Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	28.0	2136.0	76.0	-0.282	0.033	1000.0	-1000.0	-0.03	-1000.0
TCGA08_retinoblastoma	27.0	220.0	8.0	-0.064	0.082	1000.0	-1000.0	-0.003	-1000.0
Signaling mediated by p38-alpha and p38-beta	20.0	916.0	44.0	-0.173	0.032	1000.0	-1000.0	-0.027	-1000.0
IL23-mediated signaling events	20.0	1215.0	60.0	-0.509	0.032	1000.0	-1000.0	-0.076	-1000.0
IL4-mediated signaling events	19.0	1793.0	91.0	-0.563	0.515	1000.0	-1000.0	-0.093	-1000.0
Osteopontin-mediated events	18.0	704.0	38.0	-0.193	0.033	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by the Hedgehog family	18.0	960.0	52.0	-0.249	0.047	1000.0	-1000.0	-0.021	-1000.0
Fc-epsilon receptor I signaling in mast cells	18.0	1834.0	97.0	-0.119	0.042	1000.0	-1000.0	-0.043	-1000.0
Endothelins	18.0	1729.0	96.0	-0.24	0.033	1000.0	-1000.0	-0.049	-1000.0
Wnt signaling	18.0	131.0	7.0	-0.127	0.027	1000.0	-1000.0	-0.016	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	18.0	1265.0	68.0	-0.393	0.186	1000.0	-1000.0	-0.081	-1000.0
Noncanonical Wnt signaling pathway	17.0	457.0	26.0	-0.127	0.032	1000.0	-1000.0	-0.035	-1000.0
Glucocorticoid receptor regulatory network	17.0	2008.0	114.0	-0.461	0.293	1000.0	-1000.0	-0.05	-1000.0
Ephrin B reverse signaling	16.0	779.0	48.0	-0.107	0.041	1000.0	-1000.0	-0.033	-1000.0
Syndecan-1-mediated signaling events	15.0	531.0	34.0	-0.137	0.035	1000.0	-1000.0	-0.029	-1000.0
Thromboxane A2 receptor signaling	15.0	1670.0	105.0	-0.158	0.055	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	15.0	1354.0	85.0	-0.106	0.067	1000.0	-1000.0	-0.053	-1000.0
BCR signaling pathway	15.0	1527.0	99.0	-0.206	0.046	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1218.0	78.0	-0.175	0.074	1000.0	-1000.0	-0.036	-1000.0
IGF1 pathway	14.0	841.0	57.0	-0.072	0.059	1000.0	-1000.0	-0.036	-1000.0
FOXM1 transcription factor network	14.0	737.0	51.0	-0.249	0.04	1000.0	-1000.0	-0.079	-1000.0
Nectin adhesion pathway	13.0	877.0	63.0	-0.104	0.051	1000.0	-1000.0	-0.037	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1239.0	93.0	-0.114	0.046	1000.0	-1000.0	-0.04	-1000.0
EGFR-dependent Endothelin signaling events	13.0	280.0	21.0	-0.076	0.046	1000.0	-1000.0	-0.033	-1000.0
IL12-mediated signaling events	12.0	1077.0	87.0	-0.205	0.036	1000.0	-1000.0	-0.051	-1000.0
IL1-mediated signaling events	12.0	787.0	62.0	-0.15	0.048	1000.0	-1000.0	-0.033	-1000.0
Glypican 1 network	11.0	567.0	48.0	-0.051	0.032	1000.0	-1000.0	-0.02	-1000.0
IFN-gamma pathway	11.0	767.0	68.0	-0.101	0.042	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	364.0	31.0	-0.197	0.037	1000.0	-1000.0	-0.034	-1000.0
LPA receptor mediated events	11.0	1208.0	102.0	-0.2	0.033	1000.0	-1000.0	-0.075	-1000.0
BMP receptor signaling	10.0	876.0	81.0	-0.161	0.054	1000.0	-1000.0	-0.037	-1000.0
S1P1 pathway	10.0	361.0	36.0	-0.189	0.032	1000.0	-1000.0	-0.032	-1000.0
TCGA08_p53	10.0	74.0	7.0	-0.039	0.032	1000.0	-1000.0	-0.007	-1000.0
FAS signaling pathway (CD95)	10.0	497.0	47.0	-0.152	0.08	1000.0	-1000.0	-0.028	-1000.0
IL27-mediated signaling events	10.0	519.0	51.0	-0.19	0.121	1000.0	-1000.0	-0.049	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	764.0	74.0	-0.099	0.05	1000.0	-1000.0	-0.053	-1000.0
Caspase cascade in apoptosis	9.0	684.0	74.0	-0.056	0.045	1000.0	-1000.0	-0.035	-1000.0
Syndecan-2-mediated signaling events	9.0	662.0	69.0	-0.12	0.035	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	9.0	599.0	62.0	-0.072	0.067	1000.0	-1000.0	-0.009	-1000.0
amb2 Integrin signaling	9.0	783.0	82.0	-0.108	0.037	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	9.0	387.0	43.0	-0.066	0.049	1000.0	-1000.0	-0.036	-1000.0
Syndecan-4-mediated signaling events	9.0	661.0	67.0	-0.069	0.032	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling in keratinocytes	9.0	425.0	43.0	-0.033	0.042	1000.0	-1000.0	-0.024	-1000.0
Arf6 downstream pathway	8.0	357.0	43.0	-0.052	0.045	1000.0	-1000.0	-0.019	-1000.0
TRAIL signaling pathway	8.0	400.0	48.0	-0.039	0.032	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling events	8.0	40.0	5.0	-0.004	0.028	1000.0	-1000.0	0.016	-1000.0
PLK2 and PLK4 events	7.0	22.0	3.0	-0.014	0.03	1000.0	-1000.0	-0.007	-1000.0
Signaling events mediated by PTP1B	7.0	577.0	76.0	-0.088	0.066	1000.0	-1000.0	-0.024	-1000.0
PDGFR-alpha signaling pathway	7.0	312.0	44.0	-0.116	0.049	1000.0	-1000.0	-0.046	-1000.0
Syndecan-3-mediated signaling events	7.0	277.0	35.0	-0.126	0.065	1000.0	-1000.0	-0.022	-1000.0
Integrins in angiogenesis	7.0	599.0	84.0	-0.103	0.061	1000.0	-1000.0	-0.038	-1000.0
IL6-mediated signaling events	7.0	588.0	75.0	-0.077	0.049	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	824.0	136.0	-0.399	0.097	1000.0	-1000.0	-0.034	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	428.0	65.0	-0.156	0.076	1000.0	-1000.0	-0.027	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	375.0	61.0	-0.119	0.065	1000.0	-1000.0	-0.038	-1000.0
Reelin signaling pathway	6.0	382.0	56.0	-0.073	0.077	1000.0	-1000.0	-0.034	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	303.0	45.0	-0.074	0.036	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	6.0	343.0	51.0	-0.118	0.064	1000.0	-1000.0	-0.049	-1000.0
Glypican 2 network	6.0	25.0	4.0	0.0	0.002	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	469.0	76.0	-0.062	0.053	1000.0	-1000.0	-0.05	-1000.0
Plasma membrane estrogen receptor signaling	6.0	599.0	86.0	-0.067	0.046	1000.0	-1000.0	-0.046	-1000.0
VEGFR1 specific signals	6.0	360.0	56.0	-0.04	0.035	1000.0	-1000.0	-0.052	-1000.0
Coregulation of Androgen receptor activity	5.0	414.0	76.0	-0.201	0.054	1000.0	-1000.0	-0.024	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	161.0	28.0	-0.036	0.043	1000.0	-1000.0	-0.015	-1000.0
Visual signal transduction: Cones	5.0	214.0	38.0	-0.024	0.043	1000.0	-1000.0	-0.0	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	85.0	17.0	-0.022	0.044	1000.0	-1000.0	-0.029	-1000.0
p75(NTR)-mediated signaling	5.0	641.0	125.0	-0.132	0.066	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	258.0	46.0	-0.065	0.076	1000.0	-1000.0	-0.063	-1000.0
mTOR signaling pathway	5.0	282.0	53.0	-0.019	0.083	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by PI3K	5.0	298.0	58.0	-0.087	0.036	1000.0	-1000.0	-0.034	-1000.0
Nongenotropic Androgen signaling	5.0	295.0	52.0	-0.08	0.052	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	696.0	125.0	-0.029	0.05	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by STAT5	5.0	115.0	22.0	-0.071	0.032	1000.0	-1000.0	-0.03	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	609.0	120.0	-0.143	0.087	1000.0	-1000.0	-0.04	-1000.0
Visual signal transduction: Rods	5.0	279.0	52.0	-0.073	0.05	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	4.0	285.0	69.0	-0.087	0.045	1000.0	-1000.0	-0.029	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	232.0	54.0	-0.059	0.046	1000.0	-1000.0	-0.032	-1000.0
Cellular roles of Anthrax toxin	4.0	187.0	39.0	-0.057	0.031	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	381.0	85.0	-0.097	0.078	1000.0	-1000.0	-0.039	-1000.0
Ceramide signaling pathway	4.0	373.0	76.0	-0.049	0.058	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	4.0	185.0	40.0	-0.06	0.061	1000.0	-1000.0	-0.028	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	252.0	52.0	-0.026	0.079	1000.0	-1000.0	-0.04	-1000.0
FoxO family signaling	4.0	263.0	64.0	-0.124	0.059	1000.0	-1000.0	-0.045	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	74.0	15.0	-0.032	0.031	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	4.0	260.0	58.0	-0.055	0.059	1000.0	-1000.0	-0.04	-1000.0
Atypical NF-kappaB pathway	4.0	124.0	31.0	-0.006	0.033	1000.0	-1000.0	-0.013	-1000.0
TCGA08_rtk_signaling	4.0	107.0	26.0	-0.068	0.079	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events	4.0	305.0	73.0	-0.027	0.056	1000.0	-1000.0	-0.029	-1000.0
S1P3 pathway	4.0	203.0	42.0	-0.043	0.043	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	4.0	337.0	70.0	-0.211	0.052	1000.0	-1000.0	-0.033	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	81.0	17.0	-0.014	0.032	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	4.0	273.0	67.0	-0.101	0.052	1000.0	-1000.0	-0.038	-1000.0
ErbB2/ErbB3 signaling events	3.0	248.0	65.0	-0.031	0.046	1000.0	-1000.0	-0.051	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	18.0	5.0	0.012	0.032	1000.0	-1000.0	0.017	-1000.0
EPO signaling pathway	3.0	172.0	55.0	-0.008	0.065	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	3.0	302.0	85.0	-0.015	0.089	1000.0	-1000.0	-0.032	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	135.0	37.0	-0.033	0.059	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	3.0	66.0	17.0	-0.007	0.032	1000.0	-1000.0	-0.009	-1000.0
ceramide signaling pathway	3.0	169.0	49.0	-0.028	0.042	1000.0	-1000.0	-0.033	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	130.0	36.0	-0.043	0.058	1000.0	-1000.0	-0.035	-1000.0
Regulation of Telomerase	3.0	366.0	102.0	-0.096	0.078	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	3.0	279.0	74.0	-0.048	0.084	1000.0	-1000.0	-0.035	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	349.0	88.0	-0.048	0.038	1000.0	-1000.0	-0.065	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	124.0	33.0	-0.067	0.073	1000.0	-1000.0	-0.036	-1000.0
PDGFR-beta signaling pathway	3.0	371.0	97.0	-0.045	0.08	1000.0	-1000.0	-0.04	-1000.0
S1P4 pathway	3.0	95.0	25.0	-0.012	0.043	1000.0	-1000.0	-0.018	-1000.0
LPA4-mediated signaling events	2.0	27.0	12.0	-0.012	0.046	1000.0	-1000.0	-0.024	-1000.0
Aurora A signaling	2.0	121.0	60.0	-0.004	0.061	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	2.0	75.0	32.0	-0.028	0.058	1000.0	-1000.0	-0.02	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	200.0	68.0	-0.041	0.056	1000.0	-1000.0	-0.028	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	178.0	82.0	-0.031	0.056	1000.0	-1000.0	-0.054	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	169.0	83.0	-0.028	0.059	1000.0	-1000.0	-0.027	-1000.0
Regulation of p38-alpha and p38-beta	2.0	137.0	54.0	-0.035	0.074	1000.0	-1000.0	-0.047	-1000.0
Arf6 trafficking events	2.0	201.0	71.0	-0.034	0.053	1000.0	-1000.0	-0.021	-1000.0
p38 MAPK signaling pathway	2.0	101.0	44.0	-0.017	0.059	1000.0	-1000.0	-0.016	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	36.0	23.0	0.009	0.058	1000.0	-1000.0	-0.024	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	42.0	34.0	-0.04	0.064	1000.0	-1000.0	-0.026	-1000.0
Canonical NF-kappaB pathway	1.0	76.0	39.0	-0.019	0.068	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class II	1.0	75.0	75.0	-0.039	0.06	1000.0	-1000.0	-0.018	-1000.0
BARD1 signaling events	1.0	74.0	57.0	-0.047	0.073	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	1.0	36.0	22.0	-0.01	0.047	1000.0	-1000.0	-0.03	-1000.0
Ephrin A  reverse signaling	1.0	11.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by HDAC Class I	1.0	190.0	104.0	-0.06	0.075	1000.0	-1000.0	-0.03	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	28.0	27.0	-0.0	0.063	1000.0	-1000.0	-0.029	-1000.0
Rapid glucocorticoid signaling	1.0	20.0	20.0	-0.0	0.042	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by PRL	1.0	59.0	34.0	-0.032	0.046	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.027	0.027	1000.0	-1000.0	-0.015	-1000.0
Alternative NF-kappaB pathway	1.0	21.0	13.0	-0.0	0.074	1000.0	-1000.0	-0.0	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.0	0.053	1000.0	-1000.0	-0.011	-1000.0
Effects of Botulinum toxin	0.0	20.0	26.0	-0.008	0.054	1000.0	-1000.0	-0.002	-1000.0
Arf1 pathway	0.0	28.0	54.0	-0.002	0.043	1000.0	-1000.0	-0.018	-1000.0
Total	937	58788	7203	-12.0618862953	7.65427475956	131000	-131000	-4.13989211038	-131000