Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.046 -9999.0 0.0 -0.279 6.0 6.0 epithelial cell differentiation -0.008 0.051 -9999.0 0.0 -0.343 6.0 6.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.046 0.044 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.011 0.115 -9999.0 0.0 -0.574 10.0 10.0 EPHA2 0.009 0.041 -9999.0 0.0 -0.652 1.0 1.0 MYO6 0.021 0.074 -9999.0 0.0 -0.438 6.0 6.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.076 0.177 -9999.0 0.0 -0.523 33.0 33.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.023 0.053 -9999.0 0.0 -0.319 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.112 -9999.0 0.0 -0.335 26.0 26.0 EGF -0.07 0.195 -9999.0 0.0 -0.507 41.0 41.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.027 0.101 -9999.0 0.0 -0.49 10.0 10.0 cortical microtubule organization -0.008 0.051 -9999.0 0.0 -0.343 6.0 6.0 GO:0000145 0.022 0.05 -9999.0 0.0 -0.305 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.019 0.056 -9999.0 0.0 -0.347 6.0 6.0 MLLT4 0.006 0.058 -9999.0 0.0 -0.652 2.0 2.0 ARF6/GDP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.035 -9999.0 0.0 -0.367 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.032 0.052 -9999.0 0.0 -0.297 6.0 6.0 PVRL2 0.009 0.041 -9999.0 0.0 -0.652 1.0 1.0 ZYX 0.023 0.053 -9999.0 0.0 -0.324 6.0 6.0 ARF6/GTP 0.03 0.032 -9999.0 0.0 -0.336 2.0 2.0 CDH1 -0.001 0.091 -9999.0 0.0 -0.652 5.0 5.0 EGFR/EGFR/EGF/EGF -0.052 0.11 -9999.0 0.0 -0.323 31.0 31.0 RhoA/GDP -0.007 0.048 -9999.0 0.0 -0.321 6.0 6.0 actin cytoskeleton organization 0.024 0.078 -9999.0 0.0 -0.463 6.0 6.0 IGF-1R heterotetramer -0.014 0.127 -9999.0 0.0 -0.65 10.0 10.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.014 0.127 -9999.0 0.0 -0.652 10.0 10.0 IGF1 -0.017 0.126 -9999.0 0.0 -0.552 13.0 13.0 DIAPH1 -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.008 0.051 0.343 6.0 -9999.0 0.0 6.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.009 0.041 -9999.0 0.0 -0.652 1.0 1.0 VCL 0.024 0.081 -9999.0 0.0 -0.478 6.0 6.0 EFNA1 0.009 0.041 -9999.0 0.0 -0.652 1.0 1.0 LPP 0.027 0.055 -9999.0 0.0 -0.305 7.0 7.0 Ephrin A1/EPHA2 -0.009 0.053 -9999.0 0.0 -0.313 2.0 2.0 SEC6/SEC8 -0.01 0.058 -9999.0 0.0 -0.59 1.0 1.0 MGAT3 -0.007 0.114 -9999.0 0.0 -0.341 26.0 26.0 HGF/MET -0.053 0.132 -9999.0 0.0 -0.576 7.0 7.0 HGF -0.031 0.155 -9999.0 0.0 -0.57 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.046 -9999.0 0.0 -0.281 6.0 6.0 actin cable formation 0.06 0.041 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.02 0.102 -9999.0 0.0 -0.509 8.0 8.0 KIFC3 0.023 0.053 -9999.0 0.0 -0.324 6.0 6.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.023 0.053 -9999.0 0.0 -0.324 6.0 6.0 NCK1/GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.008 0.051 -9999.0 0.0 -0.343 6.0 6.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.023 0.053 -9999.0 0.0 -0.324 6.0 6.0 PIP5K1C 0.023 0.053 -9999.0 0.0 -0.324 6.0 6.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.042 0.049 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.034 0.097 -9999.0 0.0 -0.658 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.032 0.102 -9999.0 0.0 -0.35 22.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.011 0.053 -9999.0 0.0 -0.482 3.0 3.0 MET -0.045 0.182 -9999.0 0.0 -0.609 24.0 24.0 PLEKHA7 0.021 0.068 -9999.0 0.0 -0.373 7.0 7.0 mol:GTP 0.026 0.034 -9999.0 0.0 -0.365 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.04 0.064 -9999.0 0.0 -0.559 1.0 1.0 cortical actin cytoskeleton stabilization 0.019 0.046 -9999.0 0.0 -0.279 6.0 6.0 regulation of cell-cell adhesion 0.024 0.078 -9999.0 0.0 -0.463 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.046 -9999.0 0.0 -0.281 6.0 6.0