E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.192 -9999.0 0.0 -0.447 16.0 16.0 KLHL20 -0.012 0.1 0.176 2.0 -0.3 2.0 4.0 CYFIP2 0.02 0.057 -9999.0 0.0 -0.501 1.0 1.0 Rac1/GDP -0.031 0.129 -9999.0 0.0 -0.315 10.0 10.0 ENAH -0.071 0.193 -9999.0 0.0 -0.455 16.0 16.0 AP1M1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.01 0.102 -9999.0 0.0 -0.421 2.0 2.0 ABI1/Sra1/Nap1 -0.032 0.056 -9999.0 0.0 -0.201 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.005 0.134 -9999.0 0.0 -0.278 15.0 15.0 RAPGEF1 -0.055 0.174 -9999.0 0.0 -0.416 14.0 14.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.072 0.2 -9999.0 0.0 -0.459 16.0 16.0 CRK -0.064 0.191 -9999.0 0.0 -0.433 16.0 16.0 E-cadherin/gamma catenin/alpha catenin -0.021 0.147 -9999.0 0.0 -0.325 15.0 15.0 alphaE/beta7 Integrin 0.028 0.058 -9999.0 0.0 -0.217 4.0 4.0 IQGAP1 0.021 0.057 -9999.0 0.0 -0.501 1.0 1.0 NCKAP1 0.022 0.057 -9999.0 0.0 -0.501 1.0 1.0 Rap1/GTP/I-afadin 0.039 0.054 -9999.0 0.0 -0.28 2.0 2.0 DLG1 -0.071 0.192 -9999.0 0.0 -0.446 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.022 0.067 -9999.0 0.0 -0.295 2.0 2.0 MLLT4 0.014 0.08 -9999.0 0.0 -0.502 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.039 0.051 -9999.0 0.0 -0.281 1.0 1.0 PI3K -0.025 0.089 -9999.0 0.0 -0.397 2.0 2.0 ARF6 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.043 0.167 -9999.0 0.0 -0.38 16.0 16.0 TIAM1 0.01 0.081 -9999.0 0.0 -0.301 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.003 0.117 -9999.0 0.0 -0.262 13.0 13.0 AKT1 -0.012 0.054 -9999.0 0.0 -0.215 2.0 2.0 PIK3R1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.06 0.196 -9999.0 0.0 -0.501 14.0 14.0 RhoA/GDP -0.022 0.135 0.341 1.0 -0.314 10.0 11.0 actin cytoskeleton organization -0.006 0.075 0.146 2.0 -0.272 1.0 3.0 CDC42/GDP -0.024 0.137 0.341 1.0 -0.314 10.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.035 0.112 -9999.0 0.0 -0.261 15.0 15.0 ITGB7 0.013 0.076 -9999.0 0.0 -0.313 4.0 4.0 RAC1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.004 0.125 -9999.0 0.0 -0.279 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.006 0.111 -9999.0 0.0 -0.261 13.0 13.0 mol:GDP -0.043 0.152 0.352 1.0 -0.368 10.0 11.0 CDC42/GTP/IQGAP1 0.031 0.039 -9999.0 0.0 -0.308 1.0 1.0 JUP 0.008 0.098 -9999.0 0.0 -0.501 3.0 3.0 p120 catenin/RhoA/GDP -0.025 0.138 0.34 1.0 -0.388 4.0 5.0 RAC1/GTP/IQGAP1 0.03 0.039 -9999.0 0.0 -0.308 1.0 1.0 PIP5K1C/AP1M1 0.041 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.075 0.162 3.0 -0.213 5.0 8.0 NME1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.067 0.197 -9999.0 0.0 -0.467 15.0 15.0 regulation of cell-cell adhesion -0.016 0.085 -9999.0 0.0 -0.361 2.0 2.0 WASF2 -0.002 0.041 -9999.0 0.0 -0.142 1.0 1.0 Rap1/GTP -0.01 0.115 -9999.0 0.0 -0.486 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.143 -9999.0 0.0 -0.28 16.0 16.0 CCND1 -0.007 0.09 0.184 3.0 -0.266 5.0 8.0 VAV2 -0.073 0.221 -9999.0 0.0 -0.579 8.0 8.0 RAP1/GDP -0.008 0.128 0.373 1.0 -0.403 3.0 4.0 adherens junction assembly -0.064 0.19 -9999.0 0.0 -0.451 15.0 15.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.006 0.14 -9999.0 0.0 -0.267 16.0 16.0 E-cadherin/beta catenin -0.054 0.141 -9999.0 0.0 -0.342 16.0 16.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.076 0.202 -9999.0 0.0 -0.461 16.0 16.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.072 0.13 -9999.0 0.0 -0.407 5.0 5.0 E-cadherin/beta catenin/alpha catenin -0.009 0.13 -9999.0 0.0 -0.306 13.0 13.0 ITGAE 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.074 0.205 -9999.0 0.0 -0.47 16.0 16.0