Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.156 0.224 -9999.0 0.0 -0.714 30.0 30.0 IHH -0.292 0.299 -9999.0 0.0 -0.562 271.0 271.0 SHH Np/Cholesterol/GAS1 -0.027 0.114 0.192 1.0 -0.308 68.0 69.0 LRPAP1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.027 0.113 0.306 68.0 -0.19 1.0 69.0 SMO/beta Arrestin2 -0.198 0.219 -9999.0 0.0 -0.389 257.0 257.0 SMO -0.213 0.221 -9999.0 0.0 -0.404 265.0 265.0 AKT1 -0.107 0.152 -9999.0 0.0 -0.562 31.0 31.0 ARRB2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.029 0.23 2.0 -0.533 1.0 3.0 ADRBK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.21 0.218 -9999.0 0.0 -0.399 265.0 265.0 STIL -0.167 0.178 0.238 1.0 -0.458 70.0 71.0 DHH N/PTCH2 0.001 0.114 -9999.0 0.0 -0.4 36.0 36.0 DHH N/PTCH1 -0.174 0.199 -9999.0 0.0 -0.324 294.0 294.0 PIK3CA 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.022 0.143 -9999.0 0.0 -0.533 36.0 36.0 PTHLH -0.195 0.255 -9999.0 0.0 -0.72 29.0 29.0 determination of left/right symmetry -0.21 0.218 -9999.0 0.0 -0.399 265.0 265.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.194 0.254 -9999.0 0.0 -0.713 29.0 29.0 IHH N/Hhip -0.412 0.274 -9999.0 0.0 -0.54 387.0 387.0 DHH N/Hhip -0.257 0.219 -9999.0 0.0 -0.415 314.0 314.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.21 0.218 -9999.0 0.0 -0.399 265.0 265.0 pancreas development -0.316 0.268 -9999.0 0.0 -0.532 302.0 302.0 HHAT 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.07 -9999.0 0.0 -0.533 8.0 8.0 somite specification -0.21 0.218 -9999.0 0.0 -0.399 265.0 265.0 SHH Np/Cholesterol/PTCH1 -0.17 0.187 -9999.0 0.0 -0.43 90.0 90.0 SHH Np/Cholesterol/PTCH2 -0.024 0.109 0.192 1.0 -0.306 63.0 64.0 SHH Np/Cholesterol/Megalin -0.174 0.189 -9999.0 0.0 -0.34 263.0 263.0 SHH -0.056 0.125 0.289 1.0 -0.392 60.0 61.0 catabolic process -0.175 0.201 -9999.0 0.0 -0.342 281.0 281.0 SMO/Vitamin D3 -0.196 0.214 -9999.0 0.0 -0.475 94.0 94.0 SHH Np/Cholesterol/Hhip -0.216 0.183 -9999.0 0.0 -0.344 310.0 310.0 LRP2 -0.249 0.277 -9999.0 0.0 -0.533 243.0 243.0 receptor-mediated endocytosis -0.301 0.25 -9999.0 0.0 -0.557 202.0 202.0 SHH Np/Cholesterol/BOC -0.02 0.101 -9999.0 0.0 -0.307 52.0 52.0 SHH Np/Cholesterol/CDO -0.025 0.11 0.192 1.0 -0.305 65.0 66.0 mesenchymal cell differentiation 0.214 0.182 0.342 310.0 -9999.0 0.0 310.0 mol:Vitamin D3 -0.167 0.193 -9999.0 0.0 -0.44 86.0 86.0 IHH N/PTCH2 -0.176 0.196 -9999.0 0.0 -0.353 267.0 267.0 CDON 0.017 0.055 -9999.0 0.0 -0.533 5.0 5.0 IHH N/PTCH1 -0.168 0.213 -9999.0 0.0 -0.345 281.0 281.0 Megalin/LRPAP1 -0.173 0.21 -9999.0 0.0 -0.389 241.0 241.0 PTCH2 0.02 0.045 0.23 2.0 -0.533 3.0 5.0 SHH Np/Cholesterol -0.03 0.102 -9999.0 0.0 -0.303 60.0 60.0 PTCH1 -0.175 0.202 -9999.0 0.0 -0.343 281.0 281.0 HHIP -0.317 0.268 -9999.0 0.0 -0.533 302.0 302.0