Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.024 0.016 -9999.0 0.0 -0.224 2.0 2.0 epithelial cell differentiation -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.003 0.06 -9999.0 0.0 -0.499 7.0 7.0 ENAH 0.048 0.031 -9999.0 0.0 -0.287 1.0 1.0 EGFR -0.005 0.086 -9999.0 0.0 -0.508 14.0 14.0 EPHA2 -0.0 0.072 -9999.0 0.0 -0.499 10.0 10.0 MYO6 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.004 0.035 -9999.0 0.0 -0.29 7.0 7.0 AQP5 -0.102 0.171 -9999.0 0.0 -0.418 108.0 108.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.111 0.126 -9999.0 0.0 -0.46 1.0 1.0 EGF -0.089 0.206 -9999.0 0.0 -0.516 92.0 92.0 NCKAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.017 0.084 -9999.0 0.0 -0.439 18.0 18.0 cortical microtubule organization -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.005 0.032 -9999.0 0.0 -0.392 1.0 1.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.006 0.038 -9999.0 0.0 -0.257 11.0 11.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.037 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.005 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.008 0.032 -9999.0 0.0 -0.499 2.0 2.0 EGFR/EGFR/EGF/EGF -0.049 0.096 -9999.0 0.0 -0.463 3.0 3.0 RhoA/GDP -0.001 0.014 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.008 0.032 -9999.0 0.0 -0.498 2.0 2.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.008 0.032 -9999.0 0.0 -0.499 2.0 2.0 IGF1 -0.002 0.076 -9999.0 0.0 -0.5 11.0 11.0 DIAPH1 -0.008 0.067 -9999.0 0.0 -0.559 7.0 7.0 Wnt receptor signaling pathway 0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.005 0.032 -9999.0 0.0 -0.393 1.0 1.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.009 0.023 -9999.0 0.0 -0.499 1.0 1.0 LPP 0.034 0.019 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.006 0.037 -9999.0 0.0 -0.449 1.0 1.0 SEC6/SEC8 -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.113 0.128 -9999.0 0.0 -0.469 1.0 1.0 HGF/MET -0.027 0.077 -9999.0 0.0 -0.459 4.0 4.0 HGF -0.018 0.117 -9999.0 0.0 -0.501 27.0 27.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.024 0.016 -9999.0 0.0 -0.225 2.0 2.0 actin cable formation 0.06 0.031 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.034 0.027 -9999.0 0.0 -0.447 1.0 1.0 KIFC3 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.028 -9999.0 0.0 -0.342 1.0 1.0 adherens junction assembly 0.045 0.038 -9999.0 0.0 -0.524 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.007 0.037 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.023 0.126 -9999.0 0.0 -0.508 31.0 31.0 PLEKHA7 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.006 0.038 -9999.0 0.0 -0.255 11.0 11.0 establishment of epithelial cell apical/basal polarity 0.049 0.015 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.024 0.016 -9999.0 0.0 -0.224 2.0 2.0 regulation of cell-cell adhesion 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.024 0.016 -9999.0 0.0 -0.225 2.0 2.0