Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	21.0	739.0	34.0	-0.278	0.014	1000.0	-1000.0	-0.061	-1000.0
Ephrin A  reverse signaling	20.0	142.0	7.0	-0.171	-0.0	1000.0	-1000.0	-0.03	-1000.0
TCGA08_retinoblastoma	19.0	159.0	8.0	-0.131	0.084	1000.0	-1000.0	-0.015	-1000.0
Syndecan-1-mediated signaling events	16.0	561.0	34.0	-0.289	0.014	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by the Hedgehog family	14.0	730.0	52.0	-0.309	0.178	1000.0	-1000.0	-0.08	-1000.0
IL4-mediated signaling events	13.0	1204.0	91.0	-0.774	0.692	1000.0	-1000.0	-0.145	-1000.0
E-cadherin signaling events	11.0	56.0	5.0	-0.121	0.014	1000.0	-1000.0	-0.045	-1000.0
p75(NTR)-mediated signaling	10.0	1364.0	125.0	-0.335	0.027	1000.0	-1000.0	-0.107	-1000.0
Glucocorticoid receptor regulatory network	10.0	1237.0	114.0	-0.744	0.36	1000.0	-1000.0	-0.082	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	825.0	82.0	-0.208	0.014	1000.0	-1000.0	-0.087	-1000.0
Reelin signaling pathway	9.0	505.0	56.0	-0.276	0.021	1000.0	-1000.0	-0.085	-1000.0
Endothelins	9.0	933.0	96.0	-0.255	0.014	1000.0	-1000.0	-0.088	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	406.0	44.0	-0.125	0.014	1000.0	-1000.0	-0.048	-1000.0
Integrins in angiogenesis	9.0	785.0	84.0	-0.26	0.027	1000.0	-1000.0	-0.102	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	627.0	68.0	-0.369	0.08	1000.0	-1000.0	-0.126	-1000.0
IL23-mediated signaling events	9.0	580.0	60.0	-0.484	0.014	1000.0	-1000.0	-0.16	-1000.0
amb2 Integrin signaling	8.0	732.0	82.0	-0.318	0.014	1000.0	-1000.0	-0.089	-1000.0
Ephrin B reverse signaling	8.0	385.0	48.0	-0.18	0.051	1000.0	-1000.0	-0.074	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	773.0	93.0	-0.166	0.083	1000.0	-1000.0	-0.083	-1000.0
Caspase cascade in apoptosis	7.0	528.0	74.0	-0.139	0.069	1000.0	-1000.0	-0.04	-1000.0
IL12-mediated signaling events	7.0	683.0	87.0	-0.287	0.027	1000.0	-1000.0	-0.122	-1000.0
Thromboxane A2 receptor signaling	7.0	735.0	105.0	-0.191	0.053	1000.0	-1000.0	-0.068	-1000.0
HIF-1-alpha transcription factor network	7.0	592.0	76.0	-0.31	0.026	1000.0	-1000.0	-0.153	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	357.0	46.0	-0.376	0.023	1000.0	-1000.0	-0.09	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	237.0	31.0	-0.299	0.014	1000.0	-1000.0	-0.096	-1000.0
Nongenotropic Androgen signaling	7.0	371.0	52.0	-0.137	0.071	1000.0	-1000.0	-0.054	-1000.0
Syndecan-4-mediated signaling events	7.0	514.0	67.0	-0.171	0.017	1000.0	-1000.0	-0.093	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	847.0	120.0	-0.238	0.179	1000.0	-1000.0	-0.075	-1000.0
LPA4-mediated signaling events	6.0	73.0	12.0	-0.095	0.017	1000.0	-1000.0	-0.025	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	527.0	85.0	-0.143	0.014	1000.0	-1000.0	-0.073	-1000.0
BMP receptor signaling	6.0	545.0	81.0	-0.223	0.043	1000.0	-1000.0	-0.106	-1000.0
Glypican 1 network	6.0	319.0	48.0	-0.201	0.018	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	6.0	809.0	125.0	-0.107	0.021	1000.0	-1000.0	-0.1	-1000.0
Wnt signaling	6.0	48.0	7.0	-0.091	0.014	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	462.0	76.0	-0.121	0.021	1000.0	-1000.0	-0.083	-1000.0
BCR signaling pathway	6.0	648.0	99.0	-0.25	0.016	1000.0	-1000.0	-0.097	-1000.0
Coregulation of Androgen receptor activity	5.0	400.0	76.0	-0.165	0.024	1000.0	-1000.0	-0.053	-1000.0
ErbB4 signaling events	5.0	369.0	69.0	-0.193	0.15	1000.0	-1000.0	-0.091	-1000.0
Visual signal transduction: Cones	5.0	197.0	38.0	-0.077	0.014	1000.0	-1000.0	-0.067	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	308.0	54.0	-0.198	0.029	1000.0	-1000.0	-0.1	-1000.0
Arf6 signaling events	5.0	327.0	62.0	-0.267	0.016	1000.0	-1000.0	-0.059	-1000.0
TCGA08_p53	5.0	40.0	7.0	-0.099	0.054	1000.0	-1000.0	-0.013	-1000.0
Effects of Botulinum toxin	5.0	145.0	26.0	-0.128	0.014	1000.0	-1000.0	-0.071	-1000.0
Glypican 2 network	5.0	22.0	4.0	-0.023	-0.022	1000.0	-1000.0	-0.023	-1000.0
IL27-mediated signaling events	5.0	256.0	51.0	-0.177	0.072	1000.0	-1000.0	-0.081	-1000.0
IL6-mediated signaling events	5.0	446.0	75.0	-0.216	0.056	1000.0	-1000.0	-0.09	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	375.0	74.0	-0.16	0.069	1000.0	-1000.0	-0.091	-1000.0
EGFR-dependent Endothelin signaling events	5.0	106.0	21.0	-0.124	0.021	1000.0	-1000.0	-0.077	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	494.0	88.0	-0.265	0.016	1000.0	-1000.0	-0.118	-1000.0
Visual signal transduction: Rods	5.0	291.0	52.0	-0.188	0.014	1000.0	-1000.0	-0.085	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.023	-1000.0	1000.0	-1000.0	-0.01	-1000.0
ErbB2/ErbB3 signaling events	4.0	317.0	65.0	-0.146	0.023	1000.0	-1000.0	-0.069	-1000.0
Osteopontin-mediated events	4.0	159.0	38.0	-0.141	0.018	1000.0	-1000.0	-0.122	-1000.0
Noncanonical Wnt signaling pathway	4.0	122.0	26.0	-0.115	0.014	1000.0	-1000.0	-0.059	-1000.0
Syndecan-2-mediated signaling events	4.0	293.0	69.0	-0.134	0.035	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PTP1B	4.0	313.0	76.0	-0.16	0.024	1000.0	-1000.0	-0.077	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	255.0	61.0	-0.274	0.034	1000.0	-1000.0	-0.08	-1000.0
PDGFR-alpha signaling pathway	4.0	178.0	44.0	-0.221	0.028	1000.0	-1000.0	-0.068	-1000.0
S1P1 pathway	4.0	144.0	36.0	-0.101	0.014	1000.0	-1000.0	-0.059	-1000.0
FAS signaling pathway (CD95)	4.0	215.0	47.0	-0.262	0.028	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	4.0	402.0	85.0	-0.152	0.094	1000.0	-1000.0	-0.099	-1000.0
IGF1 pathway	4.0	258.0	57.0	-0.08	0.021	1000.0	-1000.0	-0.098	-1000.0
FOXM1 transcription factor network	4.0	206.0	51.0	-0.141	0.141	1000.0	-1000.0	-0.172	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	450.0	136.0	-0.223	0.219	1000.0	-1000.0	-0.072	-1000.0
BARD1 signaling events	3.0	199.0	57.0	-0.05	0.044	1000.0	-1000.0	-0.072	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	208.0	65.0	-0.248	0.071	1000.0	-1000.0	-0.07	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	373.0	97.0	-0.141	0.034	1000.0	-1000.0	-0.092	-1000.0
Nectin adhesion pathway	3.0	244.0	63.0	-0.124	0.024	1000.0	-1000.0	-0.081	-1000.0
HIF-2-alpha transcription factor network	3.0	132.0	43.0	-0.144	0.029	1000.0	-1000.0	-0.095	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	49.0	15.0	-0.02	0.019	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	3.0	201.0	58.0	-0.138	0.019	1000.0	-1000.0	-0.076	-1000.0
Syndecan-3-mediated signaling events	3.0	119.0	35.0	-0.107	0.015	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by PI3K	3.0	178.0	58.0	-0.096	0.036	1000.0	-1000.0	-0.087	-1000.0
Canonical Wnt signaling pathway	3.0	192.0	51.0	-0.274	0.052	1000.0	-1000.0	-0.05	-1000.0
LPA receptor mediated events	3.0	365.0	102.0	-0.141	0.041	1000.0	-1000.0	-0.09	-1000.0
IL2 signaling events mediated by STAT5	3.0	76.0	22.0	-0.071	0.015	1000.0	-1000.0	-0.049	-1000.0
VEGFR1 specific signals	3.0	168.0	56.0	-0.094	0.014	1000.0	-1000.0	-0.074	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	102.0	33.0	-0.139	0.027	1000.0	-1000.0	-0.067	-1000.0
Regulation of Androgen receptor activity	3.0	257.0	70.0	-0.304	0.027	1000.0	-1000.0	-0.067	-1000.0
Aurora B signaling	3.0	254.0	67.0	-0.134	0.014	1000.0	-1000.0	-0.077	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	59.0	28.0	-0.038	0.025	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	-0.008	0.002	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	44.0	17.0	-0.039	0.027	1000.0	-1000.0	-0.069	-1000.0
Cellular roles of Anthrax toxin	2.0	90.0	39.0	-0.07	0.018	1000.0	-1000.0	-0.036	-1000.0
Aurora C signaling	2.0	18.0	7.0	-0.03	0.0	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	2.0	156.0	68.0	-0.165	0.036	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by HDAC Class III	2.0	91.0	40.0	-0.125	0.031	1000.0	-1000.0	-0.051	-1000.0
TRAIL signaling pathway	2.0	126.0	48.0	-0.041	0.031	1000.0	-1000.0	-0.072	-1000.0
IL1-mediated signaling events	2.0	150.0	62.0	-0.097	0.064	1000.0	-1000.0	-0.101	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	134.0	52.0	-0.148	0.034	1000.0	-1000.0	-0.061	-1000.0
Regulation of p38-alpha and p38-beta	2.0	137.0	54.0	-0.16	0.033	1000.0	-1000.0	-0.064	-1000.0
Regulation of Telomerase	2.0	261.0	102.0	-0.164	0.036	1000.0	-1000.0	-0.118	-1000.0
Plasma membrane estrogen receptor signaling	2.0	197.0	86.0	-0.068	0.04	1000.0	-1000.0	-0.088	-1000.0
S1P3 pathway	2.0	96.0	42.0	-0.096	0.021	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	2.0	109.0	43.0	-0.12	0.017	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	192.0	78.0	-0.058	0.048	1000.0	-1000.0	-0.068	-1000.0
p38 MAPK signaling pathway	2.0	96.0	44.0	-0.152	0.028	1000.0	-1000.0	-0.071	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	49.0	17.0	-0.039	0.022	1000.0	-1000.0	-0.053	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.014	0.021	1000.0	-1000.0	-0.027	-1000.0
Aurora A signaling	1.0	104.0	60.0	-0.128	0.042	1000.0	-1000.0	-0.054	-1000.0
Arf6 downstream pathway	1.0	45.0	43.0	-0.027	0.027	1000.0	-1000.0	-0.038	-1000.0
PLK1 signaling events	1.0	120.0	85.0	-0.031	0.026	1000.0	-1000.0	-0.047	-1000.0
Insulin-mediated glucose transport	1.0	43.0	32.0	-0.141	0.034	1000.0	-1000.0	-0.062	-1000.0
Ceramide signaling pathway	1.0	111.0	76.0	-0.068	0.034	1000.0	-1000.0	-0.069	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	60.0	37.0	-0.054	0.037	1000.0	-1000.0	-0.06	-1000.0
S1P5 pathway	1.0	26.0	17.0	-0.03	0.026	1000.0	-1000.0	-0.045	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	155.0	83.0	-0.141	0.053	1000.0	-1000.0	-0.075	-1000.0
FoxO family signaling	1.0	96.0	64.0	-0.141	0.103	1000.0	-1000.0	-0.073	-1000.0
Atypical NF-kappaB pathway	1.0	38.0	31.0	-0.047	0.027	1000.0	-1000.0	-0.051	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	67.0	45.0	-0.06	0.057	1000.0	-1000.0	-0.095	-1000.0
TCGA08_rtk_signaling	1.0	50.0	26.0	-0.049	0.041	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events	1.0	80.0	73.0	-0.16	0.041	1000.0	-1000.0	-0.079	-1000.0
Insulin Pathway	1.0	124.0	74.0	-0.135	0.039	1000.0	-1000.0	-0.089	-1000.0
Rapid glucocorticoid signaling	1.0	33.0	20.0	-0.044	0.014	1000.0	-1000.0	-0.046	-1000.0
PDGFR-beta signaling pathway	1.0	190.0	97.0	-0.081	0.031	1000.0	-1000.0	-0.079	-1000.0
Signaling events mediated by PRL	1.0	61.0	34.0	-0.059	0.021	1000.0	-1000.0	-0.04	-1000.0
S1P4 pathway	1.0	42.0	25.0	-0.03	0.021	1000.0	-1000.0	-0.054	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.01	0.045	1000.0	-1000.0	-0.07	-1000.0
Canonical NF-kappaB pathway	0.0	22.0	39.0	-0.024	0.079	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class II	0.0	53.0	75.0	-0.051	0.039	1000.0	-1000.0	-0.062	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.011	0.038	1000.0	-1000.0	-0.06	-1000.0
EPO signaling pathway	0.0	32.0	55.0	-0.03	0.079	1000.0	-1000.0	-0.093	-1000.0
mTOR signaling pathway	0.0	37.0	53.0	-0.012	0.033	1000.0	-1000.0	-0.062	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.141	0.052	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	0.0	36.0	49.0	-0.024	0.046	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class I	0.0	81.0	104.0	-0.051	0.042	1000.0	-1000.0	-0.065	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.044	0.043	1000.0	-1000.0	-0.072	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	0.0	0.036	1000.0	-1000.0	-0.055	-1000.0
Arf6 trafficking events	0.0	29.0	71.0	-0.054	0.047	1000.0	-1000.0	-0.074	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.004	0.039	1000.0	-1000.0	-0.048	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	0.0	0.015	1000.0	-1000.0	-0.061	-1000.0
Total	562	35127	7203	-19.3636415681	-994.093084935	131000	-131000	-9.33263543711	-131000