Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	186.0	746.0	4.0	-0.206	-0.132	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	140.0	12401.0	88.0	-0.603	0.057	1000.0	-1000.0	-0.096	-1000.0
FOXM1 transcription factor network	129.0	6628.0	51.0	-0.562	0.01	1000.0	-1000.0	-0.185	-1000.0
Aurora B signaling	119.0	7997.0	67.0	-0.413	0.01	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by the Hedgehog family	116.0	6045.0	52.0	-0.369	0.177	1000.0	-1000.0	-0.066	-1000.0
Aurora C signaling	74.0	519.0	7.0	-0.266	0.005	1000.0	-1000.0	-0.036	-1000.0
Endothelins	68.0	6617.0	96.0	-0.303	0.022	1000.0	-1000.0	-0.075	-1000.0
PLK1 signaling events	67.0	5707.0	85.0	-0.299	0.06	1000.0	-1000.0	-0.044	-1000.0
HIF-1-alpha transcription factor network	66.0	5020.0	76.0	-0.491	0.016	1000.0	-1000.0	-0.16	-1000.0
Visual signal transduction: Cones	64.0	2453.0	38.0	-0.17	0.01	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-alpha and p38-beta	61.0	2694.0	44.0	-0.115	0.01	1000.0	-1000.0	-0.048	-1000.0
IL4-mediated signaling events	57.0	5252.0	91.0	-0.787	0.517	1000.0	-1000.0	-0.164	-1000.0
Osteopontin-mediated events	54.0	2078.0	38.0	-0.36	0.011	1000.0	-1000.0	-0.081	-1000.0
BMP receptor signaling	52.0	4226.0	81.0	-0.352	0.027	1000.0	-1000.0	-0.071	-1000.0
Fc-epsilon receptor I signaling in mast cells	48.0	4687.0	97.0	-0.146	0.028	1000.0	-1000.0	-0.074	-1000.0
amb2 Integrin signaling	48.0	3998.0	82.0	-0.463	0.01	1000.0	-1000.0	-0.075	-1000.0
TCGA08_retinoblastoma	45.0	366.0	8.0	-0.153	0.05	1000.0	-1000.0	-0.016	-1000.0
Glucocorticoid receptor regulatory network	42.0	4874.0	114.0	-0.417	0.25	1000.0	-1000.0	-0.073	-1000.0
TCGA08_p53	42.0	294.0	7.0	-0.105	0.054	1000.0	-1000.0	-0.012	-1000.0
FOXA2 and FOXA3 transcription factor networks	41.0	1899.0	46.0	-0.494	0.016	1000.0	-1000.0	-0.115	-1000.0
Syndecan-1-mediated signaling events	39.0	1339.0	34.0	-0.339	0.01	1000.0	-1000.0	-0.049	-1000.0
Signaling events regulated by Ret tyrosine kinase	39.0	3215.0	82.0	-0.159	0.01	1000.0	-1000.0	-0.075	-1000.0
Visual signal transduction: Rods	39.0	2052.0	52.0	-0.15	0.01	1000.0	-1000.0	-0.074	-1000.0
LPA4-mediated signaling events	36.0	436.0	12.0	-0.12	0.013	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	36.0	1909.0	52.0	-0.258	0.044	1000.0	-1000.0	-0.059	-1000.0
Canonical Wnt signaling pathway	35.0	1825.0	51.0	-0.343	0.148	1000.0	-1000.0	-0.047	-1000.0
Thromboxane A2 receptor signaling	34.0	3586.0	105.0	-0.089	0.029	1000.0	-1000.0	-0.054	-1000.0
Arf6 signaling events	34.0	2157.0	62.0	-0.187	0.012	1000.0	-1000.0	-0.055	-1000.0
p75(NTR)-mediated signaling	33.0	4239.0	125.0	-0.294	0.019	1000.0	-1000.0	-0.084	-1000.0
Glypican 1 network	33.0	1584.0	48.0	-0.116	0.019	1000.0	-1000.0	-0.041	-1000.0
Integrins in angiogenesis	31.0	2647.0	84.0	-0.363	0.025	1000.0	-1000.0	-0.075	-1000.0
Effects of Botulinum toxin	31.0	831.0	26.0	-0.09	0.01	1000.0	-1000.0	-0.055	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	31.0	3832.0	120.0	-0.254	0.196	1000.0	-1000.0	-0.062	-1000.0
Ephrin B reverse signaling	30.0	1458.0	48.0	-0.093	0.054	1000.0	-1000.0	-0.053	-1000.0
IL23-mediated signaling events	29.0	1761.0	60.0	-0.277	0.015	1000.0	-1000.0	-0.15	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	28.0	1906.0	68.0	-0.136	0.028	1000.0	-1000.0	-0.12	-1000.0
Aurora A signaling	27.0	1636.0	60.0	-0.294	0.015	1000.0	-1000.0	-0.048	-1000.0
EGFR-dependent Endothelin signaling events	27.0	576.0	21.0	-0.089	0.01	1000.0	-1000.0	-0.056	-1000.0
Presenilin action in Notch and Wnt signaling	26.0	1603.0	61.0	-0.344	0.021	1000.0	-1000.0	-0.06	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	24.0	808.0	33.0	-0.147	0.025	1000.0	-1000.0	-0.057	-1000.0
PDGFR-alpha signaling pathway	23.0	1012.0	44.0	-0.316	0.027	1000.0	-1000.0	-0.051	-1000.0
Nongenotropic Androgen signaling	23.0	1206.0	52.0	-0.057	0.01	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	23.0	1790.0	75.0	-0.33	0.042	1000.0	-1000.0	-0.101	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	22.0	777.0	34.0	-0.04	0.01	1000.0	-1000.0	-0.049	-1000.0
ErbB4 signaling events	21.0	1449.0	69.0	-0.191	0.208	1000.0	-1000.0	-0.081	-1000.0
Syndecan-3-mediated signaling events	21.0	743.0	35.0	-0.203	0.01	1000.0	-1000.0	-0.05	-1000.0
Wnt signaling	21.0	147.0	7.0	-0.059	0.009	1000.0	-1000.0	-0.025	-1000.0
Class IB PI3K non-lipid kinase events	21.0	63.0	3.0	-0.012	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Regulation of Androgen receptor activity	20.0	1425.0	70.0	-0.261	0.027	1000.0	-1000.0	-0.056	-1000.0
HIF-2-alpha transcription factor network	19.0	830.0	43.0	-0.127	0.064	1000.0	-1000.0	-0.091	-1000.0
PLK2 and PLK4 events	18.0	54.0	3.0	-0.018	-0.003	1000.0	-1000.0	-0.021	-1000.0
Syndecan-2-mediated signaling events	18.0	1251.0	69.0	-0.096	0.032	1000.0	-1000.0	-0.044	-1000.0
Coregulation of Androgen receptor activity	16.0	1267.0	76.0	-0.147	0.018	1000.0	-1000.0	-0.042	-1000.0
Nectin adhesion pathway	16.0	1054.0	63.0	-0.041	0.013	1000.0	-1000.0	-0.065	-1000.0
Reelin signaling pathway	16.0	938.0	56.0	-0.095	0.01	1000.0	-1000.0	-0.074	-1000.0
Syndecan-4-mediated signaling events	16.0	1135.0	67.0	-0.169	0.016	1000.0	-1000.0	-0.083	-1000.0
Noncanonical Wnt signaling pathway	15.0	405.0	26.0	-0.059	0.01	1000.0	-1000.0	-0.072	-1000.0
IL12-mediated signaling events	14.0	1257.0	87.0	-0.097	0.038	1000.0	-1000.0	-0.121	-1000.0
Signaling events mediated by HDAC Class III	13.0	526.0	40.0	-0.114	0.018	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	13.0	613.0	47.0	-0.243	0.012	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	13.0	1684.0	125.0	-0.316	0.034	1000.0	-1000.0	-0.081	-1000.0
LPA receptor mediated events	13.0	1356.0	102.0	-0.121	0.03	1000.0	-1000.0	-0.079	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1069.0	78.0	-0.039	0.038	1000.0	-1000.0	-0.08	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	12.0	1093.0	85.0	-0.041	0.03	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by PTP1B	12.0	969.0	76.0	-0.092	0.017	1000.0	-1000.0	-0.069	-1000.0
S1P1 pathway	12.0	467.0	36.0	-0.063	0.011	1000.0	-1000.0	-0.048	-1000.0
EPHB forward signaling	12.0	1091.0	85.0	-0.066	0.049	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by PRL	12.0	429.0	34.0	-0.182	0.021	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	11.0	865.0	74.0	-0.041	0.032	1000.0	-1000.0	-0.045	-1000.0
BARD1 signaling events	11.0	653.0	57.0	-0.182	0.03	1000.0	-1000.0	-0.056	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	597.0	54.0	-0.135	0.021	1000.0	-1000.0	-0.083	-1000.0
Ephrin A  reverse signaling	11.0	77.0	7.0	-0.01	0.008	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	11.0	694.0	62.0	-0.148	0.049	1000.0	-1000.0	-0.084	-1000.0
S1P5 pathway	11.0	199.0	17.0	-0.033	0.03	1000.0	-1000.0	-0.048	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1100.0	93.0	-0.075	0.043	1000.0	-1000.0	-0.076	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	345.0	31.0	-0.073	0.012	1000.0	-1000.0	-0.08	-1000.0
S1P4 pathway	11.0	280.0	25.0	-0.033	0.011	1000.0	-1000.0	-0.046	-1000.0
Regulation of p38-alpha and p38-beta	10.0	547.0	54.0	-0.075	0.018	1000.0	-1000.0	-0.051	-1000.0
BCR signaling pathway	10.0	1014.0	99.0	-0.131	0.026	1000.0	-1000.0	-0.084	-1000.0
ErbB2/ErbB3 signaling events	9.0	640.0	65.0	-0.095	0.019	1000.0	-1000.0	-0.057	-1000.0
IL2 signaling events mediated by STAT5	9.0	206.0	22.0	-0.119	0.055	1000.0	-1000.0	-0.047	-1000.0
Plasma membrane estrogen receptor signaling	9.0	795.0	86.0	-0.035	0.03	1000.0	-1000.0	-0.066	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1157.0	136.0	-0.107	0.051	1000.0	-1000.0	-0.07	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	121.0	15.0	-0.0	0.022	1000.0	-1000.0	-0.024	-1000.0
IL27-mediated signaling events	7.0	359.0	51.0	-0.107	0.011	1000.0	-1000.0	-0.07	-1000.0
Arf6 trafficking events	7.0	512.0	71.0	-0.081	0.034	1000.0	-1000.0	-0.066	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	192.0	28.0	-0.033	0.021	1000.0	-1000.0	-0.048	-1000.0
Cellular roles of Anthrax toxin	6.0	238.0	39.0	-0.045	0.015	1000.0	-1000.0	-0.03	-1000.0
Retinoic acid receptors-mediated signaling	6.0	361.0	58.0	-0.172	0.032	1000.0	-1000.0	-0.066	-1000.0
Regulation of Telomerase	6.0	705.0	102.0	-0.092	0.03	1000.0	-1000.0	-0.094	-1000.0
Insulin Pathway	6.0	509.0	74.0	-0.153	0.03	1000.0	-1000.0	-0.08	-1000.0
VEGFR1 specific signals	6.0	375.0	56.0	-0.316	0.042	1000.0	-1000.0	-0.067	-1000.0
p38 MAPK signaling pathway	6.0	287.0	44.0	-0.082	0.025	1000.0	-1000.0	-0.055	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	105.0	17.0	-0.014	0.021	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class II	5.0	401.0	75.0	-0.046	0.027	1000.0	-1000.0	-0.057	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	90.0	17.0	-0.013	0.031	1000.0	-1000.0	-0.056	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	386.0	65.0	-0.174	0.054	1000.0	-1000.0	-0.063	-1000.0
Ceramide signaling pathway	5.0	383.0	76.0	-0.089	0.036	1000.0	-1000.0	-0.052	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	439.0	83.0	-0.067	0.04	1000.0	-1000.0	-0.063	-1000.0
FoxO family signaling	5.0	321.0	64.0	-0.126	0.055	1000.0	-1000.0	-0.079	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	386.0	74.0	-0.113	0.06	1000.0	-1000.0	-0.073	-1000.0
Class I PI3K signaling events	5.0	373.0	73.0	-0.075	0.023	1000.0	-1000.0	-0.055	-1000.0
IFN-gamma pathway	4.0	310.0	68.0	-0.082	0.047	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by HDAC Class I	4.0	467.0	104.0	-0.046	0.043	1000.0	-1000.0	-0.057	-1000.0
IL2 signaling events mediated by PI3K	4.0	271.0	58.0	-0.148	0.066	1000.0	-1000.0	-0.077	-1000.0
Circadian rhythm pathway	3.0	79.0	22.0	-0.029	0.034	1000.0	-1000.0	-0.062	-1000.0
Arf6 downstream pathway	3.0	164.0	43.0	-0.039	0.026	1000.0	-1000.0	-0.032	-1000.0
TCGA08_rtk_signaling	3.0	97.0	26.0	-0.023	0.037	1000.0	-1000.0	-0.021	-1000.0
IGF1 pathway	3.0	218.0	57.0	-0.037	0.04	1000.0	-1000.0	-0.082	-1000.0
S1P3 pathway	3.0	154.0	42.0	-0.032	0.023	1000.0	-1000.0	-0.052	-1000.0
TRAIL signaling pathway	2.0	128.0	48.0	-0.008	0.04	1000.0	-1000.0	-0.051	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	118.0	45.0	-0.012	0.062	1000.0	-1000.0	-0.083	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	181.0	76.0	-0.041	0.05	1000.0	-1000.0	-0.072	-1000.0
Rapid glucocorticoid signaling	2.0	59.0	20.0	-0.007	0.01	1000.0	-1000.0	-0.032	-1000.0
PDGFR-beta signaling pathway	2.0	226.0	97.0	-0.036	0.048	1000.0	-1000.0	-0.072	-1000.0
Canonical NF-kappaB pathway	1.0	44.0	39.0	-0.014	0.066	1000.0	-1000.0	-0.074	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.002	0.009	1000.0	-1000.0	-0.026	-1000.0
EPO signaling pathway	1.0	88.0	55.0	-0.006	0.058	1000.0	-1000.0	-0.081	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	65.0	37.0	-0.005	0.037	1000.0	-1000.0	-0.045	-1000.0
ceramide signaling pathway	1.0	57.0	49.0	-0.012	0.04	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	-0.002	0.01	1000.0	-1000.0	-0.039	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	-0.003	0.036	1000.0	-1000.0	-0.053	-1000.0
Insulin-mediated glucose transport	0.0	24.0	32.0	-0.003	0.035	1000.0	-1000.0	-0.055	-1000.0
mTOR signaling pathway	0.0	13.0	53.0	-0.001	0.026	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	25.0	68.0	-0.034	0.046	1000.0	-1000.0	-0.057	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	24.0	36.0	-0.003	0.018	1000.0	-1000.0	-0.056	-1000.0
Atypical NF-kappaB pathway	0.0	21.0	31.0	-0.002	0.038	1000.0	-1000.0	-0.047	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.001	0.024	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in keratinocytes	0.0	28.0	43.0	-0.007	0.037	1000.0	-1000.0	-0.056	-1000.0
Arf1 pathway	0.0	30.0	54.0	-0.006	0.024	1000.0	-1000.0	-0.032	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.01	1000.0	-1000.0	-0.052	-1000.0
Total	2936	168642	7203	-18.5403954466	-995.19694686	131000	-131000	-8.17694065134	-131000