Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.206 0.405 -9999.0 0.0 -0.901 18.0 18.0 IHH -0.058 0.138 -9999.0 0.0 -0.515 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.031 0.147 -9999.0 0.0 -0.414 10.0 10.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.031 0.146 0.411 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.092 0.238 -9999.0 0.0 -0.618 11.0 11.0 SMO -0.105 0.251 -9999.0 0.0 -0.658 11.0 11.0 AKT1 -0.022 0.107 -9999.0 0.0 -0.315 1.0 1.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.027 0.15 -9999.0 0.0 -0.571 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.102 0.246 -9999.0 0.0 -0.646 11.0 11.0 STIL -0.101 0.242 -9999.0 0.0 -0.653 11.0 11.0 DHH N/PTCH2 -0.092 0.203 -9999.0 0.0 -0.437 21.0 21.0 DHH N/PTCH1 -0.14 0.285 -9999.0 0.0 -0.699 14.0 14.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.032 0.164 -9999.0 0.0 -0.624 6.0 6.0 PTHLH -0.223 0.435 -9999.0 0.0 -0.976 18.0 18.0 determination of left/right symmetry -0.102 0.246 -9999.0 0.0 -0.646 11.0 11.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.219 0.427 -9999.0 0.0 -0.959 18.0 18.0 IHH N/Hhip -0.276 0.255 -9999.0 0.0 -0.493 48.0 48.0 DHH N/Hhip -0.247 0.265 -9999.0 0.0 -0.474 46.0 46.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.102 0.246 -9999.0 0.0 -0.646 11.0 11.0 pancreas development -0.309 0.306 -9999.0 0.0 -0.595 45.0 45.0 HHAT 0.006 0.073 -9999.0 0.0 -0.66 1.0 1.0 PI3K 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.053 0.197 -9999.0 0.0 -0.624 9.0 9.0 somite specification -0.102 0.246 -9999.0 0.0 -0.646 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.11 0.246 -9999.0 0.0 -0.64 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.054 0.14 -9999.0 0.0 -0.315 19.0 19.0 SHH Np/Cholesterol/Megalin -0.091 0.191 -9999.0 0.0 -0.392 23.0 23.0 SHH 0.0 0.082 -9999.0 0.0 -0.426 3.0 3.0 catabolic process -0.133 0.289 -9999.0 0.0 -0.764 12.0 12.0 SMO/Vitamin D3 -0.101 0.24 -9999.0 0.0 -0.633 11.0 11.0 SHH Np/Cholesterol/Hhip -0.179 0.197 -9999.0 0.0 -0.356 45.0 45.0 LRP2 -0.155 0.288 -9999.0 0.0 -0.641 22.0 22.0 receptor-mediated endocytosis -0.183 0.243 -9999.0 0.0 -0.63 15.0 15.0 SHH Np/Cholesterol/BOC -0.015 0.105 -9999.0 0.0 -0.319 9.0 9.0 SHH Np/Cholesterol/CDO -0.033 0.163 -9999.0 0.0 -0.484 9.0 9.0 mesenchymal cell differentiation 0.178 0.196 0.354 45.0 -9999.0 0.0 45.0 mol:Vitamin D3 -0.108 0.248 -9999.0 0.0 -0.643 12.0 12.0 IHH N/PTCH2 -0.103 0.204 -9999.0 0.0 -0.447 21.0 21.0 CDON -0.057 0.207 -9999.0 0.0 -0.66 9.0 9.0 IHH N/PTCH1 -0.134 0.292 -9999.0 0.0 -0.77 12.0 12.0 Megalin/LRPAP1 -0.106 0.216 -9999.0 0.0 -0.47 22.0 22.0 PTCH2 -0.095 0.228 -9999.0 0.0 -0.567 16.0 16.0 SHH Np/Cholesterol -0.005 0.063 -9999.0 0.0 -0.332 3.0 3.0 PTCH1 -0.134 0.291 -9999.0 0.0 -0.768 12.0 12.0 HHIP -0.309 0.307 -9999.0 0.0 -0.596 45.0 45.0