Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.039 0.131 -9999.0 0.0 -0.275 20.0 20.0 epithelial cell differentiation -0.069 0.138 -9999.0 0.0 -0.344 17.0 17.0 CYFIP2 0.006 0.073 -9999.0 0.0 -0.66 1.0 1.0 ENAH -0.002 0.143 -9999.0 0.0 -0.414 5.0 5.0 EGFR -0.033 0.173 -9999.0 0.0 -0.66 6.0 6.0 EPHA2 0.006 0.073 -9999.0 0.0 -0.66 1.0 1.0 MYO6 -0.04 0.15 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.062 -9999.0 0.0 -0.411 2.0 2.0 AQP5 -0.145 0.201 -9999.0 0.0 -0.538 13.0 13.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.031 0.143 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.072 0.176 -9999.0 0.0 -0.621 2.0 2.0 EGF -0.052 0.194 -9999.0 0.0 -0.613 9.0 9.0 NCKAP1 0.006 0.073 -9999.0 0.0 -0.66 1.0 1.0 AQP3 -0.106 0.176 -9999.0 0.0 -0.594 6.0 6.0 cortical microtubule organization -0.069 0.138 -9999.0 0.0 -0.344 17.0 17.0 GO:0000145 -0.03 0.137 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.139 -9999.0 0.0 -0.347 17.0 17.0 MLLT4 -0.01 0.124 -9999.0 0.0 -0.66 3.0 3.0 ARF6/GDP -0.072 0.163 -9999.0 0.0 -0.607 5.0 5.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.009 0.118 -9999.0 0.0 -0.441 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.138 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.032 0.145 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.024 0.101 -9999.0 0.0 -0.404 5.0 5.0 CDH1 -0.121 0.27 -9999.0 0.0 -0.66 17.0 17.0 EGFR/EGFR/EGF/EGF -0.113 0.182 -9999.0 0.0 -0.726 3.0 3.0 RhoA/GDP -0.064 0.128 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.031 0.145 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.032 0.168 -9999.0 0.0 -0.641 6.0 6.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.032 0.168 -9999.0 0.0 -0.642 6.0 6.0 IGF1 -0.068 0.214 -9999.0 0.0 -0.621 11.0 11.0 DIAPH1 -0.019 0.123 -9999.0 0.0 -0.813 2.0 2.0 Wnt receptor signaling pathway 0.069 0.138 0.344 17.0 -9999.0 0.0 17.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.072 0.163 -9999.0 0.0 -0.607 5.0 5.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.032 0.148 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 -0.025 0.159 -9999.0 0.0 -0.66 5.0 5.0 LPP -0.022 0.139 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.085 0.191 -9999.0 0.0 -0.707 5.0 5.0 SEC6/SEC8 -0.066 0.143 -9999.0 0.0 -0.59 3.0 3.0 MGAT3 -0.073 0.179 -9999.0 0.0 -0.636 2.0 2.0 HGF/MET -0.16 0.195 -9999.0 0.0 -0.694 5.0 5.0 HGF -0.143 0.267 -9999.0 0.0 -0.592 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.039 0.132 -9999.0 0.0 -0.277 20.0 20.0 actin cable formation 0.02 0.135 -9999.0 0.0 -0.369 5.0 5.0 KIAA1543 -0.073 0.22 -9999.0 0.0 -0.629 8.0 8.0 KIFC3 -0.032 0.145 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.032 0.145 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.069 0.138 -9999.0 0.0 -0.344 17.0 17.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.032 0.145 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.032 0.145 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.01 0.124 -9999.0 0.0 -0.66 3.0 3.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.162 -9999.0 0.0 -0.51 5.0 5.0 adherens junction assembly -0.052 0.215 -9999.0 0.0 -0.6 8.0 8.0 IGF-1R heterotetramer/IGF1 -0.12 0.178 -9999.0 0.0 -0.645 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.003 0.094 -9999.0 0.0 -0.486 3.0 3.0 MET -0.049 0.197 -9999.0 0.0 -0.66 8.0 8.0 PLEKHA7 -0.047 0.17 -9999.0 0.0 -0.636 2.0 2.0 mol:GTP -0.026 0.109 -9999.0 0.0 -0.438 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.009 0.16 -9999.0 0.0 -0.558 3.0 3.0 cortical actin cytoskeleton stabilization -0.039 0.131 -9999.0 0.0 -0.275 20.0 20.0 regulation of cell-cell adhesion -0.031 0.145 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.039 0.132 -9999.0 0.0 -0.277 20.0 20.0