Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	212.0	10856.0	51.0	-0.027	0.741	1000.0	-1000.0	-0.111	-1000.0
Glypican 2 network	171.0	687.0	4.0	0.093	0.136	1000.0	-1000.0	0.017	-1000.0
Angiopoietin receptor Tie2-mediated signaling	143.0	12621.0	88.0	-0.569	0.109	1000.0	-1000.0	-0.053	-1000.0
Aurora B signaling	119.0	8020.0	67.0	-0.154	0.274	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by the Hedgehog family	112.0	5872.0	52.0	-0.217	0.102	1000.0	-1000.0	-0.018	-1000.0
HIF-1-alpha transcription factor network	110.0	8378.0	76.0	-0.069	0.424	1000.0	-1000.0	-0.031	-1000.0
Endothelins	78.0	7567.0	96.0	-0.308	0.189	1000.0	-1000.0	-0.039	-1000.0
PLK1 signaling events	72.0	6196.0	85.0	-0.048	0.19	1000.0	-1000.0	-0.019	-1000.0
Aurora C signaling	67.0	475.0	7.0	-0.0	0.163	1000.0	-1000.0	-0.007	-1000.0
Signaling mediated by p38-alpha and p38-beta	59.0	2632.0	44.0	-0.102	0.021	1000.0	-1000.0	-0.021	-1000.0
Visual signal transduction: Cones	58.0	2207.0	38.0	-0.08	0.119	1000.0	-1000.0	-0.016	-1000.0
Signaling events regulated by Ret tyrosine kinase	55.0	4540.0	82.0	-0.074	0.06	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	54.0	2511.0	46.0	-0.191	0.153	1000.0	-1000.0	-0.067	-1000.0
Fc-epsilon receptor I signaling in mast cells	52.0	5061.0	97.0	-0.092	0.021	1000.0	-1000.0	-0.043	-1000.0
Osteopontin-mediated events	51.0	1964.0	38.0	-0.001	0.23	1000.0	-1000.0	-0.017	-1000.0
BMP receptor signaling	51.0	4149.0	81.0	-0.181	0.214	1000.0	-1000.0	-0.019	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	51.0	2679.0	52.0	-0.145	0.045	1000.0	-1000.0	-0.027	-1000.0
IL4-mediated signaling events	49.0	4490.0	91.0	-0.628	0.342	1000.0	-1000.0	-0.103	-1000.0
amb2 Integrin signaling	48.0	3985.0	82.0	-0.288	0.078	1000.0	-1000.0	-0.026	-1000.0
Visual signal transduction: Rods	45.0	2360.0	52.0	-0.08	0.098	1000.0	-1000.0	-0.031	-1000.0
Ephrin B reverse signaling	43.0	2102.0	48.0	-0.075	0.075	1000.0	-1000.0	-0.022	-1000.0
Syndecan-1-mediated signaling events	40.0	1382.0	34.0	-0.0	0.205	1000.0	-1000.0	-0.027	-1000.0
p75(NTR)-mediated signaling	38.0	4851.0	125.0	-0.15	0.129	1000.0	-1000.0	-0.041	-1000.0
Canonical Wnt signaling pathway	37.0	1937.0	51.0	-0.206	0.096	1000.0	-1000.0	-0.033	-1000.0
Thromboxane A2 receptor signaling	35.0	3689.0	105.0	-0.121	0.07	1000.0	-1000.0	-0.037	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	34.0	2379.0	68.0	-0.146	0.064	1000.0	-1000.0	-0.05	-1000.0
IL23-mediated signaling events	34.0	2040.0	60.0	-0.204	0.026	1000.0	-1000.0	-0.1	-1000.0
LPA4-mediated signaling events	33.0	406.0	12.0	-0.072	0.0	1000.0	-1000.0	-0.017	-1000.0
Integrins in angiogenesis	33.0	2796.0	84.0	-0.071	0.225	1000.0	-1000.0	-0.037	-1000.0
TCGA08_retinoblastoma	33.0	269.0	8.0	-0.022	0.097	1000.0	-1000.0	-0.002	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	33.0	4008.0	120.0	-0.163	0.144	1000.0	-1000.0	-0.036	-1000.0
Arf6 signaling events	32.0	2015.0	62.0	-0.105	0.07	1000.0	-1000.0	-0.036	-1000.0
TCGA08_p53	32.0	224.0	7.0	-0.022	0.019	1000.0	-1000.0	-0.008	-1000.0
Presenilin action in Notch and Wnt signaling	31.0	1915.0	61.0	-0.206	0.096	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	30.0	1722.0	56.0	-0.038	0.048	1000.0	-1000.0	-0.02	-1000.0
Glucocorticoid receptor regulatory network	29.0	3340.0	114.0	-0.262	0.156	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	29.0	1253.0	43.0	-0.13	0.136	1000.0	-1000.0	-0.038	-1000.0
Aurora A signaling	28.0	1687.0	60.0	-0.028	0.18	1000.0	-1000.0	-0.02	-1000.0
Glypican 1 network	27.0	1317.0	48.0	-0.06	0.037	1000.0	-1000.0	-0.021	-1000.0
Effects of Botulinum toxin	27.0	713.0	26.0	-0.0	0.044	1000.0	-1000.0	-0.009	-1000.0
Wnt signaling	27.0	191.0	7.0	-0.021	0.038	1000.0	-1000.0	-0.007	-1000.0
IL6-mediated signaling events	27.0	2078.0	75.0	-0.15	0.05	1000.0	-1000.0	-0.052	-1000.0
Noncanonical Wnt signaling pathway	24.0	647.0	26.0	-0.043	0.038	1000.0	-1000.0	-0.026	-1000.0
Nongenotropic Androgen signaling	24.0	1251.0	52.0	-0.062	0.045	1000.0	-1000.0	-0.023	-1000.0
EGFR-dependent Endothelin signaling events	24.0	521.0	21.0	-0.027	0.07	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	784.0	33.0	-0.07	0.095	1000.0	-1000.0	-0.021	-1000.0
Nectin adhesion pathway	22.0	1430.0	63.0	-0.044	0.051	1000.0	-1000.0	-0.033	-1000.0
LPA receptor mediated events	22.0	2254.0	102.0	-0.058	0.078	1000.0	-1000.0	-0.048	-1000.0
Syndecan-4-mediated signaling events	22.0	1510.0	67.0	-0.043	0.12	1000.0	-1000.0	-0.03	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	21.0	737.0	34.0	-0.036	0.06	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	21.0	966.0	44.0	-0.189	0.038	1000.0	-1000.0	-0.028	-1000.0
IL1-mediated signaling events	21.0	1329.0	62.0	-0.082	0.041	1000.0	-1000.0	-0.039	-1000.0
FoxO family signaling	21.0	1353.0	64.0	0.0	0.189	1000.0	-1000.0	-0.048	-1000.0
Regulation of Androgen receptor activity	21.0	1517.0	70.0	-0.144	0.125	1000.0	-1000.0	-0.041	-1000.0
Syndecan-2-mediated signaling events	20.0	1399.0	69.0	-0.048	0.052	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	18.0	1289.0	69.0	-0.111	0.146	1000.0	-1000.0	-0.029	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	18.0	1005.0	54.0	-0.034	0.101	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	18.0	884.0	47.0	-0.235	0.034	1000.0	-1000.0	-0.033	-1000.0
EPHB forward signaling	18.0	1604.0	85.0	-0.031	0.084	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.02	-1000.0
ErbB2/ErbB3 signaling events	17.0	1157.0	65.0	-0.049	0.03	1000.0	-1000.0	-0.044	-1000.0
IL12-mediated signaling events	17.0	1526.0	87.0	-0.132	0.057	1000.0	-1000.0	-0.067	-1000.0
S1P5 pathway	17.0	289.0	17.0	-0.016	0.021	1000.0	-1000.0	-0.003	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1662.0	93.0	-0.043	0.033	1000.0	-1000.0	-0.037	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	553.0	31.0	-0.039	0.03	1000.0	-1000.0	-0.036	-1000.0
Plasma membrane estrogen receptor signaling	17.0	1512.0	86.0	-0.059	0.056	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	16.0	1255.0	76.0	-0.057	0.095	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	16.0	50.0	3.0	-0.007	0.036	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PTP1B	16.0	1239.0	76.0	-0.056	0.07	1000.0	-1000.0	-0.027	-1000.0
Ceramide signaling pathway	16.0	1261.0	76.0	-0.019	0.07	1000.0	-1000.0	-0.022	-1000.0
S1P4 pathway	16.0	400.0	25.0	-0.019	0.027	1000.0	-1000.0	-0.015	-1000.0
S1P1 pathway	15.0	544.0	36.0	-0.09	0.02	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	15.0	1898.0	125.0	-0.189	0.042	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1182.0	78.0	-0.038	0.023	1000.0	-1000.0	-0.032	-1000.0
Caspase cascade in apoptosis	14.0	1092.0	74.0	-0.03	0.085	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1251.0	85.0	-0.057	0.035	1000.0	-1000.0	-0.04	-1000.0
Syndecan-3-mediated signaling events	14.0	505.0	35.0	-0.118	0.045	1000.0	-1000.0	-0.014	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1099.0	74.0	-0.087	0.07	1000.0	-1000.0	-0.042	-1000.0
BCR signaling pathway	14.0	1479.0	99.0	-0.047	0.08	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	13.0	536.0	40.0	-0.06	0.06	1000.0	-1000.0	-0.035	-1000.0
Regulation of p38-alpha and p38-beta	13.0	722.0	54.0	-0.035	0.06	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	12.0	715.0	57.0	-0.046	0.111	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by STAT5	11.0	255.0	22.0	-0.024	0.091	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by PRL	11.0	386.0	34.0	-0.021	0.081	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	10.0	529.0	51.0	-0.044	0.03	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events	10.0	749.0	73.0	-0.033	0.06	1000.0	-1000.0	-0.031	-1000.0
Ephrin A  reverse signaling	9.0	63.0	7.0	-0.012	0.028	1000.0	-1000.0	-0.011	-1000.0
Hedgehog signaling events mediated by Gli proteins	9.0	629.0	65.0	-0.137	0.048	1000.0	-1000.0	-0.027	-1000.0
IFN-gamma pathway	9.0	623.0	68.0	-0.028	0.063	1000.0	-1000.0	-0.036	-1000.0
Insulin Pathway	9.0	668.0	74.0	-0.097	0.051	1000.0	-1000.0	-0.032	-1000.0
VEGFR1 specific signals	9.0	522.0	56.0	-0.189	0.047	1000.0	-1000.0	-0.025	-1000.0
PDGFR-beta signaling pathway	9.0	950.0	97.0	-0.032	0.052	1000.0	-1000.0	-0.038	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1129.0	136.0	-0.171	0.07	1000.0	-1000.0	-0.029	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	145.0	17.0	-0.012	0.046	1000.0	-1000.0	-0.018	-1000.0
Cellular roles of Anthrax toxin	7.0	310.0	39.0	-0.031	0.027	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	7.0	393.0	55.0	-0.025	0.045	1000.0	-1000.0	-0.025	-1000.0
mTOR signaling pathway	7.0	405.0	53.0	-0.055	0.025	1000.0	-1000.0	-0.029	-1000.0
ceramide signaling pathway	7.0	347.0	49.0	-0.007	0.028	1000.0	-1000.0	-0.026	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	596.0	83.0	-0.056	0.045	1000.0	-1000.0	-0.025	-1000.0
Retinoic acid receptors-mediated signaling	7.0	453.0	58.0	-0.094	0.046	1000.0	-1000.0	-0.031	-1000.0
Arf6 trafficking events	7.0	506.0	71.0	-0.037	0.038	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	130.0	17.0	-0.004	0.031	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class I	6.0	658.0	104.0	-0.035	0.047	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by PI3K	6.0	358.0	58.0	-0.014	0.076	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	306.0	45.0	-0.015	0.05	1000.0	-1000.0	-0.031	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	501.0	76.0	-0.03	0.051	1000.0	-1000.0	-0.042	-1000.0
Regulation of Telomerase	6.0	700.0	102.0	-0.02	0.098	1000.0	-1000.0	-0.034	-1000.0
IGF1 pathway	6.0	350.0	57.0	-0.031	0.047	1000.0	-1000.0	-0.026	-1000.0
p38 MAPK signaling pathway	6.0	289.0	44.0	-0.004	0.063	1000.0	-1000.0	-0.017	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	161.0	28.0	-0.015	0.034	1000.0	-1000.0	-0.017	-1000.0
TCGA08_rtk_signaling	5.0	149.0	26.0	-0.013	0.047	1000.0	-1000.0	-0.004	-1000.0
E-cadherin signaling in keratinocytes	5.0	242.0	43.0	-0.015	0.039	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class II	4.0	355.0	75.0	-0.021	0.056	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	4.0	91.0	22.0	-0.004	0.045	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	4.0	182.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	304.0	68.0	-0.029	0.044	1000.0	-1000.0	-0.023	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	72.0	15.0	-0.017	0.022	1000.0	-1000.0	-0.021	-1000.0
S1P3 pathway	4.0	197.0	42.0	-0.021	0.034	1000.0	-1000.0	-0.023	-1000.0
Canonical NF-kappaB pathway	2.0	91.0	39.0	-0.015	0.041	1000.0	-1000.0	-0.019	-1000.0
Insulin-mediated glucose transport	2.0	72.0	32.0	-0.015	0.038	1000.0	-1000.0	-0.023	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	98.0	37.0	-0.023	0.05	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	2.0	136.0	48.0	-0.017	0.046	1000.0	-1000.0	-0.019	-1000.0
Rapid glucocorticoid signaling	2.0	46.0	20.0	-0.007	0.026	1000.0	-1000.0	-0.009	-1000.0
Arf1 pathway	2.0	144.0	54.0	-0.008	0.034	1000.0	-1000.0	-0.014	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	26.0	23.0	-0.0	0.036	1000.0	-1000.0	-0.022	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.019	0.029	1000.0	-1000.0	0.019	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	62.0	36.0	-0.037	0.039	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	1.0	33.0	31.0	-0.017	0.028	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.038	1000.0	-1000.0	0.015	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	26.0	27.0	-0.018	0.045	1000.0	-1000.0	-0.026	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.056	1000.0	-1000.0	-0.0	-1000.0
Total	3346	197475	7203	-9.53082753549	10.5001251176	131000	-131000	-3.75802332026	-131000