Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.209 0.247 -9999.0 0.0 -0.649 85.0 85.0 IHH -0.306 0.27 -9999.0 0.0 -0.54 276.0 276.0 SHH Np/Cholesterol/GAS1 -0.04 0.101 -9999.0 0.0 -0.278 71.0 71.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.1 0.276 71.0 -9999.0 0.0 71.0 SMO/beta Arrestin2 -0.208 0.214 -9999.0 0.0 -0.503 97.0 97.0 SMO -0.224 0.226 -9999.0 0.0 -0.395 277.0 277.0 AKT1 -0.092 0.106 -9999.0 0.0 -0.302 18.0 18.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.033 -9999.0 0.0 -0.508 2.0 2.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.221 0.222 -9999.0 0.0 -0.389 277.0 277.0 STIL -0.193 0.216 -9999.0 0.0 -0.478 134.0 134.0 DHH N/PTCH2 -0.029 0.097 -9999.0 0.0 -0.352 40.0 40.0 DHH N/PTCH1 -0.191 0.194 -9999.0 0.0 -0.489 93.0 93.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.031 0.138 -9999.0 0.0 -0.499 39.0 39.0 PTHLH -0.273 0.287 -9999.0 0.0 -0.77 85.0 85.0 determination of left/right symmetry -0.221 0.222 -9999.0 0.0 -0.389 277.0 277.0 PIK3R1 0.009 0.023 -9999.0 0.0 -0.499 1.0 1.0 skeletal system development -0.27 0.284 -9999.0 0.0 -0.761 85.0 85.0 IHH N/Hhip -0.369 0.256 -9999.0 0.0 -0.493 368.0 368.0 DHH N/Hhip -0.219 0.2 -9999.0 0.0 -0.381 280.0 280.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.221 0.222 -9999.0 0.0 -0.389 277.0 277.0 pancreas development -0.269 0.252 -9999.0 0.0 -0.498 268.0 268.0 HHAT 0.008 0.032 -9999.0 0.0 -0.499 2.0 2.0 PI3K -0.001 0.016 -9999.0 0.0 -0.352 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.004 0.082 -9999.0 0.0 -0.499 13.0 13.0 somite specification -0.221 0.222 -9999.0 0.0 -0.389 277.0 277.0 SHH Np/Cholesterol/PTCH1 -0.174 0.194 -9999.0 0.0 -0.459 108.0 108.0 SHH Np/Cholesterol/PTCH2 -0.034 0.088 -9999.0 0.0 -0.263 63.0 63.0 SHH Np/Cholesterol/Megalin -0.104 0.148 -9999.0 0.0 -0.292 173.0 173.0 SHH -0.029 0.123 -9999.0 0.0 -0.352 62.0 62.0 catabolic process -0.197 0.199 -9999.0 0.0 -0.491 85.0 85.0 SMO/Vitamin D3 -0.198 0.214 -9999.0 0.0 -0.503 107.0 107.0 SHH Np/Cholesterol/Hhip -0.178 0.164 -9999.0 0.0 -0.302 288.0 288.0 LRP2 -0.126 0.225 -9999.0 0.0 -0.499 130.0 130.0 receptor-mediated endocytosis -0.254 0.225 -9999.0 0.0 -0.517 166.0 166.0 SHH Np/Cholesterol/BOC -0.035 0.089 -9999.0 0.0 -0.263 64.0 64.0 SHH Np/Cholesterol/CDO -0.039 0.097 -9999.0 0.0 -0.27 71.0 71.0 mesenchymal cell differentiation 0.177 0.163 0.3 288.0 -9999.0 0.0 288.0 mol:Vitamin D3 -0.175 0.196 -9999.0 0.0 -0.462 108.0 108.0 IHH N/PTCH2 -0.175 0.165 -9999.0 0.0 -0.317 276.0 276.0 CDON -0.002 0.075 -9999.0 0.0 -0.499 11.0 11.0 IHH N/PTCH1 -0.199 0.201 -9999.0 0.0 -0.497 85.0 85.0 Megalin/LRPAP1 -0.094 0.155 -9999.0 0.0 -0.352 130.0 130.0 PTCH2 0.009 0.023 -9999.0 0.0 -0.499 1.0 1.0 SHH Np/Cholesterol -0.034 0.09 -9999.0 0.0 -0.27 62.0 62.0 PTCH1 -0.198 0.2 -9999.0 0.0 -0.493 85.0 85.0 HHIP -0.27 0.253 -9999.0 0.0 -0.499 268.0 268.0