Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	8.0	419.0	51.0	-0.639	0.037	1000.0	-1000.0	-0.111	-1000.0
HIF-1-alpha transcription factor network	5.0	419.0	76.0	-0.466	0.051	1000.0	-1000.0	-0.053	-1000.0
TCGA08_retinoblastoma	5.0	42.0	8.0	-0.105	0.054	1000.0	-1000.0	-0.007	-1000.0
Osteopontin-mediated events	4.0	174.0	38.0	-0.312	0.04	1000.0	-1000.0	-0.05	-1000.0
Endothelins	4.0	404.0	96.0	-0.264	0.048	1000.0	-1000.0	-0.06	-1000.0
IL23-mediated signaling events	4.0	259.0	60.0	-0.567	0.036	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by the Hedgehog family	3.0	171.0	52.0	-0.278	0.116	1000.0	-1000.0	-0.048	-1000.0
IL4-mediated signaling events	3.0	333.0	91.0	-0.717	0.575	1000.0	-1000.0	-0.119	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	360.0	97.0	-0.159	0.038	1000.0	-1000.0	-0.069	-1000.0
TCGA08_p53	3.0	25.0	7.0	-0.086	0.053	1000.0	-1000.0	-0.012	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	143.0	44.0	-0.139	0.038	1000.0	-1000.0	-0.028	-1000.0
IL27-mediated signaling events	3.0	169.0	51.0	-0.215	0.153	1000.0	-1000.0	-0.057	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	246.0	68.0	-0.467	0.166	1000.0	-1000.0	-0.085	-1000.0
EGFR-dependent Endothelin signaling events	3.0	72.0	21.0	-0.105	0.052	1000.0	-1000.0	-0.051	-1000.0
Caspase cascade in apoptosis	2.0	150.0	74.0	-0.063	0.051	1000.0	-1000.0	-0.042	-1000.0
IL12-mediated signaling events	2.0	221.0	87.0	-0.276	0.038	1000.0	-1000.0	-0.069	-1000.0
Syndecan-1-mediated signaling events	2.0	101.0	34.0	-0.164	0.038	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Cones	2.0	107.0	38.0	-0.158	0.043	1000.0	-1000.0	-0.006	-1000.0
Thromboxane A2 receptor signaling	2.0	242.0	105.0	-0.095	0.047	1000.0	-1000.0	-0.045	-1000.0
Syndecan-2-mediated signaling events	2.0	141.0	69.0	-0.187	0.062	1000.0	-1000.0	-0.044	-1000.0
Arf6 signaling events	2.0	136.0	62.0	-0.105	0.038	1000.0	-1000.0	-0.021	-1000.0
BMP receptor signaling	2.0	165.0	81.0	-0.203	0.074	1000.0	-1000.0	-0.057	-1000.0
mTOR signaling pathway	2.0	107.0	53.0	-0.065	0.038	1000.0	-1000.0	-0.041	-1000.0
amb2 Integrin signaling	2.0	220.0	82.0	-0.151	0.048	1000.0	-1000.0	-0.032	-1000.0
Nectin adhesion pathway	2.0	176.0	63.0	-0.108	0.057	1000.0	-1000.0	-0.047	-1000.0
Glucocorticoid receptor regulatory network	2.0	263.0	114.0	-0.404	0.083	1000.0	-1000.0	-0.056	-1000.0
IL1-mediated signaling events	2.0	147.0	62.0	-0.143	0.063	1000.0	-1000.0	-0.038	-1000.0
Ephrin B reverse signaling	2.0	140.0	48.0	-0.12	0.038	1000.0	-1000.0	-0.029	-1000.0
Syndecan-3-mediated signaling events	2.0	86.0	35.0	-0.187	0.049	1000.0	-1000.0	-0.021	-1000.0
Integrins in angiogenesis	2.0	193.0	84.0	-0.158	0.043	1000.0	-1000.0	-0.059	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.025	-0.0	1000.0	-1000.0	-0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	77.0	31.0	-0.238	0.039	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	366.0	125.0	-0.126	0.052	1000.0	-1000.0	-0.062	-1000.0
Wnt signaling	2.0	14.0	7.0	-0.093	0.036	1000.0	-1000.0	-0.024	-1000.0
IL6-mediated signaling events	2.0	168.0	75.0	-0.45	0.044	1000.0	-1000.0	-0.055	-1000.0
BCR signaling pathway	2.0	239.0	99.0	-0.194	0.065	1000.0	-1000.0	-0.073	-1000.0
Syndecan-4-mediated signaling events	2.0	174.0	67.0	-0.113	0.04	1000.0	-1000.0	-0.045	-1000.0
Plasma membrane estrogen receptor signaling	2.0	254.0	86.0	-0.201	0.189	1000.0	-1000.0	-0.06	-1000.0
Visual signal transduction: Rods	2.0	150.0	52.0	-0.209	0.05	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	194.0	78.0	-0.116	0.044	1000.0	-1000.0	-0.069	-1000.0
Coregulation of Androgen receptor activity	1.0	86.0	76.0	-0.216	0.05	1000.0	-1000.0	-0.017	-1000.0
ErbB4 signaling events	1.0	83.0	69.0	-0.302	0.073	1000.0	-1000.0	-0.048	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	-0.013	0.036	1000.0	-1000.0	-0.005	-1000.0
Noncanonical Wnt signaling pathway	1.0	43.0	26.0	-0.093	0.036	1000.0	-1000.0	-0.041	-1000.0
Cellular roles of Anthrax toxin	1.0	47.0	39.0	-0.059	0.035	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	134.0	85.0	-0.11	0.045	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PTP1B	1.0	135.0	76.0	-0.143	0.092	1000.0	-1000.0	-0.045	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	65.0	61.0	-0.16	0.048	1000.0	-1000.0	-0.061	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	61.0	46.0	-0.242	0.043	1000.0	-1000.0	-0.079	-1000.0
Glypican 1 network	1.0	53.0	48.0	-0.009	0.051	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	1.0	92.0	85.0	-0.139	0.054	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	1.0	99.0	68.0	-0.107	0.039	1000.0	-1000.0	-0.062	-1000.0
Reelin signaling pathway	1.0	56.0	56.0	-0.033	0.057	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	1.0	77.0	48.0	-0.029	0.038	1000.0	-1000.0	-0.034	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	56.0	52.0	-0.089	0.066	1000.0	-1000.0	-0.048	-1000.0
HIF-2-alpha transcription factor network	1.0	54.0	43.0	-0.159	0.085	1000.0	-1000.0	-0.058	-1000.0
S1P1 pathway	1.0	54.0	36.0	-0.133	0.036	1000.0	-1000.0	-0.046	-1000.0
FAS signaling pathway (CD95)	1.0	83.0	47.0	-0.104	0.047	1000.0	-1000.0	-0.039	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	165.0	93.0	-0.056	0.052	1000.0	-1000.0	-0.052	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	50.0	45.0	-0.05	0.05	1000.0	-1000.0	-0.045	-1000.0
Canonical Wnt signaling pathway	1.0	69.0	51.0	-0.16	0.094	1000.0	-1000.0	-0.055	-1000.0
EPHB forward signaling	1.0	110.0	85.0	-0.068	0.078	1000.0	-1000.0	-0.067	-1000.0
Nongenotropic Androgen signaling	1.0	57.0	52.0	-0.029	0.046	1000.0	-1000.0	-0.037	-1000.0
TCGA08_rtk_signaling	1.0	28.0	26.0	-0.083	0.052	1000.0	-1000.0	-0.01	-1000.0
LPA receptor mediated events	1.0	160.0	102.0	-0.222	0.062	1000.0	-1000.0	-0.069	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	126.0	74.0	-0.109	0.054	1000.0	-1000.0	-0.066	-1000.0
IGF1 pathway	1.0	75.0	57.0	-0.055	0.06	1000.0	-1000.0	-0.044	-1000.0
Insulin Pathway	1.0	146.0	74.0	-0.13	0.06	1000.0	-1000.0	-0.041	-1000.0
VEGFR1 specific signals	1.0	62.0	56.0	-0.027	0.038	1000.0	-1000.0	-0.046	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	33.0	33.0	-0.139	0.098	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by PRL	1.0	44.0	34.0	-0.106	0.054	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in keratinocytes	1.0	52.0	43.0	-0.083	0.037	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	-0.007	0.035	1000.0	-1000.0	0.014	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	22.0	17.0	-0.0	0.041	1000.0	-1000.0	-0.032	-1000.0
Aurora B signaling	1.0	105.0	67.0	-0.105	0.044	1000.0	-1000.0	-0.042	-1000.0
LPA4-mediated signaling events	0.0	4.0	12.0	-0.005	0.049	1000.0	-1000.0	-0.02	-1000.0
ErbB2/ErbB3 signaling events	0.0	25.0	65.0	-0.021	0.076	1000.0	-1000.0	-0.078	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	107.0	136.0	-0.157	0.153	1000.0	-1000.0	-0.042	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	-0.003	0.067	1000.0	-1000.0	-0.028	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	9.0	34.0	-0.042	0.083	1000.0	-1000.0	-0.034	-1000.0
Canonical NF-kappaB pathway	0.0	13.0	39.0	-0.016	0.079	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class II	0.0	42.0	75.0	-0.112	0.072	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	0.0	16.0	57.0	-0.076	0.079	1000.0	-1000.0	-0.042	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	22.0	28.0	-0.034	0.041	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	0.0	13.0	22.0	-0.094	0.077	1000.0	-1000.0	-0.05	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	26.0	54.0	-0.039	0.051	1000.0	-1000.0	-0.051	-1000.0
Ephrin A  reverse signaling	0.0	6.0	7.0	-0.0	0.028	1000.0	-1000.0	-0.001	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	9.0	17.0	-0.003	0.081	1000.0	-1000.0	-0.04	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.035	0.054	1000.0	-1000.0	0.009	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	58.0	65.0	-0.244	0.08	1000.0	-1000.0	-0.057	-1000.0
Aurora A signaling	0.0	28.0	60.0	-0.043	0.084	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	0.0	98.0	125.0	-0.171	0.088	1000.0	-1000.0	-0.051	-1000.0
Arf6 downstream pathway	0.0	22.0	43.0	-0.047	0.051	1000.0	-1000.0	-0.037	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.026	0.042	1000.0	-1000.0	-0.017	-1000.0
EPO signaling pathway	0.0	30.0	55.0	0.0	0.076	1000.0	-1000.0	-0.047	-1000.0
Insulin-mediated glucose transport	0.0	4.0	32.0	-0.026	0.06	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	0.0	34.0	44.0	-0.065	0.061	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	59.0	68.0	-0.026	0.064	1000.0	-1000.0	-0.048	-1000.0
Ceramide signaling pathway	0.0	69.0	76.0	-0.062	0.052	1000.0	-1000.0	-0.036	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	16.0	37.0	-0.005	0.088	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class III	0.0	19.0	40.0	-0.088	0.069	1000.0	-1000.0	-0.023	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	77.0	82.0	-0.044	0.049	1000.0	-1000.0	-0.069	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.024	0.038	1000.0	-1000.0	-0.02	-1000.0
ceramide signaling pathway	0.0	21.0	49.0	-0.062	0.044	1000.0	-1000.0	-0.047	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	20.0	83.0	-0.04	0.07	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	17.0	104.0	-0.054	0.079	1000.0	-1000.0	-0.038	-1000.0
FoxO family signaling	0.0	46.0	64.0	-0.251	0.052	1000.0	-1000.0	-0.054	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.042	0.036	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	0.0	37.0	58.0	-0.016	0.074	1000.0	-1000.0	-0.048	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.074	0.077	1000.0	-1000.0	-0.047	-1000.0
Atypical NF-kappaB pathway	0.0	11.0	31.0	0.0	0.054	1000.0	-1000.0	-0.016	-1000.0
IL2 signaling events mediated by PI3K	0.0	24.0	58.0	-0.031	0.073	1000.0	-1000.0	-0.048	-1000.0
Regulation of p38-alpha and p38-beta	0.0	28.0	54.0	-0.046	0.07	1000.0	-1000.0	-0.051	-1000.0
Effects of Botulinum toxin	0.0	19.0	26.0	-0.029	0.033	1000.0	-1000.0	-0.009	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	60.0	76.0	-0.041	0.06	1000.0	-1000.0	-0.073	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.064	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by STAT5	0.0	13.0	22.0	-0.064	0.045	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events	0.0	51.0	73.0	-0.04	0.038	1000.0	-1000.0	-0.042	-1000.0
Arf6 trafficking events	0.0	5.0	71.0	-0.051	0.066	1000.0	-1000.0	-0.035	-1000.0
Regulation of Telomerase	0.0	85.0	102.0	-0.111	0.071	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	0.0	26.0	42.0	-0.034	0.041	1000.0	-1000.0	-0.042	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	48.0	88.0	-0.11	0.087	1000.0	-1000.0	-0.075	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.0	0.033	1000.0	-1000.0	-0.003	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	94.0	120.0	-0.112	0.088	1000.0	-1000.0	-0.057	-1000.0
PDGFR-beta signaling pathway	0.0	44.0	97.0	-0.041	0.089	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	0.0	1.0	3.0	-0.029	0.029	1000.0	-1000.0	-0.011	-1000.0
S1P4 pathway	0.0	6.0	25.0	-0.0	0.041	1000.0	-1000.0	-0.033	-1000.0
p38 MAPK signaling pathway	0.0	26.0	44.0	-0.075	0.061	1000.0	-1000.0	-0.034	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.0	0.043	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.095	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	50.0	70.0	-0.218	0.049	1000.0	-1000.0	-0.049	-1000.0
Total	141	11662	7203	-15.4501068985	8.26394277294	131000	-131000	-5.4885502322	-131000