Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.108 0.248 -9999.0 0.0 -0.549 17.0 17.0 IHH -0.026 0.086 -9999.0 0.0 -0.225 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.001 0.078 -9999.0 0.0 -0.355 3.0 3.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.077 0.353 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.035 0.15 -9999.0 0.0 -0.509 3.0 3.0 SMO -0.052 0.147 -9999.0 0.0 -0.485 4.0 4.0 AKT1 -0.009 0.106 -9999.0 0.0 -0.376 4.0 4.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.006 0.086 -9999.0 0.0 -0.292 6.0 6.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.149 -9999.0 0.0 -0.477 4.0 4.0 STIL -0.039 0.151 -9999.0 0.0 -0.388 6.0 6.0 DHH N/PTCH2 -0.025 0.127 -9999.0 0.0 -0.236 20.0 20.0 DHH N/PTCH1 -0.066 0.172 -9999.0 0.0 -0.356 18.0 18.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.003 0.118 -9999.0 0.0 -0.418 6.0 6.0 PTHLH -0.125 0.311 -9999.0 0.0 -0.846 11.0 11.0 determination of left/right symmetry -0.045 0.149 -9999.0 0.0 -0.477 4.0 4.0 PIK3R1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.123 0.307 -9999.0 0.0 -0.833 11.0 11.0 IHH N/Hhip -0.153 0.168 -9999.0 0.0 -0.293 45.0 45.0 DHH N/Hhip -0.129 0.185 -9999.0 0.0 -0.278 45.0 45.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.149 -9999.0 0.0 -0.477 4.0 4.0 pancreas development -0.174 0.209 -9999.0 0.0 -0.352 45.0 45.0 HHAT 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.121 -9999.0 0.0 -0.394 7.0 7.0 somite specification -0.045 0.149 -9999.0 0.0 -0.477 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.055 0.136 -9999.0 0.0 -0.301 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.013 0.072 -9999.0 0.0 -0.285 2.0 2.0 SHH Np/Cholesterol/Megalin -0.047 0.133 -9999.0 0.0 -0.293 18.0 18.0 SHH -0.006 0.028 -9999.0 0.0 -0.168 2.0 2.0 catabolic process -0.068 0.169 -9999.0 0.0 -0.37 17.0 17.0 SMO/Vitamin D3 -0.034 0.151 -9999.0 0.0 -0.499 3.0 3.0 SHH Np/Cholesterol/Hhip -0.078 0.126 -9999.0 0.0 -0.275 19.0 19.0 LRP2 -0.097 0.218 -9999.0 0.0 -0.456 22.0 22.0 receptor-mediated endocytosis -0.086 0.172 -9999.0 0.0 -0.424 10.0 10.0 SHH Np/Cholesterol/BOC 0.006 0.054 -9999.0 0.0 -0.285 1.0 1.0 SHH Np/Cholesterol/CDO -0.014 0.105 -9999.0 0.0 -0.314 9.0 9.0 mesenchymal cell differentiation 0.078 0.125 0.274 19.0 -9999.0 0.0 19.0 mol:Vitamin D3 -0.033 0.157 -9999.0 0.0 -0.302 15.0 15.0 IHH N/PTCH2 -0.038 0.118 -9999.0 0.0 -0.25 16.0 16.0 CDON -0.029 0.163 -9999.0 0.0 -0.501 9.0 9.0 IHH N/PTCH1 -0.055 0.177 -9999.0 0.0 -0.372 17.0 17.0 Megalin/LRPAP1 -0.054 0.166 -9999.0 0.0 -0.327 22.0 22.0 PTCH2 -0.032 0.128 -9999.0 0.0 -0.287 16.0 16.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.068 0.17 -9999.0 0.0 -0.371 17.0 17.0 HHIP -0.174 0.209 -9999.0 0.0 -0.353 45.0 45.0