Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.276 -9999.0 0.0 -0.557 44.0 44.0 IHH -0.015 0.089 -9999.0 0.0 -0.259 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.045 0.144 -9999.0 0.0 -0.322 30.0 30.0 LRPAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.143 0.32 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.117 0.234 -9999.0 0.0 -0.539 24.0 24.0 SMO -0.13 0.239 -9999.0 0.0 -0.537 27.0 27.0 AKT1 -0.093 0.212 -9999.0 0.0 -0.701 13.0 13.0 ARRB2 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.235 -9999.0 0.0 -0.528 27.0 27.0 STIL -0.077 0.157 -9999.0 0.0 -0.364 20.0 20.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.301 42.0 42.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.249 0.451 -9999.0 0.0 -0.96 43.0 43.0 determination of left/right symmetry -0.128 0.235 -9999.0 0.0 -0.528 27.0 27.0 PIK3R1 0.004 0.099 -9999.0 0.0 -0.51 5.0 5.0 skeletal system development -0.246 0.444 -9999.0 0.0 -0.946 43.0 43.0 IHH N/Hhip -0.055 0.157 -9999.0 0.0 -0.423 21.0 21.0 DHH N/Hhip -0.024 0.136 -9999.0 0.0 -0.371 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.235 -9999.0 0.0 -0.528 27.0 27.0 pancreas development -0.058 0.179 -9999.0 0.0 -0.51 20.0 20.0 HHAT -0.007 0.14 -9999.0 0.0 -0.51 11.0 11.0 PI3K 0.004 0.075 -9999.0 0.0 -0.371 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.056 0.188 -9999.0 0.0 -0.51 22.0 22.0 somite specification -0.128 0.235 -9999.0 0.0 -0.528 27.0 27.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.294 48.0 48.0 SHH Np/Cholesterol/PTCH2 0.007 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/Megalin 0.001 0.091 -9999.0 0.0 -0.294 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.371 12.0 12.0 catabolic process -0.07 0.174 -9999.0 0.0 -0.337 43.0 43.0 SMO/Vitamin D3 -0.103 0.204 -9999.0 0.0 -0.462 25.0 25.0 SHH Np/Cholesterol/Hhip -0.044 0.127 -9999.0 0.0 -0.297 29.0 29.0 LRP2 0.02 0.052 -9999.0 0.0 -0.51 1.0 1.0 receptor-mediated endocytosis -0.102 0.195 -9999.0 0.0 -0.47 22.0 22.0 SHH Np/Cholesterol/BOC -0.001 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.087 -9999.0 0.0 -0.29 12.0 12.0 mesenchymal cell differentiation 0.043 0.126 0.295 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.07 0.163 -9999.0 0.0 -0.295 48.0 48.0 IHH N/PTCH2 0.015 0.06 -9999.0 0.0 -0.325 1.0 1.0 CDON 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.18 -9999.0 0.0 -0.34 43.0 43.0 Megalin/LRPAP1 0.034 0.044 -9999.0 0.0 -0.371 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.082 -9999.0 0.0 -0.286 12.0 12.0 PTCH1 -0.07 0.174 -9999.0 0.0 -0.338 43.0 43.0 HHIP -0.058 0.179 -9999.0 0.0 -0.51 20.0 20.0