E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.069 -9999.0 0.0 -0.307 22.0 22.0 KLHL20 -0.002 0.052 0.163 2.0 -0.208 12.0 14.0 CYFIP2 0.015 0.041 -9999.0 0.0 -0.321 7.0 7.0 Rac1/GDP -0.011 0.061 0.282 5.0 -0.253 8.0 13.0 ENAH -0.006 0.07 -9999.0 0.0 -0.308 23.0 23.0 AP1M1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.028 -9999.0 0.0 -0.139 16.0 16.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.026 -9999.0 0.0 -0.173 3.0 3.0 RAPGEF1 -0.009 0.058 0.213 2.0 -0.314 7.0 9.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.072 -9999.0 0.0 -0.314 23.0 23.0 CRK -0.01 0.052 -9999.0 0.0 -0.297 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.038 0.019 -9999.0 0.0 -0.193 2.0 2.0 alphaE/beta7 Integrin 0.028 0.015 -9999.0 0.0 -0.226 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.015 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.004 0.066 -9999.0 0.0 -0.311 20.0 20.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.025 0.015 -9999.0 0.0 -0.131 1.0 1.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.048 0.055 0.208 40.0 -0.17 6.0 46.0 PI3K -0.03 0.019 -9999.0 0.0 -0.165 1.0 1.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.018 -9999.0 0.0 -0.226 2.0 2.0 TIAM1 0.015 0.041 -9999.0 0.0 -0.321 7.0 7.0 E-cadherin(dimer)/Ca2+ 0.045 0.02 -9999.0 0.0 -0.158 2.0 2.0 AKT1 -0.017 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.019 0.016 -9999.0 0.0 -0.321 1.0 1.0 CDH1 0.019 0.022 -9999.0 0.0 -0.321 2.0 2.0 RhoA/GDP -0.012 0.063 0.282 5.0 -0.249 8.0 13.0 actin cytoskeleton organization 0.0 0.043 0.17 5.0 -0.157 10.0 15.0 CDC42/GDP -0.012 0.063 0.282 5.0 -0.254 9.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.013 -9999.0 0.0 -0.186 2.0 2.0 ITGB7 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.021 -9999.0 0.0 -0.169 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.016 -9999.0 0.0 -0.152 2.0 2.0 mol:GDP -0.012 0.069 0.293 5.0 -0.289 9.0 14.0 CDC42/GTP/IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.005 0.059 0.228 2.0 -0.256 5.0 7.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.006 0.037 0.133 12.0 -0.14 6.0 18.0 NME1 0.047 0.085 0.316 44.0 -9999.0 0.0 44.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.001 0.055 -9999.0 0.0 -0.308 13.0 13.0 regulation of cell-cell adhesion -0.024 0.018 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.024 -9999.0 0.0 -0.093 1.0 1.0 Rap1/GTP -0.023 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.03 -9999.0 0.0 -0.172 3.0 3.0 CCND1 0.007 0.043 0.148 10.0 -0.16 8.0 18.0 VAV2 -0.011 0.129 -9999.0 0.0 -0.567 20.0 20.0 RAP1/GDP -0.019 0.043 0.194 1.0 -0.226 4.0 5.0 adherens junction assembly 0.001 0.054 -9999.0 0.0 -0.299 13.0 13.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.027 -9999.0 0.0 -0.164 3.0 3.0 E-cadherin/beta catenin 0.004 0.02 -9999.0 0.0 -0.276 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.069 -9999.0 0.0 -0.308 22.0 22.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.007 0.068 -9999.0 0.0 -0.321 16.0 16.0 E-cadherin/beta catenin/alpha catenin 0.039 0.018 -9999.0 0.0 -0.182 2.0 2.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.074 -9999.0 0.0 -0.319 23.0 23.0