Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.025 -9999.0 0.0 -0.187 7.0 7.0 epithelial cell differentiation 0.041 0.018 -9999.0 0.0 -0.156 2.0 2.0 CYFIP2 0.015 0.041 -9999.0 0.0 -0.321 7.0 7.0 ENAH -0.018 0.055 0.304 3.0 -0.226 1.0 4.0 EGFR 0.015 0.041 0.316 1.0 -0.321 6.0 7.0 EPHA2 0.013 0.049 -9999.0 0.0 -0.321 10.0 10.0 MYO6 -0.018 0.038 0.231 8.0 -0.163 1.0 9.0 CTNNB1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.022 -9999.0 0.0 -0.193 3.0 3.0 AQP5 -0.061 0.164 0.426 3.0 -0.369 94.0 97.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.039 0.222 9.0 -9999.0 0.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.086 0.075 0.163 3.0 -0.163 227.0 230.0 EGF 0.07 0.118 0.316 85.0 -0.321 4.0 89.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.02 0.069 0.236 1.0 -0.315 22.0 23.0 cortical microtubule organization 0.041 0.018 -9999.0 0.0 -0.156 2.0 2.0 GO:0000145 -0.017 0.037 0.211 9.0 -0.154 1.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.02 -9999.0 0.0 -0.158 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.023 -9999.0 0.0 -0.163 5.0 5.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.035 -9999.0 0.0 -0.178 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.038 0.216 9.0 -0.212 1.0 10.0 PVRL2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.018 0.04 0.224 9.0 -0.164 2.0 11.0 ARF6/GTP 0.043 0.035 -9999.0 0.0 -0.17 6.0 6.0 CDH1 0.019 0.022 -9999.0 0.0 -0.321 2.0 2.0 EGFR/EGFR/EGF/EGF 0.041 0.053 0.233 1.0 -0.176 9.0 10.0 RhoA/GDP 0.041 0.019 -9999.0 0.0 -0.153 2.0 2.0 actin cytoskeleton organization -0.019 0.036 0.216 8.0 -0.167 1.0 9.0 IGF-1R heterotetramer 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 GIT1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 IGF1 0.014 0.051 0.316 1.0 -0.321 10.0 11.0 DIAPH1 0.017 0.114 -9999.0 0.0 -0.548 11.0 11.0 Wnt receptor signaling pathway -0.041 0.018 0.156 2.0 -9999.0 0.0 2.0 RHOA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.033 0.025 -9999.0 0.0 -0.182 6.0 6.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.037 0.218 8.0 -0.17 1.0 9.0 EFNA1 0.017 0.017 -9999.0 0.0 -0.321 1.0 1.0 LPP -0.021 0.038 0.214 9.0 -9999.0 0.0 9.0 Ephrin A1/EPHA2 0.027 0.034 -9999.0 0.0 -0.174 9.0 9.0 SEC6/SEC8 -0.024 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.087 0.075 0.164 3.0 -0.165 227.0 230.0 HGF/MET 0.021 0.055 -9999.0 0.0 -0.166 32.0 32.0 HGF 0.008 0.075 0.316 4.0 -0.321 21.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.025 -9999.0 0.0 -0.188 7.0 7.0 actin cable formation 0.01 0.084 0.286 19.0 -0.255 2.0 21.0 KIAA1543 -0.019 0.027 0.178 7.0 -0.156 1.0 8.0 KIFC3 -0.022 0.02 0.164 3.0 -9999.0 0.0 3.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.018 0.038 0.224 9.0 -9999.0 0.0 9.0 NCK1/GIT1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.018 -9999.0 0.0 -0.156 2.0 2.0 EXOC4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.02 0.028 0.193 6.0 -0.163 1.0 7.0 PIP5K1C -0.018 0.039 0.224 9.0 -9999.0 0.0 9.0 LIMA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.078 0.31 10.0 -0.256 1.0 11.0 adherens junction assembly -0.022 0.084 0.342 7.0 -0.417 8.0 15.0 IGF-1R heterotetramer/IGF1 0.03 0.035 -9999.0 0.0 -0.159 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.013 0.068 0.316 6.0 -0.321 15.0 21.0 PLEKHA7 -0.02 0.029 0.189 7.0 -9999.0 0.0 7.0 mol:GTP 0.038 0.034 -9999.0 0.0 -0.178 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.02 0.096 0.306 17.0 -9999.0 0.0 17.0 cortical actin cytoskeleton stabilization 0.01 0.025 -9999.0 0.0 -0.187 7.0 7.0 regulation of cell-cell adhesion -0.019 0.036 0.216 8.0 -0.167 1.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.025 -9999.0 0.0 -0.188 7.0 7.0