13 8 8 11 6 5 0 0.556 1.000 1.000 526 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(1), CASP8(4), FADD(1), MAP2K1(6), MAP2K4(3), MAP3K1(4), MAPK3(1), MAPK8(3), NFKB1(3), NSMAF(2), RAF1(3), RIPK1(4), SMPD1(2), TRAF2(1) 7064879 39 31 39 14 8 6 14 5 6 0 0.639 1.000 1.000 527 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(10), ADRB2(2), CFTR(6), GNAS(7), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), SLC9A3R1(1) 4478782 38 31 38 16 3 12 12 5 6 0 0.904 1.000 1.000 528 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL13(1), IL4(1), MAF(1), MAP2K3(6), MAPK14(1), NFATC1(3), NFATC2(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 4203753 39 31 38 13 4 16 8 2 9 0 0.618 1.000 1.000 529 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 MAP2K1(6), MAP2K2(1), MAP2K3(6), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(11), PIK3R1(3), SP1(1) 6044226 38 31 35 13 4 10 10 6 8 0 0.754 1.000 1.000 530 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(8), BCL2(1), CASP3(4), CASP9(3), DAXX(6), FAS(3), FASLG(3), HSPB1(1), HSPB2(1), IL1A(3), MAPKAPK2(3), MAPKAPK3(1) 3892084 41 31 41 16 5 10 8 11 7 0 0.895 1.000 1.000 531 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(5), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(1), FUT8(4), MAN1B1(2), MGAT1(2), MGAT3(4), MGAT4A(3), MGAT4B(1), MGAT5(6), RPN2(4) 6863359 41 31 41 11 8 11 11 6 5 0 0.344 1.000 1.000 532 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(3), CHUK(3), GH1(2), GHR(5), NFKB1(3), NFKBIA(1), PDPK1(1), PIK3CA(11), PIK3R1(3), PPP2CA(1) 4800756 33 30 30 17 2 8 12 4 7 0 0.987 1.000 1.000 533 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(8), ARHGAP5(7), CASP1(2), CASP10(6), CASP3(4), CASP8(4), CASP9(3), GZMB(3), JUN(1), PRF1(5) 4422677 43 30 43 12 5 11 9 11 7 0 0.632 1.000 1.000 534 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(4), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(5), PKLR(11), TPI1(6) 3205771 38 30 37 15 5 13 11 4 5 0 0.766 1.000 1.000 535 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(11), FASN(4), MCAT(1), OLAH(7), OXSM(5) 5490275 38 30 38 21 6 15 12 2 3 0 0.983 1.000 1.000 536 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(2), LCMT2(4), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(2), PRMT6(4), PRMT7(6), PRMT8(8), WBSCR22(1) 4872662 42 30 42 13 10 7 19 3 3 0 0.436 1.000 1.000 537 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(10), CHST2(4), CHST6(3), FUT8(4), ST3GAL1(3), ST3GAL2(3), ST3GAL3(1), ST3GAL4(2) 4290773 39 30 38 22 12 6 12 4 5 0 0.968 1.000 1.000 538 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR2(1), SEC22B(5), SNAP23(1), SNAP25(4), STX11(1), STX12(2), STX16(3), STX17(1), STX18(2), STX19(3), STX2(8), STX3(3), STX7(2), STX8(3), TSNARE1(1), VTI1A(1) 5810875 41 30 40 18 7 9 8 8 9 0 0.957 1.000 1.000 539 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(3), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), RIPK1(4), TANK(2), TNFRSF1B(1), TRAF2(1), TRAF3(3) 7701270 33 30 33 17 2 7 13 4 7 0 0.977 1.000 1.000 540 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CCL4(1), CCR5(1), CXCL12(1), CXCR4(3), FOS(1), GNAQ(2), JUN(1), MAPK14(1), MAPK8(3), PLCG1(5), PRKCA(7), PTK2B(8), SYT1(3) 4713049 39 29 39 17 10 12 10 1 6 0 0.842 1.000 1.000 541 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), HMGCS1(5), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(3), PMVK(1), SC4MOL(2), SC5DL(3), SQLE(1) 4565802 34 29 33 13 2 13 10 7 1 1 0.845 1.000 1.000 542 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 12 AOX1(14), CD38(3), ENPP1(6), NADSYN1(1), NMNAT1(1), NMNAT2(3), NNMT(5), NNT(4), NT5E(2), NT5M(1), QPRT(2) 4394052 42 29 42 19 4 17 7 10 4 0 0.952 1.000 1.000 543 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), AMT(1), ATIC(3), DHFR(1), GART(4), MTHFD1(1), MTHFD1L(4), MTHFD2(1), MTHFR(1), MTR(11), SHMT1(2), SHMT2(2) 6166512 36 29 36 18 9 13 5 3 5 1 0.963 1.000 1.000 544 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(2), NFKB1(3), NFKBIA(1), PLCB1(18), PRKCA(7) 2821738 31 29 31 11 6 10 9 0 6 0 0.770 1.000 1.000 545 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(2), GNB1(2), GNGT1(2), HTR2C(5), PLCB1(18), TUB(3) 2457628 34 29 34 10 5 14 9 0 6 0 0.575 1.000 1.000 546 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(5), C5(2), C6(14), C8A(6), C9(10) 3812163 37 28 37 17 6 14 9 2 6 0 0.973 1.000 1.000 547 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(4), CYP2A6(4), CYP2A7(4), NAT1(3), NAT2(2), XDH(11) 2737695 30 28 30 10 1 11 9 3 6 0 0.507 1.000 1.000 548 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(2), FUT3(2), FUT7(2), FUT9(7), GCNT2(2), ST3GAL6(3), ST8SIA1(2) 5541571 32 28 31 19 7 6 10 6 3 0 0.980 1.000 1.000 549 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(10), POLR2A(9), POLR2B(5), POLR2C(4), POLR2D(4), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1) 4631296 38 28 37 16 8 8 12 6 4 0 0.873 1.000 1.000 550 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(8), UBE2A(4), UBE2D2(1), UBE2D3(3), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(8) 3617742 37 28 36 14 9 10 4 7 7 0 0.810 1.000 1.000 551 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 5 ADAM17(7), ERBB4(21), NRG2(2), PRKCA(7), PSEN1(1) 2639683 38 27 38 12 5 16 11 3 3 0 0.737 1.000 1.000 552 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(4), TGDS(2) 4028339 40 27 40 16 12 10 9 7 2 0 0.735 1.000 1.000 553 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(1), MRPS7(2), RPL11(1), RPL12(1), RPL14(1), RPL19(2), RPL21(1), RPL23A(2), RPL24(1), RPL27A(1), RPL29(1), RPL3(1), RPL30(4), RPL35(1), RPL36A(1), RPL37(1), RPL3L(2), RPL6(3), RPL7(1), RPL8(1), RPS10(1), RPS11(1), RPS12(1), RPS13(2), RPS18(1), RPS26(1), RPS29(1), RPS4Y1(1), RPSA(1) 7817602 39 27 39 14 9 11 8 5 6 0 0.772 1.000 1.000 554 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(8), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP3(4), CASP6(1), CASP7(1), CASP8(4), CASP9(3), DFFA(3), DFFB(2) 4694500 34 27 34 13 4 8 9 5 8 0 0.889 1.000 1.000 555 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(20), MEF2A(2), MEF2B(1), MEF2C(2), MEF2D(1), MYOD1(5) 2782808 33 27 33 12 3 13 6 5 6 0 0.850 1.000 1.000 556 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(2), GZMB(3), HLA-A(2), ITGAL(20), ITGB2(2), PRF1(5) 3004022 35 26 35 14 5 8 10 6 6 0 0.773 1.000 1.000 557 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(2), FOS(1), JUN(1), MAPK3(1), OPRK1(5), POLR2A(9), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1) 4408021 31 26 31 10 6 9 9 3 4 0 0.590 1.000 1.000 558 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(1), CYP11B2(7), CYP17A1(3), HSD11B1(4), HSD11B2(1), HSD3B1(7), HSD3B2(13) 2393737 41 26 41 15 7 17 8 6 3 0 0.689 1.000 1.000 559 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(8), BAX(1), BCL10(1), BCL2(1), BCL2L11(2), BID(1), CASP8AP2(10), CASP9(3), CES1(3) 3918877 30 26 30 15 4 10 8 5 3 0 0.982 1.000 1.000 560 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(8), JAK2(4), JAK3(5), MAPK3(1), STAT3(8), TYK2(2) 4066582 28 26 28 13 3 5 7 9 4 0 0.938 1.000 1.000 561 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(3), ARFGAP3(2), ARFGEF2(6), CLTB(1), COPA(10), GBF1(7), GPLD1(4), KDELR1(1), KDELR2(1), KDELR3(5) 5529892 40 25 40 10 6 16 7 5 6 0 0.488 1.000 1.000 562 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREBBP(4), EP300(2), NCOA3(8), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), RARA(3), RXRA(1) 7131289 31 25 31 11 4 11 9 3 4 0 0.756 1.000 1.000 563 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19) 2303740 29 25 29 12 7 3 13 4 2 0 0.623 1.000 1.000 564 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(1), EPO(3), FLT3(10), IGF1(5), IL1A(3), IL3(1), TGFB1(2), TGFB2(8), TGFB3(1) 2810059 34 25 34 12 4 12 4 8 6 0 0.755 1.000 1.000 565 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(2), HS3ST2(2), HS3ST3A1(4), HS3ST3B1(1), XYLT1(19) 2303740 29 25 29 12 7 3 13 4 2 0 0.623 1.000 1.000 566 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(6), FADS2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(3), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(2), PLA2G3(5), PLA2G4A(10), PLA2G6(1) 3505761 38 25 38 15 10 13 6 7 2 0 0.864 1.000 1.000 567 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(5), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(7), ESCO2(2), MYST3(8), MYST4(8), NAT6(1), PNPLA3(2), SH3GLB1(1) 5698207 37 25 37 12 5 13 6 8 5 0 0.717 1.000 1.000 568 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), FDXR(2), SHMT1(2) 5516610 35 25 35 13 10 7 9 7 2 0 0.685 1.000 1.000 569 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(3), FOSL2(1), IFNAR2(2), IFNB1(4), MAPK8(3), NFKB1(3), TNFRSF11A(7), TNFSF11(1), TRAF6(4) 3820407 29 25 28 11 6 6 6 4 7 0 0.842 1.000 1.000 570 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(3), HK2(9), HK3(12), IMPA1(1), PGM1(2), PGM3(4), TGDS(2) 3534386 37 25 37 15 10 10 9 6 2 0 0.779 1.000 1.000 571 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(1), FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST8SIA1(2) 3668122 27 24 27 14 7 2 11 6 1 0 0.935 1.000 1.000 572 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(1), AFMID(2), CS(1), GRHPR(1), HAO1(4), HAO2(8), MDH1(2), MDH2(2), MTHFD1(1), MTHFD1L(4), MTHFD2(1) 4599007 31 24 31 11 6 12 5 3 5 0 0.715 1.000 1.000 573 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(3), NDUFB2(4), NDUFB4(1), NDUFB5(4), NDUFB6(1), NDUFS1(7), NDUFS2(6), NDUFV1(3) 2394195 33 24 33 13 4 8 8 5 8 0 0.856 1.000 1.000 574 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(7), GNB1(2), GNGT1(2), PRKACB(3), PRKACG(1), PRKAR1A(1), PRKAR1B(6), PRKAR2A(1), PRKCA(7) 3291875 32 23 32 12 7 10 10 1 4 0 0.838 1.000 1.000 575 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2) 5182499 33 23 33 13 10 7 7 7 2 0 0.757 1.000 1.000 576 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CAMK1(2), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(8), CAMKK1(2), CAMKK2(1), SYT1(3) 3999256 26 23 26 10 2 12 3 5 4 0 0.825 1.000 1.000 577 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2) 5182499 33 23 33 13 10 7 7 7 2 0 0.757 1.000 1.000 578 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT9(7), GLA(4), HEXA(1), NAGA(3), ST3GAL1(3), ST3GAL2(3), ST3GAL4(2), ST8SIA1(2) 3455839 27 23 27 13 7 2 10 6 2 0 0.886 1.000 1.000 579 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(1), CARS2(1), CTH(1), GOT1(2), GOT2(3), LDHA(3), LDHAL6A(3), LDHB(2), LDHC(5), SDS(2), SULT1C2(2), SULT1C4(1), SULT4A1(3) 4126809 29 23 29 16 6 10 5 6 2 0 0.987 1.000 1.000 580 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(2), LPL(5), NCOA1(5), NCOA2(6), PPARG(3), RXRA(1) 6362994 26 23 26 15 3 10 6 4 3 0 0.990 1.000 1.000 581 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(3), CREBBP(4), EP300(2), FADD(1), HDAC3(1), IKBKB(3), NFKB1(3), NFKBIA(1), RIPK1(4), TNFRSF1B(1), TRAF6(4) 7715697 27 23 26 17 5 4 7 3 8 0 0.993 1.000 1.000 582 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(6), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(2), ATP6V1D(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2) 5182499 33 23 33 13 10 7 7 7 2 0 0.757 1.000 1.000 583 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(10), AGT(2), AGTR1(5), AGTR2(2), BDKRB2(1), KNG1(3), NOS3(2), REN(1) 3453091 26 22 26 17 2 10 10 2 2 0 0.992 1.000 1.000 584 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(2), FDPS(1), HMGCR(4), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(3), NQO2(2), PMVK(1), SC5DL(3), SQLE(1), VKORC1(1) 3835979 27 22 26 13 3 10 7 5 2 0 0.927 1.000 1.000 585 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(3), IKBKAP(5), IKBKB(3), MAP3K1(4), MAP3K14(1), NFKB1(3), NFKBIA(1), TRAF3(3), TRAF6(4) 6216892 27 22 26 16 4 3 11 2 7 0 0.988 1.000 1.000 586 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(8), HADH(4), HADHA(3), HSD17B4(5), SIRT1(1), SIRT2(2), SIRT7(3), VNN2(4) 4077574 30 22 28 10 1 12 6 3 7 1 0.856 1.000 1.000 587 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(2), ESR1(1), GREB1(14), HSPB1(1), HSPB2(1), MTA1(1), MTA3(3), PDZK1(2), TUBA8(1) 3783767 28 22 28 11 6 7 11 3 1 0 0.631 1.000 1.000 588 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(3), CHST11(1), CHST12(3), CHST13(3), PAPSS1(3), PAPSS2(4), SULT1A2(1), SULT1E1(1), SULT2A1(3), SULT2B1(1), SUOX(5) 3174169 28 21 28 10 2 9 10 5 2 0 0.733 1.000 1.000 589 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(1), CRY1(3), CRY2(2), CSNK1D(2), CSNK1E(5), NPAS2(1), NR1D1(3), PER1(3), PER2(4), PER3(1) 5916673 27 21 27 12 8 9 8 0 2 0 0.854 1.000 1.000 590 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(10), AOC2(3), AOC3(5), CES1(3), ESD(1) 2085274 22 20 22 10 3 9 6 2 2 0 0.862 1.000 1.000 591 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(10), GNAS(7), GNB1(2), GNGT1(2), PRKAR1A(1) 2243513 22 19 22 13 2 6 7 3 4 0 0.981 1.000 1.000 592 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(9), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), UGDH(4) 2946314 24 19 24 11 3 7 8 4 2 0 0.848 1.000 1.000 593 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(3), ACOX3(6), ELOVL2(4), ELOVL6(1), FADS2(1), FASN(4), HADHA(3), HSD17B12(1), PECR(1) 4953499 24 19 24 13 4 6 8 4 1 1 0.910 1.000 1.000 594 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(4), CDC25B(1), CDC25C(3), GRB2(4), PRKCA(7), PTPRA(5), SRC(2) 3158597 27 19 27 10 6 10 5 4 2 0 0.772 1.000 1.000 595 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(1), GSS(3), NFKB1(3), NOX1(4), XDH(11) 3426069 23 18 23 10 3 7 8 2 3 0 0.838 1.000 1.000 596 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(2), COPS5(1), EDN1(1), EP300(2), EPO(3), HIF1A(1), JUN(1), LDHA(3), NOS3(2), P4HB(4), VHL(1) 5899498 23 18 23 15 2 8 4 2 6 1 0.999 1.000 1.000 597 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(5), CAPNS2(2), CDK5(1), CSNK1A1(1), CSNK1D(2), GSK3B(2), MAPT(8), PPP2CA(1) 3277448 22 18 22 12 4 9 5 3 1 0 0.948 1.000 1.000 598 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), CKM(1), EIF4E(3), LDHA(3), LDHB(2), LDHC(5), MAPK14(1), NCL(4) 3040891 23 18 23 10 4 5 7 3 4 0 0.872 1.000 1.000 599 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(3), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(3), TNFRSF13B(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(2), TRAF6(4) 5003421 23 18 22 15 5 2 8 2 6 0 0.989 1.000 1.000 600 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(9), APOBEC1(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1) 2524038 19 17 19 10 5 7 4 1 2 0 0.948 1.000 1.000 601 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(1), EPO(3), EPOR(1), GRIN1(2), HIF1A(1), JAK2(4), NFKB1(3), NFKBIA(1), SOD2(1) 4383747 19 16 19 14 2 7 4 2 4 0 0.997 1.000 1.000 602 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 12 CYSLTR1(1), CYSLTR2(3), GPR109B(1), GPR171(1), GPR18(2), GPR34(3), GPR39(2), GPR45(3), GPR75(2) 3115316 18 16 18 13 1 3 7 5 2 0 0.989 1.000 1.000 603 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(3), GOT1(2), GOT2(3), PAH(3), TAT(4), YARS(1), YARS2(2) 2995549 21 16 21 10 6 9 4 1 1 0 0.874 1.000 1.000 604 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(4), NR1I3(5), PTGS1(5), PTGS2(4) 1823069 20 15 20 10 5 4 6 3 2 0 0.891 1.000 1.000 605 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), GOT1(2), GOT2(3), LDHA(3), LDHB(2), LDHC(5) 2352288 17 14 17 11 5 4 4 2 2 0 0.980 1.000 1.000 606 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(1), FH(7), IDH2(2), MDH1(2), OGDH(1), SDHA(4) 3216534 18 13 18 14 5 4 4 3 2 0 0.987 1.000 1.000 607 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO3(2), FARS2(1), GOT1(2), GOT2(3), PAH(3), TAT(4), YARS(1) 2843951 19 13 19 10 5 9 3 2 0 0 0.915 1.000 1.000 608 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(4), SDHA(4), SDHB(1), SDHD(1) 2269619 13 11 13 14 2 1 8 1 1 0 1.000 1.000 1.000 609 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2B(1), ADORA3(2), LTB4R(2), P2RY1(5), P2RY6(1) 2030772 12 11 12 11 2 1 5 2 2 0 0.979 1.000 1.000 610 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(2), ESR1(1), MAPK3(1), PELP1(2), SRC(2) 5057923 12 10 12 6 4 1 5 0 2 0 0.777 1.000 1.000 611 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 5 ASRGL1(1), GBA(3), GGT1(1), SHMT1(2), SHMT2(2) 1626358 9 8 9 7 3 2 4 0 0 0 0.930 1.000 1.000 612 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT3(2), ST3GAL3(1) 1754827 6 6 6 4 3 0 2 1 0 0 0.872 1.000 1.000 613 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), MST1(1), MST1R(4) 2269848 6 6 6 8 1 2 3 0 0 0 0.998 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 628834 5 5 5 4 0 1 0 4 0 0 0.964 1.000 1.000 615 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 248236 1 1 1 3 1 0 0 0 0 0 0.998 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 718144 1 1 1 2 0 0 0 1 0 0 0.990 1.000 1.000