Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.031 0.112 -9999.0 0.0 -0.253 16.0 16.0 epithelial cell differentiation -0.001 0.114 -9999.0 0.0 -0.259 13.0 13.0 CYFIP2 0.02 0.057 -9999.0 0.0 -0.501 1.0 1.0 ENAH -0.026 0.118 0.349 2.0 -0.346 5.0 7.0 EGFR -0.011 0.135 -9999.0 0.0 -0.501 6.0 6.0 EPHA2 0.021 0.057 -9999.0 0.0 -0.501 1.0 1.0 MYO6 -0.014 0.123 0.339 2.0 -0.249 14.0 16.0 CTNNB1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.058 -9999.0 0.0 -0.309 2.0 2.0 AQP5 -0.078 0.175 -9999.0 0.0 -0.476 11.0 11.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.113 0.349 1.0 -0.245 13.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.131 0.337 2.0 -0.264 14.0 16.0 EGF -0.016 0.135 -9999.0 0.0 -0.39 9.0 9.0 NCKAP1 0.022 0.057 -9999.0 0.0 -0.501 1.0 1.0 AQP3 -0.043 0.13 -9999.0 0.0 -0.54 3.0 3.0 cortical microtubule organization -0.001 0.114 -9999.0 0.0 -0.259 13.0 13.0 GO:0000145 -0.027 0.104 0.338 1.0 -0.234 13.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.117 -9999.0 0.0 -0.262 13.0 13.0 MLLT4 0.014 0.08 -9999.0 0.0 -0.501 2.0 2.0 ARF6/GDP -0.052 0.12 -9999.0 0.0 -0.471 5.0 5.0 ARF6 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.099 -9999.0 0.0 -0.329 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.023 0.091 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.014 0.112 0.339 2.0 -0.25 12.0 14.0 ARF6/GTP 0.047 0.096 -9999.0 0.0 -0.307 5.0 5.0 CDH1 -0.06 0.196 -9999.0 0.0 -0.501 14.0 14.0 EGFR/EGFR/EGF/EGF -0.038 0.146 -9999.0 0.0 -0.299 15.0 15.0 RhoA/GDP 0.001 0.11 -9999.0 0.0 -0.246 13.0 13.0 actin cytoskeleton organization -0.018 0.118 0.324 2.0 -0.243 14.0 16.0 IGF-1R heterotetramer -0.001 0.115 -9999.0 0.0 -0.451 5.0 5.0 GIT1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.001 0.115 -9999.0 0.0 -0.451 5.0 5.0 IGF1 -0.026 0.151 -9999.0 0.0 -0.426 10.0 10.0 DIAPH1 -0.005 0.183 -9999.0 0.0 -0.729 3.0 3.0 Wnt receptor signaling pathway 0.001 0.114 0.259 13.0 -9999.0 0.0 13.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.121 -9999.0 0.0 -0.471 5.0 5.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.12 0.326 2.0 -0.248 14.0 16.0 EFNA1 -0.005 0.124 -9999.0 0.0 -0.501 5.0 5.0 LPP -0.023 0.1 -9999.0 0.0 -0.242 10.0 10.0 Ephrin A1/EPHA2 -0.017 0.151 -9999.0 0.0 -0.37 11.0 11.0 SEC6/SEC8 -0.026 0.1 -9999.0 0.0 -0.401 3.0 3.0 MGAT3 -0.031 0.133 0.339 2.0 -0.268 14.0 16.0 HGF/MET -0.073 0.158 -9999.0 0.0 -0.3 22.0 22.0 HGF -0.063 0.166 -9999.0 0.0 -0.334 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.032 0.112 -9999.0 0.0 -0.254 16.0 16.0 actin cable formation 0.023 0.153 0.348 8.0 -0.365 3.0 11.0 KIAA1543 -0.031 0.123 0.329 2.0 -0.254 14.0 16.0 KIFC3 -0.017 0.107 -9999.0 0.0 -0.25 13.0 13.0 NCK1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.12 0.339 2.0 -0.249 13.0 15.0 NCK1/GIT1 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.114 -9999.0 0.0 -0.259 13.0 13.0 EXOC4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.019 0.105 -9999.0 0.0 -0.25 13.0 13.0 PIP5K1C -0.013 0.114 0.352 1.0 -0.249 13.0 14.0 LIMA1 0.01 0.098 -9999.0 0.0 -0.501 3.0 3.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.155 0.413 4.0 -0.411 5.0 9.0 adherens junction assembly -0.014 0.144 0.465 2.0 -0.509 2.0 4.0 IGF-1R heterotetramer/IGF1 -0.041 0.137 -9999.0 0.0 -0.274 19.0 19.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.064 -9999.0 0.0 -0.363 2.0 2.0 MET -0.023 0.154 -9999.0 0.0 -0.501 8.0 8.0 PLEKHA7 -0.018 0.132 0.339 2.0 -0.266 14.0 16.0 mol:GTP 0.038 0.098 -9999.0 0.0 -0.327 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.001 0.136 0.43 3.0 -0.387 3.0 6.0 cortical actin cytoskeleton stabilization -0.031 0.112 -9999.0 0.0 -0.253 16.0 16.0 regulation of cell-cell adhesion -0.018 0.118 0.324 2.0 -0.243 14.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.032 0.112 -9999.0 0.0 -0.254 16.0 16.0